| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ayumi Fukazawa, Amane Hori, Hotta Norio, Kimiaki Katanosaka, Juan A Estrada, Rie Ishizawa, Han-Kyul Kim, Gary A Iwamoto, Scott A Smith, Wanpen Vongpatanasin, Masaki Mizun. Antagonism of TRPV4 channels partially reduces mechanotransduction in rat skeletal muscle afferents. The Journal of physiology vol issue 2023 36869605 |
fluorescence immunostaining revealed that 20.1 \xc2\xb1 10.1% of trpv4 positive neurons were expressed with dii-labeled small dorsal root ganglia (drg) neurons, and 9.5 \xc2\xb1 6.1% of trpv4 were co-localized with c-fibre marker, peripherin-positive neurons. |
2023-03-04 |
2023-03-06 |
rat |
| Ayumi Fukazawa, Amane Hori, Hotta Norio, Kimiaki Katanosaka, Juan A Estrada, Rie Ishizawa, Han-Kyul Kim, Gary A Iwamoto, Scott A Smith, Wanpen Vongpatanasin, Masaki Mizun. Antagonism of TRPV4 channels partially reduces mechanotransduction in rat skeletal muscle afferents. The Journal of physiology vol issue 2023 36869605 |
in vitro whole-cell patch clamp recordings from cultured rat drg neurons demonstrated that mechanically-activated current amplitude was significantly attenuated after the application of the trpv4 antagonist, hc067047 compared to control (p = 0.004). |
2023-03-04 |
2023-03-06 |
rat |
| Ayumi Fukazawa, Amane Hori, Hotta Norio, Kimiaki Katanosaka, Juan A Estrada, Rie Ishizawa, Han-Kyul Kim, Gary A Iwamoto, Scott A Smith, Wanpen Vongpatanasin, Masaki Mizun. Antagonism of TRPV4 channels partially reduces mechanotransduction in rat skeletal muscle afferents. The Journal of physiology vol issue 2023 36869605 |
in addition, we show that the trpv4 antagonist, hc067047, decreases the responsiveness of thin fibre afferents to mechanical stimulation at the muscle tissue level as well as at the level of dorsal root ganglion neurons. |
2023-03-04 |
2023-03-06 |
rat |
| Ayumi Fukazawa, Amane Hori, Hotta Norio, Kimiaki Katanosaka, Juan A Estrada, Rie Ishizawa, Han-Kyul Kim, Gary A Iwamoto, Scott A Smith, Wanpen Vongpatanasin, Masaki Mizun. Antagonism of TRPV4 channels partially reduces mechanotransduction in rat skeletal muscle afferents. The Journal of physiology vol issue 2023 36869605 |
the trpv4 antagonist, hc067047, reduces the responsiveness of thin fibre muscle afferents and small dorsal root ganglion neurons to mechanical stimulation. |
2023-03-04 |
2023-03-06 |
rat |
| Francesco De Logu, Roberto Maglie, Mustafa Titiz, Giulio Poli, Lorenzo Landini, Matilde Marini, Daniel Souza Monteiro de Araujo, Gaetano De Siena, Marco Montini, Daniela Almeida Cabrini, Michel Fleith Otuki, Priscila L\\xc3\\xbacia Pawloski, Emiliano Antiga, Tiziano Tuccinardi, Jo\\xc3\\xa3o Batista Calixto, Pierangelo Geppetti, Romina Nassini, Eunice Andr\\xc3\\xa. miRNA-203b-3p Induces Acute and Chronic Pruritus through 5-HTR2B and TRPV4. The Journal of investigative dermatology vol 143 issue 1 2022 36049541 |
human psoriatic lesions showed increased expression of several micrornas, including the mir-203b-3p, which induced a calcium ion response in rodent dorsal root ganglion neurons and scratching behavior in mice through 5-htr2b activation and the protein kinase c\xe2\x80\x92dependent phosphorylation of trpv4. |
2022-12-27 |
2023-03-06 |
mouse |
| Shota Tobori, Haruka Hiyama, Takahito Miyake, Yuichi Yano, Kazuki Nagayasu, Hisashi Shirakawa, Takayuki Nakagawa, Yasuo Mori, Shuji Kanek. MrgprB4 in trigeminal neurons expressing TRPA1 modulates unpleasant sensations. Journal of pharmacological sciences vol 146 issue 4 2021 34116733 |
we examined small populations of mrgprb4-positive neurons in the trigeminal ganglion and the dorsal root ganglion, and most of these were sensitive to transient receptor potential ankyrin 1 (trpa1) agonist but not trpv1, trpm8, or trpv4 agonists. |
2021-11-12 |
2023-01-26 |
mouse |
| Yuan-Yuan Cui, Meng-Ying Li, Yu-Ting Li, Jia-Yi Ning, Xing-Chun Gou, Juan Shi, Yun-Qing L. Expression and functional characterization of transient receptor potential vanilloid 4 in the dorsal root ganglion and spinal cord of diabetic rats with mechanical allodynia. Brain research bulletin vol 162 issue 2021 32479780 |
we investigated the spatial and temporal expression patterns of trpv4 in the dorsal root ganglion (drg) and spinal dorsal horn (sdh) by qrt-pcr, western blotting and immunofluorescence assays. |
2021-09-29 |
2023-01-26 |
rat |
| Yuan-Yuan Cui, Meng-Ying Li, Yu-Ting Li, Jia-Yi Ning, Xing-Chun Gou, Juan Shi, Yun-Qing L. Expression and functional characterization of transient receptor potential vanilloid 4 in the dorsal root ganglion and spinal cord of diabetic rats with mechanical allodynia. Brain research bulletin vol 162 issue 2021 32479780 |
the increase in trpv4 was mainly observed in the soma and central processes of calcitonin gene-related peptide (cgrp)- or neurofilament 200 kda (nf200)-containing drg neurons. |
2021-09-29 |
2023-01-26 |
rat |
| Jinjin Yan, Fan Ye, Ying Ju, Dijun Wang, Jiao Chen, Xinyu Zhang, Zhi Yin, Changming Wang, Yan Yang, Chan Zhu, Yuan Zhou, Peng Cao, Yang Xu, Guang Yu, Zongxiang Tan. Cimifugin relieves pruritus in psoriasis by inhibiting TRPV4. Cell calcium vol 97 issue 2021 34087722 |
according to our results, psoriasis induced itch was trpv4 dependent, and trpv4 expression in both epidermis and drg were up-regulated in psoriasis. |
2021-07-06 |
2023-01-26 |
Not clear |
| Hui Wei, Wen-Shuang Gao, Lei Qi, Lei Jia, Yu-Juan Qu, Shou-Wei Yue, Yang Zhan. Effect of cGMP-activated aquaporin 1 on TRPV4 in rats with allodynia induced by chronic compression of the dorsal root ganglion. Neuroscience letters vol 716 issue 2020 31790718 |
effect of cgmp-activated aquaporin 1 on trpv4 in rats with allodynia induced by chronic compression of the dorsal root ganglion. |
2020-12-14 |
2023-01-26 |
rat |
| Hui Wei, Wen-Shuang Gao, Lei Qi, Lei Jia, Yu-Juan Qu, Shou-Wei Yue, Yang Zhan. Effect of cGMP-activated aquaporin 1 on TRPV4 in rats with allodynia induced by chronic compression of the dorsal root ganglion. Neuroscience letters vol 716 issue 2020 31790718 |
the aim of this study was to investigate the effects of aquaporin 1 (aqp1) knockdown on allodynia in rats with chronic compression of the dorsal root ganglia (drg) and the role of trpv4 in these effects. |
2020-12-14 |
2023-01-26 |
rat |
| Andy Tay, Ali Sohrabi, Kate Poole, Stephanie Seidlits, Dino Di Carl. A 3D Magnetic Hyaluronic Acid Hydrogel for Magnetomechanical Neuromodulation of Primary Dorsal Root Ganglion Neurons. Advanced materials (Deerfield Beach, Fla.) vol issue 2020 29888402 |
by testing with different neurotoxins, and micropillar substrate deflections with electrophysical recordings, it is found that acute magnetomechanical stimulation induces calcium influx in drg neurons primarily via endogenous, mechanosensitive trpv4 and piezo2 channels. |
2020-09-30 |
2023-01-26 |
Not clear |
| Hui Kan Hong, Yi Ma, Hengtao Xi. TRPV1 and spinal astrocyte activation contribute to remifentanil-induced hyperalgesia in rats. Neuroreport vol 30 issue 16 2020 31568203 |
protein expressions of trpv1 and protein kinase c (pkc) in dorsal root ganglion were assayed by western blotting and mrna level of trpv1, trpa1, trpv4, and trpm8 were assayed by real-time pcr. |
2020-07-14 |
2023-01-26 |
rat |
| Simone Li Puma, Lorenzo Landini, Sergio J Macedo, Viola Seravalli, Ilaria M Marone, Elisabetta Coppi, Riccardo Patacchini, Pierangelo Geppetti, Serena Materazzi, Romina Nassini, Francesco De Log. TRPA1 mediates the antinociceptive properties of the constituent of Crocus sativus L., safranal. Journal of cellular and molecular medicine vol 23 issue 3 2020 30636360 |
safranal by binding to specific cysteine/lysine residues, stimulates trpa1, but not the trp vanilloid 1 and 4 channels (trpv1 and trpv4), evoking calcium responses and currents in human cells and rat and mouse dorsal root ganglion (drg) neurons. |
2020-06-25 |
2023-01-26 |
rat |
| Simone Li Puma, Lorenzo Landini, Sergio J Macedo, Viola Seravalli, Ilaria M Marone, Elisabetta Coppi, Riccardo Patacchini, Pierangelo Geppetti, Serena Materazzi, Romina Nassini, Francesco De Log. TRPA1 mediates the antinociceptive properties of the constituent of Crocus sativus L., safranal. Journal of cellular and molecular medicine vol 23 issue 3 2020 30636360 |
after exposure to safranal the ability of allyl isothiocyanate (trpa1 agonist), but not that of capsaicin (trpv1 agonist) or gsk1016790a (trpv4 agonist), to evoke currents in drg neurons, contraction of urinary bladder strips and cgrp release from spinal cord slices in rats, and acute nociception in mice underwent desensitization. |
2020-06-25 |
2023-01-26 |
rat |
| Fabiana C Dias, Vin\\xc3\\xadcius S Alves, Daiane O Matias, Claudia P Figueiredo, Ana Luisa P Miranda, Giselle F Passos, Robson Cost. The selective TRPV4 channel antagonist HC-067047 attenuates mechanical allodynia in diabetic mice. European journal of pharmacology vol 856 issue 2020 31129158 |
immunohistochemistry assay showed that trpv4 expression was not different in sciatic nerve, dorsal root ganglia (drg) or hind paw plantar skin from diabetic and non-diabetic mice, suggesting that hc-067047 acts on constitutive receptors to inhibit mechanical allodynia. |
2020-01-13 |
2023-01-26 |
mouse |
| Mikie Hinata, Sunao Imai, Takao Sanaki, Junji Tsuchida, Takeshi Yoshioka, Kenichi Higashino, Miyuki Yamamoto, Masayuki Imai, Masahiko Soga, Narumi Horita, Isao Fukuda, Minoru Ikeda, Shoji Yamane, Atsushi Morita, Toshiyuki Kanemasa, Gaku Sakaguchi, Minoru Hasegawa, Masabumi Minami, Yasuhide Moriok. Sensitization of transient receptor potential vanilloid 4 and increasing its endogenous ligand 5,6-epoxyeicosatrienoic acid in rats with monoiodoacetate-induced osteoarthritis. Pain vol 159 issue 5 2019 29438227 |
trpv4 expression was not increased in knee joints of mia rats; however, the levels of phosphorylated trpv4 at ser824 were increased in dorsal root ganglion neurons. |
2019-06-04 |
2023-01-26 |
rat |
| Mikie Hinata, Sunao Imai, Takao Sanaki, Junji Tsuchida, Takeshi Yoshioka, Kenichi Higashino, Miyuki Yamamoto, Masayuki Imai, Masahiko Soga, Narumi Horita, Isao Fukuda, Minoru Ikeda, Shoji Yamane, Atsushi Morita, Toshiyuki Kanemasa, Gaku Sakaguchi, Minoru Hasegawa, Masabumi Minami, Yasuhide Moriok. Sensitization of transient receptor potential vanilloid 4 and increasing its endogenous ligand 5,6-epoxyeicosatrienoic acid in rats with monoiodoacetate-induced osteoarthritis. Pain vol 159 issue 5 2019 29438227 |
in conclusion, trpv4 was sensitized in the knee joints of mia rats through phosphorylation in dorsal root ganglion neurons, along with an increase in the levels of its endogenous ligand 5,6-eet. |
2019-06-04 |
2023-01-26 |
rat |
| Seungil Kim, Devin M Barry, Xian-Yu Liu, Shijin Yin, Admire Munanairi, Qing-Tao Meng, Wei Cheng, Ping Mo, Li Wan, Shen-Bin Liu, Kasun Ratnayake, Zhong-Qiu Zhao, Narasimhan Gautam, Jie Zheng, W K Ajith Karunarathne, Zhou-Feng Che. Facilitation of TRPV4 by TRPV1 is required for itch transmission in some sensory neuron populations. Science signaling vol 9 issue 437 2017 27436359 |
biochemical and biophysical studies suggested a close proximity between trpv4 and trpv1 in dorsal root ganglion neurons and in cultured cells. |
2017-11-20 |
2023-01-25 |
mouse |
| Kent Sakai, Kristen M Sanders, Marina R Youssef, Kevin M Yanushefski, Liselotte Jensen, Gil Yosipovitch, Tasuku Akiyam. Mouse model of imiquimod-induced psoriatic itch. Pain vol 157 issue 11 2017 27437787 |
trpv4 mrna expression was transiently increased in the drg cells, whereas trpm8 mrna was significantly decreased. |
2017-11-07 |
2023-01-25 |
mouse |