All Relations between (2R)-amino-5-phosphonovaleric acid (AP5) and hippocampus

Publication Sentence Publish Date Extraction Date Species
Cynthia J Gibson, Rebecca C Meyer, Robert J Ham. Traumatic brain injury and the effects of diazepam, diltiazem, and MK-801 on GABA-A receptor subunit expression in rat hippocampus. Journal of biomedical science. vol 17. 2010-09-01. PMID:20482789. traumatic brain injury and the effects of diazepam, diltiazem, and mk-801 on gaba-a receptor subunit expression in rat hippocampus. 2010-09-01 2023-08-12 rat
Yu Feng, Xiao-Dong Wang, Chun-Mei Guo, Yang Yang, Ji-Tao Li, Yun-Ai Su, Tian-Mei S. Expressions of neuregulin 1beta and ErbB4 in prefrontal cortex and hippocampus of a rat schizophrenia model induced by chronic MK-801 administration. Journal of biomedicine & biotechnology. vol 2010. 2010-08-30. PMID:20467458. expressions of neuregulin 1beta and erbb4 in prefrontal cortex and hippocampus of a rat schizophrenia model induced by chronic mk-801 administration. 2010-08-30 2023-08-12 human
Jialie Luo, Wenming Li, Yuming Zhao, Hongjun Fu, Dik-Lung Ma, Jing Tang, Chaoying Li, Robert W Peoples, Fushun Li, Qinwen Wang, Pingbo Huang, Jun Xia, Yuanping Pang, Yifan Ha. Pathologically activated neuroprotection via uncompetitive blockade of N-methyl-D-aspartate receptors with fast off-rate by novel multifunctional dimer bis(propyl)-cognitin. The Journal of biological chemistry. vol 285. issue 26. 2010-08-24. PMID:20404346. more interestingly, under nmda receptor-mediated physiological conditions, bis(propyl)-cognitin enhanced long-term potentiation in hippocampal slices, whereas mk-801 reduced and memantine did not alter this process. 2010-08-24 2023-08-12 rat
P Elyse Schauwecke. Neuroprotection by glutamate receptor antagonists against seizure-induced excitotoxic cell death in the aging brain. Experimental neurology. vol 224. issue 1. 2010-06-28. PMID:20353782. thus, we compared the effects of the nmda receptor antagonist, mk-801 and of the ampa receptor antagonist nbqx on hippocampal damage in the kainate model of seizure-induced excitotoxic cell death in young, middle-aged, and aged c57bl/6 and fvb/n mice, when given 90 min following kainate-induced status epilepticus. 2010-06-28 2023-08-12 mouse
P Elyse Schauwecke. Neuroprotection by glutamate receptor antagonists against seizure-induced excitotoxic cell death in the aging brain. Experimental neurology. vol 224. issue 1. 2010-06-28. PMID:20353782. administration of mk-801 significantly reduced the extent of hippocampal damage in young, mature and aged fvb/n mice, while application of nbqx was only effective at attenuating cell death in young and aged mice throughout all hippocampal subfields. 2010-06-28 2023-08-12 mouse
Valentina Contrusciere, Silvia Paradisi, Andrea Matteucci, Fiorella Malchiodi-Albed. Branched-chain amino acids induce neurotoxicity in rat cortical cultures. Neurotoxicity research. vol 17. issue 4. 2010-06-23. PMID:19763733. our results show that (i) high concentrations of bcaas are neurotoxic and increase excitotoxicity in cortical neurons; (ii) neurotoxicity is brain area specific, being detected in cortical, but not in hippocampal neurons; (iii) it is related to nmda receptor overstimulation, since it is abolished in the presence of mk-801, a specific nmda channel blocker; (iv) it depends on the presence of astrocytes. 2010-06-23 2023-08-12 rat
Harald D Müller, Christian Berger, Stefan Schwab, Clemens Somme. Pravastatin treatment causes a shift in the balance of hippocampal neurotransmitter binding densities towards inhibition. Brain research. vol 1316. 2010-05-06. PMID:20026313. using quantitative receptor autoradiography, ligand binding densities of [(3)h]mk-801, [(3)h]ampa, and [(3)h]muscimol for labeling of nmda, ampa, and gaba(a) receptors were analyzed in sensorimotor cortices par1 and par2, the striatum, and the hippocampus. 2010-05-06 2023-08-12 rat
Ming-Chi Lai, Chun-Chung Lui, San-Nan Yang, Jia-Yi Wang, Li-Tung Huan. Epileptogenesis is increased in rats with neonatal isolation and early-life seizure and ameliorated by MK-801: a long-term MRI and histological study. Pediatric research. vol 66. issue 4. 2010-02-05. PMID:19581840. there was a significant decrease in the number of hippocampal neun-ir cells in the nr-se and ni-se groups, compared with the nr group, and mk-801 treatment ameliorated the neuronal loss. 2010-02-05 2023-08-12 rat
Aliz Mayer, Bernadett K Szasz, Janos P Kis. Inhibitory effect of antidepressants on the NMDA-evoked [(3)H]noradrenaline release from rat hippocampal slices. Neurochemistry international. vol 55. issue 6. 2009-10-09. PMID:19393275. the nmda-induced hippocampal [(3)h]na release was effectively blocked by the selective, non-competitive nmda antagonist mk-801 (ic(50)=0.54 microm), indicating that the [(3)h]na release was mediated through nmda receptors. 2009-10-09 2023-08-12 rat
Deborah J Watson, Mark E Stanto. Intrahippocampal administration of an NMDA-receptor antagonist impairs spatial discrimination reversal learning in weanling rats. Neurobiology of learning and memory. vol 92. issue 1. 2009-08-17. PMID:19248837. nmda-receptor antagonism in the hippocampus is sufficient to account for the previously reported effects of systemic mk-801 on reversal of t-maze position discrimination. 2009-08-17 2023-08-12 rat
Iu A Zolotarev, Iu Iu Firstova, D A Abaimov, A K Dadaian, V S Kosik, A V Novikov, N V Krasnov, B V Vas'kovskiĭ, I V Nazimov, G I Kovalev, N F Miasoedo. [Ligands of glutamate and dopamine receptors evenly labeled with hydrogen isotopes]. Bioorganicheskaia khimiia. vol 35. issue 3. 2009-08-11. PMID:19621047. it was demonstrated that [g-(3)h]mk-801 specifically binds to hippocampus membranes with k(d) 8.3 +/- 1.4 nm, b(max) being 3345 +/- 300 fmol/mg protein. 2009-08-11 2023-08-12 rat
Katrin Frauenknecht, Konstanze Plaschke, Clemens Somme. Transient oligemia is associated with long-term changes in binding densities of cortical inhibitory GABAA receptors in the rat brain. Brain research. vol 1271. 2009-07-28. PMID:19328192. since hippocampal excitatory and inhibitory neurotransmitter receptors are crucially involved in spatial memory processes, quantitative in vitro receptor autoradiography was performed using [(3)h]mk-801, [(3)h]ampa, and [(3)h]muscimol for labeling of nmda, ampa, and gaba(a) receptors, respectively. 2009-07-28 2023-08-12 rat
Teresa Marie du Bois, Chao Deng, Mei Han, Kelly Anne Newell, Xu-Feng Huan. Excitatory and inhibitory neurotransmission is chronically altered following perinatal NMDA receptor blockade. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 19. issue 4. 2009-05-20. PMID:19150227. [3h]mk-801 binding was significantly increased in pcp-treated rats in the thalamus from pn18 to pn96, in the prefrontal and anterior cingulate cortices at pn32, and in the hippocampus at pn96. 2009-05-20 2023-08-12 rat
Deborah J Watson, Mariel R Herbert, Mark E Stanto. NMDA receptor involvement in spatial delayed alternation in developing rats. Behavioral neuroscience. vol 123. issue 1. 2009-04-15. PMID:19170429. disruption of hippocampal plasticity may account for the effects produced by systemic mk-801 administration. 2009-04-15 2023-08-12 rat
Wendy Adams, Snezana Kusljic, Maarten van den Buus. Serotonin depletion in the dorsal and ventral hippocampus: effects on locomotor hyperactivity, prepulse inhibition and learning and memory. Neuropharmacology. vol 55. issue 6. 2009-04-14. PMID:18634810. there was no enhancement of locomotor hyperactivity induced by amphetamine or mk-801 or after 5,7-dht lesions of the drn or ventral hippocampus. 2009-04-14 2023-08-12 rat
A Siddiqui, T Lacroix, M R Stasko, J J Scott-McKean, A C S Costa, K J Gardine. Molecular responses of the Ts65Dn and Ts1Cje mouse models of Down syndrome to MK-801. Genes, brain, and behavior. vol 7. issue 7. 2009-04-10. PMID:19125866. to investigate the molecular basis for the responses to mk-801, we have measured levels of a subset of chr21 and phosphorylated non-chr21 proteins, in the cortex and hippocampus of ts65dn and ts1cje mice and euploid controls, with and without treatment with mk-801. 2009-04-10 2023-08-12 mouse
Qing Wang, Ayse Zengin, Chao Deng, Yun Li, Kelly A Newell, Guo-Yuan Yang, Ying Lu, Einar P Wilder-Smith, Heng Zhao, Xu-Feng Huan. High dose of simvastatin induces hyperlocomotive and anxiolytic-like activities: The association with the up-regulation of NMDA receptor binding in the rat brain. Experimental neurology. vol 216. issue 1. 2009-03-20. PMID:19100736. simvastatin increased [(3)h] mk-801 binding, predominantly in the prefrontal cortex (20%, p=0.003), primary motor cortex (20%, p<0.001), cingulate cortex (28%, p<0.001), hippocampus (41%, p<0.001), caudate putamen (30%, p=0.029), nucleus accumbens (27%, p=0.035) and amygdala (45%, p<0.001) compared to controls. 2009-03-20 2023-08-12 rat
Toby J Roberts, Steven C R Williams, Michel Mod. A pharmacological MRI assessment of dizocilpine (MK-801) in the 3-nitroproprionic acid-lesioned rat. Neuroscience letters. vol 444. issue 1. 2009-02-03. PMID:18703114. activity in the mpfc has been associated with the dissociative properties of this agent and has been suggested to be the neurological substrate of positive psychotic symptoms, whereas rs and hippocampus have been the main sites of neurotoxic actions of mk-801. 2009-02-03 2023-08-12 rat
Francesco Errico, Silvia Rossi, Francesco Napolitano, Valeria Catuogno, Enza Topo, Gilberto Fisone, Antimo D'Aniello, Diego Centonze, Alessandro Usiell. D-aspartate prevents corticostriatal long-term depression and attenuates schizophrenia-like symptoms induced by amphetamine and MK-801. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 41. 2008-11-03. PMID:18842900. in the present study, we demonstrated that nonphysiological high levels of d-aspartate (1) increased in vivo nmdar activity, (2) attenuated prepulse inhibition deficits induced by amphetamine and mk-801 [(+)-5-methyl-10,11-dihydro-5h-dibenzo[a,d]-cyclohepten-5,10-imine hydrogen maleate], (3) produced striatal adaptations of glutamate synapses resembling those observed after chronic haloperidol treatment, and (4) enhanced hippocampal nmdar-dependent memory. 2008-11-03 2023-08-12 mouse
Luiz Fernando Freire Royes, Michele Rechia Fighera, Ana Flávia Furian, Mauro Schneider Oliveira, Natália Gindri Fiorenza, Juliano Ferreira, André Cesar da Silva, Margareth Rose Priel, Erika Sayuri Ueda, João Batista Calixto, Esper Abrão Cavalheiro, Carlos Fernando Mell. Neuromodulatory effect of creatine on extracellular action potentials in rat hippocampus: role of NMDA receptors. Neurochemistry international. vol 53. issue 1-2. 2008-10-10. PMID:18541342. accordingly, creatine (0.01-1mm) increased [3h]mk-801 binding to hippocampal membranes by 55%, further indicating that this compound modulates nmda receptor function. 2008-10-10 2023-08-12 rat