| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fatemeh Ardalan Moghadam Al, Mohammad Mahdi Forghanifard, Vajiheh Zarrinpou. PYGO2 increases proliferation and migration capacities through critical signaling pathways in esophageal squamous cell carcinoma. Journal of biochemical and molecular toxicology. vol 38. issue 1. 2024-01-17. PMID:38229324. |
the development of esophageal squamous cell carcinoma (escc) involves various genetic abnormalities that affect key cell signaling pathways, including wnt, hh, apoptosis, mapk, egfr, akt, notch, and emt. |
2024-01-17 |
2024-01-19 |
Not clear |
| Fatemeh Ardalan Moghadam Al, Mohammad Mahdi Forghanifard, Vajiheh Zarrinpou. PYGO2 increases proliferation and migration capacities through critical signaling pathways in esophageal squamous cell carcinoma. Journal of biochemical and molecular toxicology. vol 38. issue 1. 2024-01-17. PMID:38229324. |
furthermore, pygo2 gene expression induction analysis showed the correlation of several involved genes in wnt, hh, apoptosis, mapk, egfr, akt, and emt pathways with various lncrnas. |
2024-01-17 |
2024-01-19 |
Not clear |
| He Sun, Dandan Xiao, Wei Liu, Xue Li, Zhe Lin, Yong Li, Yuling Din. Well-known polypeptides of deer antler velvet with key actives: modern pharmacological advances. Naunyn-Schmiedeberg's archives of pharmacology. 2023-08-09. PMID:37555852. |
the results showed that deer antler polypeptides (daps), by regulating egf, egfr, mapk, p38, erk, nf-κb, wnt, pi3k, akt, mmp, ampk, stir1, nlrp3, ho-1, nrf, rho, tlr, tgf-β, smad, ang ii, etc., revealed their effects on seven system-related diseases and their mechanisms, including osteoarthritis, intervertebral disc degeneration, osteoporosis, alzheimer's, parkinson's, triple-negative breast cancer, liver injury, liver fibrosis, cardiovascular disease, acute lung injury, and late-onset hypogonadism. |
2023-08-09 |
2023-08-16 |
Not clear |
| Eric Mayo. Neurotrophic effects of intermittent fasting, calorie restriction and exercise: a review and annotated bibliography. Frontiers in aging. vol 4. 2023-06-19. PMID:37334045. |
the most researched signaling pathways (pi3k, akt, mtor, ampk, gsk3β, ulk, mapk, pgc-1α, nf-κb, sirtuins, notch, sonic hedgehog and wnt) and processes (e.g., anti-inflammation, autophagy, apoptosis) that support or thwart neuroprotection, synaptic plasticity and neurogenesis are then briefly presented. |
2023-06-19 |
2023-08-14 |
Not clear |
| Huibin Zhang, Jinglin Wang, Fan Xie, Yangguang Liu, Mengyao Qiu, Zheng Han, Yueyun Ding, Xianrui Zheng, Zongjun Yin, Xiaodong Zhan. Identification of microRNAs implicated in modulating resveratrol-induced apoptosis in porcine granulosa cells. Frontiers in cell and developmental biology. vol 11. 2023-05-30. PMID:37250898. |
in the high vs. con group, rsv functions were associated with metabolic processes and responses to stimuli, while the pathways were related to pi3k24, akt, wnt, and apoptosis. |
2023-05-30 |
2023-08-14 |
Not clear |
| Chithravel Vadivalagan, Anand Krishnan, Siang-Jyun Chen, You-Cheng Hseu, Sathish Muthu, Rajib Dhar, Alaa A A Aljabali, Murtaza M Tambuwal. The Warburg effect in osteoporosis: Cellular signaling and epigenetic regulation of energy metabolic events to targeting the osteocalcin for phenotypic alteration. Cellular signalling. 2022-10-08. PMID:36208706. |
however, it seems to improve their effectiveness in the osteoblast phenotype by connecting the selected pathways such as wnt, notch, akt, and insulin signaling by targeting osteocalcin resulting in phenotypic alteration. |
2022-10-08 |
2023-08-14 |
Not clear |
| Md Mominur Rahman, Md Taslim Sarker, Mst Afroza Alam Tumpa, Md Yamin, Tamanna Islam, Moon Nyeo Park, Md Rezaul Islam, Abdur Rauf, Rohit Sharma, Simona Cavalu, Bonglee Ki. Exploring the recent trends in perturbing the cellular signaling pathways in cancer by natural products. Frontiers in pharmacology. vol 13. 2022-09-26. PMID:36160435. |
these natural chemicals are known to affect numerous important cellular signaling pathways, such as nf-b, mapk, wnt, notch, akt, p53, ar, er, and many others, to cause cell death signals and induce apoptosis in pre-cancerous or cancer cells without harming normal cells. |
2022-09-26 |
2023-08-14 |
human |
| Nan Xing, Xianli Meng, Shaohui Wan. Isobavachalcone: A comprehensive review of its plant sources, pharmacokinetics, toxicity, pharmacological activities and related molecular mechanisms. Phytotherapy research : PTR. 2022-06-10. PMID:35684981. |
mechanically, ibc can induce the production of reactive oxygen species (ros), inhibit akt, erk, and wnt pathways, and promote apoptosis of cancer cells through mitochondrial or endoplasmic reticulum pathways. |
2022-06-10 |
2023-08-14 |
Not clear |
| Sibi Raj, Kavindra Kumar Kesari, Arun Kumar, Brijesh Rathi, Ashok Sharma, Piyush Kumar Gupta, Saurabh Kumar Jha, Niraj Kumar Jha, Petr Slama, Shubhadeep Roychoudhury, Dhruv Kuma. Molecular mechanism(s) of regulation(s) of c-MET/HGF signaling in head and neck cancer. Molecular cancer. vol 21. issue 1. 2022-01-27. PMID:35081970. |
c-met pathway acts on several downstream effectors including phospholipase c gamma (plcγ), cellular src kinase (c-src), phosphotidylinsitol-3-oh kinase (pi3k), alpha serine/threonine-protein kinase (akt), mitogen-activated protein kinase (mapk), and wingless-related integration site (wnt) pathways. |
2022-01-27 |
2023-08-13 |
human |
| Nidhi Rohatgi, Maria S Remedi, Guim Kwon, Kirk L Pappan, Connie A Marshall, Michael L McDanie. Therapeutic Strategies to Increase Human β-Cell Growth and Proliferation by Regulating mTOR and GSK-3/β-Catenin Pathways. The open endocrinology journal. vol 4. 2021-10-21. PMID:24339841. |
human islets displayed a high level of insulin resistance consistent with the inability of exogenous insulin to activate akt and engage the wnt pathway by gsk-3 inhibition. |
2021-10-21 |
2023-08-12 |
human |
| Wenqing Liang, Xiaozhen Chen, Songou Zhang, Jian Fang, Meikai Chen, Yifan Xu, Xuerong Che. Mesenchymal stem cells as a double-edged sword in tumor growth: focusing on MSC-derived cytokines. Cellular & molecular biology letters. vol 26. issue 1. 2021-10-06. PMID:33472580. |
however, other studies have shown that mscs suppress tumor growth by suppressing angiogenesis, incrementing inflammatory infiltration, apoptosis and cell cycle arrest, and inhibiting the akt and wnt signaling pathways. |
2021-10-06 |
2023-08-13 |
Not clear |
| Shengli Zhao, Jing Xie, Changhua Zhao, Wen Cao, Yangping Y. Ultrasound-Targeted Microbubble Destruction Enhances the Inhibitive Efficacy of miR-21 Silencing in HeLa Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 27. 2021-05-28. PMID:33606670. |
in addition, mir-21 overexpression significantly increased the expression of p-akt, akt, bcl-2, wnt, ß-catenin, matrix metalloprotein-9 (mmp-9), and epidermal growth factor (egfr) levels, and decreased bax expression. |
2021-05-28 |
2023-08-13 |
Not clear |
| Levi Arnold, Jonathan Enders, Sufi Mary Thoma. Activated HGF-c-Met Axis in Head and Neck Cancer. Cancers. vol 9. issue 12. 2020-10-01. PMID:29231907. |
the receptor and its ligand act on several downstream effectors including phospholipase c gamma (plcγ), cellular src kinase (c-src), phosphotidylinsitol-3-oh kinase (pi3k) alpha serine/threonine-protein kinase (akt), mitogen activate protein kinase (mapk), and wingless-related integration site (wnt) pathways. |
2020-10-01 |
2023-08-13 |
Not clear |
| Weiming Qiu, Mingxing Lei, Ling Zhou, Xiufeng Bai, Xiangdong Lai, Yu Yu, Tian Yang, Xiaohua Lia. Hair follicle stem cell proliferation, Akt and Wnt signaling activation in TPA-induced hair regeneration. Histochemistry and cell biology. vol 147. issue 6. 2018-01-12. PMID:28185006. |
meanwhile, we observed akt signaling was activated in epidermis, hair infundibulum, bulge and hair bulb, and wnt signaling was also activated after hair follicle stem cells proliferation. |
2018-01-12 |
2023-08-13 |
mouse |
| Hong Zhang, Xiuli Wang, Xinxin Che. Potential Role of Long Non-Coding RNA ANRIL in Pediatric Medulloblastoma Through Promotion on Proliferation and Migration by Targeting miR-323. Journal of cellular biochemistry. vol 118. issue 12. 2018-01-02. PMID:28513871. |
anril inhibition repressed cell proliferation and migration but promoted cell apoptosis through mir-323-mediated regulation of bri3, which could activate p38 mapk, erk, and akt as well as wnt signaling pathway. |
2018-01-02 |
2023-08-13 |
Not clear |
| Ki-Jong Rhee, Jong In Lee, Young Woo Eo. Mesenchymal Stem Cell-Mediated Effects of Tumor Support or Suppression. International journal of molecular sciences. vol 16. issue 12. 2016-10-05. PMID:26694366. |
in contrast to the tumor-promoting properties, mscs inhibit tumor growth by increasing inflammatory infiltration, inhibiting angiogenesis, suppressing wnt signaling and akt signaling, and inducing cell cycle arrest and apoptosis. |
2016-10-05 |
2023-08-13 |
Not clear |
| Dandan Liu, Changqing Yi, Chi-Chun Fong, Qinghui Jin, Zuankai Wang, Wai-Kin Yu, Dong Sun, Jianlong Zhao, Mengsu Yan. Activation of multiple signaling pathways during the differentiation of mesenchymal stem cells cultured in a silicon nanowire microenvironment. Nanomedicine : nanotechnology, biology, and medicine. vol 10. issue 6. 2015-03-30. PMID:24566272. |
the results showed that the microenvironment of sinw array activated a number of mechanosensitive pathways (including integrin, tgf-β/bmp, akt, mapk, insulin, and wnt pathways) in mscs, which converged to stimulate the osteogenesis and chondrogenesis via the ras-raf-mek-erk cascade. |
2015-03-30 |
2023-08-12 |
Not clear |
| Mousumi Tania, Md Asaduzzaman Khan, Junjiang F. Epithelial to mesenchymal transition inducing transcription factors and metastatic cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 8. 2015-01-13. PMID:24880591. |
a number of studies have reported that emt-inducing transcription factors (emt-tfs), such as twist, snail, slug, and zeb, are directly or indirectly involved in cancer cell metastasis through a different signaling cascades, including the akt, signal transducer and activator of transcription 3 (stat3), mitogen-activated protein kinase (mapk) and wnt pathways, with the ultimate consequence of the downregulation of e-cadherin and upregulation of metastatic proteins, such as n-cadherin, vimentin, matrix metalloproteinase (mmp)-2, etc. |
2015-01-13 |
2023-08-13 |
Not clear |
| Boban M Erovic, Luke Harris, Mina Jamali, David P Goldstein, Jonathan C Irish, Sylvia L Asa, Ozgur Met. Biomarkers of parathyroid carcinoma. Endocrine pathology. vol 23. issue 4. 2013-05-23. PMID:23001705. |
we constructed a tissue microarray of parathyroid carcinomas from 10 patients as well as parathyroid adenomas from 25 patients and stained the slides for 34 proteins involved in angiogenesis (platelet-derived growth factor receptor (pdgfr)-α, pdgfr-β, vascular endothelial growth factor receptor-2 (vegfr-2), and epidermal growth factor receptor (egfr)), inflammation (cyclooxygenase (cox)-1 and cox-2), cell adhesion (matrix metalloproteinase (mmp)-1, cd9, and keratin 7), cell cycle (cdc2p34, cyclin d1, retinoblastoma (rb), p27, p21, parafibromin, bmi-1, 14-3-3σ, and p53), and apoptosis (bcl-2a, mcl-1, bcl-xl, and glutathione-s-transferase-isoenzyme π (gst-π)) along with some markers of the sonic hedgehog (smo, shh, gli-1, gli-2, gli-3, and patched), mtor (akt, mammalian target of rapamycin (mtor), and forkhead box o (foxo)-1), and wnt (wisp-1, wisp-2, and β-catenin) signal transduction pathways. |
2013-05-23 |
2023-08-12 |
Not clear |
| Boban M Erovic, Dae Kim, Clarissa Cassol, David P Goldstein, Jonathan C Irish, Sylvia L Asa, Ozgur Met. Prognostic and predictive markers in medullary thyroid carcinoma. Endocrine pathology. vol 23. issue 4. 2013-05-23. PMID:23150029. |
we therefore examined morphologic features of aggressive behavior and the expression of 41 proteins involved in apoptosis, cell cycle, angiogenesis, inflammation, cell adhesion, tumor-specific markers, and wnt, shh, and akt pathways using tissue microarray from 23 patients with medullary thyroid carcinoma. |
2013-05-23 |
2023-08-12 |
Not clear |