All Relations between tph1 and serotonin

Publication Sentence Publish Date Extraction Date Species
Neeshu Saroj, Shiv Shanker, Eduardo Serrano-Hernández, Gabriel Manjarrez-Gutiérrez, José-Antonio Mondragón, Saidel Moreno-Martínez, Rosa A Jarillo-Luna, Pedro López-Sánchez, José A Terró. Expression of tryptophan hydroxylase in rat adrenal glands: Upregulation of TPH2 by chronic stress. Psychoneuroendocrinology. vol 171. 2024-10-28. PMID:39467477. on day 15, adrenal glands were collected for tph1 and tph2 immunohistochemistry, western blot, and rt-pcr; tph activity was estimated by quantification of 5-hydroxytryptophan (5-htp) and, indirectly, through measurement of 5-ht and 5-hydroxindolacetic acid (5-hiaa) levels and turnover (5-hiaa/5-ht ratio) by hplc. 2024-10-28 2024-10-31 rat
Ekaterina Legchenko, Philippe Chouvarine, Fatimunnisa Qadri, Edgar Specker, Marc Nazaré, Radoslaw Wesolowski, Susann Matthes, Michael Bader, Georg Hansman. Novel Tryptophan Hydroxylase Inhibitor TPT-001 Reverses PAH, Vascular Remodeling, and Proliferative-Proinflammatory Gene Expression. JACC. Basic to translational science. vol 9. issue 7. 2024-08-22. PMID:39170954. we developed a highly specific inhibitor of the serotonin synthesizing enzyme tryptophan hydroxylase 1 (tph1), tpt-001 (tphi). 2024-08-22 2024-08-24 human
Tianlong Ling, Zhanghan Dai, Houming Wang, Tran Trung Kien, Rong Cui, Tachung Yu, Jianjun Che. Serotonylation in tumor-associated fibroblasts contributes to the tumor-promoting roles of serotonin in colorectal cancer. Cancer letters. 2024-08-03. PMID:39097134. this study revealed that depleting 5-ht, either through genetic silencing of tph1 or using a selective tph1 inhibitor, effectively reduced the growth of crc tumors. 2024-08-03 2024-08-06 Not clear
Dongna Li, Xianghuan Si, Yuanqing Hua, Yunzhi Qian, Hongjia Li, Na Lv, Qijun Fang, Xiaojuan Han, Tianshu X. Tongbian formula alleviates slow transit constipation by increasing intestinal butyric acid to activate the 5-HT signaling. Scientific reports. vol 14. issue 1. 2024-08-02. PMID:39095450. when ba was combined with a tryptophan hydroxylase-1 (tph1) inhibitor, which is crucial for 5-ht synthesis, its therapeutic efficacy for treating stc was compromised. 2024-08-02 2024-08-06 rat
Jie Yu, Yujie Zhang, Hao Yao, Ziping Zhang, Xiao Yang, Wei Zhu, Jie X. ERβ activation improves nonylphenol-induced depression and neurotransmitter secretion disruption via the TPH2/5-HT pathway. Ecotoxicology and environmental safety. vol 280. 2024-06-08. PMID:38850708. both in vivo and in vitro, np group showed a decrease in the expression levels of erβ, tryptophan hydroxylase (tph1), and tryptophan hydroxylase-2 (tph2) genes and proteins, and reduced levels of da, ne, and 5-hydroxytryptophan (5-ht) neurotransmitters. 2024-06-08 2024-06-11 rat
Jie Yu, Yujie Zhang, Hao Yao, Ziping Zhang, Xiao Yang, Wei Zhu, Jie X. ERβ activation improves nonylphenol-induced depression and neurotransmitter secretion disruption via the TPH2/5-HT pathway. Ecotoxicology and environmental safety. vol 280. 2024-06-08. PMID:38850708. the expression levels of erβ, tph1, tph2, 5-ht and 5-hitt proteins were decreased in the np group, suggesting np-induced depression-like behaviours as well as disturbances in the secretion of serum hormones and monoamine neurotransmitters. 2024-06-08 2024-06-11 rat
Sena L Field, Everardo Anta Galvan, Laura L Hernandez, Jimena Laport. Exploring the contribution of mammary-derived serotonin on liver and pancreas metabolism during lactation. PloS one. vol 19. issue 6. 2024-06-05. PMID:38837989. to investigate this, we utilized c57/bl6j mice with a lactation and mammary-specific deletion of the gene coding for the rate-limiting enzyme in serotonin synthesis (tph1, wap-cre x tph1fl/fl) to understand the metabolic contributions of mammary-derived serotonin during lactation. 2024-06-05 2024-06-08 mouse
Teresa Zelante, Giuseppe Paolicelli, Francesca Fallarino, Marco Gargaro, Gianluca Vascelli, Marco De Zuani, Jan Fric, Petra Laznickova, Marcela Hortova Kohoutkova, Antonio Macchiarulo, Daniela Dolciami, Giuseppe Pieraccini, Lorenzo Gaetani, Giulia Scalisi, Caterina Trevisan, Barbara Frossi, Carlo Pucillo, Antonella De Luca, Emilia Nunzi, Roberta Spaccapelo, Marilena Pariano, Monica Borghi, Francesca Boscaro, Riccardo Romoli, Andrea Mancini, Lucia Gentili, Giorgia Renga, Claudio Costantini, Matteo Puccetti, Stefano Giovagnoli, Maurizio Ricci, Martina Antonini, Paolo Calabresi, Paolo Puccetti, Massimiliano Di Filippo, Luigina Roman. A microbially produced AhR ligand promotes a Tph1-driven tolerogenic program in multiple sclerosis. Scientific reports. vol 14. issue 1. 2024-03-21. PMID:38509264. as a result, in peripheral lymph nodes, microbial 3-iald, affected mast-cell tryptophan metabolism, forcing mast cells to produce serotonin via tph1. 2024-03-21 2024-03-23 Not clear
Karisa M Renteria, Ethan Constantine, Chin May Teoh, Analynn Cooper, Nissi Lozano, Spenser Bauer, Gar Yee Ko. Combination of vitamin D Nutrition research (New York, N.Y.). vol 125. 2024-03-03. PMID:38432179. colonic vd receptor was elevated in vf-treated mice in both sexes, compared with ctr, which was positively correlated to colonic tph1, a rate-limiting enzyme for serotonin synthesis. 2024-03-03 2024-03-06 mouse
Sarita Pyatha, Haesoo Kim, Daeun Lee, Kisok Ki. Co-exposure to lead, mercury, and cadmium induces neurobehavioral impairments in mice by interfering with dopaminergic and serotonergic neurotransmission in the striatum. Frontiers in public health. vol 11. 2023-12-01. PMID:38026429. furthermore, compared to the control group, the metal mixture exposure group showed a significantly lower expression level of tyrosine hydroxylase (th) and significantly higher expression levels of dopamine transporter (dat), tryptophan hydroxylase 1 (tph1), and serotonin reuptake transporter (sert). 2023-12-01 2023-12-10 mouse
Sarita Pyatha, Haesoo Kim, Daeun Lee, Kisok Ki. Co-exposure to lead, mercury, and cadmium induces neurobehavioral impairments in mice by interfering with dopaminergic and serotonergic neurotransmission in the striatum. Frontiers in public health. vol 11. 2023-12-01. PMID:38026429. these findings suggest that the key proteins involved in the synthesis and reuptake of dopamine (th and dat, respectively), as well as in the synthesis and reuptake of serotonin (tph1 and sert, respectively), play crucial roles in the neurotoxic effects associated with exposure to metal mixtures. 2023-12-01 2023-12-10 mouse
Amanda Marie Vanslette, Pernille Baumann Toft, Mari Lilith Lund, Thomas Moritz, Tulika Aror. Serotonin receptor 4 agonism prevents high fat diet induced reduction in GLP-1 in mice. European journal of pharmacology. 2023-11-05. PMID:37926275. in this study, we found that two weeks of high fat diet (hfd) feeding reduced rna expression of gut hormones, including proglucagon (gcg) gene encoding glp-1 and tryptophan hydroxylase1 (tph1) gene encoding rate limiting enzyme in 5-ht synthesis, specifically in the colon and reduced plasma glp-1 levels. 2023-11-05 2023-11-08 mouse
Takanori Ikenaga, Tastufumi Nakamura, Tatsushi Tajiri, Minaki Tsuji, Dai-Ichiro Kato, Toshinao Ineno, Yasuhisa Kobayashi, Naoaki Tsutsui, Sadao Kiyohar. Diversity and evolution of serotonergic cells in taste buds of elasmobranchs and ancestral actinopterygian fish. Cell and tissue research. 2023-10-18. PMID:37851111. mrna of tryptophan hydroxylase 1 (tph1), a rate-limiting enzyme of the serotonin synthesis, is expressed in both the elongated and basal cells of stingray taste buds, indicating that these cells synthesize the serotonin by themselves. 2023-10-18 2023-11-08 Not clear
Mieszko Wieckiewicz, Helena Martynowicz, Gilles Lavigne, Frank Lobbezoo, Takafumi Kato, Efraim Winocur, Joanna Wezgowiec, Dariusz Danel, Anna Wojakowska, Grzegorz Mazur, Joanna Smard. An exploratory study on the association between serotonin and sleep breathing disorders. Scientific reports. vol 13. issue 1. 2023-07-21. PMID:37479853. peripheral blood samples were collected to estimate the serum levels of serotonin, tryptophan hydroxylase 1 (tph1), and aromatic l-amino acid decarboxylase (aadc). 2023-07-21 2023-08-14 Not clear
Mieszko Wieckiewicz, Helena Martynowicz, Gilles Lavigne, Frank Lobbezoo, Takafumi Kato, Efraim Winocur, Joanna Wezgowiec, Dariusz Danel, Anna Wojakowska, Grzegorz Mazur, Joanna Smard. An exploratory study on the association between serotonin and sleep breathing disorders. Scientific reports. vol 13. issue 1. 2023-07-21. PMID:37479853. a tendency to sleep-disordered breathing seemed to co-occur with lower blood serotonin and higher tph1 levels.clinical trial registration : www.clinicaltrials.gov , identifier nct04214561. 2023-07-21 2023-08-14 Not clear
Gabriela Souza Rodrigues Queiroz, Juliana Carron, Ligia Traldi Macedo, Carmen Silvia Passos Lima, Gustavo Jacob Lourenç. Influence of variants in serotonin modulating genes on the risk, aggressiveness, and prognosis of oropharynx cancer. Head & neck. 2023-05-09. PMID:37158249. single-nucleotide variations (snvs) in tph1 rs623580 (t>a), tph2 rs4570625 (g>t), and htr1d rs674386 (g>a) may affect 5-ht levels. 2023-05-09 2023-08-14 Not clear
Dane H Tow, Catherine G Tran, Luis C Borbon, Maclain Ridder, Guiying Li, Courtney A Kaemmer, Ellen Abusada, Aswanth Harish Mahalingam, Anguraj Sadanandam, Chandrikha Chandrasekaran, Joseph Dillon, Douglas R Spitz, Dawn E Quelle, Carlos H F Chan, Andrew Bellizzi, James R Howe, Po Hien Ea. Inhibition of serotonin biosynthesis in neuroendocrine neoplasm suppresses tumor growth bioRxiv : the preprint server for biology. 2023-04-17. PMID:37066322. sbnets express high levels of tryptophan hydroxylase 1 (tph1), a key enzyme in serotonin biosynthesis. 2023-04-17 2023-08-14 Not clear
Dane H Tow, Catherine G Tran, Luis C Borbon, Maclain Ridder, Guiying Li, Courtney A Kaemmer, Ellen Abusada, Aswanth Harish Mahalingam, Anguraj Sadanandam, Chandrikha Chandrasekaran, Joseph Dillon, Douglas R Spitz, Dawn E Quelle, Carlos H F Chan, Andrew Bellizzi, James R Howe, Po Hien Ea. Inhibition of serotonin biosynthesis in neuroendocrine neoplasm suppresses tumor growth bioRxiv : the preprint server for biology. 2023-04-17. PMID:37066322. patients with high serotonin level may develop carcinoid syndrome, which can be treated with somatostatin analogues and the tph1 inhibitor telotristat ethyl in severe cases. 2023-04-17 2023-08-14 Not clear
D V Sherbakov, A B Arefieva, P D Komleva, A E Iz'urov, N V Khotskin, D V Bazovkina, A V Kuliko. [Alterations in the Level of mRNA of TPH1, TPH2 Genes, Tryptophan Hydroxylase Activity and Serotonin Metabolism in Mouse Brain Five Days after Lipopolysaccharide Administration]. Molekuliarnaia biologiia. vol 57. issue 2. 2023-03-31. PMID:37000657. [alterations in the level of mrna of tph1, tph2 genes, tryptophan hydroxylase activity and serotonin metabolism in mouse brain five days after lipopolysaccharide administration]. 2023-03-31 2023-08-14 mouse
D V Sherbakov, A B Arefieva, P D Komleva, A E Iz'urov, N V Khotskin, D V Bazovkina, A V Kuliko. [Alterations in the Level of mRNA of TPH1, TPH2 Genes, Tryptophan Hydroxylase Activity and Serotonin Metabolism in Mouse Brain Five Days after Lipopolysaccharide Administration]. Molekuliarnaia biologiia. vol 57. issue 2. 2023-03-31. PMID:37000657. tryptophan hydroxylases 1 and 2 (tph1 and tph2) play a key role in the synthesis of serotonin (5-ht), a hormone and neurotransmitter, in the peripheral organs and brain, respectively. 2023-03-31 2023-08-14 mouse