| Ernest W Wang, Gregory L Brown, Mechelle M Lewis, Leslie C Jellen, Cunfeng Pu, Melinda L Johnson, Hairong Chen, Lan Kong, Guangwei Du, Xuemei Huan. Susceptibility Magnetic Resonance Imaging Correlates with Glial Density and Tau in the Substantia Nigra Pars Compacta. Movement disorders : official journal of the Movement Disorder Society vol issue 2023 36598274
||susceptibility magnetic resonance imaging correlates with glial density and tau in the substantia nigra pars compacta.
| Biswanath Dinda, Manikarna Dinda, Goutam Kulsi, Ankita Chakraborty, Subhajit Dind. Therapeutic potentials of plant iridoids in Alzheimer's and Parkinson's diseases: A review. European journal of medicinal chemistry vol 169 issue 2019 30877973
||ad is characterized by deposition of extracellular beta-amyloid (a\xce\xb2) proteins and intracellular neurofibrillary tangles (nft), composed of hyperphosphorylated tau proteins in the neurons located particularly in hippocampus and cerebral cortex regions of brain, resulting the neuronal loss, while pd is characterized by deposition of intraneuronal aggregates of mostly composed of alpha-synuclein gene as lewy bodies (lb) in the striatal region, known as substantia nigra pars compacta (snpc) of brain, leading to the death of dopaminergic neurons.
| Sivaraman Purushothuman, Charith Nandasena, Daniel M Johnstone, Jonathan Stone, John Mitrofani. The impact of near-infrared light on dopaminergic cell survival in a transgenic mouse model of parkinsonism. Brain research vol 1535 issue 2014 23998985
||we have examined whether near-infrared light (nir) treatment mitigates oxidative stress and increased expression of hyperphosphorylated tau in a tau transgenic mouse strain (k3) that has a progressive degeneration of dopaminergic cells in the substantia nigra pars compacta (snc).
| Isidro Ferrer, Ana G\\xc3\\xb3mez, Margarita Carmona, Gema Huesa, Silvia Porta, Miquel Riera-Codina, Marta Biagioli, Stefano Gustincich, Ester As. Neuronal hemoglobin is reduced in Alzheimer's disease, argyrophilic grain disease, Parkinson's disease, and dementia with Lewy bodies. Journal of Alzheimer's disease : JAD vol 23 issue 3 2011 21157025
||double labeling immunofluorescence and confocal microscopy revealed reduced hemoglobin \xce\xb1-chain and \xce\xb2-chain in practically all neurons with small amounts of granular or punctuate hyperphosphorylated tau deposits and in neurons with tangles in the hippocampus and frontal cortex in ad and in the hippocampus in agd; in ballooned neurons containing \xce\xb1b-crystallin in the amygdala in ad and agd; and in about 80% of neurons with punctuate \xce\xb1-synuclein deposits and in neurons with lewy bodies in the substantia nigra pars compacta and in vulnerable neurons of the medulla oblongata in pd and dlb; and in neurons with lewy bodies in the frontal cortex in dlb.
| Jos\\xc3\\xa9-F\\xc3\\xa9lix Mart\\xc3\\xad-Mass\\xc3\\xb3, Javier Ruiz-Mart\\xc3\\xadnez, Maria J Bola\\xc3\\xb1o, Irune Ruiz, Ana Gorostidi, Fermin Moreno, Isidre Ferrer, Adolfo L\\xc3\\xb3pez de Munai. Neuropathology of Parkinson's disease with the R1441G mutation in LRRK2. Movement disorders : official journal of the Movement Disorder Society vol 24 issue 13 2010 19735093
||the neuropathological examination disclosed mild neuronal loss in the substantia nigra pars compacta without alpha-synuclein, tau, lrrk2, or ubiquitin cytoplasmic inclusions.
| Gabriel Santpere, Isidre Ferre. LRRK2 and neurodegeneration. Acta neuropathologica vol 117 issue 3 2009 19142648
||neuropathology is characterized by loss of dopaminergic neurons in the substantia nigra pars compacta in all cases with accompanying lewy pathology, or tau pathology or without intraneuronal inclusions, thus indicating that mutations in lrrk2 are not always manifested as lewy body disease (lbd) or as alpha-synucleinopathy.
| Ronald L Klein, Robert D Dayton, Wen-Lang Lin, Dennis W Dickso. Tau gene transfer, but not alpha-synuclein, induces both progressive dopamine neuron degeneration and rotational behavior in the rat. Neurobiology of disease vol 20 issue 1 2005 16137567
||the mutant tau vector caused progressive loss of pars compacta dopaminergic neurons over time, reduced striatal dopamine content, and amphetamine-stimulated rotational behavior consistent with a specific lesion effect.