All Relations between (2R)-amino-5-phosphonovaleric acid (AP5) and hippocampus

Publication Sentence Publish Date Extraction Date Species
Tonghui Su, Yi Lu, Chaoying Fu, Yang Geng, Yelin Che. GluN2A mediates ketamine-induced rapid antidepressant-like responses. Nature neuroscience. 2023-09-14. PMID:37709995. moreover, treatment with ketamine or mk-801 rapidly increased the intrinsic excitability of hippocampal principal neurons through glun2a, but not glun2b. 2023-09-14 2023-10-07 mouse
Jaqueline Rocha Borges Dos Santos, Mariana Rae, Simone Aparecida Teixeira, Marcelo Nicolás Muscará, Karen K Szumlinski, Rosana Camarin. The effect of MK-801 on stress-ethanol cross-sensitization is dissociable from its effects on nNOS activity. Alcohol (Fayetteville, N.Y.). 2023-07-21. PMID:37479092. however, mk-801 prevented the enhanced nnos activity in stress-exposed groups (challenged with saline or ethanol) in the pfc; the antagonist also prevented the ethanol-induced increase in nnos activity and reduced this enzyme activity in mice exposed to stress in the hippocampus. 2023-07-21 2023-08-14 mouse
P Abad-Perez, Molina-Payá F J, L Martínez-Otero, V Borrell, R L Redondo, J R Brotons-Ma. Theta/gamma co-modulation disruption after nmdar blockade by mk801 is associated with spatial working memory deficits in mice. Neuroscience. 2023-03-29. PMID:36990270. we implanted mice with tetrodes in the dorsal/intermediate hippocampus and medial prefrontal cortex (mpfc), administered the nmdar antagonist mk-801, and recorded oscillations during spontaneous exploration in an open field and in the y-maze spatial working memory test. 2023-03-29 2023-08-14 mouse
P Abad-Perez, Molina-Payá F J, L Martínez-Otero, V Borrell, R L Redondo, J R Brotons-Ma. Theta/gamma co-modulation disruption after nmdar blockade by mk801 is associated with spatial working memory deficits in mice. Neuroscience. 2023-03-29. PMID:36990270. in the hippocampus, mk-801 increased gamma oscillations and disrupted theta/gamma coupling during spatial working memory. 2023-03-29 2023-08-14 mouse
Luis A Márquez, Ernesto Griego, Carolina López Rubalcava, Emilio J Galvá. NMDA receptor activity during postnatal development determines intrinsic excitability and mossy fiber long-term potentiation of CA3 pyramidal cells. Hippocampus. 2023-03-20. PMID:36938755. blockade of nmdars with mk-801 during early postnatal development alters glutamate release and impairs the induction of nmdar-dependent long-term plasticity at the ca1 area of the hippocampus. 2023-03-20 2023-08-14 Not clear
Luis A Márquez, Ernesto Griego, Carolina López Rubalcava, Emilio J Galvá. NMDA receptor activity during postnatal development determines intrinsic excitability and mossy fiber long-term potentiation of CA3 pyramidal cells. Hippocampus. 2023-03-20. PMID:36938755. however, it remains unknown if other forms of hippocampal plasticity, such as α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (ampar)-mediated short- and long-term potentiation, are compromised in response to neonatal treatment with mk-801. 2023-03-20 2023-08-14 Not clear
Enrico Patrono, Karolina Hrůzova, Jan Svoboda, Aleš Stuchlí. The role of optogenetic stimulations of parvalbumin-positive interneurons in the prefrontal cortex and the ventral hippocampus on an acute MK-801 model of schizophrenia-like cognitive inflexibility. Schizophrenia research. vol 252. 2023-01-19. PMID:36657364. the role of optogenetic stimulations of parvalbumin-positive interneurons in the prefrontal cortex and the ventral hippocampus on an acute mk-801 model of schizophrenia-like cognitive inflexibility. 2023-01-19 2023-08-14 rat
Enrico Patrono, Karolina Hrůzova, Jan Svoboda, Aleš Stuchlí. The role of optogenetic stimulations of parvalbumin-positive interneurons in the prefrontal cortex and the ventral hippocampus on an acute MK-801 model of schizophrenia-like cognitive inflexibility. Schizophrenia research. vol 252. 2023-01-19. PMID:36657364. the second set of experiments demonstrated that specific optogenetic stimulation at specific frequencies of parvalbumin-positive interneurons in the prefrontal cortex and ventral hippocampus rescued the cognitive flexibility rats that received acute mk-801. 2023-01-19 2023-08-14 rat
Zhichao Wang, Lin Su, Tong Wu, Lei Sun, Zhenghai Sun, Yuchen Wang, Ping Li, Guangcheng Cu. Inhibition of MicroRNA-182/183 Cluster Ameliorates Schizophrenia by Activating the Axon Guidance Pathway and Upregulating DCC. Oxidative medicine and cellular longevity. vol 2022. 2022-11-21. PMID:36406766. moreover, rat primary hippocampal neurons were exposed to mk-801 to simulate injury of hippocampal neurons. 2022-11-21 2023-08-14 rat
Bo Pan, Lianlian Xu, Jianjun Weng, Yuting Wang, Hongyan Ji, Bing Han, Xiaoli Zhu, Yanqing Li. Effects of icariin on alleviating schizophrenia-like symptoms by regulating the miR-144-3p/ATP1B2/mTOR signalling pathway. Neuroscience letters. 2022-10-19. PMID:36261079. hematoxylin-eosin (he) staining on hippocampus slices, and mtt assay and calcein/pi staining on the sk-n-sh cells treated with mk-801 were carried out to assess the neuroprotective effects of icariin. 2022-10-19 2023-08-14 rat
Hakan Kayir, Bryan W Jenkins, Begüm Alural, Jibran Y Khokha. Clozapine Increases Nestin Concentration in the Adult Male Rat Hippocampus: A Preliminary Study. International journal of molecular sciences. vol 23. issue 7. 2022-04-12. PMID:35408792. mk-801 alone did not alter nestin concentration, while clozapine alone enhanced hippocampal nestin concentration; this effect was not apparent in animals with mk-801 and clozapine co-administration. 2022-04-12 2023-08-13 rat
Che-Wen Tsai, Shih-Jen Tsai, Yi-Ju Pan, Hsin-Mei Lin, Tsung-Yu Pan, Feng-Yi Yan. Transcranial Ultrasound Stimulation Reverses Behavior Changes and the Expression of Calcium-Binding Protein in a Rodent Model of Schizophrenia. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2022-03-01. PMID:35229268. lipus stimulation significantly increased hippocampal levels of cb and pv and restored the cell densities of pv + and cb + in the cingulate cortex in the mk-801 plus lipus-treated group. 2022-03-01 2023-08-13 rat
David Kolar, Lenka Kleteckova, Katerina Skalova, Hana Brozka, Martin Kalous, Karel Vale. Glycolytic and Krebs cycle enzymes activity in rat prefrontal cortex, hippocampus, and striatum after single and repeated NMDA inhibition by MK-801. Neurotoxicology. 2022-02-27. PMID:35219782. glycolytic and krebs cycle enzymes activity in rat prefrontal cortex, hippocampus, and striatum after single and repeated nmda inhibition by mk-801. 2022-02-27 2023-08-13 rat
Agnieszka Wąsik, Magdalena Białoń, Danuta Jantas, Marcelina Żarnowsk. The Impact of the Combined Administration of 1MeTIQ and MK-801 on Cell Viability, Oxidative Stress Markers, and Glutamate Release in the Rat Hippocampus. Neurotoxicity research. vol 39. issue 6. 2021-12-04. PMID:34665405. the impact of the combined administration of 1metiq and mk-801 on cell viability, oxidative stress markers, and glutamate release in the rat hippocampus. 2021-12-04 2023-08-13 rat
Agnieszka Wąsik, Magdalena Białoń, Danuta Jantas, Marcelina Żarnowsk. The Impact of the Combined Administration of 1MeTIQ and MK-801 on Cell Viability, Oxidative Stress Markers, and Glutamate Release in the Rat Hippocampus. Neurotoxicity research. vol 39. issue 6. 2021-12-04. PMID:34665405. the aim of the present study was to evaluate the effect of combined treatment with 1metiq and mk-801 on cell viability, antioxidant enzyme activity, and glutamate release in the rat hippocampus. 2021-12-04 2023-08-13 rat
Murat Sırrı Akosman, Ruhi Türkmen, Hasan Hüseyin Demire. Investigation of the protective effect of resveratrol in an MK-801-induced mouse model of schizophrenia. Environmental science and pollution research international. vol 28. issue 46. 2021-12-02. PMID:34322799. according to the results obtained, this study showed for the first time that resveratrol prevented glial cell infiltration induced in the brain by mk-801 and shrinkage of nerve cell nuclei in the hippocampus and corpus callosum. 2021-12-02 2023-08-13 mouse
Paulina Cieślik, Anna Siekierzycka, Adrianna Radulska, Agata Płoska, Grzegorz Burnat, Piotr Brański, Leszek Kalinowski, Joanna M Wierońsk. Nitric Oxide-Dependent Mechanisms Underlying MK-801- or Scopolamine-Induced Memory Dysfunction in Animals: Mechanistic Studies. International journal of molecular sciences. vol 22. issue 22. 2021-11-30. PMID:34830164. administration of mk-801 induced a decrease in the cgmp level in the hippocampus, accompanied by decreased nmda expression, while increased cgmp production and decreased nmda receptor expression were observed after scopolamine administration. 2021-11-30 2023-08-13 mouse
Wenhui Huang, Xuefeng Gu, Yingying Wang, Yuhan Bi, Yu Yang, Guoqing Wan, Nianhong Chen, Keshen L. Effects of the co-administration of MK-801 and clozapine on MiRNA expression profiles in rats. Basic & clinical pharmacology & toxicology. vol 128. issue 6. 2021-11-17. PMID:33656787. herein, the hippocampal mirna expression profiles of sprague-dawley rats pretreated with mk-801 were examined after antipsychotic clozapine (clo) treatment. 2021-11-17 2023-08-13 rat
Jin-Qiong Zhan, Chun-Nuan Chen, Si-Xian Wu, Han-Jun Wu, Ke Zou, Jian-Wen Xiong, Bo Wei, Yuan-Jian Yan. Flavonoid fisetin reverses impaired hippocampal synaptic plasticity and cognitive function by regulating the function of AMPARs in a male rat model of schizophrenia. Journal of neurochemistry. vol 158. issue 2. 2021-11-12. PMID:33882624. in parallel with these behavioral results, fisetin treatment in mk-801 rats reversed the impairment of hippocampal ltp. 2021-11-12 2023-08-13 rat
Josiane Budni, Morgana Moretti, Andiara E Freitas, Vivian B Neis, Camille M Ribeiro, Grasiela de Oliveira Balen, Débora K Rieger, Rodrigo B Leal, Ana Lúcia S Rodrigue. Behavioral and neurochemical effects of folic acid in a mouse model of depression induced by TNF-α. Behavioural brain research. vol 414. 2021-11-04. PMID:34358572. this study examined: a) the efficacy of folic acid in a mouse model of depression induced by tumor necrosis factor (tnf-α); b) whether the administration of subthreshold doses of folic acid and antidepressants (fluoxetine, imipramine, and bupropion), mk-801, or 7-nitroindazole cause antidepressant-like effects; c) the effects of tnf-α and/or folic acid on hippocampal p38 2021-11-04 2023-08-13 mouse