| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Man-Xiu Xie, Jun-Hua Rao, Xiao-Yu Tian, Jin-Kun Liu, Xiao Li, Zi-Yi Chen, Yan Cao, An-Nan Chen, Hai-Hua Shu, Xiao-Long Zhan. ATF4 inhibits TRPV4 function and controls itch perception in rodents and nonhuman primates. Pain. 2024-02-29. PMID:38422489. |
in addition, interference with atf4 increases the itch sensitivity in nonhuman primates and enhances trpv4 currents in nonhuman primates drg neurons; atf4 and trpv4 also co-expresses in human sensory neurons. |
2024-02-29 |
2024-03-03 |
mouse |
| Jijun Xu, Ping Huang, Bihua Bie, Yang Dai, Salma Ben-Salem, Nozha Borjini, Lingjun Zhang, Jin Chen, Mitchell Olman, Jianguo Cheng, Feng Li. Complement Receptor C3aR1 Contributes to Paclitaxel-Induced Peripheral Neuropathic Pain in Mice and Rats. Journal of immunology (Baltimore, Md. : 1950). 2023-10-20. PMID:37861348. |
we also found that paclitaxel induced less severe pima, along with a reduced drg expression of transient receptor potential channels of the vanilloid subtype 4 (trpv4), an essential mediator for pima, in c3ar1 ko than in wt mice. |
2023-10-20 |
2023-11-08 |
mouse |
| Jijun Xu, Ping Huang, Bihua Bie, Yang Dai, Salma Ben-Salem, Nozha Borjini, Lingjun Zhang, Jin Chen, Mitchell Olman, Jianguo Cheng, Feng Li. Complement Receptor C3aR1 Contributes to Paclitaxel-Induced Peripheral Neuropathic Pain in Mice and Rats. Journal of immunology (Baltimore, Md. : 1950). 2023-10-20. PMID:37861348. |
treating wt mice or rats with a c3ar1 antagonist markedly attenuated pima in association with downregulated drg trpv4 expression, reduced drg macrophages expansion, suppressed drg neuron hyperexcitability, and alleviated peripheral intraepidermal nerve fiber loss. |
2023-10-20 |
2023-11-08 |
mouse |
| Jijun Xu, Ping Huang, Bihua Bie, Yang Dai, Salma Ben-Salem, Nozha Borjini, Lingjun Zhang, Jin Chen, Mitchell Olman, Jianguo Cheng, Feng Li. Complement Receptor C3aR1 Contributes to Paclitaxel-Induced Peripheral Neuropathic Pain in Mice and Rats. Journal of immunology (Baltimore, Md. : 1950). 2023-10-20. PMID:37861348. |
these results suggest that complement regulates pima development through c3ar1 to upregulate trpv4 on drg neurons and promote drg macrophage expansion. |
2023-10-20 |
2023-11-08 |
mouse |
| Amanda B Sidwell, Celia McClintock, Katharine I Beča, Susan E Campbell, Beatrice M Girard, Margaret A Vizzar. Repeated variate stress increased voiding frequency and altered TrpV1 and TrpV4 transcript expression in lower urinary tract (LUT) pathways in female mice. Frontiers in urology. vol 2. 2023-09-11. PMID:37692906. |
quantitative pcr demonstrated significant (p ≤ 0.05) changes in trpv1 and trpv4 mrna expression between control and rvs cohorts in the urothelium, lumbosacral spinal cord, and drg. |
2023-09-11 |
2023-10-07 |
mouse |
| Zhen-Hua Xu, Zheng Niu, Yun Liu, Pei-Lin Liu, Xiao-Long Lin, Ling Zhang, Long Chen, Yu Song, Ren Sun, Hai-Long Zhan. TET1-TRPV4 Signaling Contributes to Bone Cancer Pain in Rats. Brain sciences. vol 13. issue 4. 2023-05-16. PMID:37190609. |
here, we demonstrated that trpv4, one of the transient receptor potential ion channel family members, was significantly elevated in the l4-6 drg of bcp rats. |
2023-05-16 |
2023-08-14 |
rat |
| Zhen-Hua Xu, Zheng Niu, Yun Liu, Pei-Lin Liu, Xiao-Long Lin, Ling Zhang, Long Chen, Yu Song, Ren Sun, Hai-Long Zhan. TET1-TRPV4 Signaling Contributes to Bone Cancer Pain in Rats. Brain sciences. vol 13. issue 4. 2023-05-16. PMID:37190609. |
interestingly, we found that tet1 inhibition downregulated trpv4 expression in the l4-6 drg of bcp rats. |
2023-05-16 |
2023-08-14 |
rat |
| Zhen-Hua Xu, Zheng Niu, Yun Liu, Pei-Lin Liu, Xiao-Long Lin, Ling Zhang, Long Chen, Yu Song, Ren Sun, Hai-Long Zhan. TET1-TRPV4 Signaling Contributes to Bone Cancer Pain in Rats. Brain sciences. vol 13. issue 4. 2023-05-16. PMID:37190609. |
as a result, these findings suggested that tet1 may contribute to bone cancer pain by upregulating trpv4 expression in the l4-6 drg of bcp rats and that tet1 or trpv4 may become therapeutic targets for bone cancer pain. |
2023-05-16 |
2023-08-14 |
rat |
| Ayumi Fukazawa, Amane Hori, Hotta Norio, Kimiaki Katanosaka, Juan A Estrada, Rie Ishizawa, Han-Kyul Kim, Gary A Iwamoto, Scott A Smith, Wanpen Vongpatanasin, Masaki Mizun. Antagonism of TRPV4 channels partially reduces mechanotransduction in rat skeletal muscle afferents. The Journal of physiology. 2023-03-04. PMID:36869605. |
fluorescence immunostaining revealed that 20.1 ± 10.1% of trpv4 positive neurons were expressed with dii-labeled small dorsal root ganglia (drg) neurons, and 9.5 ± 6.1% of trpv4 were co-localized with c-fibre marker, peripherin-positive neurons. |
2023-03-04 |
2023-08-14 |
rat |
| Ayumi Fukazawa, Amane Hori, Hotta Norio, Kimiaki Katanosaka, Juan A Estrada, Rie Ishizawa, Han-Kyul Kim, Gary A Iwamoto, Scott A Smith, Wanpen Vongpatanasin, Masaki Mizun. Antagonism of TRPV4 channels partially reduces mechanotransduction in rat skeletal muscle afferents. The Journal of physiology. 2023-03-04. PMID:36869605. |
in vitro whole-cell patch clamp recordings from cultured rat drg neurons demonstrated that mechanically-activated current amplitude was significantly attenuated after the application of the trpv4 antagonist, hc067047 compared to control (p = 0.004). |
2023-03-04 |
2023-08-14 |
rat |
| Ayumi Fukazawa, Amane Hori, Hotta Norio, Kimiaki Katanosaka, Juan A Estrada, Rie Ishizawa, Han-Kyul Kim, Gary A Iwamoto, Scott A Smith, Wanpen Vongpatanasin, Masaki Mizun. Antagonism of TRPV4 channels partially reduces mechanotransduction in rat skeletal muscle afferents. The Journal of physiology. 2023-03-04. PMID:36869605. |
in addition, we show that the trpv4 antagonist, hc067047, decreases the responsiveness of thin fibre afferents to mechanical stimulation at the muscle tissue level as well as at the level of dorsal root ganglion neurons. |
2023-03-04 |
2023-08-14 |
rat |
| Ayumi Fukazawa, Amane Hori, Hotta Norio, Kimiaki Katanosaka, Juan A Estrada, Rie Ishizawa, Han-Kyul Kim, Gary A Iwamoto, Scott A Smith, Wanpen Vongpatanasin, Masaki Mizun. Antagonism of TRPV4 channels partially reduces mechanotransduction in rat skeletal muscle afferents. The Journal of physiology. 2023-03-04. PMID:36869605. |
the trpv4 antagonist, hc067047, reduces the responsiveness of thin fibre muscle afferents and small dorsal root ganglion neurons to mechanical stimulation. |
2023-03-04 |
2023-08-14 |
rat |
| Shota Tobori, Haruka Hiyama, Takahito Miyake, Yuichi Yano, Kazuki Nagayasu, Hisashi Shirakawa, Takayuki Nakagawa, Yasuo Mori, Shuji Kanek. MrgprB4 in trigeminal neurons expressing TRPA1 modulates unpleasant sensations. Journal of pharmacological sciences. vol 146. issue 4. 2021-11-12. PMID:34116733. |
we examined small populations of mrgprb4-positive neurons in the trigeminal ganglion and the dorsal root ganglion, and most of these were sensitive to transient receptor potential ankyrin 1 (trpa1) agonist but not trpv1, trpm8, or trpv4 agonists. |
2021-11-12 |
2023-08-13 |
mouse |
| Yuan-Yuan Cui, Meng-Ying Li, Yu-Ting Li, Jia-Yi Ning, Xing-Chun Gou, Juan Shi, Yun-Qing L. Expression and functional characterization of transient receptor potential vanilloid 4 in the dorsal root ganglion and spinal cord of diabetic rats with mechanical allodynia. Brain research bulletin. vol 162. 2021-09-29. PMID:32479780. |
we investigated the spatial and temporal expression patterns of trpv4 in the dorsal root ganglion (drg) and spinal dorsal horn (sdh) by qrt-pcr, western blotting and immunofluorescence assays. |
2021-09-29 |
2023-08-13 |
rat |
| Yuan-Yuan Cui, Meng-Ying Li, Yu-Ting Li, Jia-Yi Ning, Xing-Chun Gou, Juan Shi, Yun-Qing L. Expression and functional characterization of transient receptor potential vanilloid 4 in the dorsal root ganglion and spinal cord of diabetic rats with mechanical allodynia. Brain research bulletin. vol 162. 2021-09-29. PMID:32479780. |
the increase in trpv4 was mainly observed in the soma and central processes of calcitonin gene-related peptide (cgrp)- or neurofilament 200 kda (nf200)-containing drg neurons. |
2021-09-29 |
2023-08-13 |
rat |
| Jinjin Yan, Fan Ye, Ying Ju, Dijun Wang, Jiao Chen, Xinyu Zhang, Zhi Yin, Changming Wang, Yan Yang, Chan Zhu, Yuan Zhou, Peng Cao, Yang Xu, Guang Yu, Zongxiang Tan. Cimifugin relieves pruritus in psoriasis by inhibiting TRPV4. Cell calcium. vol 97. 2021-07-06. PMID:34087722. |
according to our results, psoriasis induced itch was trpv4 dependent, and trpv4 expression in both epidermis and drg were up-regulated in psoriasis. |
2021-07-06 |
2023-08-13 |
Not clear |
| Hui Wei, Wen-Shuang Gao, Lei Qi, Lei Jia, Yu-Juan Qu, Shou-Wei Yue, Yang Zhan. Effect of cGMP-activated aquaporin 1 on TRPV4 in rats with allodynia induced by chronic compression of the dorsal root ganglion. Neuroscience letters. vol 716. 2020-12-14. PMID:31790718. |
effect of cgmp-activated aquaporin 1 on trpv4 in rats with allodynia induced by chronic compression of the dorsal root ganglion. |
2020-12-14 |
2023-08-13 |
rat |
| Hui Wei, Wen-Shuang Gao, Lei Qi, Lei Jia, Yu-Juan Qu, Shou-Wei Yue, Yang Zhan. Effect of cGMP-activated aquaporin 1 on TRPV4 in rats with allodynia induced by chronic compression of the dorsal root ganglion. Neuroscience letters. vol 716. 2020-12-14. PMID:31790718. |
the aim of this study was to investigate the effects of aquaporin 1 (aqp1) knockdown on allodynia in rats with chronic compression of the dorsal root ganglia (drg) and the role of trpv4 in these effects. |
2020-12-14 |
2023-08-13 |
rat |
| Andy Tay, Ali Sohrabi, Kate Poole, Stephanie Seidlits, Dino Di Carl. A 3D Magnetic Hyaluronic Acid Hydrogel for Magnetomechanical Neuromodulation of Primary Dorsal Root Ganglion Neurons. Advanced materials (Deerfield Beach, Fla.). 2020-09-30. PMID:29888402. |
by testing with different neurotoxins, and micropillar substrate deflections with electrophysical recordings, it is found that acute magnetomechanical stimulation induces calcium influx in drg neurons primarily via endogenous, mechanosensitive trpv4 and piezo2 channels. |
2020-09-30 |
2023-08-13 |
Not clear |
| Hui Kan Hong, Yi Ma, Hengtao Xi. TRPV1 and spinal astrocyte activation contribute to remifentanil-induced hyperalgesia in rats. Neuroreport. vol 30. issue 16. 2020-07-14. PMID:31568203. |
protein expressions of trpv1 and protein kinase c (pkc) in dorsal root ganglion were assayed by western blotting and mrna level of trpv1, trpa1, trpv4, and trpm8 were assayed by real-time pcr. |
2020-07-14 |
2023-08-13 |
rat |