| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mojtaba Moradi, Mohammad Arshia Hashemian, Azita Faramarzi, Nader Goodarzi, Amir Hossein Hashemian, Hadi Cheraghi, Cyrus Jalil. Therapeutic effect of sodium alginate on bleomycin, etoposide and cisplatin (BEP)-induced reproductive toxicity by inhibiting nitro-oxidative stress, inflammation and apoptosis. Scientific reports. vol 14. issue 1. 2024-01-18. PMID:38238398. |
then, sperm parameters, testosterone levels, testicular histopathology and stereological parameters, testicular levels of malondialdehyde (mda), nitric oxide (no), and total antioxidant capacity (tac), and the expression of apoptosis-associated genes including bcl2, bax, caspase3, p53, and tnf-α were evaluated. |
2024-01-18 |
2024-01-21 |
rat |
| Zhen Yang, Han Li, Dan Yan, Pengcheng Luo, Yuqi Guan, Mandi Luo, Hao Nie, Yi Huang, Le Zhang, Lei Ruan, Jinhua Yan, Cuntai Zhan. Counteracting age-related Netrin-1 signaling insufficiency ameliorates endothelial cell senescence and angiogenesis impairment. The journals of gerontology. Series A, Biological sciences and medical sciences. 2023-08-10. PMID:37561046. |
furthermore, we revealed that low-dose netrin-1 recombinant protein significantly reduced sa-β-gal-positive cells, inhibited the p53 pathway, promoted cell migration, increased tubule formation, and elevated nitric oxide production in senescent endothelial cells. |
2023-08-10 |
2023-08-16 |
mouse |
| Anjali Suman, Archisman Mahapatra, Priya Gupta, Shubhendu Shekhar Ray, Rahul Kumar Sing. Polystyrene microplastics modulated bdnf expression triggering neurotoxicity via apoptotic pathway in zebrafish embryos. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2023-07-16. PMID:37454885. |
on the last day of exposure, behaviour, accumulation, embryotoxicity, acridine orange staining, antioxidant enzyme assay, acetylcholinesterase assay, nitric oxide (no) estimation, along with neurotransmitter (serotonin, dopamine) quantification and gene expression using qrt-pcr (bdnf, p53, bcl-2, caspase-3, caspase-9) were performed. |
2023-07-16 |
2023-08-14 |
human |
| Paulina Sobierajska, Benita Wiatrak, Paulina Jawien, Maciej Janeczek, Katarzyna Wiglusz, Adam Szeląg, Rafal J Wiglus. Imatinib-Functionalized Galactose Hydrogels Loaded with Nanohydroxyapatite as a Drug Delivery System for Osteosarcoma: In Vitro Studies. ACS omega. vol 8. issue 20. 2023-05-30. PMID:37251195. |
this study reports an impact of structure (xrpd, ft-ir) and surface morphology (sem-eds) of imatinib-functionalized galactose hydrogels, loaded and unloaded with nhap, on osteosarcoma cell (saos-2 and u-2os) viability, levels of free oxygen radicals, and nitric oxide, levels of bcl-2, p53, and caspase 3 and 9, as well as glycoprotein-p activity. |
2023-05-30 |
2023-08-14 |
Not clear |
| Titilope M Dokunmu, Sandra C Opara, Ngozi Awa Imaga, Omiete U Awani, David O Enoma, Bababode I Adelan. P53 Gene Expression and Nitric Oxide Levels after Artemisinin-Caffeine Treatment in Breast, Lungs and Liver of DMBA-Induced Tumorigenesis. Asian Pacific journal of cancer prevention : APJCP. vol 24. issue 2. 2023-02-28. PMID:36853292. |
p53 gene expression and nitric oxide levels after artemisinin-caffeine treatment in breast, lungs and liver of dmba-induced tumorigenesis. |
2023-02-28 |
2023-08-14 |
rat |
| Robert Y S Cheng, Sandra Burkett, Stefan Ambs, Terry Moody, David A Wink, Lisa A Ridnou. Chronic Exposure to Nitric Oxide Induces P53 Mutations and Malignant-like Features in Human Breast Epithelial Cells. Biomolecules. vol 13. issue 2. 2023-02-25. PMID:36830680. |
chronic exposure to nitric oxide induces p53 mutations and malignant-like features in human breast epithelial cells. |
2023-02-25 |
2023-08-14 |
human |
| Yanting Cui, Nannan Zhao, Cong Wang, Jinnan Long, Yigeng Chen, Zhitong Deng, Zhihao Zhang, Ruiyang Zhao, Jinfeng Sun, Zhongkai Wang, Fei Liu, Kefeng Xu, Renjie Wang, Yuquan L. Acute ammonia stress-induced oxidative and heat shock responses modulated by transcription factors in Litopenaeus vannamei. Fish & shellfish immunology. 2022-08-02. PMID:35917888. |
the hepatopancreas was sampled to measure the levels of glutathione (gsh), malondialdehyde (mda), nitric oxide (no); the activities of superoxide dismutase (sod), catalase (cat), nitric oxide synthase (nos); and the expression levels of gsh-px (encoding glutathione peroxidase), gst (encoding glutathione-s-transferase), hsp70 (encoding heat shock protein 70), hsp90 (encoding heat shock protein 90), p53, relish, and akirin. |
2022-08-02 |
2023-08-14 |
cat |
| Jianhong Shi, Ruizhi Li, Yuanxiao Yang, Liting Ji, Changyu L. Protective effect of α-asarone and β-asarone on Aβ -induced inflammatory response in PC12 cells and its. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. vol 50. issue 5. 2022-01-05. PMID:34986541. |
the levels of inflammatory cytokines interleukin (il)-1, , tumor necrosis factor (tnf)-α, oxidation-related inducible nitric oxide synthase (inos), nitric oxide (no), apoptosis factors caspase-3 and p53 were detected by elisa method. |
2022-01-05 |
2023-08-13 |
Not clear |
| Hebatallah A Mahgoub, Mohamed A M El-Adl, Christopher J Martyniu. Fucoidan ameliorates acute and sub-chronic in vivo toxicity of the fungicide cholorothalonil in Oreochromis niloticus (Nile tilapia). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 245. 2021-08-31. PMID:33774206. |
survival analysis was performed, together with assessment of histopathology, oxidative stress (i.e., antioxidant status, hydrogen peroxide levels, malondialdehyde and nitric oxide levels) and immunohistochemistry to measure indicators of hepatic damage (i.e., caspase 3, p53, mini-chromosome maintenance proteins (mcm), and glutathione peroxidase). |
2021-08-31 |
2023-08-13 |
Not clear |
| Tianyuan Wang, Adnin Ashrafi, Pouya Modareszadeh, Alexander R Deese, Maria Del Carmen Chacon Castro, Parinaz Sadat Alemi, Li Zhan. An Analysis of the Multifaceted Roles of Heme in the Pathogenesis of Cancer and Related Diseases. Cancers. vol 13. issue 16. 2021-08-30. PMID:34439295. |
these include btb and cnc homology 1 (bach1), tumor suppressor p53 protein, progesterone receptor membrane component 1 protein (pgrmc1), cystathionine-β-synthase (cbs), soluble guanylate cyclase (sgc), and nitric oxide synthases (nos). |
2021-08-30 |
2023-08-13 |
Not clear |
| Israa F Mosa, Haitham H Abd, Abdelsalam Abuzreda, Amenh B Yousif, Nadhom Assa. Chitosan and Curcumin Nanoformulations against Potential Cardiac Risks Associated with Hydroxyapatite Nanoparticles in Wistar Male Rats. International journal of biomaterials. vol 2021. 2021-08-11. PMID:34373695. |
in this study, the cardiac toxicity of rats orally exposed to hydroxyapatite nanoparticles (hapnps) has been observed through an increase in myocardial infarction serum markers including ck-mb and alterations in routine blood factors, expression of apoptosis-related protein p53, and increased levels of serum inflammatory markers represented by the tumor necrosis factor alpha and interleukin-6, as well as a decline in heart antioxidant enzymes and reduced glutathione level, while an induction in lipid peroxidation and nitric oxide has been observed, as well as notable histological and histochemical alterations in the heart of these animals. |
2021-08-11 |
2023-08-13 |
rat |
| Mojtaba Moradi, Nader Goodarzi, Azita Faramarzi, Hadi Cheraghi, Amir Hossein Hashemian, Cyrus Jalil. Melatonin protects rats testes against bleomycin, etoposide, and cisplatin-induced toxicity via mitigating nitro-oxidative stress and apoptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 138. 2021-07-22. PMID:33752059. |
at the end of the study, sperm parameters, testosterone level, stereology of testes, testicular levels of malondialdehyde (mda), nitric oxide (no), and total antioxidant capacity (tac), the expression of apoptosis-associated genes such as bcl2, bax, caspase-3, p53, and tnf-α (real-time pcr and immunohistochemistry) were evaluated. |
2021-07-22 |
2023-08-13 |
rat |
| Pragalathan Naidoo, Rajen N Naidoo, Prithiksha Ramkaran, Anil A Chuturgoo. Effect of maternal HIV infection, BMI and NOx air pollution exposure on birth outcomes in South African pregnant women genotyped for the p53 Pro72Arg (rs1042522). International journal of immunogenetics. vol 47. issue 5. 2021-06-09. PMID:32080966. |
maternal nitrogen oxide (nox) air pollution exposure, body mass index (bmi), human immunodeficiency virus (hiv) infection and p53 pro72arg (rs1042522) affect foetal growth. |
2021-06-09 |
2023-08-13 |
human |
| Sameerah Shaheen, Maha M Arafah, Aliah R Alshanwani, Laila Mohammed Fadda, Ahlam M Alhusaini, Hanaa M Ali, Iman H Hasan, Hanan Hagar, Fatima Mb Alharbi, Alaa AlHarthi. Chitosan nanoparticles as a promising candidate for liver injury induced by 2-nitropropane: Implications of P53, iNOS, VEGF, PCNA, and CD68 pathways. Science progress. vol 104. issue 2. 2021-05-04. PMID:33940981. |
immunohistochemistry investigations revealed that the hepatic protein expression of collagen i, inducible nitric oxide synthetase, proliferating cell nuclear antigen, cluster of differentiation, and p53 were upregulated. |
2021-05-04 |
2023-08-13 |
rat |
| Mokhtar Ibrahim Yousef, Haitham Hassan Abd, Yasser Mohamed Helmy, Maher Abdel-Nabi Kame. Synergistic effect of curcumin and chitosan nanoparticles on nano-hydroxyapatite-induced reproductive toxicity in rats. Environmental science and pollution research international. vol 28. issue 8. 2021-02-18. PMID:33141380. |
lh and fsh, abnormal sperm, oxidative stress parameters (thiobarbituric acid-reactive substances (tbars), nitric oxide (no), and 8-hydroxy-deoxyguanosine (8-ohdg)), p53, tnfα, and interleukin-6 were significantly increased. |
2021-02-18 |
2023-08-13 |
rat |
| Vishal Kumar Gupta, Pradip Kumar Jaiswara, Pratishtha Sonker, Shiv Govind Rawat, Rajan Kumar Tiwari, Ajay Kuma. Lysophosphatidic acid promotes survival of T lymphoma cells by altering apoptosis and glucose metabolism. Apoptosis : an international journal on programmed cell death. vol 25. issue 1-2. 2020-11-19. PMID:31867678. |
observations of this investigation suggest that lpa supports survival of t lymphoma cells via altering apoptosis and glucose metabolism through changing the level of reactive species, namely nitric oxide and reactive oxygen species along with expression of various survival and glucose metabolism regulatory molecules, including hypoxia-inducible factor 1-alpha, p53, bcl2, and glucose transporter 3, hexokinase ii, pyruvate kinase muscle isozyme 2, monocarboxylate transporter 1, pyruvate dehydrogenase kinase 1. |
2020-11-19 |
2023-08-13 |
Not clear |
| Poliana Camila Marinello, Carolina Panis, Thamara Nishida Xavier Silva, Renata Binato, Eliana Abdelhay, Juliana Alves Rodrigues, André Luiz Mencalha, Natália Medeiros Dias Lopes, Rodrigo Cabral Luiz, Rubens Cecchini, Alessandra Lourenço Cecchin. Metformin prevention of doxorubicin resistance in MCF-7 and MDA-MB-231 involves oxidative stress generation and modulation of cell adaptation genes. Scientific reports. vol 9. issue 1. 2020-10-06. PMID:30971831. |
the dox-res group presented increased thiols and reduced lipoperoxidation, increased levels of nitric oxide, nuclear nf-kb and nrf2, and reduced nuclear p53 labelling. |
2020-10-06 |
2023-08-13 |
human |
| Poliana Camila Marinello, Carolina Panis, Thamara Nishida Xavier Silva, Renata Binato, Eliana Abdelhay, Juliana Alves Rodrigues, André Luiz Mencalha, Natália Medeiros Dias Lopes, Rodrigo Cabral Luiz, Rubens Cecchini, Alessandra Lourenço Cecchin. Metformin prevention of doxorubicin resistance in MCF-7 and MDA-MB-231 involves oxidative stress generation and modulation of cell adaptation genes. Scientific reports. vol 9. issue 1. 2020-10-06. PMID:30971831. |
the met-dox group was more sensitive to dox-induced os, presented lower levels of nitric oxide, nuclear nf-kb and nrf2, and increased nuclear p53. |
2020-10-06 |
2023-08-13 |
human |
| Carolina Sánchez-Rodríguez, Concepción Peiró, Leocadio Rodríguez-Mañas, Julián Nevad. Polyphenols Attenuate Highly-Glycosylated Haemoglobin-Induced Damage in Human Peritoneal Mesothelial Cells. Antioxidants (Basel, Switzerland). vol 9. issue 7. 2020-09-28. PMID:32630324. |
we studied several amadori-induced effects in pro-apoptotic and oxidative stress markers, as well as the expression of several pro-inflammatory genes (nuclear factor-kappab, nf-kb; inducible nitric oxide synthetase, inos), different caspase-activities, level of p53 protein or production of different reactive oxygen species in the presence of different polyphenols. |
2020-09-28 |
2023-08-13 |
human |
| Saori Furuta, Gang Ren, Jian-Hua Mao, Mina J Bissel. Laminin signals initiate the reciprocal loop that informs breast-specific gene expression and homeostasis by activating NO, p53 and microRNAs. eLife. vol 7. 2019-06-24. PMID:29560860. |
we report a surprising reciprocal circuitry comprising positive players: laminin-5 (ln5), nitric oxide (no), p53, hoxd10 and three micrornas (mirnas) - that are involved in the formation of mammary acini in 3d. |
2019-06-24 |
2023-08-13 |
Not clear |