All Relations between (2R)-amino-5-phosphonovaleric acid (AP5) and hippocampus

Reference Sentence Publish Date Extraction Date Species
Michael L Berger, Thomas P\\xc3\\xb6hler, Oliver Schadt, Maximilian Stanger, Patrick Rebernik, Petra Scholze, Christian R No. Exploring the polyamine regulatory site of the NMDA receptor: a parallel synthesis approach. ChemMedChem vol 8 issue 1 2013 23225329 the obtained compounds were tested as modulators of [(3) h]mk-801 binding to rat brain membranes and of nmda-induced currents in cultured rat hippocampal neurons. 2013-05-28 2022-01-12 Not clear
E M Anderson, A Y Del Valle-Pinero, S K Suckow, T A Nolan, J K Neubert, R M Caudl. Morphine and MK-801 administration leads to alternative N-methyl-D-aspartate receptor 1 splicing and associated changes in reward seeking behavior and nociception on an operant orofacial assay. Neuroscience vol 214 issue 2013 22531378 when combined, mk-801 and morphine had an additive effect which led to altered splicing in the accumbens, amy, and the hipp. 2013-04-29 2022-01-12 Not clear
Daniel R Thomases, Daryn K Cass, Kuei Y Tsen. Periadolescent exposure to the NMDA receptor antagonist MK-801 impairs the functional maturation of local GABAergic circuits in the adult prefrontal cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 33 issue 1 2013 23283319 in vivo electrophysiological analyses revealed that mk-801 administration during periadolescence elicits an enduring disinhibited prefrontal local field potential (lfp) response to ventral hippocampal stimulation at 20 hz (beta) and 40 hz (gamma) in adulthood (p65-p85). 2013-03-12 2022-01-12 Not clear
Hui Jiang, Shunlian Tian, Yan Zeng, Jing Sh. Nerve growth factor inhibits Gd(3+)-sensitive calcium influx and reduces chemical anoxic neuronal death. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban vol 28 issue 4 2013 18704295 when combination of 20 micromol/l mk-801 (glutamate receptor antagonist), 40 micromol/l cnqx (ampa receptor antagonist) and 5 micromol/l nimodipine (voltage-gated calcium channel antagonist) (hereafter denoted as mcn) were administrated to hippocampal cultures, levels of [ca(2+)](i) and cell death rate induced by kcn were partially reduced by 35.9% and 47.5% respectively. 2013-02-11 2022-01-13 Not clear
Leonardo Magno Rambo, Leandro Rodrigo Ribeiro, Vanessa Grigoletto Schramm, Andriely Moreira Berch, Daniel Neis Stamm, Iuri Domingues Della-Pace, Luiz Fernando Almeida Silva, Ana Fl\\xc3\\xa1via Furian, Mauro Schneider Oliveira, Michele Rechia Fighera, Luiz Fernando Freire Roye. Creatine increases hippocampal Na(+),K(+)-ATPase activity via NMDA-calcineurin pathway. Brain research bulletin vol 88 issue 6 2012 22742935 the incubation of hippocampal slices with n-methyl-d-aspartate (nmda; mk-801, 10 \xce\xbcm) and nmda receptor 2b (nr2b; ifenprodil, 3 \xce\xbcm) antagonists but not with the \xce\xb1-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (ampa)/kainate antagonist (dnqx, 10 \xce\xbcm) and nitric oxide synthase inhibitor (nos; l-name, 100 \xce\xbcm), blunted the effect of creatine on na(+),k(+)-atpase activity. 2012-11-23 2022-01-12 Not clear
Maren Klug, Rachel A Hill, Kwok Ho Christopher Choy, Michael Kyrios, Anthony J Hannan, Maarten van den Buus. Long-term behavioral and NMDA receptor effects of young-adult corticosterone treatment in BDNF heterozygous mice. Neurobiology of disease vol 46 issue 3 2012 22426399 the nmda receptor effects in hippocampal sub-regions could be related to the spatial memory deficits and the loss of the effect of mk-801 on startle in these mice, respectively. 2012-09-14 2022-01-12 Not clear
Jos\\xc3\\xa9 Antonio Troca-Mar\\xc3\\xadn, Alexandra Alves-Sampaio, Mar\\xc3\\xada Luz Montesino. An increase in basal BDNF provokes hyperactivation of the Akt-mammalian target of rapamycin pathway and deregulation of local dendritic translation in a mouse model of Down's syndrome. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 31 issue 26 2011 21715609 the nmdar inhibitors apv, mk-801, and memantine also restore the normal levels of phospho-mtor in dendrites of ts1cje hippocampal neurons. 2011-09-13 2022-01-12 Not clear
Omar J Cassol, Clarissa M Comim, Larissa S Constantino, Daniela V F Rosa, Luiz Alexandre V Mango, Laura Stertz, Fl\\xc3\\xa1vio Kapczinski, Marco A Romano-Silva, Jo\\xc3\\xa3o Quevedo, Felipe Dal-Pizzo. Acute low dose of MK-801 prevents memory deficits without altering hippocampal DARPP-32 expression and BDNF levels in sepsis survivor rats. Journal of neuroimmunology vol 230 issue 1-2 2011 20864183 acute low dose of mk-801 prevents memory deficits without altering hippocampal darpp-32 expression and bdnf levels in sepsis survivor rats. 2011-02-16 2022-01-12 Not clear
Omar J Cassol, Clarissa M Comim, Larissa S Constantino, Daniela V F Rosa, Luiz Alexandre V Mango, Laura Stertz, Fl\\xc3\\xa1vio Kapczinski, Marco A Romano-Silva, Jo\\xc3\\xa3o Quevedo, Felipe Dal-Pizzo. Acute low dose of MK-801 prevents memory deficits without altering hippocampal DARPP-32 expression and BDNF levels in sepsis survivor rats. Journal of neuroimmunology vol 230 issue 1-2 2011 20864183 we assessed the effects of acute low dose of mk-801 on the memory impairment, hippocampal bdnf levels and darpp-32 expression ten days after sepsis. 2011-02-16 2022-01-12 Not clear
Omar J Cassol, Clarissa M Comim, Larissa S Constantino, Daniela V F Rosa, Luiz Alexandre V Mango, Laura Stertz, Fl\\xc3\\xa1vio Kapczinski, Marco A Romano-Silva, Jo\\xc3\\xa3o Quevedo, Felipe Dal-Pizzo. Acute low dose of MK-801 prevents memory deficits without altering hippocampal DARPP-32 expression and BDNF levels in sepsis survivor rats. Journal of neuroimmunology vol 230 issue 1-2 2011 20864183 mk-801 prevented cognitive impairment, but did not affect the hippocampal bdnf levels. 2011-02-16 2022-01-12 Not clear
Omar J Cassol, Clarissa M Comim, Larissa S Constantino, Daniela V F Rosa, Luiz Alexandre V Mango, Laura Stertz, Fl\\xc3\\xa1vio Kapczinski, Marco A Romano-Silva, Jo\\xc3\\xa3o Quevedo, Felipe Dal-Pizzo. Acute low dose of MK-801 prevents memory deficits without altering hippocampal DARPP-32 expression and BDNF levels in sepsis survivor rats. Journal of neuroimmunology vol 230 issue 1-2 2011 20864183 thus, we demonstrated that a single low dose of mk-801 prevented memory impairment without altering hippocampal darpp-32 expression and bdnf levels. 2011-02-16 2022-01-12 Not clear
Donovan M Ashby, Diala Habib, Hans C Dringenberg, James N Reynolds, Richard J Beninge. Subchronic MK-801 treatment and post-weaning social isolation in rats: differential effects on locomotor activity and hippocampal long-term potentiation. Behavioural brain research vol 212 issue 1 2010 20382186 subchronic mk-801 treatment and post-weaning social isolation in rats: differential effects on locomotor activity and hippocampal long-term potentiation. 2010-11-12 2022-01-12 Not clear
Donovan M Ashby, Diala Habib, Hans C Dringenberg, James N Reynolds, Richard J Beninge. Subchronic MK-801 treatment and post-weaning social isolation in rats: differential effects on locomotor activity and hippocampal long-term potentiation. Behavioural brain research vol 212 issue 1 2010 20382186 subsequent electrophysiological experiments (under urethane anesthesia) assessing changes in plasticity of hippocampal synapses showed that subchronic mk-801 treatment resulted in an increase in long-term potentiation in area ca1 in response to high frequency stimulation of the contralateral ca3 area, while housing condition had no effect. 2010-11-12 2022-01-12 Not clear
Donovan M Ashby, Diala Habib, Hans C Dringenberg, James N Reynolds, Richard J Beninge. Subchronic MK-801 treatment and post-weaning social isolation in rats: differential effects on locomotor activity and hippocampal long-term potentiation. Behavioural brain research vol 212 issue 1 2010 20382186 these data are the first to demonstrate an enhancement in hippocampal long-term plasticity in vivo following subchronic mk-801 administration, an effect that may be related to the well-characterized changes in glutamatergic and gabaergic systems seen after subchronic nmda receptor blockade. 2010-11-12 2022-01-12 Not clear
Shunsuke Saito, Akiko Okada, Takako Ouwa, Akane Kato, Masaaki Akagi, Chiaki Kame. Interaction between hippocampal gamma-aminobutyric acid(A) and N-methyl-D-aspartate receptors in the retention of spatial working memory in rats. Biological & pharmaceutical bulletin vol 33 issue 3 2010 20190406 to clarify the interaction between hippocampal gamma-aminobutyric acid (gaba)(a) receptor and n-methyl-d-aspartate (nmda) receptor in the retention of spatial working memory, the effects of muscimol, (+)mk-801, cyclosporin a and combined use of these drugs were studied on the retention of spatial working memory in a delayed spatial win-shift (swsh) task. 2010-09-20 2022-01-12 Not clear
Jialie Luo, Wenming Li, Yuming Zhao, Hongjun Fu, Dik-Lung Ma, Jing Tang, Chaoying Li, Robert W Peoples, Fushun Li, Qinwen Wang, Pingbo Huang, Jun Xia, Yuanping Pang, Yifan Ha. Pathologically activated neuroprotection via uncompetitive blockade of N-methyl-D-aspartate receptors with fast off-rate by novel multifunctional dimer bis(propyl)-cognitin. The Journal of biological chemistry vol 285 issue 26 2010 20404346 more interestingly, under nmda receptor-mediated physiological conditions, bis(propyl)-cognitin enhanced long-term potentiation in hippocampal slices, whereas mk-801 reduced and memantine did not alter this process. 2010-08-24 2022-01-12 Not clear
P Elyse Schauwecke. Neuroprotection by glutamate receptor antagonists against seizure-induced excitotoxic cell death in the aging brain. Experimental neurology vol 224 issue 1 2010 20353782 thus, we compared the effects of the nmda receptor antagonist, mk-801 and of the ampa receptor antagonist nbqx on hippocampal damage in the kainate model of seizure-induced excitotoxic cell death in young, middle-aged, and aged c57bl/6 and fvb/n mice, when given 90 min following kainate-induced status epilepticus. 2010-06-28 2022-01-12 Not clear
P Elyse Schauwecke. Neuroprotection by glutamate receptor antagonists against seizure-induced excitotoxic cell death in the aging brain. Experimental neurology vol 224 issue 1 2010 20353782 administration of mk-801 significantly reduced the extent of hippocampal damage in young, mature and aged fvb/n mice, while application of nbqx was only effective at attenuating cell death in young and aged mice throughout all hippocampal subfields. 2010-06-28 2022-01-12 Not clear
Valentina Contrusciere, Silvia Paradisi, Andrea Matteucci, Fiorella Malchiodi-Albed. Branched-chain amino acids induce neurotoxicity in rat cortical cultures. Neurotoxicity research vol 17 issue 4 2010 19763733 our results show that (i) high concentrations of bcaas are neurotoxic and increase excitotoxicity in cortical neurons; (ii) neurotoxicity is brain area specific, being detected in cortical, but not in hippocampal neurons; (iii) it is related to nmda receptor overstimulation, since it is abolished in the presence of mk-801, a specific nmda channel blocker; (iv) it depends on the presence of astrocytes. 2010-06-23 2022-01-12 Not clear
Ming-Chi Lai, Chun-Chung Lui, San-Nan Yang, Jia-Yi Wang, Li-Tung Huan. Epileptogenesis is increased in rats with neonatal isolation and early-life seizure and ameliorated by MK-801: a long-term MRI and histological study. Pediatric research vol 66 issue 4 2010 19581840 there was a significant decrease in the number of hippocampal neun-ir cells in the nr-se and ni-se groups, compared with the nr group, and mk-801 treatment ameliorated the neuronal loss. 2010-02-05 2022-01-12 Not clear
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