| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hong-Hua Li, Xi-Fei Wang, Bing Wang, Fei-Yong Ji. Vitamin D3 improves iminodipropionitrile-induced tic-like behavior in rats through regulation of GDNF/c-Ret signaling activity. European child & adolescent psychiatry. 2024-02-24. PMID:38396228. |
all groups were tested for behavior, serum and striatal 25(oh)d and dopamine (da), mrna expressions of vitamin d receptor (vdr), glial cell line-derived neurotrophic factor (gdnf), protooncogene tyrosine-protein kinase receptor ret (c-ret), and da d1 (drd1) and d2 (drd2) receptor genes in the striatum. |
2024-02-24 |
2024-02-26 |
rat |
| Daniel R Garton, Giorgio Turconi, Vilma Iivanainen, Jaan-Olle Andresso. Opposing Spatially Segregated Function of Endogenous GDNF-RET Signaling in Cocaine Addiction. Biomolecules. vol 13. issue 5. 2023-05-27. PMID:37238631. |
as a potent neurotrophic factor modulating the function of dopamine neurons, glial cell line-derived neurotrophic factor (gdnf) acting through its receptor ret on dopamine neurons may provide a novel therapeutic avenue towards psychostimulant addiction. |
2023-05-27 |
2023-08-14 |
Not clear |
| Daniel R Garton, Giorgio Turconi, Vilma Iivanainen, Jaan-Olle Andresso. Opposing Spatially Segregated Function of Endogenous GDNF-RET Signaling in Cocaine Addiction. Biomolecules. vol 13. issue 5. 2023-05-27. PMID:37238631. |
here, we utilized a conditional knockout approach to reduce the expression of the gdnf receptor tyrosine kinase ret from dopamine neurons in the ventral tegmental area (vta) after the onset of cocaine-induced conditioned place preference. |
2023-05-27 |
2023-08-14 |
Not clear |
| Daniel R Garton, Giorgio Turconi, Vilma Iivanainen, Jaan-Olle Andresso. Opposing Spatially Segregated Function of Endogenous GDNF-RET Signaling in Cocaine Addiction. Biomolecules. vol 13. issue 5. 2023-05-27. PMID:37238631. |
we find that the reduction of ret within the vta hastens cocaine-induced conditioned place preference extinction and reduces reinstatement, while the reduction of gdnf within the nac does the opposite: prolongs cocaine-induced conditioned place preference and increases preference during reinstatement. |
2023-05-27 |
2023-08-14 |
Not clear |
| Daniel R Garton, Giorgio Turconi, Vilma Iivanainen, Jaan-Olle Andresso. Opposing Spatially Segregated Function of Endogenous GDNF-RET Signaling in Cocaine Addiction. Biomolecules. vol 13. issue 5. 2023-05-27. PMID:37238631. |
thus, ret antagonism in the vta coupled with intact or enhanced accumbal gdnf function may provide a new approach towards cocaine addiction treatment. |
2023-05-27 |
2023-08-14 |
Not clear |
| Ella A Kasanga, Yoonhee Han, Walter Navarrete, Robert McManus, Marla K Shifflet, Caleb Parry, Arturo Barahona, Fredric P Manfredsson, Vicki A Nejtek, Jason R Richardson, Michael F Salvator. Differential expression of RET and GDNF family receptor, GFR-α1, between striatum and substantia nigra following nigrostriatal lesion: A case for diminished GDNF-signaling. Experimental neurology. 2023-05-13. PMID:37178997. |
differential expression of ret and gdnf family receptor, gfr-α1, between striatum and substantia nigra following nigrostriatal lesion: a case for diminished gdnf-signaling. |
2023-05-13 |
2023-08-14 |
rat |
| Ella A Kasanga, Yoonhee Han, Walter Navarrete, Robert McManus, Marla K Shifflet, Caleb Parry, Arturo Barahona, Fredric P Manfredsson, Vicki A Nejtek, Jason R Richardson, Michael F Salvator. Differential expression of RET and GDNF family receptor, GFR-α1, between striatum and substantia nigra following nigrostriatal lesion: A case for diminished GDNF-signaling. Experimental neurology. 2023-05-13. PMID:37178997. |
with nigrostriatal terminal loss exceeding 70% at pd diagnosis, we utilized hemiparkinsonian rats to determine if expression of gdnf family receptor, gfr-α1, and receptor tyrosine kinase, ret, differed between striatum and sn at 1 and 4 weeks following a 6-hydroxydopamine (6-ohda) hemilesion. |
2023-05-13 |
2023-08-14 |
rat |
| Ella A Kasanga, Yoonhee Han, Walter Navarrete, Robert McManus, Marla K Shifflet, Caleb Parry, Arturo Barahona, Fredric P Manfredsson, Vicki A Nejtek, Jason R Richardson, Michael F Salvator. Differential expression of RET and GDNF family receptor, GFR-α1, between striatum and substantia nigra following nigrostriatal lesion: a case for diminished GDNF-signaling. bioRxiv : the preprint server for biology. 2023-03-13. PMID:36909534. |
differential expression of ret and gdnf family receptor, gfr-α1, between striatum and substantia nigra following nigrostriatal lesion: a case for diminished gdnf-signaling. |
2023-03-13 |
2023-08-14 |
rat |
| Ella A Kasanga, Yoonhee Han, Walter Navarrete, Robert McManus, Marla K Shifflet, Caleb Parry, Arturo Barahona, Fredric P Manfredsson, Vicki A Nejtek, Jason R Richardson, Michael F Salvator. Differential expression of RET and GDNF family receptor, GFR-α1, between striatum and substantia nigra following nigrostriatal lesion: a case for diminished GDNF-signaling. bioRxiv : the preprint server for biology. 2023-03-13. PMID:36909534. |
with nigrostriatal terminal loss exceeding 70% at pd diagnosis, we utilized hemi-parkinsonian rats to determine if expression of gdnf family receptor, gfr-α1, and receptor tyrosine kinase, ret, differed between striatum and sn at 1 and 4 weeks following a 6-hydroxydopamine (6-ohda) lesion. |
2023-03-13 |
2023-08-14 |
rat |
| Praseeda Mol, Rex Devasahayam Arokia Balaya, Shobha Dagamajalu, Sreeranjini Babu, Pavithra Chandrasekaran, Reshma Raghavan, Sneha Suresh, Namitha Ravishankara, Anu Hemalatha Raju, Bipin Nair, Prashant Kumar Modi, Anita Mahadevan, Thottethodi Subrahmanya Keshava Prasad, Rajesh Raj. A network map of GDNF/RET signaling pathway in physiological and pathological conditions. Journal of cell communication and signaling. 2023-01-30. PMID:36715855. |
glial cell line-derived neurotrophic factor (gdnf) signals through a multi-component receptor system predominantly consisting of glycosyl-phosphatidylinositol-anchored gdnf family receptor alpha-1 (gfrα1) and the rearranged during transfection (ret) receptor tyrosine kinase. |
2023-01-30 |
2023-08-14 |
Not clear |
| Apostolos Mikroulis, Eliška Waloschková, Johan Bengzon, David Woldbye, Lars H Pinborg, Bo Jespersen, Anna Sanchez Avila, Zsofia I Laszlo, Christopher Henstridge, Marco Ledri, Merab Kokai. GDNF Increases Inhibitory Synaptic Drive on Principal Neurons in the Hippocampus via Activation of the Ret Pathway. International journal of molecular sciences. vol 23. issue 21. 2022-11-11. PMID:36361981. |
gdnf increases inhibitory synaptic drive on principal neurons in the hippocampus via activation of the ret pathway. |
2022-11-11 |
2023-08-14 |
mouse |
| Miaomiao Wang, Xiao Han, Wei Zha, Xiaoyu Wang, Liyun Liu, Zimu Li, Yefeng Shi, Xugang Kan, Gui Wang, Dianshuai Gao, Baole Zhan. GDNF Promotes Astrocyte Abnormal Proliferation and Migration Through the GFRα1/RET/MAPK/pCREB/LOXL2 Signaling Axis. Molecular neurobiology. 2022-08-04. PMID:35925441. |
high concentrations of gdnf promote loxl2 expression and secretion in ra cells through gdnf family receptor alpha-1(gfrα1)/rearranged during transfection proto-oncogene (ret)/mitogen-activated protein kinase (mapk)/phosphorylated cyclic amp response element binding protein (pcreb) signaling. |
2022-08-04 |
2023-08-14 |
human |
| Masahide Takahash. RET receptor signaling: Function in development, metabolic disease, and cancer. Proceedings of the Japan Academy. Series B, Physical and biological sciences. vol 98. issue 3. 2022-03-14. PMID:35283407. |
ret receptors are physiologically activated by glial cell line-derived neurotrophic factor (gdnf) family ligands that bind to the coreceptor gdnf family receptor α (gfrα). |
2022-03-14 |
2023-08-13 |
human |
| Kristijan Pazur, Ioannis Giannios, Mathias Lesche, Eva Rodriguez-Aznar, Anthony Gavala. Hoxb1 Regulates Distinct Signaling Pathways in Neuromesodermal and Hindbrain Progenitors to Promote Cell Survival and Specification. Stem cells (Dayton, Ohio). 2022-03-08. PMID:35257173. |
finally, hoxb1 synergizes with exogenous glial cell line-derived neurotrophic factor (gdnf) to strengthen ret expression and further promote the generation of fbm-like progenitors. |
2022-03-08 |
2023-08-13 |
mouse |
| James A Conway, Edgar R Krame. Is activation of GDNF/RET signaling the answer for successful treatment of Parkinson's disease? A discussion of data from the culture dish to the clinic. Neural regeneration research. vol 17. issue 7. 2021-12-17. PMID:34916419. |
the neurotrophic signaling of glial cell line-derived neurotrophic factor (gdnf) with its canonical receptor, the receptor tyrosine kinase ret, coupled together with the gdnf family receptor alpha 1 is important for dopaminergic neuron survival and physiology in cell culture experiments and animal models. |
2021-12-17 |
2023-08-13 |
Not clear |
| V Mesa-Infante, D Afonso-Oramas, J Salas-Hernández, J Rodríguez-Núñez, P Barroso-Chine. Long-term exposure to GDNF induces dephosphorylation of Ret, AKT, and ERK1/2, and is ineffective at protecting midbrain dopaminergic neurons in cellular models of Parkinson's disease. Molecular and cellular neurosciences. vol 118. 2021-12-07. PMID:34826608. |
long-term exposure to gdnf induces dephosphorylation of ret, akt, and erk1/2, and is ineffective at protecting midbrain dopaminergic neurons in cellular models of parkinson's disease. |
2021-12-07 |
2023-08-13 |
rat |
| V Mesa-Infante, D Afonso-Oramas, J Salas-Hernández, J Rodríguez-Núñez, P Barroso-Chine. Long-term exposure to GDNF induces dephosphorylation of Ret, AKT, and ERK1/2, and is ineffective at protecting midbrain dopaminergic neurons in cellular models of Parkinson's disease. Molecular and cellular neurosciences. vol 118. 2021-12-07. PMID:34826608. |
considering that gdnf action mechanisms are mediated by its receptor tyrosine kinase ret, which activates pi3k/akt and mapk/erk signaling pathways, we aimed to investigate ret activation and its effect over both signaling pathways in midbrain cell cultures treated with gdnf at different doses (0.3, 1, and 10 ng/ml) and times (15 min, 24 h, 24 h (7 days), and 7 continuous days). |
2021-12-07 |
2023-08-13 |
rat |
| V Mesa-Infante, D Afonso-Oramas, J Salas-Hernández, J Rodríguez-Núñez, P Barroso-Chine. Long-term exposure to GDNF induces dephosphorylation of Ret, AKT, and ERK1/2, and is ineffective at protecting midbrain dopaminergic neurons in cellular models of Parkinson's disease. Molecular and cellular neurosciences. vol 118. 2021-12-07. PMID:34826608. |
the results showed that short-term or acute (15 min, 24 h, and 24 h (7 days)) gdnf treatment in rat midbrain neurons increases tyrosine hydroxylase (th) expression and the phosphorylation levels of ret (tyr 1062), akt (ser 473), erk1/2 (thr202/tyr204), s6 (ser 235/236), and gsk3-β (ser 9). |
2021-12-07 |
2023-08-13 |
rat |
| Ana Paula De Vincenti, Fernando C Alsina, Facundo Ferrero Restelli, Håkan Hedman, Fernanda Ledda, Gustavo Paratch. Lrig1 and Lrig3 cooperate to control Ret receptor signaling, sensory axonal growth and epidermal innervation. Development (Cambridge, England). vol 148. issue 16. 2021-10-27. PMID:34338291. |
our findings show that, whereas a single deletion of either lrig1 or lrig3 fails to promote ret-mediated axonal growth, haploinsufficiency of lrig1 in lrig3 mutants significantly potentiates ret signaling and axonal growth of drg neurons in response to gdnf ligands. |
2021-10-27 |
2023-08-13 |
mouse |
| Tapan Behl, Ishnoor Kaur, Arun Kumar, Vineet Mehta, Gokhan Zengin, Sandeep Aror. Gene Therapy in the Management of Parkinson's Disease: Potential of GDNF as a Promising Therapeutic Strategy. Current gene therapy. vol 20. issue 3. 2021-08-18. PMID:32811394. |
the binding of gdnf family ligands with associated receptors leads to the formation of a receptor-ligand complex activating ret receptor of tyrosine kinase family, which is only expressed in dopaminergic neurons, playing an important role in parkinson's disease, via its association with the essential protein encoded genes. |
2021-08-18 |
2023-08-13 |
Not clear |