| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Praseeda Mol, Rex Devasahayam Arokia Balaya, Shobha Dagamajalu, Sreeranjini Babu, Pavithra Chandrasekaran, Reshma Raghavan, Sneha Suresh, Namitha Ravishankara, Anu Hemalatha Raju, Bipin Nair, Prashant Kumar Modi, Anita Mahadevan, Thottethodi Subrahmanya Keshava Prasad, Rajesh Raj. A network map of GDNF/RET signaling pathway in physiological and pathological conditions. Journal of cell communication and signaling. 2023-01-30. PMID:36715855. |
glial cell line-derived neurotrophic factor (gdnf) signals through a multi-component receptor system predominantly consisting of glycosyl-phosphatidylinositol-anchored gdnf family receptor alpha-1 (gfrα1) and the rearranged during transfection (ret) receptor tyrosine kinase. |
2023-01-30 |
2023-08-14 |
Not clear |
| Miaomiao Wang, Xiao Han, Wei Zha, Xiaoyu Wang, Liyun Liu, Zimu Li, Yefeng Shi, Xugang Kan, Gui Wang, Dianshuai Gao, Baole Zhan. GDNF Promotes Astrocyte Abnormal Proliferation and Migration Through the GFRα1/RET/MAPK/pCREB/LOXL2 Signaling Axis. Molecular neurobiology. 2022-08-04. PMID:35925441. |
high concentrations of gdnf promote loxl2 expression and secretion in ra cells through gdnf family receptor alpha-1(gfrα1)/rearranged during transfection proto-oncogene (ret)/mitogen-activated protein kinase (mapk)/phosphorylated cyclic amp response element binding protein (pcreb) signaling. |
2022-08-04 |
2023-08-14 |
human |
| Huiling Chen, Tiyun Han, Liping Gao, Bin Xiong, Xiaoli Li, Guoqing Qi, Pengyun Zeng, Ye Chai, Dekui Zhan. [IL-1β and TNF-α up-regulate the expression of glial cell line-derived neurotrophic factor (GDNF) and down-regulate its receptors in rat intestinal smooth muscle cells]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 36. issue 5. 2020-10-30. PMID:32696749. |
the relative mrna expression of gdnf, receptor tyrosine kinase (ret) and gdnf family receptor alpha-1 (gfrα1) were measured by real-time quantitative pcr. |
2020-10-30 |
2023-08-13 |
rat |
| Wenxian Li, Di Wei, Jiaxing Lin, Jianye Liang, Xiaomei Xie, Kangping Song, Li'an Huan. Dl-3-n-Butylphthalide Reduces Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion Through GDNF/GFRα1/Ret Signaling Preventing Hippocampal Neuron Apoptosis. Frontiers in cellular neuroscience. vol 13. 2020-09-29. PMID:31456664. |
glial cell line-derived neurotrophic factor (gdnf)/gdnf family receptor alpha-1 (gfrα1)/receptor tyrosine kinase (ret) signaling is altered in the hippocampus of cch rats; however, nbp treatment improved cognitive function, protected against hippocampal neuron apoptosis |
2020-09-29 |
2023-08-13 |
rat |
| Tuulia Saarenpää, Konstantin Kogan, Yulia Sidorova, Arun Kumar Mahato, Igor Tascón, Heidi Kaljunen, Liying Yu, Jukka Kallijärvi, Jaana Jurvansuu, Mart Saarma, Adrian Goldma. Zebrafish GDNF and its co-receptor GFRα1 activate the human RET receptor and promote the survival of dopaminergic neurons in vitro. PloS one. vol 12. issue 5. 2017-09-18. PMID:28467503. |
glial cell line-derived neurotrophic factor (gdnf) is a ligand that activates, through co-receptor gdnf family receptor alpha-1 (gfrα1) and receptor tyrosine kinase "ret", several signaling pathways crucial in the development and sustainment of multiple neuronal populations. |
2017-09-18 |
2023-08-13 |
mouse |
| M Curcio, I L Salazar, A R Inácio, E P Duarte, L M T Canzoniero, C B Duart. Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons. Cell death & disease. vol 6. 2016-01-25. PMID:25675305. |
the glial cell line-derived neurotrophic factor (gdnf) has an important role in neuronal survival through binding to the gfrα1 (gdnf family receptor alpha-1) receptor and activation of the receptor tyrosine kinase ret. |
2016-01-25 |
2023-08-13 |
mouse |
| Nikolai Kholodilov, Sang Ryong Kim, Olga Yarygina, Tatyana Kareva, Jin Whan Cho, Amy Baohan, Robert E Burk. Glial cell line-derived neurotrophic factor receptor-α1 expressed in striatum in trans regulates development and injury response of dopamine neurons of the substantia nigra. Journal of neurochemistry. vol 116. issue 4. 2011-03-22. PMID:21133924. |
many of the cellular effects of glial cell line-derived neurotrophic factor are initiated by binding to gndf family receptor alpha-1 (gfrα1), and mediated by diverse intracellular signaling pathways, most notably through the ret tyrosine kinase. |
2011-03-22 |
2023-08-12 |
mouse |
| H Qi, D-Q Li, F Bian, E Y Chuang, D B Jones, S C Pflugfelde. Expression of glial cell-derived neurotrophic factor and its receptor in the stem-cell-containing human limbal epithelium. The British journal of ophthalmology. vol 92. issue 9. 2008-10-01. PMID:18723744. |
to evaluate the expression pattern of glial cell line-derived neurotrophic factor (gdnf) with its receptors gdnf family receptor alpha-1 (gfr alpha-1) and ret in the human corneal and limbal tissues, as well as in the primary human limbal epithelial cultures (phlec). |
2008-10-01 |
2023-08-12 |
human |
| Selma Esseghir, S Katrina Todd, Toby Hunt, Richard Poulsom, Ivan Plaza-Menacho, Jorge S Reis-Filho, Clare M Isack. A role for glial cell derived neurotrophic factor induced expression by inflammatory cytokines and RET/GFR alpha 1 receptor up-regulation in breast cancer. Cancer research. vol 67. issue 24. 2008-01-15. PMID:18089803. |
by screening a tissue microarray of invasive breast tumors, we have shown that the receptor tyrosine kinase ret (rearranged during transfection) and its coreceptor gfr alpha 1 (gdnf receptor family alpha-1) are overexpressed in a subset of estrogen receptor-positive tumors. |
2008-01-15 |
2023-08-12 |
Not clear |
| Marina Quartu, Maria Pina Serra, Marianna Boi, Maria Teresa Ferretti, Maria Letizia Lai, Marina Del Fiacc. Tissue distribution of Ret, GFRalpha-1, GFRalpha-2 and GFRalpha-3 receptors in the human brainstem at fetal, neonatal and adult age. Brain research. vol 1173. 2008-01-09. PMID:17825269. |
occurrence and localization of receptor components of the glial cell line-derived neurotrophic factor (gdnf) family ligands, the ret receptor tyrosine kinase and the gdnf family receptor (gfr) alpha-1 to -3, were examined by immunohistochemistry in the normal human brainstem at fetal, neonatal, and adult age. |
2008-01-09 |
2023-08-12 |
human |
| Yuko Suzuki, Itaru Mizoguchi, Nobuhiko Uchid. Detection of neurotrophic factors in taste buds by laser capture microdissection, immunohistochemistry, and in situ hybridization. Archives of histology and cytology. vol 70. issue 2. 2007-12-07. PMID:17827669. |
results showed mrnas of the ciliary neurotrophic factor (cntf), its receptor (cntfr), glial cell line-derived neurotrophic factor (gdnf), gdnf family receptors alpha-1 (gfralpha-1), gfralpha-2, and ret tyrosine kinase receptor (ret), neurotrophin (nt)3, nt4/5, tyrosine kinase (trk) c, nerve growth factor (ngf), and trka were expressed in the isolated taste buds. |
2007-12-07 |
2023-08-12 |
mouse |
| Katja Linher, De Wu, Julang L. Glial cell line-derived neurotrophic factor: an intraovarian factor that enhances oocyte developmental competence in vitro. Endocrinology. vol 148. issue 9. 2007-09-26. PMID:17540724. |
gdnf and both its coreceptors, gdnf family receptor alpha-1 (gfr alpha-1) and the rearranged during transformation (ret) receptor, were expressed in oocytes and their surrounding cumulus cells derived from small and large follicles. |
2007-09-26 |
2023-08-12 |
Not clear |
| Vivian Vargas-Leal, Roxana Bruno, Tobias Derfuss, Markus Krumbholz, Reinhard Hohlfeld, Edgar Mein. Expression and function of glial cell line-derived neurotrophic factor family ligands and their receptors on human immune cells. Journal of immunology (Baltimore, Md. : 1950). vol 175. issue 4. 2005-11-30. PMID:16081799. |
gdnf and ntn signaling is mediated by a two-component receptor: a signal-transducing component, ret, which is shared by both ligands, and a ligand-specific binding component, gfr alpha-1 (higher gdnf affinity) or gfr alpha-2 (higher ntn affinity). |
2005-11-30 |
2023-08-12 |
human |
| Asako Hase, Fumiaki Saito, Hiroki Yamada, Ken Arai, Teruo Shimizu, Kiichiro Matsumur. Characterization of glial cell line-derived neurotrophic factor family receptor alpha-1 in peripheral nerve Schwann cells. Journal of neurochemistry. vol 95. issue 2. 2005-11-02. PMID:16086681. |
glial cell line-derived neurotrophic factor (gdnf) family receptor alpha-1 (gfralpha-1) is a receptor component of gdnf that associates with and activates the tyrosine kinase receptor ret. |
2005-11-02 |
2023-08-12 |
rat |
| Maria Pina Serra, Marina Quartu, Francesca Mascia, Annalisa Manca, Marianna Boi, M Giuseppina Pisu, Maria Letizia Lai, Marina Del Fiacc. Ret, GFRalpha-1, GFRalpha-2 and GFRalpha-3 receptors in the human hippocampus and fascia dentata. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 23. issue 5. 2005-09-26. PMID:16002253. |
the immunohistochemical occurrence and localization of the receptor components of the glial cell line-derived neurotrophic factor (gdnf) family ligands, the ret receptor tyrosine kinase and gdnf family receptor (gfr) alpha-1 to -3, is described in the human post-mortem hippocampal formation at pre- and full-term newborn, and adult age. |
2005-09-26 |
2023-08-12 |
human |
| Marie-Claude Hofmann, Laura Braydich-Stolle, Martin Dy. Isolation of male germ-line stem cells; influence of GDNF. Developmental biology. vol 279. issue 1. 2005-04-18. PMID:15708562. |
the isolated cells express ret, a tyrosine kinase transmembrane receptor that mediates the intracellular response to gdnf via gfr alpha-1. |
2005-04-18 |
2023-08-12 |
mouse |
| Armin Blesch, Mark H Tuszynsk. Cellular GDNF delivery promotes growth of motor and dorsal column sensory axons after partial and complete spinal cord transections and induces remyelination. The Journal of comparative neurology. vol 467. issue 3. 2004-01-23. PMID:14608602. |
glial cell line-derived neurotrophic factor (gdnf) is the prototypical member of a growth factor family that signals via the cognate receptors ret and gdnf-receptor alpha-1. |
2004-01-23 |
2023-08-12 |
Not clear |
| I Rajan, C Gestblom, R P Kapu. RET(Men2B)-transgene produces sympathoadrenal tumors but does not prevent intestinal aganglionosis in gdnf-/- or gfr alpha-1(-/-) mice. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. vol 4. issue 5. 2002-01-25. PMID:11779046. |
we find that expression of the ret(men2b) transgene in enteric neural progenitors, after they colonize the gut, does not prevent intestinal aganglionosis associated with gdnf or gfr alpha-1 deficiency. |
2002-01-25 |
2023-08-12 |
mouse |
| I Rajan, C Gestblom, R P Kapu. RET(Men2B)-transgene produces sympathoadrenal tumors but does not prevent intestinal aganglionosis in gdnf-/- or gfr alpha-1(-/-) mice. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. vol 4. issue 5. 2002-01-25. PMID:11779046. |
the ligand, gdnf, stimulates ret activity through a co-receptor, gfr alpha-1. |
2002-01-25 |
2023-08-12 |
mouse |
| I Rajan, C Gestblom, R P Kapu. RET(Men2B)-transgene produces sympathoadrenal tumors but does not prevent intestinal aganglionosis in gdnf-/- or gfr alpha-1(-/-) mice. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. vol 4. issue 5. 2002-01-25. PMID:11779046. |
we report that ganglioneuromatous tumors caused by a ret(men2b) transgene in mice are not affected grossly or microscopically by the absence of gdnf or gfr alpha-1. |
2002-01-25 |
2023-08-12 |
mouse |