| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rosalinda Mejía-Rodríguez, Daniel Romero-Trejo, Rosa O González, José Segovi. Combined treatments with AZD5363, AZD8542, curcumin or resveratrol induce death of human glioblastoma cells by suppressing the PI3K/AKT and SHH signaling pathways. Biochemistry and biophysics reports. vol 33. 2023-01-30. PMID:36714540. |
we found that the combined treatments with azd5363+azd8542+curcumin and azd8542+curcumin+resveratrol inhibit the pi3k/akt and shh survival pathways by decreasing the activity of akt, the reduction of the expression of smo, pp70s6k, ps6k, gli1, p21 and p27, and the activation of caspase-3 as a marker of apoptosis. |
2023-01-30 |
2023-08-14 |
human |
| Lakhan S Khara, Declan W Al. The endocannabinoid system's involvement in motor development relies on cannabinoid receptors, TRP channels, and Sonic Hedgehog signaling. Physiological reports. vol 11. issue 1. 2023-01-13. PMID:36636759. |
to investigate the involvement of canonical and non-canonical cannabinoid receptors, trp channels, and the shh pathway in the development of sensorimotor function in zebrafish, we treated developing animals with pharmacological inhibitors of the cb1r, cb2r, trpa1/trpv1/trpm8, and a smoothened (smo) agonist, along with inhibitors of the ecs catabolic enzymes fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl) during the first ~24 h of zebrafish embryogenesis. |
2023-01-13 |
2023-08-14 |
zebrafish |
| Jiapeng Wang, Kierra Ware, Alicia Bedolla, Emily Allgire, Flavia Correa Turcato, Maxwell Weed, Renu Sah, Yu Lu. Disruption of Sonic Hedgehog Signaling Accelerates Age-Related Neurogenesis Decline and Abolishes Stroke-Induced Neurogenesis and Leads to Increased Anxiety Behavior in Stroke Mice. Translational stroke research. 2022-02-11. PMID:35146631. |
however, the precise role of smoothened (smo) receptor-mediated shh signaling in adult neurogenesis during aging especially in hippocampal subgranular zone (sgz) neurogenesis remains undefined. |
2022-02-11 |
2023-08-13 |
mouse |
| Alice Del Giovane, Mariagiovanna Russo, Linda Tirou, Hélène Faure, Martial Ruat, Sonia Balestri, Carola Sposato, Francesco Basoli, Alberto Rainer, Abdelmoumen Kassoussi, Elisabeth Traiffort, Antonella Ragnini-Wilso. Smoothened/AMP-Activated Protein Kinase Signaling in Oligodendroglial Cell Maturation. Frontiers in cellular neuroscience. vol 15. 2022-01-27. PMID:35082605. |
remyelination is controlled by many signaling pathways, such as the sonic hedgehog (shh) pathway, as shown by the canonical activation of its key effector smoothened (smo), which increases the proliferation of oligodendrocyte precursor cells |
2022-01-27 |
2023-08-13 |
Not clear |
| Derek F Burton, Oswald M Boa-Amponsem, Maria S Dixon, Michael J Hopkins, Te-Andre Herbin, Shiquita Toney, Michael Tarpley, Blanca V Rodriguez, Eric W Fish, Scott E Parnell, Gregory J Cole, Kevin P William. Pharmacological activation of the Sonic hedgehog pathway with a Smoothened small molecule agonist ameliorates the severity of alcohol-induced morphological and behavioral birth defects in a zebrafish model of fetal alcohol spectrum disorder. Journal of neuroscience research. 2022-01-11. PMID:35014067. |
we observed in zebrafish embryos that shh expression was significantly decreased by ethanol exposure at 8-10 hpf, while smo expression was much less affected. |
2022-01-11 |
2023-08-13 |
zebrafish |
| Chengliang Yang, Xiaoli Zheng, Ke Ye, Yanan Sun, Yufei Lu, Qingxia Fan, Hong G. miR-135a Inhibits the Invasion and Migration of Esophageal Cancer Stem Cells through the Hedgehog Signaling Pathway by Targeting Smo. Molecular therapy. Nucleic acids. vol 19. 2021-12-02. PMID:31981861. |
after that, the expression of mir-135a and hedgehog (hh) signaling pathway-related genes (smo, gli1, shh, and gli2) in tissues and cells was measured, accompanied by evaluation of cell viability, apoptosis, invasion, and migration. |
2021-12-02 |
2023-08-13 |
Not clear |
| Chengliang Yang, Xiaoli Zheng, Ke Ye, Yanan Sun, Yufei Lu, Qingxia Fan, Hong G. miR-135a Inhibits the Invasion and Migration of Esophageal Cancer Stem Cells through the Hedgehog Signaling Pathway by Targeting Smo. Molecular therapy. Nucleic acids. vol 19. 2021-12-02. PMID:31981861. |
in addition, overexpression of mir-135a or silencing of smo decreased the expression of gli1, gli2, and shh, thus inhibiting ec cell proliferation, migration, and invasion and promoting apoptosis. |
2021-12-02 |
2023-08-13 |
Not clear |
| Danil Peregud, Mikhail Stepanichev, Natalia Gulyaev. Expression of the hippocampal PTCH during early abstinence is associated with drinking patterns in a rat model of voluntary alcohol intake. Neuroreport. vol 32. issue 9. 2021-09-17. PMID:33994522. |
however, shh, smo and gli mrna levels in the hippocampus did not change. |
2021-09-17 |
2023-08-13 |
rat |
| Ge Wang, Hongyang Zhang, Jiancong Sun, Yuwei Zhang, Fen He, Juntao Zo. Cyclosporin A impairs neurogenesis and cognitive abilities in brain development via the IFN-γ-Shh-BDNF pathway. International immunopharmacology. vol 96. 2021-06-22. PMID:33993101. |
here, we found that the immunosuppressant cyclosporin a (csa) decreased the number of brdu+, brdu+/dcx+, brdu+/neun + cells in the hippocampus, impaired learning and memory and inhibited protein levels of the shh signaling pathway, including shh, smo and gli1. |
2021-06-22 |
2023-08-13 |
Not clear |
| Judith Niesen, Jasmin Ohli, Jan Sedlacik, Lasse Dührsen, Malte Hellwig, Michael Spohn, Till Holsten, Ulrich Schülle. Pik3ca mutations significantly enhance the growth of SHH medulloblastoma and lead to metastatic tumour growth in a novel mouse model. Cancer letters. vol 477. 2020-12-30. PMID:32112900. |
these mice show mutated variants within smo, ptch1 or pik3ca genes in cerebellar granule neuron precursors, which represent the cellular origin of shh mb. |
2020-12-30 |
2023-08-13 |
mouse |
| Chihiro Adachi, Naoto Kakinuma, Soo Hyun Jo, Takayuki Ishii, Yusuke Arai, Satoshi Arai, Tetsuya Kitaguchi, Sen Takeda, Takafumi Inou. Sonic hedgehog enhances calcium oscillations in hippocampal astrocytes. The Journal of biological chemistry. vol 294. issue 44. 2020-06-12. PMID:31506300. |
here, we report that shh and smoothened agonist (sag), an activator of the signaling receptor smoothened (smo) in the shh pathway, activate ca oscillations in cultured murine hippocampal astrocytes. |
2020-06-12 |
2023-08-13 |
Not clear |
| Caitlin C Winkler, Santos J Franc. Loss of Shh signaling in the neocortex reveals heterogeneous cell recovery responses from distinct oligodendrocyte populations. Developmental biology. vol 452. issue 1. 2020-02-12. PMID:31071314. |
conditional deletion of the shh signaling effector, smo, in dorsal progenitors caused a dramatic reduction in oligodendrocyte numbers in the embryonic neocortex. |
2020-02-12 |
2023-08-13 |
Not clear |
| Clara Ortega-de San Luis, Manuel A Sanchez-Garcia, Jose Luis Nieto-Gonzalez, Pablo García-Junco-Clemente, Adoracion Montero-Sanchez, Rafael Fernandez-Chacon, Alberto Pascua. Substantia nigra dopaminergic neurons and striatal interneurons are engaged in three parallel but interdependent postnatal neurotrophic circuits. Aging cell. vol 17. issue 5. 2019-09-12. PMID:30058223. |
to define the postnatal neurotrophic connections among fast-spiking gabaergic interneurons (fs), cholinergic interneurons (ach), and da snpc, we used a genetically induced mouse model of postnatal da snpc neurodegeneration and separately eliminated smoothened (smo), the obligatory transducer of shh signaling, in striatal interneurons. |
2019-09-12 |
2023-08-13 |
mouse |
| Jian-Chun Lin, Zhong-Guo Liu, Bin Yu, Xian-Rong Zhan. MicroRNA-874 targeting SUFU involves in osteoblast proliferation and differentiation in osteoporosis rats through the Hedgehog signaling pathway. Biochemical and biophysical research communications. vol 506. issue 1. 2019-05-21. PMID:30342851. |
besides, elevated expression of mir-874, shh, ptch, smo, bmp2, runx2 and pcna, as well as increased cell viability, alp activity and calcium nodules but decreased expression of sufu and bax, and reduced cell apoptosis were confirmed when treated with mir-874 mimic. |
2019-05-21 |
2023-08-13 |
mouse |
| Chiara Di Pietro, Gina La Sala, Rafaele Matteoni, Daniela Marazziti, Glauco P Tocchini-Valentin. Genetic ablation of Gpr37l1 delays tumor occurrence in Ptch1 Experimental neurology. vol 312. 2019-05-01. PMID:30452905. |
genetic ablation of gpr37l1 delays tumor occurrence in ptch1 the g-protein coupled receptor 37-like 1 (gpr37l1) is specifically expressed in most astrocytic glial cells, including cerebellar bergmann astrocytes and interacts with patched 1 (ptch1), a co-receptor of the sonic hedgehog (shh)-smoothened (smo) signaling complex. |
2019-05-01 |
2023-08-13 |
mouse |
| Julien Boetto, Caroline Apra, Franck Bielle, Matthieu Peyre, Michel Kalamaride. Selective vulnerability of the primitive meningeal layer to prenatal Smo activation for skull base meningothelial meningioma formation. Oncogene. vol 37. issue 36. 2019-02-27. PMID:29789719. |
somatic activating mutations of smoothened (smo), a component of the embryonic sonic hedgehog (shh) signaling pathway, are found in 3-5% of grade i meningiomas, most of them corresponding to meningothelial meningiomas located at the anterior skull base. |
2019-02-27 |
2023-08-13 |
mouse |
| Shawn Choe, Christopher W Bond, Daniel A Harrington, Samuel I Stupp, Kevin T McVary, Carol A Podlase. Peptide amphiphile nanofiber hydrogel delivery of sonic hedgehog protein to the cavernous nerve to promote regeneration and prevent erectile dysfunction. Nanomedicine : nanotechnology, biology, and medicine. vol 13. issue 1. 2017-10-05. PMID:27609775. |
shh and its receptors patched (ptch1) and smoothened (smo) are localized in pg neurons and glia. |
2017-10-05 |
2023-08-13 |
Not clear |
| Xiaofei Zhou, Jonathan Pace, Emily Filichia, Tao Lv, Brandon Davis, Barry Hoffer, Warren Selman, Yu Lu. Effect of the sonic hedgehog receptor smoothened on the survival and function of dopaminergic neurons. Experimental neurology. vol 283. issue Pt A. 2017-05-05. PMID:27317298. |
to determine the influence of the sonic hedgehog (shh) pathway and its receptor smoothened (smo), on the survival and functionality of dopaminergic (da) neurons. |
2017-05-05 |
2023-08-13 |
Not clear |
| Suping Qin, Dexu Sun, Hui Li, Xiangyang Li, Wei Pan, Chao Yan, Renxian Tang, Xiaomei Li. The Effect of SHH-Gli Signaling Pathway on the Synovial Fibroblast Proliferation in Rheumatoid Arthritis. Inflammation. vol 39. issue 2. 2017-01-06. PMID:26552406. |
shh, ptch, smo, and gli molecules were highly expressed in rat ra-synovial fibroblast (ra-sf); after blocking the shh-gli signaling pathway with a gli specific inhibitor, gli-antagonist 61 (gant61), ra-sf proliferation was inhibited in a dose-dependent manner and the apoptosis rate of ra-sf was increased as well; the expression levels of fibroblast growth factor receptor 1 (fgfr1) and fgfr3 declined in sf cells after gant61 treatment. |
2017-01-06 |
2023-08-13 |
human |
| Jun Young Park, Lucinda J Hughes, Uk Yeol Moon, Raehee Park, Sang-Bae Kim, Khoi Tran, Ju-Seog Lee, Seo-Hee Cho, Seonhee Ki. The apical complex protein Pals1 is required to maintain cerebellar progenitor cells in a proliferative state. Development (Cambridge, England). vol 143. issue 1. 2016-07-25. PMID:26657772. |
furthermore, enhanced shh signaling through activated smo cannot overcome impaired cerebellar cell generation, arguing for an epistatic role of pals1 in proliferation capacity. |
2016-07-25 |
2023-08-13 |
mouse |