| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Saku T Sinkkonen, Anni-Maija Lindén, Esa R Korpi, Garry Won. Selective reduction of gamma-aminobutyric acid type A receptor delta subunit mRNA levels by MK-801 in rat dentate gyrus. Neuroscience letters. vol 364. issue 2. 2004-07-27. PMID:15196688. |
a significant decrease in delta subunit mrna levels, that reached approximately 70% of saline-treated values, was observed in the hippocampal dentate gyrus following mk-801 administration. |
2004-07-27 |
2023-08-12 |
rat |
| Adrian Bueno, Soledad de Olmos, Fernando Manzini, Nancy L Desmond, Jose de Olmo. Strain and colony differences in the neurotoxic sequelae of MK-801 visualized with the amino-cupric-silver method. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 55. issue 4. 2004-07-20. PMID:14703775. |
moreover, mk-801 treatment led to somatodendritic degeneration in the dentate gyrus of the dorsal hippocampus and basolateral amygdala in wistar rats from charles river laboratories but not those from ferreyra institute. |
2004-07-20 |
2023-08-12 |
rat |
| Romina S Almirón, Mariela F Pérez, Oscar A Ramíre. MK-801 prevents the increased NMDA-NR1 and NR2B subunits mRNA expression observed in the hippocampus of rats tolerant to diazepam. Brain research. vol 1008. issue 1. 2004-06-28. PMID:15081382. |
mk-801 prevents the increased nmda-nr1 and nr2b subunits mrna expression observed in the hippocampus of rats tolerant to diazepam. |
2004-06-28 |
2023-08-12 |
rat |
| Romina S Almirón, Mariela F Pérez, Oscar A Ramíre. MK-801 prevents the increased NMDA-NR1 and NR2B subunits mRNA expression observed in the hippocampus of rats tolerant to diazepam. Brain research. vol 1008. issue 1. 2004-06-28. PMID:15081382. |
mk-801, a non-competitive antagonist of n-methyl-d-aspartate receptor, impairs both the development of conditioned tolerance to diazepam and the hippocampal long-term potentiation generation. |
2004-06-28 |
2023-08-12 |
rat |
| Romina S Almirón, Mariela F Pérez, Oscar A Ramíre. MK-801 prevents the increased NMDA-NR1 and NR2B subunits mRNA expression observed in the hippocampus of rats tolerant to diazepam. Brain research. vol 1008. issue 1. 2004-06-28. PMID:15081382. |
our results demonstrate that the development of tolerance to the hypolocomotive effect of diazepam, along with the increased hippocampal synaptic plasticity and the associated over expression of the mrna nr1 and nr2b n-methyl-d-aspartate receptor subunits, were blocked by previous mk-801 administration. |
2004-06-28 |
2023-08-12 |
rat |
| Jennifer L Nargi-Aizenman, Michael B Havert, Ming Zhang, David N Irani, Jeffrey D Rothstein, Diane E Griffi. Glutamate receptor antagonists protect from virus-induced neural degeneration. Annals of neurology. vol 55. issue 4. 2004-05-07. PMID:15048893. |
both apoptotic and necrotic neurons in the hippocampus were decreased in animals treated with mk-801, an nmda receptor antagonist, or gyki-52466, an ampa receptor antagonist. |
2004-05-07 |
2023-08-12 |
mouse |
| Stéphanie Grojean, Grégory Pourié, Paul Vert, Jean-Luc Dava. Differential neuronal fates in the CA1 hippocampus after hypoxia in newborn and 7-day-old rats: effects of pre-treatment with MK-801. Hippocampus. vol 13. issue 8. 2004-03-12. PMID:14750659. |
differential neuronal fates in the ca1 hippocampus after hypoxia in newborn and 7-day-old rats: effects of pre-treatment with mk-801. |
2004-03-12 |
2023-08-12 |
human |
| Stéphanie Grojean, Grégory Pourié, Paul Vert, Jean-Luc Dava. Differential neuronal fates in the CA1 hippocampus after hypoxia in newborn and 7-day-old rats: effects of pre-treatment with MK-801. Hippocampus. vol 13. issue 8. 2004-03-12. PMID:14750659. |
moreover, pre-treatment with mk-801 was ineffective in protecting hippocampal neurons from hypoxic injury in newborn rats, but significantly reduced necrosis in older subjects. |
2004-03-12 |
2023-08-12 |
human |
| Tamar Dugladze, Eka Lepsveridze, Jörg Breustedt, Colin Kehrer, Uwe Heinemann, Tengis Glovel. Effects of phencyclidines on signal transfer from the entorhinal cortex to the hippocampus in rats. Neuroscience letters. vol 354. issue 3. 2004-03-08. PMID:14700727. |
we studied the effects of systemic administration of mk-801 on the signal transfer from the ec layer iii to the hippocampal area ca1. |
2004-03-08 |
2023-08-12 |
rat |
| M T Fernández-Sánchez, R Díaz-Trelles, A Groppetti, B Manfredi, A T Brini, G Biella, M L Sotgiu, A Novell. Nefopam, an analogue of orphenadrine, protects against both NMDA receptor-dependent and independent veratridine-induced neurotoxicity. Amino acids. vol 23. issue 1-3. 2004-02-26. PMID:12373515. |
moreover, nefopam failed to displace mk-801 binding to hippocampal membranes. |
2004-02-26 |
2023-08-12 |
Not clear |
| Anders Fredriksson, Trevor Arche. Hyperactivity following postnatal NMDA antagonist treatment: reversal by D-amphetamine. Neurotoxicity research. vol 5. issue 7. 2004-02-18. PMID:14715439. |
fluoro-jade staining per mm(2) regional brain tissue of mk-801 mice pups expressed as percent of vehicle mice pups showed also that the extensiveness of staining was markedly greater in the parietal cortex, hippocampus, frontal cortex, and lesser so in the laterodorsal thalamus. |
2004-02-18 |
2023-08-12 |
mouse |
| Gabriel Nowak, Bernadeta Szewczyk, Kystyna Sadlik, Wojciech Piekoszewski, Franciszek Trela, Ewa Florek, Andrzej Pil. Reduced potency of zinc to interact with NMDA receptors in hippocampal tissue of suicide victims. Polish journal of pharmacology. vol 55. issue 3. 2004-02-06. PMID:14506326. |
however, there is a statistically significant 26% decrease in the potency (increase in the ic(50) value) of zinc to inhibit [(3)h]mk-801 binding to nmda receptors in the hippocampal but not cortical tissue of suicide subjects. |
2004-02-06 |
2023-08-12 |
human |
| Ann-Cathrin Radesäter, Sara Johansson, Caroline Oberg, Johan Luthma. The vitamin-E analog trolox and the NMDA antagonist MK-801 protect pyramidal neurons in hippocampal slice cultures from IL-1beta-induced neurodegeneration. Neurotoxicity research. vol 5. issue 6. 2004-02-02. PMID:14715447. |
the vitamin-e analog trolox and the nmda antagonist mk-801 protect pyramidal neurons in hippocampal slice cultures from il-1beta-induced neurodegeneration. |
2004-02-02 |
2023-08-12 |
mouse |
| Tobias Bast, Wei-Ning Zhang, Joram Feldo. Dorsal hippocampus and classical fear conditioning to tone and context in rats: effects of local NMDA-receptor blockade and stimulation. Hippocampus. vol 13. issue 6. 2003-12-12. PMID:12962312. |
the present study characterized the effects of blockade or tonic stimulation of dorsal hippocampal nmda receptors by bilateral local infusion of the noncompetitive nmda receptor antagonist mk-801 (dizocilpine maleate; 6.25 microg/side) or of nmda (0.7 microg/side), respectively, on classical fear conditioning to tone and context in wistar rats. |
2003-12-12 |
2023-08-12 |
rat |
| Md Mahiuddin Ahmed, Masaru Yamamoto, Toshiyuki Chikuma, Md Khalilur Rahman, Takeshi Kat. Dose-dependent effect of MK-801 on the levels of neuropeptides processing enzymes in rat brain regions. Neuroscience research. vol 47. issue 2. 2003-12-11. PMID:14512142. |
in the present study, we investigated the dose dependent effect of (+) mk-801 on prolyl endopeptidase (pep), endopeptidase ec 24.15 (ep 24.15) and beta-d-glucuronidase activities as well as the protein levels of ep 24.15 and neuron specific enolase (nse) in the posterior cingulate/retrosplenial cortices (pc/rsc), hippocampus, frontal cortex and striatum of female rats 3 days after the treatment. |
2003-12-11 |
2023-08-12 |
rat |
| Md Mahiuddin Ahmed, Masaru Yamamoto, Toshiyuki Chikuma, Md Khalilur Rahman, Takeshi Kat. Dose-dependent effect of MK-801 on the levels of neuropeptides processing enzymes in rat brain regions. Neuroscience research. vol 47. issue 2. 2003-12-11. PMID:14512142. |
these results suggest that a low dose treatment with mk-801 causes neurotoxicity in the pc/rsc and hippocampus, and the high dose treatment causes neurotoxicity in all the brain regions examined. |
2003-12-11 |
2023-08-12 |
rat |
| Kiyotaka Katsuta, Kazuo Umemura, Noriko Ueyama, Nobuya Matsuok. Pharmacological evidence for a correlation between hippocampal CA1 cell damage and hyperlocomotion following global cerebral ischemia in gerbils. European journal of pharmacology. vol 467. issue 1-3. 2003-12-02. PMID:12706462. |
administration of any drug 30 min before global ischemia dose-dependently, and with similar potency, ameliorated both hippocampal delayed neuronal death and locomotor hyperactivity, with a rank order: tacrolimus (fk506)>nizofenone>clonindine>dizocilpine (mk-801)>6-(1h-imidazol-1-yl)-7-nitro-2,3(1h,4h)-quinoxalinedione hydrochloride (ym90k)>phencyclidine>pentobarbital>2-(4-(p-fluorobenzoyl)-piperidin-1-yl)-2'-acetonaphthone hydrochloride (e-2001)>cis-(+/-)-4-phosphonomethyl-2-piperidine carboxylic acid (cgs19755)>3,4-dichloro-n-methyl-n-[2-(1-pyrrolidinyl)-cyclohexyl]benzeneacetamide (u-50,488h)>piroxicam>eliprodil>vinpocetine. |
2003-12-02 |
2023-08-12 |
Not clear |
| Tomas Olsson, Tadeusz Wieloch, Maj-Lis Smit. Brain damage in a mouse model of global cerebral ischemia. Effect of NMDA receptor blockade. Brain research. vol 982. issue 2. 2003-12-01. PMID:12915260. |
the non-competitive n-methyl-d-aspartate receptor blocker, mk-801, did not provide protection in the hippocampus, cortex, striatum or thalamus when administered 30 min prior to ischemia or 2 h after the end of ischemia, but selectively mitigated damage in the hippocampus, when administered immediately following ischemia. |
2003-12-01 |
2023-08-12 |
mouse |
| Michelle L Byrnes, James N Reynolds, James F Brie. Brain growth spurt-prenatal ethanol exposure and the guinea pig hippocampal glutamate signaling system. Neurotoxicology and teratology. vol 25. issue 3. 2003-08-19. PMID:12757827. |
this bgs-pee regimen did not affect hippocampal stimulated glutamate release in young postnatal offspring, nmda receptors as assessed by [3h]mk-801 binding, or nos activity in near-term fetal offspring. |
2003-08-19 |
2023-08-12 |
Not clear |
| C Brandt, H Potschka, W Löscher, U Eber. N-methyl-D-aspartate receptor blockade after status epilepticus protects against limbic brain damage but not against epilepsy in the kainate model of temporal lobe epilepsy. Neuroscience. vol 118. issue 3. 2003-08-08. PMID:12710980. |
a single low dose of the n-methyl-d-aspartate (nmda) receptor blocker dizocilpine (mk-801) significantly reduced the damage in limbic regions, including the hippocampus and piriform cortex, and completely protected several rats from such damage when given after an s.e. |
2003-08-08 |
2023-08-12 |
rat |