| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shelby Travaglianti, Ahmed Alotaibi, Woonyen Wong, Magid Abou-Gharbia, Wayne Childers, Youssef Sar. Effects of novel GLT-1 modulator, MC-100093, on neuroinflammatory and neurotrophic biomarkers in mesocorticolimbic brain regions of male alcohol preferring rats exposed chronically to ethanol. Brain research bulletin. 2024-04-03. PMID:38570076. |
chronic ethanol consumption can lead to increased extracellular glutamate concentrations in key reward brain regions, such as medial prefrontal cortex (mpfc) and nucleus accumbens (nac), and consequently leading to oxidative stress and neuroinflammation. |
2024-04-03 |
2024-04-06 |
rat |
| Qiong Luo, Jing Luo, Xixi Wang, Sifei Ga. Restoration of the Activity of the Prefrontal Cortex to the Nucleus Accumbens Core Pathway Relieves Fentanyl-Induced Hyperalgesia in Male Rats. Journal of pain research. vol 17. 2024-03-25. PMID:38524691. |
functional connectivity between the prelimbic medial prefrontal cortex (pl-mpfc) and the core of the nucleus accumbens (nac core) predicts pain chronification. |
2024-03-25 |
2024-03-27 |
rat |
| Tsun Hay Jason Ng, Mohammed H Sarikahya, Roger Hudson, Hanna J Szkudlarek, Enzo Pérez-Valenzuela, Taygun C Uzuneser, Emma Proud, Dana Gummerson, Miray Youssef, Madeline Machado, Kuralay Zhaksylyk, Marieka V DeVuono, Chaochao Chen, Ken K-C Yeung, Walter J Rushlow, Steven R Laviolett. Adolescent nicotine exposure induces long-term, sex-specific disturbances in mood and anxiety-related behavioral, neuronal and molecular phenotypes in the mesocorticolimbic system. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-03-24. PMID:38521861. |
specifically, brain regions such as the medial prefrontal cortex (mpfc), the ventral tegmental area (vta), nucleus accumbens (nac) and hippocampus, are implicated in both nicotine dependence and pathological phenotypes linked to mood and anxiety disorders. |
2024-03-24 |
2024-03-26 |
rat |
| Valeria Lallai, Cristina Congiu, Giulia Craig, Letizia Manca, Yen-Chu Chen, Angeline J Dukes, Christie D Fowler, Laura Dazz. Social isolation postweaning alters reward-related dopamine dynamics in a region-specific manner in adolescent male rats. Neurobiology of stress. vol 30. 2024-03-15. PMID:38486879. |
three weeks later, extracellular dopamine concentrations were examined in the medial prefrontal cortex (mpfc) and nucleus accumbens shell (nac) during a feeding bout. |
2024-03-15 |
2024-03-17 |
human |
| Shen Lin, Cui-Ying Fan, Hao-Ran Wang, Xiao-Fan Li, Jia-Li Zeng, Pei-Xuan Lan, Hui-Xian Li, Bin Zhang, Chun Hu, Junyu Xu, Jian-Hong Lu. Frontostriatal circuit dysfunction leads to cognitive inflexibility in neuroligin-3 R451C knockin mice. Molecular psychiatry. 2024-03-08. PMID:38459194. |
additionally, fiber photometry demonstrated significant disruption in dynamic mesolimbic dopamine (da) signaling for reward prediction errors (rpes), along with reduced activity in medial prefrontal cortex (mpfc) neurons projecting to the nac in ki mice. |
2024-03-08 |
2024-03-11 |
mouse |
| Ioannis Bakoyiannis, Eva Gunnel Ducourneau, Mateo N'diaye, Alice Fermigier, Celine Ducroix-Crepy, Clementine Bosch-Bouju, Etienne Coutureau, Pierre Trifilieff, Guillaume Ferreir. Obesogenic diet induces circuit-specific memory deficits in mice. eLife. vol 13. 2024-03-04. PMID:38436653. |
here, we used an intersectional viral approach in hfd-fed male mice to chemogenetically inactivate specific vhpc efferent pathways to nucleus accumbens (nac) or medial prefrontal cortex (mpfc) during memory tasks. |
2024-03-04 |
2024-03-06 |
mouse |
| Nicholas Pintori, Alessandro Piva, Francesca Mottarlini, Fernando Castillo Díaz, Coralie Maggi, Lucia Caffino, Fabio Fumagalli, Cristiano Chiamuler. Brief exposure to enriched environment rapidly shapes the glutamate synapses in the rat brain: A metaplastic fingerprint. The European journal of neuroscience. 2024-02-20. PMID:38378276. |
adult male sprague-dawley rats were exposed to ee for 22 h and the expression of critical elements of the glutamate synapse was measured 2 h after the end of ee in the medial prefrontal cortex (mpfc), nucleus accumbens (nac) and hippocampus (hipp) brain areas, which are critical for reward and memory. |
2024-02-20 |
2024-02-23 |
rat |
| Cameron J Davidson, John H Hannigan, Shane A Perrine, Scott E Bowe. Abuse-like toluene exposure during early adolescence alters subsequent ethanol and cocaine behavioral effects and brain monoamines in male mice. Neurotoxicology and teratology. 2024-01-10. PMID:38199311. |
analysis of monoamines and their metabolites using high pressure liquid chromatography (hplc) within the medial prefrontal cortex (mpfc), nucleus accumbens (nac), dorsal striatum (dstr), and ventral tegmental area (vta) revealed subtle effects on monoamine or metabolite levels following cumulative dosing that varied by drug (cocaine and ethanol) and abstinence duration. |
2024-01-10 |
2024-01-13 |
mouse |
| Emanuele Claudio Latagliata, Cristina Orsini, Simona Cabib, Francesca Biagioni, Francesco Fornai, Stefano Puglisi-Allegr. Prefrontal Dopamine in Flexible Adaptation to Environmental Changes: A Game for Two Players. Biomedicines. vol 11. issue 12. 2023-12-23. PMID:38137410. |
the reviewed findings point to a role of catecholaminergic transmission in the medial prefrontal cortex (mpfc) in modulating da's availability in the nucleus accumbens (nac), as well as a role of nac da in modulating the motivational value of natural and conditioned stimuli. |
2023-12-23 |
2023-12-25 |
Not clear |
| Ki Bum Um, Soyoung Kwak, Sun-Ha Cheon, JuHyun Kim, Su-Kyeong Hwan. AST-001 Improves Social Deficits and Restores Dopamine Neuron Activity in a Mouse Model of Autism. Biomedicines. vol 11. issue 12. 2023-12-23. PMID:38137504. |
the core symptoms of asd are associated with deficits in mesocorticolimbic dopamine pathways that project from the ventral tegmental area (vta) to the nucleus accumbens (nac) and medial prefrontal cortex (mpfc). |
2023-12-23 |
2023-12-25 |
mouse |
| Bing Huang, Zifei Chen, Fang Huang, Fenfei Gao, Jieling Chen, Peipei Liu, Zhijie Lu, Weiyuan Chen, Jie W. Demyelination in the medial prefrontal cortex by withdrawal from chronic nicotine causes impaired cognitive memory. Progress in neuro-psychopharmacology & biological psychiatry. 2023-11-30. PMID:38036034. |
we found no effect of nicotine withdrawal on the myelination in both of the ventral tegmental area (vta) and nucleus accumbens (nac) regions, but unexpectedly, we observed a demyelination phenomenon in the medial prefrontal cortex (mpfc) after withdrawal from chronic nicotine. |
2023-11-30 |
2023-12-10 |
Not clear |
| Yong-Qing Zhang, Hyun Kyu Min, Eunchong Hong, Eunhye Yu, Sun Mi Gu, Seong Shoon Yoon, Dohyun Lee, Jaejun Lee, Jin Tae Hong, Jaesuk Yu. Abused drug-induced intracranial self-stimulation is correlated with the alteration of dopamine transporter availability in the medial prefrontal cortex and nucleus accumbens of mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 169. 2023-11-10. PMID:37948992. |
we determined dopamine transporter (dat) availability in the medial prefrontal cortex (mpfc), striatum, and nucleus accumbens (nac) after drug treatment. |
2023-11-10 |
2023-11-20 |
mouse |
| Joseph S Lonstein, Erika M Vitale, Doris Olekanma, Andrew McLocklin, Nathan Pence, Remco Bredewold, Alexa H Veenema, Alexander W Johnson, S Alexandra Bur. Anxiety, aggression, reward sensitivity, and forebrain dopamine receptor expression in a laboratory rat model of early-life disadvantage. Developmental psychobiology. vol 65. issue 7. 2023-10-20. PMID:37860907. |
d1 and d2 receptor mrna in the medial prefrontal cortex and nucleus accumbens (nac) were each affected by the early-life treatments and differently between the sexes. |
2023-10-20 |
2023-11-08 |
rat |
| Daniel J Lodge, Hannah B Elam, Angela M Boley, Jennifer J Donega. Discrete hippocampal projections are differentially regulated by parvalbumin and somatostatin interneurons. Nature communications. vol 14. issue 1. 2023-10-20. PMID:37863893. |
these results suggest vhipp interneurons differentially regulate that vhipp neurons that project to the medial prefrontal cortex (mpfc) and nac. |
2023-10-20 |
2023-11-08 |
Not clear |
| Ssu-Ju Li, Yu-Chun Lo, Hsin-Yi Tseng, Sheng-Huang Lin, Chao-Hung Kuo, Ting-Chieh Chen, Ching-Wen Chang, Yao-Wen Liang, Yi-Chen Lin, Chih-Yu Wang, Tsai-Yu Cho, Mu-Hua Wang, Ching-Te Chen, You-Yin Che. Nucleus accumbens deep brain stimulation improves depressive-like behaviors through BDNF-mediated alterations in brain functional connectivity of dopaminergic pathway. Neurobiology of stress. vol 26. 2023-09-04. PMID:37664874. |
concurrent with behavioral amelioration, the csds dbs-on group exhibited enhanced fc in the dopaminergic pathway with increased expression of bdnf- and neun-positive cells increased dopamine d1 receptor, dopamine d2 receptors, and th in the medial prefrontal cortex, nac, ventral hippocampus, ventral tegmental area, and amygdala. |
2023-09-04 |
2023-09-07 |
mouse |
| Giuseppe Tringali, Gianluca Lavanco, Valentina Castelli, Giuseppe Pizzolanti, Martin Kuchar, Diego Currò, Carla Cannizzaro, Anna Brancat. Cannabidiol tempers alcohol intake and neuroendocrine and behavioural correlates in alcohol binge drinking adolescent rats. Focus on calcitonin gene-related peptide's brain levels. Phytotherapy research : PTR. 2023-08-01. PMID:37525534. |
adolescent male rats underwent the intermittent 20% alcohol two-bottle choice paradigm; at the binge day (bd) and the 24 h withdrawal day (wd), we assessed cgrp expression in medial prefrontal cortex (mpfc), nucleus accumbens (nac), amygdala, hypothalamus and brainstem; in addition, we evaluated sucrose preference, social motivation and drive, nociceptive response, and serum corticosterone levels. |
2023-08-01 |
2023-08-14 |
rat |
| Courtney S Wilkinson, Harrison L Blount, Marek Schwendt, Lori A Knacksted. Brain Monoamine Dysfunction in Response to Predator Scent Stress Accompanies Stress-Susceptibility in Female Rats. Biomolecules. vol 13. issue 7. 2023-07-29. PMID:37509091. |
using a predator scent stress (pss) rodent model of ptsd, we sought to determine if stress-susceptible female rats show altered monoamine concentrations in brain regions associated with ptsd: the medial prefrontal cortex (mpfc), nucleus accumbens (nac), and dorsal (dhipp) and ventral (vhipp) hippocampus. |
2023-07-29 |
2023-08-14 |
rat |
| Julie-Anne Balouek, Christabel A Mclain, Adelaide R Minerva, Rebekah L Rashford, Shannon N Bennett, Forrest D Rogers, Catherine Jensen Peñ. Reactivation of early-life stress-sensitive neuronal ensembles contributes to lifelong stress hypersensitivity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-07-10. PMID:37429717. |
we found that in both male and female mice, els-activated neurons within the nucleus accumbens (nac), and to a lesser-extent the medial prefrontal cortex, were preferentially reactivated by adult stress. |
2023-07-10 |
2023-08-14 |
mouse |
| Yuan-Yuan Han, Jian-Wen Zhou, Zhi-Wei Guo, Zhuo-Qing Wu, Zai-Yong Zhang, De-Xiang Liu, Cheng Lon. Multiple brain regions are involved in reaction to acute restraint stress in CYLD-knockout mice. Stress (Amsterdam, Netherlands). vol 26. issue 1. 2023-07-03. PMID:37395260. |
here we report that cyld deficiency leads to an unexpected reaction to ars in mice, and is accompanied by significant neuronal activation of brain regions including the medial prefrontal cortex (mpfc), dorsal striatum (ds), nucleus accumbens (nac), and basal lateral amygdala (bla), but not ventral hippocampus (vhpc). |
2023-07-03 |
2023-08-14 |
mouse |
| Federica Lucantonio, Shuwen Li, Jaden Lu, Jacob Roeglin, Leonardo Bontempi, Brenda C Shields, Carlos A Zarate, Michael R Tadross, Marco Pignatell. Ketamine rescues anhedonia by cell-type and input specific adaptations in the Nucleus Accumbens. bioRxiv : the preprint server for biology. 2023-06-19. PMID:37333325. |
we found that ketamine rescues stress-induced reduction in excitatory strength at medial prefrontal cortex and ventral hippocampus inputs to nac d1-msns. |
2023-06-19 |
2023-08-14 |
mouse |