All Relations between (2R)-amino-5-phosphonovaleric acid (AP5) and hippocampus

Publication Sentence Publish Date Extraction Date Species
Mahdiyeh Faatehi, Mohsen Basiri, Akram Nezhadi, Mohammad Shabani, Yaser Masoumi-Ardakani, Zahra Soltani, Masoumeh Nozar. Early enriched environment prevents cognitive impairment in an animal model of schizophrenia induced by MK-801: Role of hippocampal BDNF. Brain research. vol 1711. 2020-08-04. PMID:30677409. this study aims to investigate the long-term effects of enriched environment (ee), which was imposed during the animals' development, on their recognition memory as well as hippocampal levels of brain-derived neurotrophic factor (bdnf), in an animal model of schizophrenia induced by chronic postnatal administration of mk-801. 2020-08-04 2023-08-13 rat
Mahdiyeh Faatehi, Mohsen Basiri, Akram Nezhadi, Mohammad Shabani, Yaser Masoumi-Ardakani, Zahra Soltani, Masoumeh Nozar. Early enriched environment prevents cognitive impairment in an animal model of schizophrenia induced by MK-801: Role of hippocampal BDNF. Brain research. vol 1711. 2020-08-04. PMID:30677409. mk-801 resulted in decreased levels of bdnf in the hippocampus, and ee exposure restored the decreased level. 2020-08-04 2023-08-13 rat
Yu-Nu Ma, Ya-Xin Sun, Ting Wang, Han Wang, Yue Zhang, Yun-Ai Su, Ji-Tao Li, Tian-Mei S. Subchronic MK-801 treatment during adolescence induces long-term, not permanent, excitatory-inhibitory imbalance in the rat hippocampus. European journal of pharmacology. vol 867. 2020-06-08. PMID:31751575. subchronic mk-801 treatment during adolescence induces long-term, not permanent, excitatory-inhibitory imbalance in the rat hippocampus. 2020-06-08 2023-08-13 rat
Yu-Nu Ma, Ya-Xin Sun, Ting Wang, Han Wang, Yue Zhang, Yun-Ai Su, Ji-Tao Li, Tian-Mei S. Subchronic MK-801 treatment during adolescence induces long-term, not permanent, excitatory-inhibitory imbalance in the rat hippocampus. European journal of pharmacology. vol 867. 2020-06-08. PMID:31751575. here, we examined hippocampal e/i biomarkers in adolescent rats treated with mk-801 (0.2 mg/kg, i.p., 14 days) and found increases in the ratio of the expression levels of vesicular glutamate transporter-1 (vglut1) and vesicular gamma-aminobutyric acid (gaba) transporter (vgat) 24 h and 7 days after mk-801 exposure. 2020-06-08 2023-08-13 rat
Mohammad Amani, Maryam Zolghadrnasab, Ali-Akbar Salar. NMDA receptor in the hippocampus alters neurobehavioral phenotypes through inflammatory cytokines in rats with sporadic Alzheimer-like disease. Physiology & behavior. vol 202. 2020-04-29. PMID:30641081. twelve days after ad induction by streptozotocin (stz), animals received either vehicle or mk-801 (nmda receptor antagonist) in the hippocampus for 10 days. 2020-04-29 2023-08-13 rat
Melissa Hernández-Frausto, Carolina López-Rubalcava, Emilio J Galvá. Progressive Alterations in Synaptic Transmission and Plasticity of Area CA1 Precede the Cognitive Impairment Associated with Neonatal Administration of MK-801. Neuroscience. vol 404. 2019-12-24. PMID:30703507. by combining behavioral evaluations with extracellular recordings in acute hippocampal slices, we uncovered a progressive alteration of synaptic transmission of animals neonatally treated with mk-801. 2019-12-24 2023-08-13 Not clear
R. J. Beninger, A. Jhamandas, H. Aujla, L. Xue, R. V. Dagnone, R. J. Boegman, K. Jhamanda. Neonatal exposure to the glutamate receptor antagonist MK-801: effects on locomotor activity and pre-pulse inhibition before and after sexual maturity in rats. Neurotoxicity research. vol 4. issue 5-6. 2019-11-20. PMID:12754161. this suggested that neonatal mk-801 might lead to behavioural changes like those reported following ventral hippocampal lesions. 2019-11-20 2023-08-12 rat
R. J. Beninger, A. Jhamandas, H. Aujla, L. Xue, R. V. Dagnone, R. J. Boegman, K. Jhamanda. Neonatal exposure to the glutamate receptor antagonist MK-801: effects on locomotor activity and pre-pulse inhibition before and after sexual maturity in rats. Neurotoxicity research. vol 4. issue 5-6. 2019-11-20. PMID:12754161. mk-801 produced an increase in tunel staining in the hippocampus and other forebrain structures, confirming the induction of apoptosis. 2019-11-20 2023-08-12 rat
R. J. Beninger, A. Jhamandas, H. Aujla, L. Xue, R. V. Dagnone, R. J. Boegman, K. Jhamanda. Neonatal exposure to the glutamate receptor antagonist MK-801: effects on locomotor activity and pre-pulse inhibition before and after sexual maturity in rats. Neurotoxicity research. vol 4. issue 5-6. 2019-11-20. PMID:12754161. it was concluded that neonatal mk-801 increases apoptotic cell loss in the hippocampus but does not produce behavioural effects like those seen after neonatal ventral hippocampal lesions. 2019-11-20 2023-08-12 rat
Susanna Rosi, Victor Ramirez-Amaya, Beatrice Hauss-Wegrzyniak, Gary L Wen. Chronic brain inflammation leads to a decline in hippocampal NMDA-R1 receptors. Journal of neuroinflammation. vol 1. issue 1. 2019-11-20. PMID:15285803. results: the current study demonstrated that chronic neuroinflammation is associated with the loss of n-methyl-d-aspartate receptors, as determined both qualitatively by immunohistochemistry and quantitatively by in vitro binding studies using [3h]mk-801, within the hippocampus and entorhinal cortex. 2019-11-20 2023-08-12 rat
Peter U Hámor, Jana Šírová, Tomáš Páleníček, Magdalena Zaniewska, Věra Bubeníková-Valešová, Marek Schwend. Chronic methamphetamine self-administration dysregulates 5-HT2A and mGlu2 receptor expression in the rat prefrontal and perirhinal cortex: Comparison to chronic phencyclidine and MK-801. Pharmacology, biochemistry, and behavior. vol 175. 2019-09-30. PMID:30240581. therefore, in the present study we examined the effects of chronic exposure to three different drugs known to produce persistent deficits in sensorimotor gating and cognition [meth, phencyclidine (pcp) and mk-801] on the expression of 5-ht2a and mglu2 within the rat medial prefrontal cortex (mpfc), dorsal hippocampus (dhpc) and perirhinal cortex (prh). 2019-09-30 2023-08-13 rat
Jonathan L C Lee, Felippe E Amorim, Lindsey F Cassini, Olavo B Amara. Different temporal windows for CB1 receptor involvement in contextual fear memory destabilisation in the amygdala and hippocampus. PloS one. vol 14. issue 1. 2019-09-27. PMID:30645588. infusion of sr141716a in the hippocampus prevented the reconsolidation-blocking effect of mk-801 when performed after reexposure, but not before it. 2019-09-27 2023-08-13 rat
Jonathan L C Lee, Felippe E Amorim, Lindsey F Cassini, Olavo B Amara. Different temporal windows for CB1 receptor involvement in contextual fear memory destabilisation in the amygdala and hippocampus. PloS one. vol 14. issue 1. 2019-09-27. PMID:30645588. in the amygdala, meanwhile, pre-reexposure infusions of sr141716a impaired reconsolidation blockade by mk-801, although the time-dependency of this effect was not as clear as in the hippocampus. 2019-09-27 2023-08-13 rat
Majid Jafari-Sabet, Shiva Amiri, Ramin Atae. Cross state-dependency of learning between tramadol and MK-801 in the mouse dorsal hippocampus: involvement of nitric oxide (NO) signaling pathway. Psychopharmacology. vol 235. issue 7. 2019-03-20. PMID:29679289. cross state-dependency of learning between tramadol and mk-801 in the mouse dorsal hippocampus: involvement of nitric oxide (no) signaling pathway. 2019-03-20 2023-08-13 mouse
Weinan Sun, Jonathan M Wong, John A Gray, Brett C Carte. Incomplete block of NMDA receptors by intracellular MK-801. Neuropharmacology. vol 143. 2019-02-25. PMID:30227149. here, we report that intracellular mk-801 (imk-801) only partially inhibits synaptic nmdar currents at +40 mv at both cortical layer 4 to layer 2/3 and hippocampal schaffer collateral to ca1 synapses. 2019-02-25 2023-08-13 Not clear
Qian Yang, Geng Zhu, Dandan Liu, Jue-Gang Ju, Zhen-Hua Liao, Yi-Xin Xiao, Yue Zhang, Naijian Chao, JieJie Wang, Weidong Li, Jian-Hong Luo, Sheng-Tian L. Extrasynaptic NMDA receptor dependent long-term potentiation of hippocampal CA1 pyramidal neurons. Scientific reports. vol 7. issue 1. 2018-12-24. PMID:28596523. here, through the use of a 5-hz stimulation and mk-801 (an irreversible antagonist of nmdars) in the ca1 neurons of adult mice hippocampal slices, synaptic nmdars were selectively inhibited and nmdar-mediated excitatory postsynaptic currents were not recovered. 2018-12-24 2023-08-13 mouse
Ewa Szczurowska, Nikhil Ahuja, Přemysl Jiruška, Eduard Kelemen, Aleš Stuchlí. Impairment of neural coordination in hippocampal neuronal ensembles after a psychotomimetic dose of dizocilpine. Progress in neuro-psychopharmacology & biological psychiatry. vol 81. 2018-07-03. PMID:28935586. to test this proposition, we studied the activity of hippocampal neurons in urethane anesthetized long evans rats after 0.15mg/kg dizocilpine (mk-801), an n-methyl-d-aspartate (nmda) glutamate receptor antagonist, which can cause psychotic symptoms in humans and cognitive control impairments in animals. 2018-07-03 2023-08-13 rat
Chelsea A Nickerson, Alexandra L Brown, Waylin Yu, Yoona Chun, Melissa J Glen. Prenatal choline supplementation attenuates MK-801-induced deficits in memory, motor function, and hippocampal plasticity in adult male rats. Neuroscience. vol 361. 2018-06-14. PMID:28790020. using doublecortin and ki67 to mark neurogenesis and cell division, respectively, in the hippocampus, we found that prenatal choline supplementation, in the face of mk-801 toxicity, protected against reduced hippocampal plasticity. 2018-06-14 2023-08-13 rat
Clément E Lemercier, Constance Holman, Zoltan Gerevic. Aberrant alpha and gamma oscillations ex vivo after single application of the NMDA receptor antagonist MK-801. Schizophrenia research. vol 188. 2018-05-30. PMID:28109667. we investigated the effects of a single intraperitoneal injection of the nmda receptor antagonist mk-801 in rats, a model of first-episode schizophrenia, on network oscillations recorded ex vivo in the hippocampus and prefrontal cortex. 2018-05-30 2023-08-13 rat
Mao-Sheng Fang, Xing Li, Hong Qian, Kuan Zeng, Meng Ye, Yong-Jie Zhou, Hui Li, Xiao-Chuan Wang, Yi L. ω-3PUFAs prevent MK-801-induced cognitive impairment in schizophrenic rats via the CREB/BDNF/TrkB pathway. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 37. issue 4. 2018-04-30. PMID:28786073. the results showed that ω-3pufas attenuated mk-801-induced cognitive impairment and hippocampal neurons loss, reversed the injury of the creb/bdnf/trkb pathway induced by mk-801, and antagonized mk-801-induced down-regulation of p-akt and p-erk in the hippocampus of rats. 2018-04-30 2023-08-13 rat