All Relations between mtor and oligodendrocyte

Publication Sentence Publish Date Extraction Date Species
Huiyang Wang, Yueyang Liu, Zhenkun Guo, Minghui Cui, Peng Pang, Jingyu Yang, Chunfu W. Enhancement of oligodendrocyte autophagy alleviates white matter injury and cognitive impairment induced by chronic cerebral hypoperfusion in rats. Acta pharmaceutica Sinica. B. vol 13. issue 5. 2023-05-30. PMID:37250159. by the 14th day, abnormal accumulation of autophagy substrate, lysosomal dysfunction, and the activation of mechanistic target of rapamycin (mtor) pathway were observed in wm, paralleled with mature oligodendrocyte death. 2023-05-30 2023-08-14 rat
Suzanne M de la Monte, Ming Tong, Busra Delikkay. Differential Early Mechanistic Frontal Lobe Responses to Choline Chloride and Soy Isoflavones in an Experimental Model of Fetal Alcohol Spectrum Disorder. International journal of molecular sciences. vol 24. issue 8. 2023-04-28. PMID:37108779. the expression levels of myelin oligodendrocyte proteins and stress-related molecules were measured by duplex enzyme-linked immunosorbent assays (elisas), and mtor signaling proteins and phosphoproteins were assessed using 11-plex magnetic bead-based elisas. 2023-04-28 2023-08-14 rat
Luipa Khandker, Marisa A Jeffries, Yun-Juan Chang, Marie L Mather, Angelina V Evangelou, Jennifer N Bourne, Azadeh K Tafreshi, Isis M Ornelas, Ozlem Bozdagi-Gunal, Wendy B Macklin, Teresa L Woo. Cholesterol biosynthesis defines oligodendrocyte precursor heterogeneity between brain and spinal cord. Cell reports. vol 38. issue 9. 2022-03-02. PMID:35235799. we further identify the mechanistic target of rapamycin (mtor) as a major regulator promoting cholesterol biosynthesis in oligodendroglia. 2022-03-02 2023-08-13 Not clear
Luipa Khandker, Marisa A Jeffries, Yun-Juan Chang, Marie L Mather, Angelina V Evangelou, Jennifer N Bourne, Azadeh K Tafreshi, Isis M Ornelas, Ozlem Bozdagi-Gunal, Wendy B Macklin, Teresa L Woo. Cholesterol biosynthesis defines oligodendrocyte precursor heterogeneity between brain and spinal cord. Cell reports. vol 38. issue 9. 2022-03-02. PMID:35235799. oligodendroglia-specific loss of mtor decreases cholesterol biosynthesis in both the brain and the spinal cord, but mtor loss in spinal cord oligodendroglia has a greater impact on cholesterol biosynthesis, consistent with more pronounced deficits in developmental myelination. 2022-03-02 2023-08-13 Not clear
Luipa Khandker, Marisa A Jeffries, Yun-Juan Chang, Marie L Mather, Angelina V Evangelou, Jennifer N Bourne, Azadeh K Tafreshi, Isis M Ornelas, Ozlem Bozdagi-Gunal, Wendy B Macklin, Teresa L Woo. Cholesterol biosynthesis defines oligodendrocyte precursor heterogeneity between brain and spinal cord. Cell reports. vol 38. issue 9. 2022-03-02. PMID:35235799. in the brain, mtor loss results in a later adult myelin deficit, including oligodendrocyte death, spontaneous demyelination, and impaired axonal function, demonstrating that mtor is required for myelin maintenance in the adult brain. 2022-03-02 2023-08-13 Not clear
Xiuyun Liu, Chen Dong, Kaiyi Liu, Huiyao Chen, Bo Liu, Xinran Dong, Yanyan Qian, Bingbing Wu, Yifeng Lin, Huijun Wang, Lin Yang, Wenhao Zho. mTOR pathway repressing expression of FoxO3 is a potential mechanism involved in neonatal white matter dysplasia. Human molecular genetics. 2022-02-27. PMID:35220433. depletion of mtor reduced genesis and proliferation of oligodendrocyte progenitor cells (opc) during embryonic stage and reduced myelination in corpus callosum besides cerebellum and spinal cord during early postnatal stages which is related to not only differentiation but also proliferation of oligodendrocyte (ol). 2022-02-27 2023-08-13 Not clear
Marisa A Jeffries, Lauren E McLane, Luipa Khandker, Marie L Mather, Angelina V Evangelou, Divyangi Kantak, Jennifer N Bourne, Wendy B Macklin, Teresa L Woo. mTOR Signaling Regulates Metabolic Function in Oligodendrocyte Precursor Cells and Promotes Efficient Brain Remyelination in the Cuprizone Model. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 40. 2021-11-23. PMID:34417330. mtor signaling regulates metabolic function in oligodendrocyte precursor cells and promotes efficient brain remyelination in the cuprizone model. 2021-11-23 2023-08-13 Not clear
Marisa A Jeffries, Lauren E McLane, Luipa Khandker, Marie L Mather, Angelina V Evangelou, Divyangi Kantak, Jennifer N Bourne, Wendy B Macklin, Teresa L Woo. mTOR Signaling Regulates Metabolic Function in Oligodendrocyte Precursor Cells and Promotes Efficient Brain Remyelination in the Cuprizone Model. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 40. 2021-11-23. PMID:34417330. while the importance of mechanistic target of rapamycin (mtor) signaling during developmental myelination is known, no studies have yet directly examined the function of mtor signaling specifically in the oligodendrocyte (ol) lineage during remyelination. 2021-11-23 2023-08-13 Not clear
Isis M Ornelas, Luipa Khandker, Stacey E Wahl, Hirokazu Hashimoto, Wendy B Macklin, Teresa L Woo. The mechanistic target of rapamycin pathway downregulates bone morphogenetic protein signaling to promote oligodendrocyte differentiation. Glia. vol 68. issue 6. 2021-08-19. PMID:31904150. prior studies have shown that the mechanistic target of rapamycin (mtor) is necessary for proper myelination of the mouse spinal cord and that bone morphogenetic protein (bmp) signaling inhibits oligodendrocyte differentiation, in part by promoting expression of inhibitor of dna binding 2 (id2). 2021-08-19 2023-08-13 mouse
Isis M Ornelas, Luipa Khandker, Stacey E Wahl, Hirokazu Hashimoto, Wendy B Macklin, Teresa L Woo. The mechanistic target of rapamycin pathway downregulates bone morphogenetic protein signaling to promote oligodendrocyte differentiation. Glia. vol 68. issue 6. 2021-08-19. PMID:31904150. here we provide evidence that mtor functions specifically in the transition from early stage opc to immature oligodendrocyte by downregulating bmp signaling during postnatal spinal cord development. 2021-08-19 2023-08-13 mouse
Isis M Ornelas, Luipa Khandker, Stacey E Wahl, Hirokazu Hashimoto, Wendy B Macklin, Teresa L Woo. The mechanistic target of rapamycin pathway downregulates bone morphogenetic protein signaling to promote oligodendrocyte differentiation. Glia. vol 68. issue 6. 2021-08-19. PMID:31904150. when mtor is deleted from the oligodendrocyte lineage, expression of the fk506 binding protein 1a (fkbp12), a suppressor of bmp receptor activity, is reduced, downstream smad activity is increased and id2 expression is elevated. 2021-08-19 2023-08-13 mouse
Isis M Ornelas, Luipa Khandker, Stacey E Wahl, Hirokazu Hashimoto, Wendy B Macklin, Teresa L Woo. The mechanistic target of rapamycin pathway downregulates bone morphogenetic protein signaling to promote oligodendrocyte differentiation. Glia. vol 68. issue 6. 2021-08-19. PMID:31904150. deletion of mtor in oligodendroglia in vivo resulted in fewer late stage opcs and fewer newly formed oligodendrocytes in the spinal cord with no effect on opc proliferation or cell cycle exit. 2021-08-19 2023-08-13 mouse
Isis M Ornelas, Luipa Khandker, Stacey E Wahl, Hirokazu Hashimoto, Wendy B Macklin, Teresa L Woo. The mechanistic target of rapamycin pathway downregulates bone morphogenetic protein signaling to promote oligodendrocyte differentiation. Glia. vol 68. issue 6. 2021-08-19. PMID:31904150. we conclude that mtor promotes early oligodendrocyte differentiation by suppressing bmp signaling in opcs. 2021-08-19 2023-08-13 mouse
Soheila Rezapour-Firouzi, Fatemeh Kheradmand, Shahram Shahabi, Ali Asghar Tehrani, Ebrahim Mazloomi, Adel Mohammadzade. Regulatory effects of hemp seed/evening primrose oil supplement in comparison with rapamycin on the expression of the mammalian target of Research in pharmaceutical sciences. vol 14. issue 1. 2020-10-01. PMID:30936931. eae was induced by using myelin oligodendrocyte glycoprotein peptide and complete freund's adjuvant (cfa) in c57bl/6 mice, total mrna was extracted from local lymph nodes and real-time polymerase chain reaction was used to evaluate the expression level of the rapamycin-insensitive companion of mtor complex 2 ( 2020-10-01 2023-08-13 mouse
Santa Mammana, Placido Bramanti, Emanuela Mazzon, Eugenio Cavalli, Maria Sofia Basile, Paolo Fagone, Maria Cristina Petralia, James Andrew McCubrey, Ferdinando Nicoletti, Katia Mangan. Preclinical evaluation of the PI3K/Akt/mTOR pathway in animal models of multiple sclerosis. Oncotarget. vol 9. issue 9. 2019-11-20. PMID:29492193. in the current study, we have firstly evaluated in silico the involvement of the mtor network on the generation and progression of ms and on oligodendrocyte function, making use of currently available whole-genome transcriptomic data. 2019-11-20 2023-08-13 Not clear
Naomi Tanga, Kazuya Kuboyama, Ayako Kishimoto, Hiroshi Kiyonari, Aki Shiraishi, Ryoko Suzuki, Toshio Watanabe, Akihiro Fujikawa, Masaharu Nod. The PTN-PTPRZ signal activates the AFAP1L2-dependent PI3K-AKT pathway for oligodendrocyte differentiation: Targeted inactivation of PTPRZ activity in mice. Glia. vol 67. issue 5. 2019-07-29. PMID:30667096. the phosphorylation levels of afap1l2, akt, and mtor were higher, and the expression of oligodendrocyte markers, including myelin basic protein (mbp) and myelin regulatory factor (myrf), was stronger in cs knock-in brains than in wild-type brains on postnatal day 10; however, these differences mostly disappeared in the adult stage. 2019-07-29 2023-08-13 mouse
Minqing Jiang, Lei Liu, Xuelian He, Haibo Wang, Wensheng Lin, Huimin Wang, Sung O Yoon, Teresa L Wood, Q Richard L. Regulation of PERK-eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes. Nature communications. vol 7. 2018-09-11. PMID:27416896. tsc1/2 negatively regulate the function of mtor, which is required for oligodendrocyte differentiation. 2018-09-11 2023-08-13 mouse
Minqing Jiang, Lei Liu, Xuelian He, Haibo Wang, Wensheng Lin, Huimin Wang, Sung O Yoon, Teresa L Wood, Q Richard L. Regulation of PERK-eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes. Nature communications. vol 7. 2018-09-11. PMID:27416896. here we report that, unexpectedly, constitutive activation of mtor signalling by tsc1 deletion in the oligodendrocyte lineage results in severe myelination defects and oligodendrocyte cell death in mice, despite an initial increase of oligodendrocyte precursors during early development. 2018-09-11 2023-08-13 mouse
Theresa Scholl, Angelika Mühlebner, Gerda Ricken, Victoria Gruber, Anna Fabing, Sharon Samueli, Gudrun Gröppel, Christian Dorfer, Thomas Czech, Johannes A Hainfellner, Avanita S Prabowo, Roy J Reinten, Lisette Hoogendijk, Jasper J Anink, Eleonora Aronica, Martha Feuch. Impaired oligodendroglial turnover is associated with myelin pathology in focal cortical dysplasia and tuberous sclerosis complex. Brain pathology (Zurich, Switzerland). vol 27. issue 6. 2018-01-26. PMID:27750396. furthermore, myelin deficiency was associated with increased mtor expression and the lower amount of oligodendroglia was linked with their precursor cells (pdgfra). 2018-01-26 2023-08-13 Not clear
Theresa Scholl, Angelika Mühlebner, Gerda Ricken, Victoria Gruber, Anna Fabing, Sharon Samueli, Gudrun Gröppel, Christian Dorfer, Thomas Czech, Johannes A Hainfellner, Avanita S Prabowo, Roy J Reinten, Lisette Hoogendijk, Jasper J Anink, Eleonora Aronica, Martha Feuch. Impaired oligodendroglial turnover is associated with myelin pathology in focal cortical dysplasia and tuberous sclerosis complex. Brain pathology (Zurich, Switzerland). vol 27. issue 6. 2018-01-26. PMID:27750396. decreased content of oligodendroglia and missing precursor cells indicated insufficient oligodendroglial development, probably mediated by mtor, which may ultimately lead to severe myelin loss. 2018-01-26 2023-08-13 Not clear