| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yosuke Nakazawa, Paul J Donaldson, Rosica S Petrov. Verification and spatial mapping of TRPV1 and TRPV4 expression in the embryonic and adult mouse lens. Experimental eye research. vol 186. 2020-02-20. PMID:31229503. |
using western blotting we have confirmed that trpv1 and trpv4 are expressed throughout all regions (epithelium, outer cortex, inner cortex/core) of the adult mouse lens. |
2020-02-20 |
2023-08-13 |
mouse |
| Yosuke Nakazawa, Paul J Donaldson, Rosica S Petrov. Verification and spatial mapping of TRPV1 and TRPV4 expression in the embryonic and adult mouse lens. Experimental eye research. vol 186. 2020-02-20. PMID:31229503. |
in the epithelium and outer cortex, intense trpv1 and trpv4 labeling was predominately associated with the cytoplasm. |
2020-02-20 |
2023-08-13 |
mouse |
| Yosuke Nakazawa, Paul J Donaldson, Rosica S Petrov. Verification and spatial mapping of TRPV1 and TRPV4 expression in the embryonic and adult mouse lens. Experimental eye research. vol 186. 2020-02-20. PMID:31229503. |
in a discrete zone in the inner cortex, labeling for both proteins was greatly diminished, but could be enhanced by incubating sections with the detergent triton x-100 to reveal trpv1 and trpv4 labelling that was associated with the membrane. |
2020-02-20 |
2023-08-13 |
mouse |
| Yosuke Nakazawa, Paul J Donaldson, Rosica S Petrov. Verification and spatial mapping of TRPV1 and TRPV4 expression in the embryonic and adult mouse lens. Experimental eye research. vol 186. 2020-02-20. PMID:31229503. |
this suggests that in this region of the lens there is a potential interacting protein that masks the binding of the trpv1 and trpv4 antibodies to their respective epitopes in the lens inner cortex. |
2020-02-20 |
2023-08-13 |
mouse |
| Yosuke Nakazawa, Paul J Donaldson, Rosica S Petrov. Verification and spatial mapping of TRPV1 and TRPV4 expression in the embryonic and adult mouse lens. Experimental eye research. vol 186. 2020-02-20. PMID:31229503. |
during subsequent stages of embryonic development trpv1 and trpv4 remained membranous in the inner cortex and core, while showing labelling that was associated with the cytoplasm in the superficial outer cortical region. |
2020-02-20 |
2023-08-13 |
mouse |
| D Balemans, J Aguilera-Lizarraga, M V Florens, P Jain, A Denadai-Souza, M F Viola, Y A Alpizar, S Van Der Merwe, P Vanden Berghe, K Talavera, S Vanner, M M Wouters, G E Boeckxstaen. Histamine-mediated potentiation of transient receptor potential (TRP) ankyrin 1 and TRP vanilloid 4 signaling in submucosal neurons in patients with irritable bowel syndrome. American journal of physiology. Gastrointestinal and liver physiology. vol 316. issue 3. 2019-12-26. PMID:30629470. |
here, we hypothesize that in parallel with trpv1, histamine sensitizes trpa1 and trpv4, contributing to increased visceral pain in patients with ibs. |
2019-12-26 |
2023-08-13 |
human |
| Jiliang Wen, Shulu Zu, Zhenghao Chen, Stephanie L Daugherty, William C de Groat, Yuqiang Liu, Mingzhen Yuan, Guanghui Cheng, Xiulin Zhan. Reduced bladder responses to capsaicin and GSK-1016790A in retired-breeder female rats with diminished volume sensitivity. American journal of physiology. Renal physiology. vol 315. issue 5. 2019-09-16. PMID:30019934. |
to investigate contributions of trpv1 or trpv4 to the age-related reduction of bladder sensory function, bladder responses to capsaicin (cap; trpv1 agonist) and gsk-1016790a (gsk; trpv4 agonist) in retired breeder (rb; 12-15 mo) and young adult (2-3 mo) female rats were compared using multiple methods. |
2019-09-16 |
2023-08-13 |
rat |
| Spyridoula Goutsou, Chrisi Tsakona, Afroditi Polia, Athanasia Moutafidi, Vassiliki Zolota, George Gatzounis, Martha Assimakopoulo. Transient receptor potential vanilloid (TRPV) channel expression in meningiomas: prognostic and predictive significance. Virchows Archiv : an international journal of pathology. vol 475. issue 1. 2019-07-15. PMID:31119368. |
the trpv1 and trpv3 immunoexpression was decreased whereas trpv4 immunoexpression was significantly greater in high-grade (who, grade ii and iii) as compared with low-grade (who, grade i) meningiomas. |
2019-07-15 |
2023-08-13 |
Not clear |
| T V Kozyreva, A A Evtushenko, I P Voronova, G M Khramova, V P Kozaru. Effect of Activation of Peripheral Ion Channel TRPM8 on Gene Expression of Thermosensitive TRP Ion Channels in the Hypothalamus. Comparison with the Effect of Cooling. Bulletin of experimental biology and medicine. vol 166. issue 2. 2019-03-18. PMID:30488220. |
neither stimulation of peripheral trpМ8, nor acute cooling affected the expression of genes for other thermosensitive ion channels (trpv1, trpv2, trpv4, trpa1, and trpМ8) in the hypothalamus. |
2019-03-18 |
2023-08-13 |
rat |
| Fan Yang, Li Zhou, Dong Wang, Li-Li Yang, Guo-Rong Yuan, Qing-Yuan Huan. Suppression of TRPV4 channels ameliorates anti-dipsogenic effects under hypoxia in the subfornical organ of rats. Scientific reports. vol 6. 2018-04-11. PMID:27436489. |
the transient receptor potential vanilloid (trpv) channels, including trpv1 and trpv4, are located in the subfornical organ (sfo). |
2018-04-11 |
2023-08-13 |
rat |
| Seungil Kim, Devin M Barry, Xian-Yu Liu, Shijin Yin, Admire Munanairi, Qing-Tao Meng, Wei Cheng, Ping Mo, Li Wan, Shen-Bin Liu, Kasun Ratnayake, Zhong-Qiu Zhao, Narasimhan Gautam, Jie Zheng, W K Ajith Karunarathne, Zhou-Feng Che. Facilitation of TRPV4 by TRPV1 is required for itch transmission in some sensory neuron populations. Science signaling. vol 9. issue 437. 2017-11-20. PMID:27436359. |
facilitation of trpv4 by trpv1 is required for itch transmission in some sensory neuron populations. |
2017-11-20 |
2023-08-13 |
mouse |
| Seungil Kim, Devin M Barry, Xian-Yu Liu, Shijin Yin, Admire Munanairi, Qing-Tao Meng, Wei Cheng, Ping Mo, Li Wan, Shen-Bin Liu, Kasun Ratnayake, Zhong-Qiu Zhao, Narasimhan Gautam, Jie Zheng, W K Ajith Karunarathne, Zhou-Feng Che. Facilitation of TRPV4 by TRPV1 is required for itch transmission in some sensory neuron populations. Science signaling. vol 9. issue 437. 2017-11-20. PMID:27436359. |
pharmacological blockade of either trpv4 or trpv1 significantly attenuated the ca(2+) response of sensory neurons exposed to histamine or chloroquine. |
2017-11-20 |
2023-08-13 |
mouse |
| Seungil Kim, Devin M Barry, Xian-Yu Liu, Shijin Yin, Admire Munanairi, Qing-Tao Meng, Wei Cheng, Ping Mo, Li Wan, Shen-Bin Liu, Kasun Ratnayake, Zhong-Qiu Zhao, Narasimhan Gautam, Jie Zheng, W K Ajith Karunarathne, Zhou-Feng Che. Facilitation of TRPV4 by TRPV1 is required for itch transmission in some sensory neuron populations. Science signaling. vol 9. issue 437. 2017-11-20. PMID:27436359. |
biochemical and biophysical studies suggested a close proximity between trpv4 and trpv1 in dorsal root ganglion neurons and in cultured cells. |
2017-11-20 |
2023-08-13 |
mouse |
| Dragana Srebro, Sonja Vučković, Milica Prostra. Participation of peripheral TRPV1, TRPV4, TRPA1 and ASIC in a magnesium sulfate-induced local pain model in rat. Neuroscience. vol 339. 2017-10-30. PMID:27687800. |
the ph-unadjusted ms solution-induced mechanical hyperalgesia decreased in a dose-dependent manner as a consequence of co-injection of capsazepine, a selective trpv1 antagonist (20, 100 and 500pmol/paw), rn-1734, a selective trpv4 antagonist (1.55, 3.1 and 6.2μmol/paw), hc-030031, a selective trpa1 antagonist (5.6, 28.1 and 140nmol/paw), and amiloride hydrochloride, a non-selective asic inhibitor (0.83, 2.5 and 7.55μmol/paw). |
2017-10-30 |
2023-08-13 |
rat |
| Dragana Srebro, Sonja Vučković, Milica Prostra. Participation of peripheral TRPV1, TRPV4, TRPA1 and ASIC in a magnesium sulfate-induced local pain model in rat. Neuroscience. vol 339. 2017-10-30. PMID:27687800. |
in ph-adjusted ms-induced hyperalgesia, the highest doses of trpv1, trpv4 and trpa1 antagonists displayed effects that were, respectively, either similar, less pronounced or delayed in comparison to the effect induced by administration of the ph-unadjusted ms solution; the asic antagonist did not have any effect. |
2017-10-30 |
2023-08-13 |
rat |
| Dragana Srebro, Sonja Vučković, Milica Prostra. Participation of peripheral TRPV1, TRPV4, TRPA1 and ASIC in a magnesium sulfate-induced local pain model in rat. Neuroscience. vol 339. 2017-10-30. PMID:27687800. |
these results suggest that the ms-induced local peripheral mechanical hyperalgesia is mediated via modulation of the activity of peripheral trpv1, trpv4, trpa1 and asics. |
2017-10-30 |
2023-08-13 |
rat |
| M Levanti, B Randazzo, E Viña, G Montalbano, O Garcia-Suarez, A Germanà, J A Vega, F Abbat. Acid-sensing ion channels and transient-receptor potential ion channels in zebrafish taste buds. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. vol 207. 2017-02-07. PMID:27513962. |
up to now asic4, trpc2, trpa1, trpv1 and trpv4 ion channels have been found in the sensory cells, while asic2 was detected in the nerves supplying the taste buds. |
2017-02-07 |
2023-08-13 |
zebrafish |
| Toru Ishikura, Hitoshi Suzuki, Kanako Shoguchi, Yuki Koreeda, Takafumi Aritomi, Takanori Matsuura, Mitsuhiro Yoshimura, Jun-ichi Ohkubo, Takashi Maruyama, Makoto Kawasaki, Hideo Ohnishi, Akinori Sakai, Atsuko Mizuno, Makoto Suzuki, Yoichi Uet. Possible involvement of TRPV1 and TRPV4 in nociceptive stimulation- induced nocifensive behavior and neuroendocrine response in mice. Brain research bulletin. vol 118. 2016-08-22. PMID:26314785. |
we subcutaneously injected saline, formalin, or the trpv4 agonist, 4α-phorbol 12,13-didecanoate (4α-pdd) into one hindpaw of wild-type (wt), trpv1-deficient (trpv1(-/-)), and trpv4-deficient (trpv4(-/-)) mice to investigate nocifensive behaviors (phase i [0-10 min] and phase ii [10-60 min]) and fos expression in the dorsal horn of the spinal cord and other brain regions related to pain, in the paraventricular nucleus (pvn), paraventricular nucleus of the thalamus, the medial habenular nucleus, the medial nucleus of the amygdala and capsular part of the central amygdala. |
2016-08-22 |
2023-08-13 |
mouse |
| Jaung-Geng Lin, Ching-Liang Hsieh, Yi-Wen Li. Analgesic Effect of Electroacupuncture in a Mouse Fibromyalgia Model: Roles of TRPV1, TRPV4, and pERK. PloS one. vol 10. issue 6. 2016-05-02. PMID:26043006. |
analgesic effect of electroacupuncture in a mouse fibromyalgia model: roles of trpv1, trpv4, and perk. |
2016-05-02 |
2023-08-13 |
mouse |
| Jaung-Geng Lin, Ching-Liang Hsieh, Yi-Wen Li. Analgesic Effect of Electroacupuncture in a Mouse Fibromyalgia Model: Roles of TRPV1, TRPV4, and pERK. PloS one. vol 10. issue 6. 2016-05-02. PMID:26043006. |
the increase in mechanical hyperalgesia was also accompanied by upregulation of trpv1 expression and phosphoactivation of extracellular signal regulated kinase (perk) in the drg, whereas drg expression levels of trpv4, p-p38, and p-jnk were unaltered. |
2016-05-02 |
2023-08-13 |
mouse |