All Relations between nac and medial prefrontal cortex

Publication Sentence Publish Date Extraction Date Species
Wei-Zhu Liu, Chun-Yan Wang, Yu Wang, Mei-Ting Cai, Wei-Xiang Zhong, Tian Liu, Zhi-Hao Wang, Han-Qing Pan, Wen-Hua Zhang, Bing-Xing Pa. Circuit- and laminar-specific regulation of medial prefrontal neurons by chronic stress. Cell & bioscience. vol 13. issue 1. 2023-05-19. PMID:37208769. the medial prefrontal cortex (mpfc) is a hub for controlling stress responses through communicating with multiple limbic structures, including the basolateral amygdala (bla) and nucleus accumbens (nac). 2023-05-19 2023-08-14 Not clear
F Javier Rubio, Daniel E Olivares, Christopher Dunn, Shiliang Zhang, Elias M Hilaire, Akeem Henry, Carlos Mejias-Aponte, Carlos J Nogueras-Ortiz, Pooja V Selvam, Fabio C Cruz, Rajtarun Madangopal, Marisela Morales, Bruce T Hop. Flow cytometry of synaptoneurosomes (FCS) reveals increased ribosomal S6 and calcineurin proteins in activated medial prefrontal cortex to nucleus accumbens synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-05-09. PMID:37160369. after injecting yfp-expressing aav into medial prefrontal cortex (mpfc) to label terminals in nucleus accumbens (nac) of rats, we injected 20 mg/kg of cocaine in a novel context (cocaine+novelty) to activate synapses, and prepared nac synaptoneurosomes 0-60 min following injections. 2023-05-09 2023-08-14 rat
Marek Lapka, Chrysostomos Charalambous, Anna Khryakova, Alina Certilina, Jiri Novotny, Lucie Hejnova, Magdalena Sustkova-Fiserov. Ghrelin/GHS-R1A antagonism in memory test and its effects on central molecular signaling involved in addiction in rats. Pharmacology, biochemistry, and behavior. 2023-03-04. PMID:36870422. the present study demonstrated for the first time that acute as well as subchronic (4 days) administration of the experimental ghs-r1a antagonist jmv2959 in usual intraperitoneal doses including 3 mg/kg, had no influence on memory functions tested in the morris water maze in rats as well as no significant effects on the molecular markers linked with memory processing in selected brain areas in rats, specifically on the β-actin, c-fos, two forms of the calcium/calmodulin-dependent protein kinase ii (camkii, p-camkii) and the camp-response element binding protein (creb, p-creb), within the medial prefrontal cortex (mpfc), nucleus accumbens (nac), dorsal striatum, and hippocampus (hipp). 2023-03-04 2023-08-14 rat
Chen Yin Ou, Ying Hao Yu, Chi-Wen Wu, Anna Kozłowska, Bai-Chung Shyu, Andrew Chih Wei Huan. Neuronal activity of the medial prefrontal cortex, nucleus accumbens, and basolateral amygdala in conditioned taste aversion and conditioned place preference induced by different doses of morphine administrations in rats. Frontiers in pharmacology. vol 14. 2023-02-10. PMID:36762112. to re-examine the paradoxical effect hypothesis of abused drugs, the present study concerned whether different doses of morphine disparately affect neuronal activity and associations among the subareas of the medial prefrontal cortex (mpfc: cingulate cortex 1-cg1, prelimbic cortex-prl, infralimbic cortex-il), the subregions of the nucleus accumbens (nac; both core and shell), and the basolateral amygdala (bla) following conditioned taste aversion (cta) and conditioned place preference (cpp). 2023-02-10 2023-08-14 rat
Xiao-Bo Wu, Qian Zhu, Ming-Hui Gao, Sheng-Xiang Yan, Pan-Yang Gu, Peng-Fei Zhang, Meng-Lin Xu, Yong-Jing Ga. Excitatory projections from the prefrontal cortex to nucleus accumbens core D1-MSNs and kappa opioid receptor modulate itch-related scratching behaviors. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-01-18. PMID:36653189. excitatory afferents from the medial prefrontal cortex (mpfc), amygdala, and hippocampus are crucial in tuning the activity of dopamine receptor d1- and d2-expressing medium spiny neurons (drd1- and drd2-msns) in the nac. 2023-01-18 2023-08-14 mouse
Alaa M Hammad, Asma'a Naser, Haneen Amawi, F Scott Hall, Amit K Tiwari, Bahaa Al-Tra. Effect of Amoxicillin/Clavulanic acid in attenuating Pregabalin-induced Condition Place Preference. Behavioural brain research. 2022-12-05. PMID:36470419. moreover, like other drugs of abuse, pregabalin also produced alterations in glutamate homeostasis, reducing the mrna expression of slc1a2 and slc7a11 in the nucleus accumbens (nac) and medial prefrontal cortex (mpfc). 2022-12-05 2023-08-14 Not clear
Jameel N Hamdan, Jorge A Sierra-Fonseca, Rodolfo J Flores, Sigifredo Saucedo, Manuel Miranda-Arango, Laura E O'Dell, Kristin L Gosselin. Early-life adversity increases anxiety-like behavior and modifies synaptic protein expression in a region-specific manner. Frontiers in behavioral neuroscience. vol 16. 2022-11-07. PMID:36338879. the hippocampus (hipp), medial prefrontal cortex (mpfc), nucleus accumbens (nac), and caudate putamen (cpu) were isolated from one subgroup of animals and subjected to western blot and protein quantitation for tyrosine hydroxylase (th), α-synuclein (alpha), nmda receptor (nmdar), dopamine receptor-1 (d1) and -2 (d2), dopamine transporter (dat), and postsynaptic density 95 (psd95). 2022-11-07 2023-08-14 rat
Ezio Carboni, Anna R Cart. BDNF Alterations in Brain Areas and the Neurocircuitry Involved in the Antidepressant Effects of Ketamine in Animal Models, Suggest the Existence of a Primary Circuit of Depression. Journal of integrative neuroscience. vol 21. issue 5. 2022-09-22. PMID:36137960. in this review we have examined the role of several brain areas: namely, the hippocampus, the medial prefrontal cortex (mpfc), the nucleus accumbens (nac), the lateral habenula (lhb), the amygdala and the bed nucleus of stria terminalis (bnst). 2022-09-22 2023-08-14 Not clear
Myung Ji Kwak, Wha Young Kim, Seung-Hyun Jung, Yeun-Jun Chung, Jeong-Hoon Ki. Differential transcriptome profile underlying risky choice in a rat gambling task. Journal of behavioral addictions. 2022-09-12. PMID:36094860. in the present study, we examined using next-generation sequencing (ngs) technique whether there are differences in gene expression profiles in the medial prefrontal cortex (mpfc) and the nucleus accumbens (nac) when rats make different choices toward risk in rgt. 2022-09-12 2023-08-14 rat
Carlos Morgan, Patricio Sáez-Briones, Rafael Barra, Andrea Reyes, Katherine Zepeda-Morales, Luis Constandil, Miguel Ríos, Paulina Ramírez, Héctor Burgos, Alejandro Hernánde. Prefrontal Cortical Control of Activity in Nucleus Accumbens Core Is Weakened by High-Fat Diet and Prevented by Co-Treatment with N-Acetylcysteine: Implications for the Development of Obesity. International journal of molecular sciences. vol 23. issue 17. 2022-09-09. PMID:36077493. a loss of neuroplastic control on nucleus accumbens (nac) neuronal activity exerted by the medial prefrontal cortex (mpfc) through long-term depression (ltd) is involved in triggering drug-seeking behavior and relapse on several substances of abuse due to impaired glutamate homeostasis in tripartite synapses of the nucleus accumbens (nac) core. 2022-09-09 2023-08-14 mouse
Yvonne S Yang, Richard J Maddock, Huailin Zhang, Junghee Lee, Gerhard Hellemann, Stephen R Marder, Michael F Gree. N-Acetylcysteine effects on glutathione and glutamate in schizophrenia: A preliminary MRS study. Psychiatry research. Neuroimaging. vol 325. 2022-07-15. PMID:35839558. we found that nac treatment was associated with increased glutathione (statistically significant) and decreased glutamate (trend-level) compared with placebo in medial prefrontal cortex but not dorsolateral prefrontal cortex. 2022-07-15 2023-08-14 Not clear
Tong Zhang, Naoya Nishitani, Kazuhei Niitani, Ryoma Nishida, Yusaku Futami, Satoshi Deyama, Katsuyuki Kaned. A spatiotemporal increase of neuronal activity accompanies the motivational effect of wheel running in mice. Behavioural brain research. 2022-07-01. PMID:35777550. immunohistochemical analyses revealed that the number of c-fos (a neuronal activity marker)-positive cells increased in the medial prefrontal cortex (mpfc), core and shell of the nucleus accumbens (nac), dorsal striatum (str), and lateral septum (ls) at day 1, day 9, and days 20-24, in a time-dependent manner. 2022-07-01 2023-08-14 mouse
Sophia C Levis, Matthew T Birnie, Jessica L Bolton, Christina R Perrone, Johanna S Montesinos, Tallie Z Baram, Stephen V Mahle. Enduring disruption of reward and stress circuit activities by early-life adversity in male rats. Translational psychiatry. vol 12. issue 1. 2022-06-15. PMID:35705547. we probe potential circuit mechanisms in males by assessing opioid-associated neuronal activation in stress and reward circuit nodes including nucleus accumbens (nac), amygdala, medial prefrontal cortex (mpfc), and paraventricular thalamus. 2022-06-15 2023-08-14 rat
Cai-N Cheng, Shaw-Jye Wu, Andrew Chih Wei Huan. Environmental Enrichment Components Required to Reduce Methamphetamine-Induced Behavioral Sensitization in Mice: Examination of Behaviors and Neural Substrates. Journal of clinical medicine. vol 11. issue 11. 2022-06-10. PMID:35683439. the c-fos expression analysis showed that the medial prefrontal cortex (i.e., cingulate cortex 1 (cg1), prelimbic cortex (prl), and infralimbic cortex (il)), nucleus accumbens (nac), basolateral amygdala (bla), ventral tegmental area (vta), caudate-putamen (cpu), and hippocampus (i.e., ca1, ca3, and dentate gyrus (dg)) contributed to mamph-induced behavioral sensitization. 2022-06-10 2023-08-14 mouse
Xiayun Wan, Akifumi Eguchi, Youge Qu, Yong Yang, Lijia Chang, Jiajing Shan, Chisato Mori, Kenji Hashimot. Gut-microbiota-brain axis in the vulnerability to psychosis in adulthood after repeated cannabis exposure during adolescence. European archives of psychiatry and clinical neuroscience. 2022-06-06. PMID:35666299. repeated administration of win55,212-2 (2 mg/kg/day) during adolescence (p35-p45) significantly increased the expression of iba1 (ionized calcium-binding adapter molecule 1) in the medial prefrontal cortex (mpfc) and nucleus accumbens (nac) of adult mice after administration of lipopolysaccharide (lps: 0.5 mg/kg). 2022-06-06 2023-08-14 mouse
Tomoyuki Ijiro, Atsushi Yaguchi, Ayaka Yokoyama, Sumiyoshi Kiguch. Rovatirelin ameliorates motor dysfunction in the cytosine arabinoside-induced rat model of spinocerebellar degeneration via acetylcholine and dopamine neurotransmission. Clinical and experimental pharmacology & physiology. 2022-05-31. PMID:35637550. moreover, rovatirelin significantly increased acetylcholine (ach) levels in the medial prefrontal cortex (mpfc) and dopamine (da) levels in the nucleus accumbens (nac) at ≥3 mg/kg and significantly increased da levels in the dorsal striatum at ≥10 mg/kg in normal rats. 2022-05-31 2023-08-13 mouse
Kerri D Pryce, Aarthi Ramakrishnan, Hope Kronnman, Andrew Nicolais, Claire Polizu, Anne Ruiz, Randal Serafini, Sevasti Gaspari, Catherine J Pena, Angelica Torres-Berrio, Vassiliki Mitsi, Matthew Darpe, L I Shen, Eric J Nestler, Venetia Zachario. A novel HDAC1/2 inhibitor alleviates physical and emotional symptoms associated with spontaneous oxycodone withdrawal in neuropathic pain mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35552957. rna-sequencing (rna-seq) and bioinformatic analyses revealed that oxycodone withdrawal alone triggers robust gene expression adaptations in the nucleus accumbens (nac), medial prefrontal cortex (mpfc), and ventral tegmental area (vta), with numerous genes and pathways selectively affected by oxycodone withdrawal under peripheral nerve injury states. 2022-05-13 2023-08-13 mouse
Yanmei Chen, Xuebing Wang, Mei Xiao, Na Kang, Wanli Zeng, Jichuan Zhan. Prenatal morphine exposure increases gamma oscillation and theta coherence in the rat reward system. Neurotoxicology. 2022-04-24. PMID:35461814. we recorded local field potentials (lfp) simultaneously in the vta, nac (nucleus accumbens), bla (basolateral amygdala) and mpfc (medial prefrontal cortex) in male adult rats prenatally treated with saline or morphine. 2022-04-24 2023-08-13 rat
Laurie Hamel, Bilgehan Cavdaroglu, Dylan Yeates, David Nguyen, Sadia Riaz, Dylan Patterson, Nisma Khan, Nardin Kirolos, Katherine Roper, Quynh An Ha, Rutsuko It. Cortico-striatal control over adaptive goal-directed responding elicited by cues signaling sucrose reward or punishment. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-03-30. PMID:35351827. the medial prefrontal cortex (mpfc) and nucleus accumbens (nac) have been associated with the expression of adaptive and maladaptive behavior elicited by fear-related and drug-associated cues. 2022-03-30 2023-08-13 Not clear
Michaela R Breach, Courtney N Dye, Anabel Galan, Kathryn M Len. Prenatal allergic inflammation in rats programs the developmental trajectory of dendritic spine patterning in brain regions associated with cognitive and social behavior. Brain, behavior, and immunity. 2022-03-04. PMID:35245680. mean dendritic spine density was calculated for neurons in brain regions associated with cognition and social behavior, including the medial prefrontal cortex (mpfc), basal ganglia, septum, nucleus accumbens (nac), and amygdala. 2022-03-04 2023-08-13 rat