| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zofia Danilczuk, Joanna Sekita-Krzak, Tomasz Lupina, Marcin Danilczuk, Krystyna Czern. Influence of dizocilpine (MK-801) on neurotoxic effect of dexamethasone: behavioral and histological studies. Acta neurobiologiae experimentalis. vol 66. issue 3. 2007-01-03. PMID:17133953. |
mk-801 alone (at non-toxic dose of 0.3 mg/kg/day), changed neither the behavior of mice nor morphology of the hippocampal neurons. |
2007-01-03 |
2023-08-12 |
mouse |
| Shizuo Nakamura, Norihito Murayama, Takafumi Noshita, Ryoko Katsuragi, Tomochika Ohn. Cognitive dysfunction induced by sequential injection of amyloid-beta and ibotenate into the bilateral hippocampus; protection by memantine and MK-801. European journal of pharmacology. vol 548. issue 1-3. 2006-12-12. PMID:16952349. |
cognitive dysfunction induced by sequential injection of amyloid-beta and ibotenate into the bilateral hippocampus; protection by memantine and mk-801. |
2006-12-12 |
2023-08-12 |
rat |
| Shizuo Nakamura, Norihito Murayama, Takafumi Noshita, Ryoko Katsuragi, Tomochika Ohn. Cognitive dysfunction induced by sequential injection of amyloid-beta and ibotenate into the bilateral hippocampus; protection by memantine and MK-801. European journal of pharmacology. vol 548. issue 1-3. 2006-12-12. PMID:16952349. |
the neuronal damage in the hippocampus, assessed as an elevation of the levels of the peripheral-type benzodiazepine-binding site (a gliosis marker for neuronal damage) produced by sequential intra-hippocampal injections of beta40 and ibotenate, at 6 weeks (39 days) after the beta40 injection, was significantly attenuated by memantine (10, 20 mg/kg/day) and mk-801 (0.624 mg/kg/day). |
2006-12-12 |
2023-08-12 |
rat |
| Shizuo Nakamura, Norihito Murayama, Takafumi Noshita, Ryoko Katsuragi, Tomochika Ohn. Cognitive dysfunction induced by sequential injection of amyloid-beta and ibotenate into the bilateral hippocampus; protection by memantine and MK-801. European journal of pharmacology. vol 548. issue 1-3. 2006-12-12. PMID:16952349. |
in naive rats, mk-801 produced a significant learning impairment in the water maze task at a dose of 0.624 mg/kg/day, while memantine (20 mg/kg/day s.c. infusion) did not, although the beta40 plus ibotenate-induced hippocampal damage was lessened by both treatments. |
2006-12-12 |
2023-08-12 |
rat |
| Jing Chen, Bao-Qiang Yua. [Neurogenesis of hippocampus following pentylenetrazol-induced status epilepticus in developing rats and the effect of MK-801 on neurogenesis]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics. vol 8. issue 5. 2006-12-04. PMID:17052406. |
[neurogenesis of hippocampus following pentylenetrazol-induced status epilepticus in developing rats and the effect of mk-801 on neurogenesis]. |
2006-12-04 |
2023-08-12 |
rat |
| Ratna Sircar, Debashish Sirca. Repeated ethanol treatment in adolescent rats alters cortical NMDA receptor. Alcohol (Fayetteville, N.Y.). vol 39. issue 1. 2006-10-06. PMID:16938629. |
groups of control and experimental rats were sacrificed 7 days after the last ethanol/saline administration, and nr activity was measured in specific brain regions (frontal cortex, hippocampus) using the [(3)h]mk-801 binding assay. |
2006-10-06 |
2023-08-12 |
rat |
| Ratna Sircar, Debashish Sirca. Repeated ethanol treatment in adolescent rats alters cortical NMDA receptor. Alcohol (Fayetteville, N.Y.). vol 39. issue 1. 2006-10-06. PMID:16938629. |
[(3)h]mk-801 binding in the hippocampus was minimally affected. |
2006-10-06 |
2023-08-12 |
rat |
| Raphaël Faucard, Vincent Armand, Anne Héron, Véronique Cochois, Jean-Charles Schwartz, Jean-Michel Arran. N-methyl-D-aspartate receptor antagonists enhance histamine neuron activity in rodent brain. Journal of neurochemistry. vol 98. issue 5. 2006-10-03. PMID:16923161. |
the enhancement of t-meha levels elicited by mk-801 (ed50 of approximately 0.1 mg/kg) was observed in the hypothalamus, cerebral cortex, striatum and hippocampus. |
2006-10-03 |
2023-08-12 |
mouse |
| Mohammad Arif, Md Mahiuddin Ahmed, Yukiko Kumabe, Hajime Hoshino, Toshiyuki Chikuma, Takeshi Kat. Clozapine but not haloperidol suppresses the changes in the levels of neuropeptides in MK-801-treated rat brain regions. Neurochemistry international. vol 49. issue 3. 2006-09-15. PMID:16567023. |
ss mrna and peptide levels significantly decreased in the pc/rsc and hippocampus but not in the frontal cortex 3 days after 0.5 mg/kg mk-801 treatment whereas cck mrna and peptide levels significantly decreased in all of the brain regions examined. |
2006-09-15 |
2023-08-12 |
rat |
| C Pandis, E Sotiriou, E Kouvaras, E Asprodini, C Papatheodoropoulos, F Angelato. Differential expression of NMDA and AMPA receptor subunits in rat dorsal and ventral hippocampus. Neuroscience. vol 140. issue 1. 2006-08-10. PMID:16542781. |
three sets of rat dorsal and ventral hippocampus slices were prepared: 1) transverse slices for examining a) the expression of the ampa (glura, glurb, glurc) and nmda (nr1, nr2a, nr2b) subunits mrna using in situ hybridization, b) the protein expression of nr2a and nr2b subunits using western blotting, and c) by using quantitative autoradiography, c(1)) the specific binding of the ampa receptor agonist [(3)h]ampa and c(2)) the specific binding of the nmda receptor antagonist [(3)h]mk-801, 2) longitudinal slices containing only the cornus ammonis 1 (ca1) region for performing [(3)h]mk-801 saturation experiments and 3) transverse slices for electrophysiological measures of nmda receptor-mediated excitatory postsynaptic potentials. |
2006-08-10 |
2023-08-12 |
rat |
| C Pandis, E Sotiriou, E Kouvaras, E Asprodini, C Papatheodoropoulos, F Angelato. Differential expression of NMDA and AMPA receptor subunits in rat dorsal and ventral hippocampus. Neuroscience. vol 140. issue 1. 2006-08-10. PMID:16542781. |
ventral compared with dorsal hippocampus showed for nmda receptors: 1) lower levels of mrna and protein expression for nr2a and nr2b subunits in ca1 with the ratio of nr2a /nr2b differing between the two poles and 2) lower levels of [(3)h]mk-801 binding in the ventral hippocampus, with the lowest value observed in ca1, apparently resulting from a decreased receptor density since the b(max) value was lower in ventral hippocampus. |
2006-08-10 |
2023-08-12 |
rat |
| Michael L Berger, Abdallah Y Bitar, Matthew J Waitner, Patrick Rebernik, Mary C O'Sulliva. Polyamines and the NMDA receptor: modifying intrinsic activities with aromatic substituents. Bioorganic & medicinal chemistry letters. vol 16. issue 11. 2006-08-02. PMID:16563762. |
thirty-four spermidine (spd) and spermine (spm) derivatives with aromatic substituents were synthesized and tested as inhibitors of specific binding of the nmda channel blocker [3h]mk-801 to membranes prepared from rat hippocampus and cerebral cortex. |
2006-08-02 |
2023-08-12 |
rat |
| Patrick J Mulholland, Rachel L Self, Allison K Hensley, Hilary J Little, John M Littleton, Mark A Prendergas. A 24 h corticosterone exposure exacerbates excitotoxic insult in rat hippocampal slice cultures independently of glucocorticoid receptor activation or protein synthesis. Brain research. vol 1082. issue 1. 2006-07-13. PMID:16510135. |
co-exposure of cultures to cort and nmda synergistically increased propidium iodide uptake in each hippocampal region, effects that were prevented by co-exposure to a non-toxic concentration of mk-801 (20 microm). |
2006-07-13 |
2023-08-12 |
rat |
| Tomoko Uekita, Yoko Okaichi, Hiroshige Okaich. Dissociation of the roles of NMDA receptor and hippocampus in rats' spatial learning: the effects of environmental familiarity and task familiarity. Reviews in the neurosciences. vol 17. issue 1-2. 2006-06-22. PMID:16703950. |
in this study, we compared the effects of mk-801 and hippocampal lesions on re-training of morris water maze place task in familiar and novel environments in rats. |
2006-06-22 |
2023-08-12 |
rat |
| Frederick P Bellinger, Mark S Davidson, Kuldip S Bedi, Peter A Wilc. Ethanol prevents NMDA receptor reduction by maternal separation in neonatal rat hippocampus. Brain research. vol 1067. issue 1. 2006-05-02. PMID:16359646. |
however, mk-801 binding and nr1 subunit immunoreactivity were greatly reduced in the hippocampus of separation control animals. |
2006-05-02 |
2023-08-12 |
rat |
| D I Orellana, R A Quintanilla, C Gonzalez-Billault, R B Maccion. Role of the JAKs/STATs pathway in the intracellular calcium changes induced by interleukin-6 in hippocampal neurons. Neurotoxicity research. vol 8. issue 3-4. 2006-04-27. PMID:16371324. |
here, we show that il-6 treatment of rat hippocampal neurons increases the calcium influx via nmda-receptor, an effect that is prevented by the specific nmda receptor antagonist mk-801 (dizocilpine). |
2006-04-27 |
2023-08-12 |
rat |
| C Bonde, J Noraberg, H Noer, J Zimme. Ionotropic glutamate receptors and glutamate transporters are involved in necrotic neuronal cell death induced by oxygen-glucose deprivation of hippocampal slice cultures. Neuroscience. vol 136. issue 3. 2006-03-30. PMID:16344151. |
under normal conditions addition of dl-threo-beta-benzyloxyaspartate in concentrations of 25 microm or more to otherwise untreated hippocampal slice cultures induced neuronal cell death, which was prevented by addition of 2,3-dihyroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline and mk-801. |
2006-03-30 |
2023-08-12 |
rat |
| Gabriela X Ayala, Ricardo Tapi. Late N-methyl-D-aspartate receptor blockade rescues hippocampal neurons from excitotoxic stress and death after 4-aminopyridine-induced epilepsy. The European journal of neuroscience. vol 22. issue 12. 2006-03-02. PMID:16367773. |
with an identical time window, mk-801 treatment also modified the pattern of hsp70 expression; the protein was expressed in the protected perfused hippocampus but no longer in the undamaged contralateral hippocampus. |
2006-03-02 |
2023-08-12 |
rat |
| Nadine Buck, Sebat Cali, Joachim Beh. Enhancement of long-term potentiation at CA1-subiculum synapses in MK-801-treated rats. Neuroscience letters. vol 392. issue 1-2. 2006-02-23. PMID:16183195. |
using the mk-801 model of psychosis, we investigated the time course of alterations of synaptic transmission and plasticity at ca1-subiculum synapses of hippocampal brain slices 4 h, 24 h and 4 weeks after mk-801 treatment. |
2006-02-23 |
2023-08-12 |
rat |
| Joseph R Moskal, Amy G Kuo, Craig Weiss, Paul L Wood, Amy O'Connor Hanson, Stephen Kelso, Robert B Harris, John F Disterhof. GLYX-13: a monoclonal antibody-derived peptide that acts as an N-methyl-D-aspartate receptor modulator. Neuropharmacology. vol 49. issue 7. 2006-01-30. PMID:16051282. |
peptides were then synthesized based on this sequence information and screened using rat hippocampal membrane preparations to measure [(3)h]mk-801 binding in the presence of 7-chlorokynurenic acid, a glycine site-specific competitive inhibitor of nmda receptor [moskal, j.r., yamamoto, h., colley, p.a., 2001. |
2006-01-30 |
2023-08-12 |
rat |