| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Simone Li Puma, Lorenzo Landini, Sergio J Macedo, Viola Seravalli, Ilaria M Marone, Elisabetta Coppi, Riccardo Patacchini, Pierangelo Geppetti, Serena Materazzi, Romina Nassini, Francesco De Log. TRPA1 mediates the antinociceptive properties of the constituent of Crocus sativus L., safranal. Journal of cellular and molecular medicine. vol 23. issue 3. 2020-06-25. PMID:30636360. |
safranal by binding to specific cysteine/lysine residues, stimulates trpa1, but not the trp vanilloid 1 and 4 channels (trpv1 and trpv4), evoking calcium responses and currents in human cells and rat and mouse dorsal root ganglion (drg) neurons. |
2020-06-25 |
2023-08-13 |
mouse |
| Simone Li Puma, Lorenzo Landini, Sergio J Macedo, Viola Seravalli, Ilaria M Marone, Elisabetta Coppi, Riccardo Patacchini, Pierangelo Geppetti, Serena Materazzi, Romina Nassini, Francesco De Log. TRPA1 mediates the antinociceptive properties of the constituent of Crocus sativus L., safranal. Journal of cellular and molecular medicine. vol 23. issue 3. 2020-06-25. PMID:30636360. |
after exposure to safranal the ability of allyl isothiocyanate (trpa1 agonist), but not that of capsaicin (trpv1 agonist) or gsk1016790a (trpv4 agonist), to evoke currents in drg neurons, contraction of urinary bladder strips and cgrp release from spinal cord slices in rats, and acute nociception in mice underwent desensitization. |
2020-06-25 |
2023-08-13 |
mouse |
| Fabiana C Dias, Vinícius S Alves, Daiane O Matias, Claudia P Figueiredo, Ana Luisa P Miranda, Giselle F Passos, Robson Cost. The selective TRPV4 channel antagonist HC-067047 attenuates mechanical allodynia in diabetic mice. European journal of pharmacology. vol 856. 2020-01-13. PMID:31129158. |
immunohistochemistry assay showed that trpv4 expression was not different in sciatic nerve, dorsal root ganglia (drg) or hind paw plantar skin from diabetic and non-diabetic mice, suggesting that hc-067047 acts on constitutive receptors to inhibit mechanical allodynia. |
2020-01-13 |
2023-08-13 |
mouse |
| Mikie Hinata, Sunao Imai, Takao Sanaki, Junji Tsuchida, Takeshi Yoshioka, Kenichi Higashino, Miyuki Yamamoto, Masayuki Imai, Masahiko Soga, Narumi Horita, Isao Fukuda, Minoru Ikeda, Shoji Yamane, Atsushi Morita, Toshiyuki Kanemasa, Gaku Sakaguchi, Minoru Hasegawa, Masabumi Minami, Yasuhide Moriok. Sensitization of transient receptor potential vanilloid 4 and increasing its endogenous ligand 5,6-epoxyeicosatrienoic acid in rats with monoiodoacetate-induced osteoarthritis. Pain. vol 159. issue 5. 2019-06-04. PMID:29438227. |
trpv4 expression was not increased in knee joints of mia rats; however, the levels of phosphorylated trpv4 at ser824 were increased in dorsal root ganglion neurons. |
2019-06-04 |
2023-08-13 |
rat |
| Mikie Hinata, Sunao Imai, Takao Sanaki, Junji Tsuchida, Takeshi Yoshioka, Kenichi Higashino, Miyuki Yamamoto, Masayuki Imai, Masahiko Soga, Narumi Horita, Isao Fukuda, Minoru Ikeda, Shoji Yamane, Atsushi Morita, Toshiyuki Kanemasa, Gaku Sakaguchi, Minoru Hasegawa, Masabumi Minami, Yasuhide Moriok. Sensitization of transient receptor potential vanilloid 4 and increasing its endogenous ligand 5,6-epoxyeicosatrienoic acid in rats with monoiodoacetate-induced osteoarthritis. Pain. vol 159. issue 5. 2019-06-04. PMID:29438227. |
in conclusion, trpv4 was sensitized in the knee joints of mia rats through phosphorylation in dorsal root ganglion neurons, along with an increase in the levels of its endogenous ligand 5,6-eet. |
2019-06-04 |
2023-08-13 |
rat |
| Seungil Kim, Devin M Barry, Xian-Yu Liu, Shijin Yin, Admire Munanairi, Qing-Tao Meng, Wei Cheng, Ping Mo, Li Wan, Shen-Bin Liu, Kasun Ratnayake, Zhong-Qiu Zhao, Narasimhan Gautam, Jie Zheng, W K Ajith Karunarathne, Zhou-Feng Che. Facilitation of TRPV4 by TRPV1 is required for itch transmission in some sensory neuron populations. Science signaling. vol 9. issue 437. 2017-11-20. PMID:27436359. |
biochemical and biophysical studies suggested a close proximity between trpv4 and trpv1 in dorsal root ganglion neurons and in cultured cells. |
2017-11-20 |
2023-08-13 |
mouse |
| Kent Sakai, Kristen M Sanders, Marina R Youssef, Kevin M Yanushefski, Liselotte Jensen, Gil Yosipovitch, Tasuku Akiyam. Mouse model of imiquimod-induced psoriatic itch. Pain. vol 157. issue 11. 2017-11-07. PMID:27437787. |
trpv4 mrna expression was transiently increased in the drg cells, whereas trpm8 mrna was significantly decreased. |
2017-11-07 |
2023-08-13 |
mouse |
| Yu-Juan Qu, Xiao Zhang, Zhen-Zhen Fan, Juan Huai, Yong-Bo Teng, Yang Zhang, Shou-Wei Yu. Effect of TRPV4-p38 MAPK Pathway on Neuropathic Pain in Rats with Chronic Compression of the Dorsal Root Ganglion. BioMed research international. vol 2016. 2017-02-13. PMID:27366753. |
the aim of this study was to investigate the relationships among trpv4, p38, and neuropathic pain in a rat model of chronic compression of the dorsal root ganglion. |
2017-02-13 |
2023-08-13 |
rat |
| Yu-Juan Qu, Xiao Zhang, Zhen-Zhen Fan, Juan Huai, Yong-Bo Teng, Yang Zhang, Shou-Wei Yu. Effect of TRPV4-p38 MAPK Pathway on Neuropathic Pain in Rats with Chronic Compression of the Dorsal Root Ganglion. BioMed research international. vol 2016. 2017-02-13. PMID:27366753. |
collectively, these results support the link between trpv4 and p38 and their intermediary role for neuropathic pain in rats with chronic compression of the dorsal root ganglion. |
2017-02-13 |
2023-08-13 |
rat |
| Tasuku Akiyama, Margaret Ivanov, Masaki Nagamine, Auva Davoodi, Mirela I Carstens, Akihiko Ikoma, Ferda Cevikbas, Cordula Kempkes, Joerg Buddenkotte, Martin Steinhoff, E Carsten. Involvement of TRPV4 in Serotonin-Evoked Scratching. The Journal of investigative dermatology. vol 136. issue 1. 2016-05-20. PMID:26763435. |
using calcium imaging in cultured primary murine dorsal root ganglion neurons, the response of neurons after 5-ht application, but not other pruritogens, was significantly lower in trpv4 knockout compared with wild-type mice. |
2016-05-20 |
2023-08-13 |
mouse |
| Tasuku Akiyama, Margaret Ivanov, Masaki Nagamine, Auva Davoodi, Mirela I Carstens, Akihiko Ikoma, Ferda Cevikbas, Cordula Kempkes, Joerg Buddenkotte, Martin Steinhoff, E Carsten. Involvement of TRPV4 in Serotonin-Evoked Scratching. The Journal of investigative dermatology. vol 136. issue 1. 2016-05-20. PMID:26763435. |
a trpv4 antagonist significantly suppressed 5-ht-evoked responses in dorsal root ganglion cells from wild-type mice. |
2016-05-20 |
2023-08-13 |
mouse |
| Tasuku Akiyama, Margaret Ivanov, Masaki Nagamine, Auva Davoodi, Mirela I Carstens, Akihiko Ikoma, Ferda Cevikbas, Cordula Kempkes, Joerg Buddenkotte, Martin Steinhoff, E Carsten. Involvement of TRPV4 in Serotonin-Evoked Scratching. The Journal of investigative dermatology. vol 136. issue 1. 2016-05-20. PMID:26763435. |
approximately 90% of 5-ht-sensitive dorsal root ganglion neurons were immunoreactive for an antibody to trpv4, as assessed by calcium imaging. |
2016-05-20 |
2023-08-13 |
mouse |
| Jaung-Geng Lin, Ching-Liang Hsieh, Yi-Wen Li. Analgesic Effect of Electroacupuncture in a Mouse Fibromyalgia Model: Roles of TRPV1, TRPV4, and pERK. PloS one. vol 10. issue 6. 2016-05-02. PMID:26043006. |
the increase in mechanical hyperalgesia was also accompanied by upregulation of trpv1 expression and phosphoactivation of extracellular signal regulated kinase (perk) in the drg, whereas drg expression levels of trpv4, p-p38, and p-jnk were unaltered. |
2016-05-02 |
2023-08-13 |
mouse |
| Jaung-Geng Lin, Ching-Liang Hsieh, Yi-Wen Li. Analgesic Effect of Electroacupuncture in a Mouse Fibromyalgia Model: Roles of TRPV1, TRPV4, and pERK. PloS one. vol 10. issue 6. 2016-05-02. PMID:26043006. |
this study strongly suggests that drg trpv1 overexpression and perk signaling, as well as sc trpv1 and trpv4 overexpression, mediate hyperalgesia in a mouse fm pain model. |
2016-05-02 |
2023-08-13 |
mouse |
| Zhanying Tang, Xuejun Cui, Zhijun Hu, Jing Xiao, Weiwei Li, Qiangling Yang, Dan Liu, Jie Lin, Yongjun Wang, Qi Sh. Yiqi Huayu recipe relieves nerve root constriction induced radicular neuralgia by down-regulating TRPV4 expression in dorsal root ganglion. International journal of clinical and experimental medicine. vol 8. issue 10. 2016-01-15. PMID:26770465. |
yiqi huayu recipe relieves nerve root constriction induced radicular neuralgia by down-regulating trpv4 expression in dorsal root ganglion. |
2016-01-15 |
2023-08-13 |
rat |
| Zhanying Tang, Xuejun Cui, Zhijun Hu, Jing Xiao, Weiwei Li, Qiangling Yang, Dan Liu, Jie Lin, Yongjun Wang, Qi Sh. Yiqi Huayu recipe relieves nerve root constriction induced radicular neuralgia by down-regulating TRPV4 expression in dorsal root ganglion. International journal of clinical and experimental medicine. vol 8. issue 10. 2016-01-15. PMID:26770465. |
the expression of trpv4 in dorsal root ganglion was detected at both mrna and protein level. |
2016-01-15 |
2023-08-13 |
rat |
| Zhanying Tang, Xuejun Cui, Zhijun Hu, Jing Xiao, Weiwei Li, Qiangling Yang, Dan Liu, Jie Lin, Yongjun Wang, Qi Sh. Yiqi Huayu recipe relieves nerve root constriction induced radicular neuralgia by down-regulating TRPV4 expression in dorsal root ganglion. International journal of clinical and experimental medicine. vol 8. issue 10. 2016-01-15. PMID:26770465. |
in conclusion, yiqi huayu recipe alleviates nerve root constriction induced radicular neuralgia by repressing trpv4 expression in dorsal root ganglion. |
2016-01-15 |
2023-08-13 |
rat |
| Hui Wei, Li-Ping Ning, Yang Zhang, Shou-Wei Yu. Role of actin filaments in allodynia induced by chronic compression of the dorsal root ganglion. Neuroscience letters. vol 600. 2015-10-19. PMID:25962822. |
the role of actin filaments in allodynia induced by chronic compression of the dorsal root ganglion (drg) (ccd) and the effects of microfilaments dynamics on transient receptor potential vanilloid 4 (trpv4) were investigated in this study. |
2015-10-19 |
2023-08-13 |
rat |
| Liping Ning, Chuanwei Wang, Xiaohua Fan, Xinli Ding, Yonghui Wang, Yang Zhang, Jie Wang, Shouwei Yu. Role of colchicine-induced microtubule depolymerization in hyperalgesia via TRPV4 in rats with chronic compression of the dorsal root ganglion. Neurological research. vol 36. issue 1. 2014-09-03. PMID:24074178. |
role of colchicine-induced microtubule depolymerization in hyperalgesia via trpv4 in rats with chronic compression of the dorsal root ganglion. |
2014-09-03 |
2023-08-12 |
rat |
| Liping Ning, Chuanwei Wang, Xiaohua Fan, Xinli Ding, Yonghui Wang, Yang Zhang, Jie Wang, Shouwei Yu. Role of colchicine-induced microtubule depolymerization in hyperalgesia via TRPV4 in rats with chronic compression of the dorsal root ganglion. Neurological research. vol 36. issue 1. 2014-09-03. PMID:24074178. |
the aim of this study is to investigate the effect of microtubule depolymerization by colchicine on hyperalgesia mediated by transient receptor potential vanilloid 4 (trpv4) in a neuropathic pain model of chronic compression of the dorsal root ganglion (drg) (hereafter termed ccd) in rat. |
2014-09-03 |
2023-08-12 |
rat |