| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marta Grabiec, Kris Turlejski, Rouzanna Djavadia. Reduction of the number of new cells reaching olfactory bulbs impairs olfactory perception in the adult opossum. Acta neurobiologiae experimentalis. vol 69. issue 2. 2009-09-17. PMID:19593331. |
we injected opossums (monodelphis domestica) for seven consecutive days with a 5ht(1a) agonist (8-oh-dpat or buspirone) or its antagonist way100635. |
2009-09-17 |
2023-08-12 |
Not clear |
| Nobukazu Kakui, Fumikazu Yokoyama, Miki Yamauchi, Koichi Kitamura, Taiichiro Imanishi, Takeshi Inoue, Tsukasa Koyam. Anxiolytic-like profile of mirtazapine in rat conditioned fear stress model: Functional significance of 5-hydroxytryptamine 1A receptor and alpha1-adrenergic receptor. Pharmacology, biochemistry, and behavior. vol 92. issue 3. 2009-08-05. PMID:19167420. |
a 5-hydroxytryptamine (5-ht) 1a receptor partial agonist, buspirone (1-5 mg/kg) exhibited a significant reduction in freezing time, and its maximal effect was reversed by a selective 5-ht(1a) antagonist, way-100635 (1 mg/kg). |
2009-08-05 |
2023-08-12 |
rat |
| Kyoko Nishi, Kazuya Kanemaru, Shu Hasegawa, Arata Watanabe, Mirko Diksi. Both acute and chronic buspirone treatments have different effects on regional 5-HT synthesis in Flinders Sensitive Line rats (a rat model of depression) than in control rats. Neurochemistry international. vol 54. issue 3-4. 2009-07-28. PMID:19084042. |
both acute and chronic buspirone treatments have different effects on regional 5-ht synthesis in flinders sensitive line rats (a rat model of depression) than in control rats. |
2009-07-28 |
2023-08-12 |
rat |
| Kyoko Nishi, Kazuya Kanemaru, Shu Hasegawa, Arata Watanabe, Mirko Diksi. Both acute and chronic buspirone treatments have different effects on regional 5-HT synthesis in Flinders Sensitive Line rats (a rat model of depression) than in control rats. Neurochemistry international. vol 54. issue 3-4. 2009-07-28. PMID:19084042. |
the main objective of this investigation was to evaluate the effects of buspirone, a 5-ht(1a) agonist with some partial agonist properties and also an antidepressant, on regional 5-ht synthesis in flinders sensitive line (fsl) rats ("depressed"), and to compare the effects to the flinders resistant line (frl) control rats (not "depressed"). |
2009-07-28 |
2023-08-12 |
rat |
| Kyoko Nishi, Kazuya Kanemaru, Shu Hasegawa, Arata Watanabe, Mirko Diksi. Both acute and chronic buspirone treatments have different effects on regional 5-HT synthesis in Flinders Sensitive Line rats (a rat model of depression) than in control rats. Neurochemistry international. vol 54. issue 3-4. 2009-07-28. PMID:19084042. |
serotonin synthesis in both fsl and frl rats was measured following acute and chronic treatments with buspirone. |
2009-07-28 |
2023-08-12 |
rat |
| Kyoko Nishi, Kazuya Kanemaru, Shu Hasegawa, Arata Watanabe, Mirko Diksi. Both acute and chronic buspirone treatments have different effects on regional 5-HT synthesis in Flinders Sensitive Line rats (a rat model of depression) than in control rats. Neurochemistry international. vol 54. issue 3-4. 2009-07-28. PMID:19084042. |
the results show that acute treatment with buspirone elevates 5-ht synthesis throughout the brain in the frl rats. |
2009-07-28 |
2023-08-12 |
rat |
| Kyoko Nishi, Kazuya Kanemaru, Shu Hasegawa, Arata Watanabe, Mirko Diksi. Both acute and chronic buspirone treatments have different effects on regional 5-HT synthesis in Flinders Sensitive Line rats (a rat model of depression) than in control rats. Neurochemistry international. vol 54. issue 3-4. 2009-07-28. PMID:19084042. |
during the chronic treatment, buspirone produced a significant reduction of 5-ht synthesis in 15 out of 30 brain regions in the frl rats. |
2009-07-28 |
2023-08-12 |
rat |
| Kyoko Nishi, Kazuya Kanemaru, Shu Hasegawa, Arata Watanabe, Mirko Diksi. Both acute and chronic buspirone treatments have different effects on regional 5-HT synthesis in Flinders Sensitive Line rats (a rat model of depression) than in control rats. Neurochemistry international. vol 54. issue 3-4. 2009-07-28. PMID:19084042. |
the acute effect in the fsl rats was somewhat similar to the effect reported previously for the spd rats, while in the frl rats, the acute buspirone treatment produced an effect observed previously in treatments with 5-ht(1a) antagonists suggesting an action of buspirone as partial agonist in frl rats. |
2009-07-28 |
2023-08-12 |
rat |
| Yoshihiro Tadori, Robert A Forbes, Robert D McQuade, Tetsuro Kikuch. Receptor reserve-dependent properties of antipsychotics at human dopamine D2 receptors. European journal of pharmacology. vol 607. issue 1-3. 2009-07-07. PMID:19217900. |
in an effort to elucidate aripiprazole's pharmacological activity in relation to clinically relevant fluctuation of dopamine d(2) receptor reserves, we compared the properties of aripiprazole to other antipsychotics, quetiapine, clozapine, olanzapine, ziprasidone, risperidone and haloperidol, a dopamine d(2) receptor partial agonist, bifeprunox, dopamine d(3) receptor modulators, bp897 (n-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]naphthalene-2-carboxamide) and gr103691 (4'-acetyl-n-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]biphenyl-4-carboxamide), and a 5-ht(1a) partial agonist, buspirone using forskolin-stimulated camp accumulation in clonal chinese hamster ovary cell lines expressing low and high densities of human dopamine d(2s) receptors (hd(2s)-low and hd(2s)-high, respectively). |
2009-07-07 |
2023-08-12 |
human |
| Jaroslava Buritova, Geraldine Berrichon, Claudie Cathala, Francis Colpaert, Didier Cussa. Region-specific changes in 5-HT1A agonist-induced Extracellular signal-Regulated Kinases 1/2 phosphorylation in rat brain: a quantitative ELISA study. Neuropharmacology. vol 56. issue 2. 2009-07-01. PMID:18809418. |
we examined perk1/2 levels in rat brain following administration of (+)8-oh-dpat, buspirone as well as of the more selective, high-efficacy 5-ht(1a) agonists f13640 and f13714. |
2009-07-01 |
2023-08-12 |
rat |
| Jaroslava Buritova, Geraldine Berrichon, Claudie Cathala, Francis Colpaert, Didier Cussa. Region-specific changes in 5-HT1A agonist-induced Extracellular signal-Regulated Kinases 1/2 phosphorylation in rat brain: a quantitative ELISA study. Neuropharmacology. vol 56. issue 2. 2009-07-01. PMID:18809418. |
furthermore, f13640, f13714, buspirone, but not (+)8-oh-dpat, exert their effects via preferential activation of presynaptic 5-ht(1a) receptors. |
2009-07-01 |
2023-08-12 |
rat |
| Ana Laura Martínez, Ma Eva González-Trujano, Eva Aguirre-Hernández, Julia Moreno, Marco Soto-Hernández, Francisco J López-Muño. Antinociceptive activity of Tilia americana var. mexicana inflorescences and quercetin in the formalin test and in an arthritic pain model in rats. Neuropharmacology. vol 56. issue 2. 2009-07-01. PMID:19027760. |
in the pifir and formalin models producing a significant and dose-dependent antinociceptive response resembling that produced by a total and a partial agonist of 5-ht(1a) receptors like 8-oh-dpat (0.1 mg/kg, s.c.) and buspirone (5 mg/kg, i.p. |
2009-07-01 |
2023-08-12 |
rat |
| Yukihiro Ohno, Saki Shimizu, Junta Imak. Effects of tandospirone, a 5-HT1A agonistic anxiolytic agent, on haloperidol-induced catalepsy and forebrain Fos expression in mice. Journal of pharmacological sciences. vol 109. issue 4. 2009-06-22. PMID:19352073. |
we studied the effects of tandospirone, a 5-ht(1a) agonistic anxiolytic agent, on haloperidol-induced catalepsy and forebrain fos expression in mice. |
2009-06-22 |
2023-08-12 |
mouse |
| Yukihiro Ohno, Saki Shimizu, Junta Imak. Effects of tandospirone, a 5-HT1A agonistic anxiolytic agent, on haloperidol-induced catalepsy and forebrain Fos expression in mice. Journal of pharmacological sciences. vol 109. issue 4. 2009-06-22. PMID:19352073. |
tandospirone (0.1 - 1 mg/kg, s.c.) significantly alleviated haloperidol-induced catalepsy in a dose-dependent manner, which was antagonized by way-100135 (a selective 5-ht(1a) antagonist). |
2009-06-22 |
2023-08-12 |
mouse |
| Jonathan R Davidso. First-line pharmacotherapy approaches for generalized anxiety disorder. The Journal of clinical psychiatry. vol 70 Suppl 2. 2009-05-05. PMID:19371504. |
several classes of drugs, including benzodiazepines, azapirones, selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, antihistamines, alpha(2)delta ca++ channel modulators, and atypical antipsychotics are consistently beneficial in patients with gad. |
2009-05-05 |
2023-08-12 |
Not clear |
| Jan Tac. Prokinetics and fundic relaxants in upper functional GI disorders. Current opinion in pharmacology. vol 8. issue 6. 2009-03-19. PMID:18940266. |
recently studied drugs include drugs under investigation including nitrates, serotonin reuptake blockers, 5-ht(1a) receptor agonists (buspirone and r137696), and muscarinc m1/m2 receptor antagonists (acotiamide or z-338). |
2009-03-19 |
2023-08-12 |
Not clear |
| Markus Storvik, Merja Häkkinen, Erkki Tupala, Jari Tiihone. 5-HT(1A) receptors in the frontal cortical brain areas in Cloninger type 1 and 2 alcoholics measured by whole-hemisphere autoradiography. Alcohol and alcoholism (Oxford, Oxfordshire). vol 44. issue 1. 2009-03-03. PMID:19029097. |
the 5-ht(1a) receptors are the binding sites for anxiolytic drug buspirone. |
2009-03-03 |
2023-08-12 |
Not clear |
| Hiroyuki Nishikawa, Takeshi Inoue, Takuya Masui, Takeshi Izumi, Shin Nakagawa, Tsukasa Koyam. Pharmacokinetic interaction between tandospirone and fluvoxamine in the rat contextual conditioned fear stress model and its functional consequence: Involvement of cytochrome P450 3A4. Psychiatry and clinical neurosciences. vol 62. issue 5. 2009-02-27. PMID:18950380. |
in a previous study it was demonstrated that the anxiolytic action of tandospirone, a 5-hydroxytryptamine (5-ht)(1a) receptor agonist, is facilitated by cytochrome p450 (cyp) 3a4 inhibitors, such as ketoconazole and cimetidine. |
2009-02-27 |
2023-08-12 |
rat |
| Herbert Y Meltzer, Tomiki Sumiyosh. Does stimulation of 5-HT(1A) receptors improve cognition in schizophrenia? Behavioural brain research. vol 195. issue 1. 2009-01-12. PMID:18707769. |
a series of studies from this laboratory involving the 5-ht(1a) partial agonists tandospirone and buspirone have reported a modest ability of these agents to improve some domains of cognition in patients receiving typical or atypical antipsychotic drugs. |
2009-01-12 |
2023-08-12 |
Not clear |
| Aleksandra Wisłowska-Stanek, Adam Hamed, Małgorzata Lehner, Andrzej Bidziński, Danuta Turzyńska, Alicja Sobolewska, Jerzy Walkowiak, Adam Płaźni. Effects of midazolam and buspirone on in vivo concentration of amino acids and monoamine metabolites in the rat hippocampus. Pharmacological reports : PR. vol 60. issue 2. 2009-01-09. PMID:18443382. |
the effects of anxiolytic doses of buspirone and midazolam (established in the conditioned fear test) on extracellular concentrations of glutamate, gaba, serotonin and dopamine metabolites in the hippocampus were examined in vivo, in freely moving rats. |
2009-01-09 |
2023-08-12 |
rat |