| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marek Lapka, Chrysostomos Charalambous, Anna Khryakova, Alina Certilina, Jiri Novotny, Lucie Hejnova, Magdalena Sustkova-Fiserov. Ghrelin/GHS-R1A antagonism in memory test and its effects on central molecular signaling involved in addiction in rats. Pharmacology, biochemistry, and behavior vol issue 2023 36870422 |
the present study demonstrated for the first time that acute as well as subchronic (4\xe2\x80\xafdays) administration of the experimental ghs-r1a antagonist jmv2959 in usual intraperitoneal doses including 3\xe2\x80\xafmg/kg, had no influence on memory functions tested in the morris water maze in rats as well as no significant effects on the molecular markers linked with memory processing in selected brain areas in rats, specifically on the \xce\xb2-actin, c-fos, two forms of the calcium/calmodulin-dependent protein kinase ii (camkii, p-camkii) and the camp-response element binding protein (creb, p-creb), within the medial prefrontal cortex (mpfc), nucleus accumbens (nac), dorsal striatum, and hippocampus (hipp). |
2023-03-04 |
2023-03-06 |
rat |
| Chen Yin Ou, Ying Hao Yu, Chi-Wen Wu, Anna Koz\\xc5\\x82owska, Bai-Chung Shyu, Andrew Chih Wei Huan. Neuronal activity of the medial prefrontal cortex, nucleus accumbens, and basolateral amygdala in conditioned taste aversion and conditioned place preference induced by different doses of morphine administrations in rats. Frontiers in pharmacology vol 14 issue 2023 36762112 |
to re-examine the paradoxical effect hypothesis of abused drugs, the present study concerned whether different doses of morphine disparately affect neuronal activity and associations among the subareas of the medial prefrontal cortex (mpfc: cingulate cortex 1-cg1, prelimbic cortex-prl, infralimbic cortex-il), the subregions of the nucleus accumbens (nac; both core and shell), and the basolateral amygdala (bla) following conditioned taste aversion (cta) and conditioned place preference (cpp). |
2023-02-10 |
2023-03-06 |
rat |
| Xiao-Bo Wu, Qian Zhu, Ming-Hui Gao, Sheng-Xiang Yan, Pan-Yang Gu, Peng-Fei Zhang, Meng-Lin Xu, Yong-Jing Ga. Excitatory projections from the prefrontal cortex to nucleus accumbens core D1-MSNs and kappa opioid receptor modulate itch-related scratching behaviors. The Journal of neuroscience : the official journal of the Society for Neuroscience vol issue 2023 36653189 |
excitatory afferents from the medial prefrontal cortex (mpfc), amygdala, and hippocampus are crucial in tuning the activity of dopamine receptor d1- and d2-expressing medium spiny neurons (drd1- and drd2-msns) in the nac. |
2023-01-18 |
2023-01-30 |
mouse |
| Alaa M Hammad, Asma'a Naser, Haneen Amawi, F Scott Hall, Amit K Tiwari, Bahaa Al-Tra. Effect of Amoxicillin/Clavulanic acid in attenuating Pregabalin-induced Condition Place Preference. Behavioural brain research vol issue 2022 36470419 |
moreover, like other drugs of abuse, pregabalin also produced alterations in glutamate homeostasis, reducing the mrna expression of slc1a2 and slc7a11 in the nucleus accumbens (nac) and medial prefrontal cortex (mpfc). |
2022-12-05 |
2023-01-30 |
Not clear |
| Jameel N Hamdan, Jorge A Sierra-Fonseca, Rodolfo J Flores, Sigifredo Saucedo, Manuel Miranda-Arango, Laura E O'Dell, Kristin L Gosselin. Early-life adversity increases anxiety-like behavior and modifies synaptic protein expression in a region-specific manner. Frontiers in behavioral neuroscience vol 16 issue 2022 36338879 |
the hippocampus (hipp), medial prefrontal cortex (mpfc), nucleus accumbens (nac), and caudate putamen (cpu) were isolated from one subgroup of animals and subjected to western blot and protein quantitation for tyrosine hydroxylase (th), \xce\xb1-synuclein (alpha), nmda receptor (nmdar), dopamine receptor-1 (d1) and -2 (d2), dopamine transporter (dat), and postsynaptic density 95 (psd95). |
2022-11-07 |
2023-01-30 |
rat |
| Ezio Carboni, Anna R Cart. BDNF Alterations in Brain Areas and the Neurocircuitry Involved in the Antidepressant Effects of Ketamine in Animal Models, Suggest the Existence of a Primary Circuit of Depression. Journal of integrative neuroscience vol 21 issue 5 2022 36137960 |
in this review we have examined the role of several brain areas: namely, the hippocampus, the medial prefrontal cortex (mpfc), the nucleus accumbens (nac), the lateral habenula (lhb), the amygdala and the bed nucleus of stria terminalis (bnst). |
2022-09-22 |
2023-01-30 |
Not clear |
| Myung Ji Kwak, Wha Young Kim, Seung-Hyun Jung, Yeun-Jun Chung, Jeong-Hoon Ki. Differential transcriptome profile underlying risky choice in a rat gambling task. Journal of behavioral addictions vol issue 2022 36094860 |
in the present study, we examined using next-generation sequencing (ngs) technique whether there are differences in gene expression profiles in the medial prefrontal cortex (mpfc) and the nucleus accumbens (nac) when rats make different choices toward risk in rgt. |
2022-09-12 |
2023-01-30 |
rat |
| Carlos Morgan, Patricio S\\xc3\\xa1ez-Briones, Rafael Barra, Andrea Reyes, Katherine Zepeda-Morales, Luis Constandil, Miguel R\\xc3\\xados, Paulina Ram\\xc3\\xadrez, H\\xc3\\xa9ctor Burgos, Alejandro Hern\\xc3\\xa1nde. Prefrontal Cortical Control of Activity in Nucleus Accumbens Core Is Weakened by High-Fat Diet and Prevented by Co-Treatment with N-Acetylcysteine: Implications for the Development of Obesity. International journal of molecular sciences vol 23 issue 17 2022 36077493 |
a loss of neuroplastic control on nucleus accumbens (nac) neuronal activity exerted by the medial prefrontal cortex (mpfc) through long-term depression (ltd) is involved in triggering drug-seeking behavior and relapse on several substances of abuse due to impaired glutamate homeostasis in tripartite synapses of the nucleus accumbens (nac) core. |
2022-09-09 |
2023-01-30 |
mouse |
| Yvonne S Yang, Richard J Maddock, Huailin Zhang, Junghee Lee, Gerhard Hellemann, Stephen R Marder, Michael F Gree. N-Acetylcysteine effects on glutathione and glutamate in schizophrenia: A preliminary MRS study. Psychiatry research. Neuroimaging vol 325 issue 2022 35839558 |
we found that nac treatment was associated with increased glutathione (statistically significant) and decreased glutamate (trend-level) compared with placebo in medial prefrontal cortex but not dorsolateral prefrontal cortex. |
2022-07-15 |
2023-01-30 |
Not clear |
| Tong Zhang, Naoya Nishitani, Kazuhei Niitani, Ryoma Nishida, Yusaku Futami, Satoshi Deyama, Katsuyuki Kaned. A spatiotemporal increase of neuronal activity accompanies the motivational effect of wheel running in mice. Behavioural brain research vol issue 2022 35777550 |
immunohistochemical analyses revealed that the number of c-fos (a neuronal activity marker)-positive cells increased in the medial prefrontal cortex (mpfc), core and shell of the nucleus accumbens (nac), dorsal striatum (str), and lateral septum (ls) at day 1, day 9, and days 20-24, in a time-dependent manner. |
2022-07-01 |
2023-01-27 |
mouse |
| Sophia C Levis, Matthew T Birnie, Jessica L Bolton, Christina R Perrone, Johanna S Montesinos, Tallie Z Baram, Stephen V Mahle. Enduring disruption of reward and stress circuit activities by early-life adversity in male rats. Translational psychiatry vol 12 issue 1 2022 35705547 |
we probe potential circuit mechanisms in males by assessing opioid-associated neuronal activation in stress and reward circuit nodes including nucleus accumbens (nac), amygdala, medial prefrontal cortex (mpfc), and paraventricular thalamus. |
2022-06-15 |
2023-01-27 |
rat |
| Cai-N Cheng, Shaw-Jye Wu, Andrew Chih Wei Huan. Environmental Enrichment Components Required to Reduce Methamphetamine-Induced Behavioral Sensitization in Mice: Examination of Behaviors and Neural Substrates. Journal of clinical medicine vol 11 issue 11 2022 35683439 |
the c-fos expression analysis showed that the medial prefrontal cortex (i.e., cingulate cortex 1 (cg1), prelimbic cortex (prl), and infralimbic cortex (il)), nucleus accumbens (nac), basolateral amygdala (bla), ventral tegmental area (vta), caudate-putamen (cpu), and hippocampus (i.e., ca1, ca3, and dentate gyrus (dg)) contributed to mamph-induced behavioral sensitization. |
2022-06-10 |
2023-01-27 |
mouse |
| Xiayun Wan, Akifumi Eguchi, Youge Qu, Yong Yang, Lijia Chang, Jiajing Shan, Chisato Mori, Kenji Hashimot. Gut-microbiota-brain axis in the vulnerability to psychosis in adulthood after repeated cannabis exposure during adolescence. European archives of psychiatry and clinical neuroscience vol issue 2022 35666299 |
repeated administration of win55,212-2 (2\xc2\xa0mg/kg/day) during adolescence (p35-p45) significantly increased the expression of iba1 (ionized calcium-binding adapter molecule 1) in the medial prefrontal cortex (mpfc) and nucleus accumbens (nac) of adult mice after administration of lipopolysaccharide (lps: 0.5\xc2\xa0mg/kg). |
2022-06-06 |
2023-01-27 |
mouse |
| Tomoyuki Ijiro, Atsushi Yaguchi, Ayaka Yokoyama, Sumiyoshi Kiguch. Rovatirelin ameliorates motor dysfunction in the cytosine arabinoside-induced rat model of spinocerebellar degeneration via acetylcholine and dopamine neurotransmission. Clinical and experimental pharmacology & physiology vol issue 2022 35637550 |
moreover, rovatirelin significantly increased acetylcholine (ach) levels in the medial prefrontal cortex (mpfc) and dopamine (da) levels in the nucleus accumbens (nac) at \xe2\x89\xa53 mg/kg and significantly increased da levels in the dorsal striatum at \xe2\x89\xa510 mg/kg in normal rats. |
2022-05-31 |
2023-01-27 |
rat |
| Kerri D Pryce, Aarthi Ramakrishnan, Hope Kronnman, Andrew Nicolais, Claire Polizu, Anne Ruiz, Randal Serafini, Sevasti Gaspari, Catherine J Pena, Angelica Torres-Berrio, Vassiliki Mitsi, Matthew Darpe, L I Shen, Eric J Nestler, Venetia Zachario. A novel HDAC1/2 inhibitor alleviates physical and emotional symptoms associated with spontaneous oxycodone withdrawal in neuropathic pain mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology vol 36 Suppl 1 issue 2022 35552957 |
rna-sequencing (rna-seq) and bioinformatic analyses revealed that oxycodone withdrawal alone triggers robust gene expression adaptations in the nucleus accumbens (nac), medial prefrontal cortex (mpfc), and ventral tegmental area (vta), with numerous genes and pathways selectively affected by oxycodone withdrawal under peripheral nerve injury states. |
2022-05-13 |
2023-01-27 |
mouse |
| Yanmei Chen, Xuebing Wang, Mei Xiao, Na Kang, Wanli Zeng, Jichuan Zhan. Prenatal morphine exposure increases gamma oscillation and theta coherence in the rat reward system. Neurotoxicology vol issue 2022 35461814 |
we recorded local field potentials (lfp) simultaneously in the vta, nac (nucleus accumbens), bla (basolateral amygdala) and mpfc (medial prefrontal cortex) in male adult rats prenatally treated with saline or morphine. |
2022-04-24 |
2023-01-27 |
rat |
| Laurie Hamel, Bilgehan Cavdaroglu, Dylan Yeates, David Nguyen, Sadia Riaz, Dylan Patterson, Nisma Khan, Nardin Kirolos, Katherine Roper, Quynh An Ha, Rutsuko It. Cortico-striatal control over adaptive goal-directed responding elicited by cues signaling sucrose reward or punishment. The Journal of neuroscience : the official journal of the Society for Neuroscience vol issue 2022 35351827 |
the medial prefrontal cortex (mpfc) and nucleus accumbens (nac) have been associated with the expression of adaptive and maladaptive behavior elicited by fear-related and drug-associated cues. |
2022-03-30 |
2023-01-27 |
Not clear |
| Michaela R Breach, Courtney N Dye, Anabel Galan, Kathryn M Len. Prenatal allergic inflammation in rats programs the developmental trajectory of dendritic spine patterning in brain regions associated with cognitive and social behavior. Brain, behavior, and immunity vol issue 2022 35245680 |
mean dendritic spine density was calculated for neurons in brain regions associated with cognition and social behavior, including the medial prefrontal cortex (mpfc), basal ganglia, septum, nucleus accumbens (nac), and amygdala. |
2022-03-04 |
2023-01-27 |
rat |
| Rodolpho Pereira de Oliveira, Jos\\xc3\\xa9 Sim\\xc3\\xb5es de Andrade, Marianna Spina, Jo\\xc3\\xa3o V\\xc3\\xadtor Chamon, Paulo Henrique Dias Silva, Ana Keyla Werder, Daniela Ortolani, Lucas de Santana Cardoso Thomaz, Simone Romariz, Daniel Araki Ribeiro, Beatriz Monteiro Longo, Regina C\\xc3\\xa9lia Spadari, Milena de Barros Viana, Liana Melo-Thomas, Isabel Cristina C\\xc3\\xa9spedes, Regina Cl\\xc3\\xa1udia Barbosa da Silv. Clozapine prevented social interaction deficits and reduced c-Fos immunoreactivity expression in several brain areas of rats exposed to acute restraint stress. PloS one vol 17 issue 3 2022 35239670 |
in the present study, we evaluate the effect of acute restraint stress (15 min) of male wistar rats on social interaction measurements and c-fos immunoreactivity (c-fos-ir) expression, a marker of neuronal activity, in areas involved with the modulation of acute physical restraint in rats, i.e., the paraventricular nucleus of the hypothalamus (pvn), median raphe nucleus (mnr), medial prefrontal cortex (mpfc), cingulate prefrontal cortex (cpfc), nucleus accumbens (nac), hippocampus (ca3), lateral septum (ls) and medial amygdala (mea). |
2022-03-03 |
2023-01-27 |
rat |
| Matthew J Muelbl, Breanna L Glaeser, Alok S Shah, Rachel A Chiariello, Natalie N Nawarawong, Brian D Stemper, Matthew D Budde, Christopher M Olse. Repeated blast mild traumatic brain injury and oxycodone self-administration produce interactive effects on neuroimaging outcomes. Addiction biology vol 27 issue 2 2022 35229952 |
we found interactive effects of rbtbi and oxycodone on fractional anisotropy (fa) in the nucleus accumbens (nac) and that fa in the medial prefrontal cortex (mpfc) was correlated with drug seeking. |
2022-03-01 |
2023-01-27 |
rat |