Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Helena Buchtová, Iveta Fajnerová, Aleš Stuchlík, Štěpán Kubí. Acute systemic MK-801 induced functional uncoupling between hippocampal areas CA3 and CA1 with distant effect in the retrosplenial cortex. Hippocampus. vol 27. issue 2. 2018-01-10. PMID:27806441. |
acute systemic mk-801 induced functional uncoupling between hippocampal areas ca3 and ca1 with distant effect in the retrosplenial cortex. |
2018-01-10 |
2023-08-13 |
rat |
Bo Zhang, Chuan-Yu Li, Xiu-Song Wan. The effect of hippocampal NMDA receptor blockade by MK-801 on cued fear extinction. Behavioural brain research. vol 332. 2017-12-12. PMID:28578988. |
the effect of hippocampal nmda receptor blockade by mk-801 on cued fear extinction. |
2017-12-12 |
2023-08-13 |
rat |
Bo Zhang, Chuan-Yu Li, Xiu-Song Wan. The effect of hippocampal NMDA receptor blockade by MK-801 on cued fear extinction. Behavioural brain research. vol 332. 2017-12-12. PMID:28578988. |
the present experiment explored the issue by bilateral pre-extinction microinjection of the noncompetitive nmdar antagonist mk-801 into the ventral hippocampus. |
2017-12-12 |
2023-08-13 |
rat |
Sonu Singh, Akanksha Mishra, Neha Srivastava, Shubha Shukl. MK-801 (Dizocilpine) Regulates Multiple Steps of Adult Hippocampal Neurogenesis and Alters Psychological Symptoms via Wnt/β-Catenin Signaling in Parkinsonian Rats. ACS chemical neuroscience. vol 8. issue 3. 2017-10-25. PMID:27977132. |
mk-801 (dizocilpine) regulates multiple steps of adult hippocampal neurogenesis and alters psychological symptoms via wnt/β-catenin signaling in parkinsonian rats. |
2017-10-25 |
2023-08-13 |
rat |
Sonu Singh, Akanksha Mishra, Neha Srivastava, Shubha Shukl. MK-801 (Dizocilpine) Regulates Multiple Steps of Adult Hippocampal Neurogenesis and Alters Psychological Symptoms via Wnt/β-Catenin Signaling in Parkinsonian Rats. ACS chemical neuroscience. vol 8. issue 3. 2017-10-25. PMID:27977132. |
herein, for the first time, we studied the effect of mk-801, an nmda receptor antagonist, on adult hippocampal neurogenesis and behavioral functions in 6-ohda (6-hydroxydopamine) induced rat model of pd. |
2017-10-25 |
2023-08-13 |
rat |
Sonu Singh, Akanksha Mishra, Neha Srivastava, Shubha Shukl. MK-801 (Dizocilpine) Regulates Multiple Steps of Adult Hippocampal Neurogenesis and Alters Psychological Symptoms via Wnt/β-Catenin Signaling in Parkinsonian Rats. ACS chemical neuroscience. vol 8. issue 3. 2017-10-25. PMID:27977132. |
mk-801 treatment (0.2 mg/kg, ip) increased neural stem cell (nsc) proliferation, self-renewal capacity, long-term survival, and neuronal differentiation in the hippocampus of rat model of pd. |
2017-10-25 |
2023-08-13 |
rat |
Sonu Singh, Akanksha Mishra, Neha Srivastava, Shubha Shukl. MK-801 (Dizocilpine) Regulates Multiple Steps of Adult Hippocampal Neurogenesis and Alters Psychological Symptoms via Wnt/β-Catenin Signaling in Parkinsonian Rats. ACS chemical neuroscience. vol 8. issue 3. 2017-10-25. PMID:27977132. |
mk-801 potentially enhanced long-term survival, improved dendritic arborization of immature neurons, and reduced 6-ohda induced neurodegeneration via maintaining the nsc pool in hippocampus, leading to decreased anxiety and depression-like phenotypes in the pd model. |
2017-10-25 |
2023-08-13 |
rat |
Sonu Singh, Akanksha Mishra, Neha Srivastava, Shubha Shukl. MK-801 (Dizocilpine) Regulates Multiple Steps of Adult Hippocampal Neurogenesis and Alters Psychological Symptoms via Wnt/β-Catenin Signaling in Parkinsonian Rats. ACS chemical neuroscience. vol 8. issue 3. 2017-10-25. PMID:27977132. |
mk-801 inhibited glycogen synthase kinase-3β (gsk-3β) through up-regulation of wnt-3a, which resulted in the activation of wnt/β-catenin signaling leading to enhanced hippocampal neurogenesis in pd model. |
2017-10-25 |
2023-08-13 |
rat |
Sonu Singh, Akanksha Mishra, Neha Srivastava, Shubha Shukl. MK-801 (Dizocilpine) Regulates Multiple Steps of Adult Hippocampal Neurogenesis and Alters Psychological Symptoms via Wnt/β-Catenin Signaling in Parkinsonian Rats. ACS chemical neuroscience. vol 8. issue 3. 2017-10-25. PMID:27977132. |
therefore, mk-801 treatment serves as a valuable tool to enhance hippocampal neurogenesis in pd, but further studies are needed to revisit the role of mk-801 in the neurodegenerative disorder before proposing a potential therapeutic candidate. |
2017-10-25 |
2023-08-13 |
rat |
Diane E Griffi. Alphavirus Encephalomyelitis: Mechanisms and Approaches to Prevention of Neuronal Damage. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 13. issue 3. 2017-09-20. PMID:27114366. |
the n-methyl-d-aspartate receptor antagonist mk-801 protected hippocampal neurons but not motor neurons, and mice still became paralyzed and died. |
2017-09-20 |
2023-08-13 |
mouse |
Ioana Inta, Emese Domonkos, Natascha Pfeiffer, Rolf Sprengel, Markus Bettendorf, Undine E Lang, Dragos Inta, Peter Gas. Puberty marks major changes in the hippocampal and cortical c-Fos activation pattern induced by NMDA receptor antagonists. Neuropharmacology. vol 112. issue Pt A. 2017-07-11. PMID:26995729. |
surprisingly, in the hippocampus, mk-801 triggered at pre-pubertal stages (especially at p24) very strong c-fos expression, followed by low levels after p30, the approximate time point of puberty onset in mice. |
2017-07-11 |
2023-08-13 |
mouse |
Ioana Inta, Emese Domonkos, Natascha Pfeiffer, Rolf Sprengel, Markus Bettendorf, Undine E Lang, Dragos Inta, Peter Gas. Puberty marks major changes in the hippocampal and cortical c-Fos activation pattern induced by NMDA receptor antagonists. Neuropharmacology. vol 112. issue Pt A. 2017-07-11. PMID:26995729. |
in comparison, the cortical activation induced by ro 25-6981 diminished from high pre-pubertal levels and was in comparison with that triggered by mk-801 low in the hippocampus. |
2017-07-11 |
2023-08-13 |
mouse |
Marianna E Jung, Daniel B Metzger, Hriday K Da. The Role of Presenilin-1 in the Excitotoxicity of Ethanol Withdrawal. The Journal of pharmacology and experimental therapeutics. vol 358. issue 3. 2017-05-26. PMID:27278235. |
additionally, we used ethanol-withdrawn ht22 cells (mouse hippocampal) treated with the inhibitor of glutamate receptors [dizocilpine (mk-801)], p38α (sb203580; 4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1h-imidazol-5-yl]pyridine), or γ-secretase [n-[n- (3,5-difluorophenacetyl)-l-alanyl]-s-phenylglycine t-butyl ester (dapt)] during ew. |
2017-05-26 |
2023-08-13 |
mouse |
Caio M Massari, Adalberto A Castro, Tharine Dal-Cim, Débora Lanznaster, Carla I Tasc. In vitro 6-hydroxydopamine-induced toxicity in striatal, cerebrocortical and hippocampal slices is attenuated by atorvastatin and MK-801. Toxicology in vitro : an international journal published in association with BIBRA. vol 37. 2017-04-04. PMID:27647473. |
in vitro 6-hydroxydopamine-induced toxicity in striatal, cerebrocortical and hippocampal slices is attenuated by atorvastatin and mk-801. |
2017-04-04 |
2023-08-13 |
rat |
Laura Osorio-Rico, Juana Villeda-Hernández, Abel Santamaría, Mina Königsberg, Sonia Galván-Arzat. The N-Methyl-d-Aspartate Receptor Antagonist MK-801 Prevents Thallium-Induced Behavioral and Biochemical Alterations in the Rat Brain. International journal of toxicology. vol 34. issue 6. 2016-09-19. PMID:26350230. |
mk-801 attenuated the tl(+)-induced hyperactivity and lipid peroxidation in the rat striatum, hippocampus and midbrain, and produced mild effects on other end points. |
2016-09-19 |
2023-08-13 |
rat |
Wenjuan Yu, Hao Zhu, Yueming Wang, Guanjun Li, Lihua Wang, Huafang L. Reactive Transformation and Increased BDNF Signaling by Hippocampal Astrocytes in Response to MK-801. PloS one. vol 10. issue 12. 2016-08-17. PMID:26700309. |
reactive transformation and increased bdnf signaling by hippocampal astrocytes in response to mk-801. |
2016-08-17 |
2023-08-13 |
rat |
Wenjuan Yu, Hao Zhu, Yueming Wang, Guanjun Li, Lihua Wang, Huafang L. Reactive Transformation and Increased BDNF Signaling by Hippocampal Astrocytes in Response to MK-801. PloS one. vol 10. issue 12. 2016-08-17. PMID:26700309. |
changes in the expression levels of glial fibrillary acid protein (gfap), a marker of astrocyte activation in response to a variety of pathogenic stimuli, were examined in the hippocampus of rats treated with the repeated mk-801 injection (0.5 mg/10 ml/kg body weight for 6 days) and in primary cultured hippocampal astrocytes incubated with mk-801 (5 or 20 μm for 24 h). |
2016-08-17 |
2023-08-13 |
rat |
Wenjuan Yu, Hao Zhu, Yueming Wang, Guanjun Li, Lihua Wang, Huafang L. Reactive Transformation and Increased BDNF Signaling by Hippocampal Astrocytes in Response to MK-801. PloS one. vol 10. issue 12. 2016-08-17. PMID:26700309. |
mk-801 treatment enhanced gfap expression in the rat hippocampus and also increased the levels of gfap protein and mrna in hippocampal astrocytes in vitro. |
2016-08-17 |
2023-08-13 |
rat |
Wenjuan Yu, Hao Zhu, Yueming Wang, Guanjun Li, Lihua Wang, Huafang L. Reactive Transformation and Increased BDNF Signaling by Hippocampal Astrocytes in Response to MK-801. PloS one. vol 10. issue 12. 2016-08-17. PMID:26700309. |
treatment of cultured hippocampal astrocytes with mk-801 enhanced protein and mrna levels of bdnf, trkb, and p75. |
2016-08-17 |
2023-08-13 |
rat |
J-T Li, Y-Y Zhao, H-L Wang, X-D Wang, Y-A Su, T-M S. Long-term effects of neonatal exposure to MK-801 on recognition memory and excitatory-inhibitory balance in rat hippocampus. Neuroscience. vol 308. 2016-07-19. PMID:26349007. |
long-term effects of neonatal exposure to mk-801 on recognition memory and excitatory-inhibitory balance in rat hippocampus. |
2016-07-19 |
2023-08-13 |
rat |