Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Mark E Bardgett, Megan Points, Christian Ramsey-Faulkner, Jeff Topmiller, John Roflow, Travis McDaniel, Timberly Lamontagne, Molly S Griffit. The effects of clonidine on discrete-trial delayed spatial alternation in two rat models of memory loss. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 33. issue 8. 2008-09-02. PMID:17882233. |
the purpose of this study was to determine if clonidine could alleviate memory deficits produced by the nmda antagonist, mk-801, or by excitotoxic hippocampal damage. |
2008-09-02 |
2023-08-12 |
rat |
Ilse Smolders, Ralph Clinckers, Alfred Meurs, Dimitri De Bundel, Jeanelle Portelli, Guy Ebinger, Yvette Michott. Direct enhancement of hippocampal dopamine or serotonin levels as a pharmacodynamic measure of combined antidepressant-anticonvulsant action. Neuropharmacology. vol 54. issue 6. 2008-07-22. PMID:18378264. |
combined anticonvulsant-antidepressant activities of the nmda antagonist mk-801 and the mglur group i antagonists (aida, mpep) were also associated with locally elicited increases in hippocampal da and/or 5-ht levels. |
2008-07-22 |
2023-08-12 |
mouse |
Jens P Bankstahl, Katrin Hoffmann, Kerstin Bethmann, W Lösche. Glutamate is critically involved in seizure-induced overexpression of P-glycoprotein in the brain. Neuropharmacology. vol 54. issue 6. 2008-07-22. PMID:18394657. |
following se in vehicle treated rats, pgp expression in brain capillary endothelial cells increased about twofold in the hippocampus, which was completely prevented by mk-801. |
2008-07-22 |
2023-08-12 |
rat |
Fleur Margaret Howells, Vivienne Ann Russel. Glutamate-stimulated release of norepinephrine in hippocampal slices of animal models of attention-deficit/hyperactivity disorder (spontaneously hypertensive rat) and depression/anxiety-like behaviours (Wistar-Kyoto rat). Brain research. vol 1200. 2008-07-18. PMID:18295191. |
(4) the nmda receptor antagonist, mk-801 (10 microm) increased glutamate-stimulated release of [(3)h]norepinephrine in shr hippocampus. |
2008-07-18 |
2023-08-12 |
rat |
Alexander Z Harris, Diana L Petti. Recruiting extrasynaptic NMDA receptors augments synaptic signaling. Journal of neurophysiology. vol 99. issue 2. 2008-06-12. PMID:18057106. |
using the irreversible use-dependent nmdar antagonist mk-801 to isolate extrasynaptic nmdars, we have tested the ability of short-stimulation trains from 5 to 400 hz to activate these receptors on ca1 hippocampal slice pyramidal neurons. |
2008-06-12 |
2023-08-12 |
rat |
Celia Goeldner, David Reiss, Jürgen Wichmann, Hamid Meziane, Brigitte L Kieffer, Abdel-Mouttalib Ouagazza. Nociceptin receptor impairs recognition memory via interaction with NMDA receptor-dependent mitogen-activated protein kinase/extracellular signal-regulated kinase signaling in the hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 9. 2008-04-08. PMID:18305252. |
when administered concurrently at subthreshold doses, ro64-6198 and mk-801 synergistically suppressed hippocampal erk activation and impaired long-term memory formation. |
2008-04-08 |
2023-08-12 |
mouse |
Celia Goeldner, David Reiss, Jürgen Wichmann, Hamid Meziane, Brigitte L Kieffer, Abdel-Mouttalib Ouagazza. Nociceptin receptor impairs recognition memory via interaction with NMDA receptor-dependent mitogen-activated protein kinase/extracellular signal-regulated kinase signaling in the hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 9. 2008-04-08. PMID:18305252. |
under resting conditions, neither ro64-6198 nor mk-801 affected spontaneous erk activity in the hippocampus at the amnesic doses whereas at higher doses, only mk-801 had a suppressive effect. |
2008-04-08 |
2023-08-12 |
mouse |
Simone Molz, Helena Decker, Tharine Dal-Cim, Carla Cremonez, Fabiano M Cordova, Rodrigo B Leal, Carla I Tasc. Glutamate-induced toxicity in hippocampal slices involves apoptotic features and p38 MAPK signaling. Neurochemical research. vol 33. issue 1. 2008-04-01. PMID:17616814. |
glutamate-induced impairment of hippocampal cell viability was completely blocked by mk-801 (non-competitive antagonist of nmda receptors) and gams (antagonist of ka/ampa glutamate receptors). |
2008-04-01 |
2023-08-12 |
Not clear |
Isabella Braun, Just Genius, Heinz Grunze, Andreas Bender, Hans-Jürgen Möller, Dan Rujesc. Alterations of hippocampal and prefrontal GABAergic interneurons in an animal model of psychosis induced by NMDA receptor antagonism. Schizophrenia research. vol 97. issue 1-3. 2008-03-04. PMID:17601703. |
compared to saline control, animals receiving mk-801 exhibited a decreased density of hippocampal parvalbumin-positive interneurons. |
2008-03-04 |
2023-08-12 |
human |
Isabella Braun, Just Genius, Heinz Grunze, Andreas Bender, Hans-Jürgen Möller, Dan Rujesc. Alterations of hippocampal and prefrontal GABAergic interneurons in an animal model of psychosis induced by NMDA receptor antagonism. Schizophrenia research. vol 97. issue 1-3. 2008-03-04. PMID:17601703. |
a co-administration of the antipsychotic drug haloperidol ameliorated this effect of mk-801 on pv(+) interneurons in the hippocampus, but led to a marked reduction of pv immunoreactivity in the prefrontal cortex, when comparing with saline, mk-801 or haloperidol treatment alone. |
2008-03-04 |
2023-08-12 |
human |
Robert Wöhrl, Sven Eisenach, Denise Manahan-Vaughan, Uwe Heinemann, Dorothea von Haeble. Acute and long-term effects of MK-801 on direct cortical input evoked homosynaptic and heterosynaptic plasticity in the CA1 region of the female rat. The European journal of neuroscience. vol 26. issue 10. 2008-02-25. PMID:18001284. |
we analysed acute and long-term effects of the n-methyl-d-aspartate receptor antagonist mk-801 on long-term heterosynaptic population spike depression (lthpsd) evoked by high-frequency stimulation of the direct cortical input in female rat hippocampal slices to understand disturbances in cognitive functions associated with an acute phencyclidine-induced psychosis. |
2008-02-25 |
2023-08-12 |
rat |
Maria Montero, Marianne Nielsen, Lars Christian B Rønn, Arne Møller, Jens Noraberg, Jens Zimme. Neuroprotective effects of the AMPA antagonist PNQX in oxygen-glucose deprivation in mouse hippocampal slice cultures and global cerebral ischemia in gerbils. Brain research. vol 1177. 2008-01-15. PMID:17894933. |
both pnqx and mk-801 displayed significant neuroprotective effects in all hippocampal subfields when present during and after ogd. |
2008-01-15 |
2023-08-12 |
mouse |
Mohammad-Reza Zarrindast, Reza Lashgari, Ameneh Rezayof, Fereshteh Motamedi, Farzaneh Nazari-Serenje. NMDA receptors of dorsal hippocampus are involved in the acquisition, but not in the expression of morphine-induced place preference. European journal of pharmacology. vol 568. issue 1-3. 2007-10-19. PMID:17509561. |
nmda-receptor agonist (nmda) and antagonist (mk-801) were injected into the ca1 region of the dorsal hippocampus (intra-ca1) and morphine was injected subcutaneously. |
2007-10-19 |
2023-08-12 |
rat |
Vincent Warnault, Hakim Houchi, Estelle Barbier, Olivier Pierrefiche, Catherine Vilpoux, Catherine Ledent, Martine Daoust, Mickaël Naassil. The lack of CB1 receptors prevents neuroadapatations of both NMDA and GABA(A) receptors after chronic ethanol exposure. Journal of neurochemistry. vol 102. issue 3. 2007-10-15. PMID:17442049. |
our results show that basal levels of hippocampal [(3)h]mk-801 ((1)-5-methyl-10,11-dihydro-5hdibenzo[a,d]cyclohepten-5,10-imine) binding sites were decreased in cb1-/- mice and that these mice were also less sensitive to the locomotor effects of mk-801. |
2007-10-15 |
2023-08-12 |
mouse |
Vincent Warnault, Hakim Houchi, Estelle Barbier, Olivier Pierrefiche, Catherine Vilpoux, Catherine Ledent, Martine Daoust, Mickaël Naassil. The lack of CB1 receptors prevents neuroadapatations of both NMDA and GABA(A) receptors after chronic ethanol exposure. Journal of neurochemistry. vol 102. issue 3. 2007-10-15. PMID:17442049. |
our results also showed that [(3)h]mk-801 binding sites were increased in cerebral cortex and hippocampus after chronic ethanol ingestion only in wild-type mice. |
2007-10-15 |
2023-08-12 |
mouse |
Katherine J Smith, Rachel L Self, Tracy R Butler, Michael M Mullins, Layla Ghayoumi, Robert C Holley, John M Littleton, Mark A Prendergas. Methamphetamine exposure antagonizes N-methyl-D-aspartate receptor-mediated neurotoxicity in organotypic hippocampal slice cultures. Brain research. vol 1157. 2007-09-07. PMID:17524372. |
the present studies examined effects of meth (0.1-100 microm) on [3h]mk-801 binding to membranes prepared from adult rat cortex, hippocampus and cerebellum, as well as the neurotoxicity produced by 24-h exposure to n-methyl-d-aspartate (5-10 microm; nmda) employing organotypic hippocampal slice cultures of neonatal rat. |
2007-09-07 |
2023-08-12 |
rat |
Li-Sha Xu, Li-Xia Yang, Wei-Wei Hu, Xiao Yu, Li Ma, Lu-Ying Liu, Er-Qing Wei, Zhong Che. Histamine ameliorates spatial memory deficits induced by MK-801 infusion into ventral hippocampus as evaluated by radial maze task in rats. Acta pharmacologica Sinica. vol 26. issue 12. 2007-09-04. PMID:16297342. |
histamine ameliorates spatial memory deficits induced by mk-801 infusion into ventral hippocampus as evaluated by radial maze task in rats. |
2007-09-04 |
2023-08-12 |
rat |
Li-Sha Xu, Li-Xia Yang, Wei-Wei Hu, Xiao Yu, Li Ma, Lu-Ying Liu, Er-Qing Wei, Zhong Che. Histamine ameliorates spatial memory deficits induced by MK-801 infusion into ventral hippocampus as evaluated by radial maze task in rats. Acta pharmacologica Sinica. vol 26. issue 12. 2007-09-04. PMID:16297342. |
to investigate the role of histamine in memory deficits induced by mk-801 infusion into the ventral hippocampus in rats. |
2007-09-04 |
2023-08-12 |
rat |
M E Gilbert, S M Lasle. Developmental lead (Pb) exposure reduces the ability of the NMDA antagonist MK-801 to suppress long-term potentiation (LTP) in the rat dentate gyrus, in vivo. Neurotoxicology and teratology. vol 29. issue 3. 2007-07-30. PMID:17350801. |
these findings are consistent with other neurochemical and behavioural observations and suggest that up-regulation of postsynaptic nmda receptors produces subsensitivity to the inhibitory effects of mk-801 on hippocampal ltp following chronic developmental pb exposure. |
2007-07-30 |
2023-08-12 |
rat |
Colin Kehrer, Tamar Dugladze, Nino Maziashvili, Anna Wójtowicz, Dietmar Schmitz, Uwe Heinemann, Tengis Glovel. Increased inhibitory input to CA1 pyramidal cells alters hippocampal gamma frequency oscillations in the MK-801 model of acute psychosis. Neurobiology of disease. vol 25. issue 3. 2007-05-17. PMID:17169567. |
increased inhibitory input to ca1 pyramidal cells alters hippocampal gamma frequency oscillations in the mk-801 model of acute psychosis. |
2007-05-17 |
2023-08-12 |
Not clear |