All Relations between (2R)-amino-5-phosphonovaleric acid (AP5) and hippocampus

Publication Sentence Publish Date Extraction Date Species
Ximena López Hill, Analía Richeri, Cecilia Scorz. Measure of anxiety-related behaviors and hippocampal BDNF levels associated to the amnesic effect induced by MK-801 evaluated in the modified elevated plus-maze in rats. Physiology & behavior. vol 147. 2016-02-23. PMID:25992477. measure of anxiety-related behaviors and hippocampal bdnf levels associated to the amnesic effect induced by mk-801 evaluated in the modified elevated plus-maze in rats. 2016-02-23 2023-08-13 rat
Ximena López Hill, Analía Richeri, Cecilia Scorz. Measure of anxiety-related behaviors and hippocampal BDNF levels associated to the amnesic effect induced by MK-801 evaluated in the modified elevated plus-maze in rats. Physiology & behavior. vol 147. 2016-02-23. PMID:25992477. therefore, we investigated if changes in anxiety-related behaviors and hippocampal bdnf levels are related with the amnesic effect induced by mk-801 in the mepm.transfer latency (tl) as an index of spatial memory in the mepm was used. 2016-02-23 2023-08-13 rat
Morgana Moretti, Josiane Budni, Andiara Espíndola Freitas, Vivian Binder Neis, Camille Mertins Ribeiro, Grasiela de Oliveira Balen, Débora Kurrle Rieger, Rodrigo Bainy Leal, Ana Lúcia S Rodrigue. TNF-α-induced depressive-like phenotype and p38(MAPK) activation are abolished by ascorbic acid treatment. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 6. 2016-02-16. PMID:25836357. additionally, we examined the effects of combined administration of ascorbic acid and antidepressants, mk-801 and 7-nitroindazole in mice exposed or not to tnf-α and the capacity of tnf-α and ascorbic acid to modulate hippocampal and cerebrocortical phosphorylation of extracellular signal-regulated kinase (erk), p38(mapk) and c-jun n-terminal kinase (jnk). 2016-02-16 2023-08-13 mouse
Kevin Blot, Shin-Ichi Kimura, Jing Bai, Anne Kemp, Denise Manahan-Vaughan, Bruno Giros, Eleni Tzavara, Satoru Otan. Modulation of hippocampus-prefrontal cortex synaptic transmission and disruption of executive cognitive functions by MK-801. Cerebral cortex (New York, N.Y. : 1991). vol 25. issue 5. 2016-01-19. PMID:24304584. in the present study, we tested in rats the effect of mk-801 on ventral hippocampus (hpc)-medial prefrontal cortex (mpfc) synaptic transmission and the performance in 2 cognitive tasks. 2016-01-19 2023-08-12 rat
Julia C Bartsch, Pawel Fidzinski, Jojanneke H J Huck, Heide Hörtnagl, Richard Kovács, Agustin Liotta, Josef Priller, Christian Wozny, Joachim Beh. Enhanced dopamine-dependent hippocampal plasticity after single MK-801 application. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 4. 2016-01-05. PMID:25315194. enhanced dopamine-dependent hippocampal plasticity after single mk-801 application. 2016-01-05 2023-08-13 Not clear
Ataç Sönmez, Oya Sayın, Seren Gülşen Gürgen, Meryem Çalişi. Neuroprotective effects of MK-801 against traumatic brain injury in immature rats. Neuroscience letters. vol 597. 2015-10-19. PMID:25943283. we aimed to investigate the effect of mk-801, a competitive nmda receptor antagonist, on hippocampal damage and behavioral deficits on 10-day-old rat pups subjected to contusion injury. 2015-10-19 2023-08-13 rat
Ataç Sönmez, Oya Sayın, Seren Gülşen Gürgen, Meryem Çalişi. Neuroprotective effects of MK-801 against traumatic brain injury in immature rats. Neuroscience letters. vol 597. 2015-10-19. PMID:25943283. the aims of the present study were to determine: (i) the short term effects of mk-801 on hippocampal bdnf, ngf and nmda receptor immunoreactivity and neuron density in hippocampus (ii) long term effects of mk-801 on cognitive dysfunction following tbi in the immature rats. 2015-10-19 2023-08-13 rat
Ataç Sönmez, Oya Sayın, Seren Gülşen Gürgen, Meryem Çalişi. Neuroprotective effects of MK-801 against traumatic brain injury in immature rats. Neuroscience letters. vol 597. 2015-10-19. PMID:25943283. additionally, treatment with mk-801 ameliorated anxiety and hippocampus dependent memory of animals subjected to trauma. 2015-10-19 2023-08-13 rat
Ataç Sönmez, Oya Sayın, Seren Gülşen Gürgen, Meryem Çalişi. Neuroprotective effects of MK-801 against traumatic brain injury in immature rats. Neuroscience letters. vol 597. 2015-10-19. PMID:25943283. these results show that acute treatment of mk-801 has a neuroprotective role against trauma induced hippocampal neuron loss and associated cognitive impairment in immature rats. 2015-10-19 2023-08-13 rat
Chen Zhang, Yiru Fang, Lin X. Glutamate receptor 1 phosphorylation at serine 845 contributes to the therapeutic effect of olanzapine on schizophrenia-like cognitive impairments. Schizophrenia research. vol 159. issue 2-3. 2015-08-19. PMID:25219486. after mk-801 application, the hippocampal ltp was profoundly impaired. 2015-08-19 2023-08-13 rat
Magalí C Cercato, Natalia Colettis, Marina Snitcofsky, Alejandra I Aguirre, Edgar E Kornisiuk, María V Baez, Diana A Jerusalinsk. Hippocampal NMDA receptors and the previous experience effect on memory. Journal of physiology, Paris. vol 108. issue 4-6. 2015-07-15. PMID:25132342. adult rats that explored twice an open field (of) before a weak though overthreshold training in inhibitory avoidance (ia), expressed ia long-term memory in spite of the hippocampal administration of mk-801, which currently leads to amnesia. 2015-07-15 2023-08-13 rat
Qianfa Long, Cairui Fan, Wang Kai, Qiang Luo, Weichuan Xin, Ping Wang, Ansheng Wang, Zhanyao Wang, Rui Han, Zhou Fei, Bensheng Qiu, Weiping Li. Hypoxia inducible factor-1α expression is associated with hippocampal apoptosis during epileptogenesis. Brain research. vol 1590. 2015-07-09. PMID:25242614. the results showed that the administration of mk-801 significantly reduced (p<0.05) hif-1α expression and hippocampal apoptosis during epileptogenesis in comparison with the positive control. 2015-07-09 2023-08-13 rat
Irina Korshunova, Michelle D Gjørlund, Sylwia Owczarek, Anders V Petersen, Jean-François Perrier, Casper René Gøtzsche, Vladimir Berezi. A neuroligin-1-derived peptide stimulates phosphorylation of the NMDA receptor NR1 subunit and rescues MK-801-induced decrease in long-term potentiation and memory impairment. Pharmacology research & perspectives. vol 3. issue 2. 2015-06-03. PMID:26038702. subsequently, we investigated effects of neurolide-1 on long-term potentiation (ltp) induction in hippocampal slices compromised by nmda receptor inhibitor mk-801. 2015-06-03 2023-08-13 Not clear
Irina Korshunova, Michelle D Gjørlund, Sylwia Owczarek, Anders V Petersen, Jean-François Perrier, Casper René Gøtzsche, Vladimir Berezi. A neuroligin-1-derived peptide stimulates phosphorylation of the NMDA receptor NR1 subunit and rescues MK-801-induced decrease in long-term potentiation and memory impairment. Pharmacology research & perspectives. vol 3. issue 2. 2015-06-03. PMID:26038702. we found that subcutaneous neurolide-1 administration, restored hippocampal ltp compromised by nmda receptor inhibitor mk-801. 2015-06-03 2023-08-13 Not clear
Hui Liu, Li-Min Wen, Hui Qiao, Shu-Cheng A. [Modulation of hippocampal glutamate and NMDA/AMPA receptor by homocysteine in chronic unpredictable mild stress-induced rat depression]. Sheng li xue bao : [Acta physiologica Sinica]. vol 65. issue 1. 2015-05-16. PMID:23426515. intrahippocampal injections of mk-801 effectively improved the depression-like behaviors induced by cums and hcy, and attenuated the elevation of glu content induced by hcy in hippocampus, whereas nbqx could not improve the depression-like behaviors, but also decreased the glu content induced by hcy remarkably. 2015-05-16 2023-08-12 rat
Yan He, Sheng-Ya Zeng, Shi-Wen Zhou, Gui-Sheng Qian, Kang Peng, Zhi-Xian Mo, Ji-Yin Zho. Effects of rhynchophylline on GluN1 and GluN2B expressions in primary cultured hippocampal neurons. Fitoterapia. vol 98. 2015-05-13. PMID:25110195. after 48 h incubation, a lower concentration of rhynchophylline (lower than 400 μmol/l) and mk-801 (lower than 200 μmol/l) have no toxicity on neonatal hippocampal neurons. 2015-05-13 2023-08-13 rat
Claudia Alva-Sanchez, Adair Rodriguez, Ivan Villanueva, Brenda Anguiano, Carmen Aceves, Jorge Pacheco-Rosad. The NMDA receptor antagonist MK-801 abolishes the increase in both p53 and Bax/Bcl2 index induced by adult-onset hypothyroidism in rat. Acta neurobiologiae experimentalis. vol 74. issue 1. 2015-04-06. PMID:24718050. in this work we measured the expression of specific proteins that control cell proliferation (cycline-d1), cell arrest (p21), damage (p53) or apoptosis (bax and bcl2) in the hippocampus of hypothyroid rats treated with the nmda receptor (nmdar) blocker mk-801 during the induction of hypothyroidism. 2015-04-06 2023-08-13 rat
Qing Wang, Jin Li, Xiaobo Wei, Jinchi Liao, Yunqi Xu, Tingting Lu, Bing Qin, Junqiang Xie, Chao Deng, Xufeng Huan. Alterations of NMDA receptor binding in various brain regions among 6-hydroxydopamine-induced Parkinsonian rats. The International journal of neuroscience. vol 124. issue 6. 2015-01-12. PMID:24102195. in the 6-ohda-induced parkinsonian rat model, nigrostriatal dopaminergic neuron loss significantly mediated the decreased [(3)h] mk-801 binding, predominantly in the hippocampus (-22.4%, p < 0.001), caudate putamen (-14.1%, p < 0.01), accumbens nucleus (-13.8%, p < 0.05), cingulate cortex (-13.4%, p < 0.001), posteromedial cortical amygdala (-14.5%, p < 0.01) and piriform cortex (-9%, p < 0.05) compared to the controls, while there was a profound reduction of tyrosine hydroxylase (th) immunohistochemistry in the substantia nigra pars compacta. 2015-01-12 2023-08-12 rat
Kang Li, Hengchuan Jia, Xiaojun She, Bo Cui, Na Zhang, Xuewei Chen, Chuanxiang Xu, Gaihong An, Qiang M. Role of NMDA receptors in noise-induced tau hyperphosphorylation in rat hippocampus and prefrontal cortex. Journal of the neurological sciences. vol 340. issue 1-2. 2014-12-22. PMID:24685355. mk-801 decreased the hyperphosphorylation of tau at ser202 and ser396 sites in the hippocampus and pfc. 2014-12-22 2023-08-12 rat
Kang Li, Hengchuan Jia, Xiaojun She, Bo Cui, Na Zhang, Xuewei Chen, Chuanxiang Xu, Gaihong An, Qiang M. Role of NMDA receptors in noise-induced tau hyperphosphorylation in rat hippocampus and prefrontal cortex. Journal of the neurological sciences. vol 340. issue 1-2. 2014-12-22. PMID:24685355. this suggests that mk-801 protects against chronic-noise-induced tau hyperphosphorylation in the hippocampus and pfc. 2014-12-22 2023-08-12 rat