| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Robert A Hodgson, Donald H Guthrie, Geoffrey B Vart. Duration of ultrasonic vocalizations in the isolated rat pup as a behavioral measure: sensitivity to anxiolytic and antidepressant drugs. Pharmacology, biochemistry, and behavior. vol 88. issue 3. 2008-04-09. PMID:17928040. |
the benzodiazepines, cdp (1-10 mg/kg) and diazepam (0.3-3 mg/kg), the 5ht(1a) partial agonist, buspirone (0.3-3 mg/kg), and the mglur5 antagonist, mtep (1-30 mg/kg), reduced usv duration at lower doses and to a greater magnitude than usv number. |
2008-04-09 |
2023-08-12 |
rat |
| Asma Khan, D J Halee. Tolerance in the anxiolytic profile following repeated administration of diazepam but not buspirone is associated with a decrease in the responsiveness of postsynaptic 5-HT-1A receptors. Acta biologica Hungarica. vol 58. issue 4. 2008-03-27. PMID:18277461. |
to understand the role of serotonin (5-hydroxytryptamine; 5-ht)-1a receptors in the treatment of anxiety and the development of tolerance to benzodiazepines the present study was designed to monitor the responsiveness of postsynaptic 5-ht-1a receptors following repeated administration of diazepam and buspirone. |
2008-03-27 |
2023-08-12 |
rat |
| R Hamish McAllister-Williams, Anna E Massey, Graeme Fairchil. Repeated cortisol administration attenuates the EEG response to buspirone in healthy volunteers: evidence for desensitization of the 5-HT1A autoreceptor. Journal of psychopharmacology (Oxford, England). vol 21. issue 8. 2008-01-29. PMID:17715208. |
this method involves the administration of the 5-ht(1a) agonist buspirone and observing the subsequent negative shift in the frequency spectrum of the electroencephalogram (eeg). |
2008-01-29 |
2023-08-12 |
human |
| b' Tiina M K\\xc3\\xa4\\xc3\\xa4ri\\xc3\\xa4inen, Marko Lehtonen, Markus M Forsberg, Jouko Savolainen, Mikko K\\xc3\\xa4enm\\xc3\\xa4ki, Pekka T M\\xc3\\xa4nnist\\xc3\\xb. Comparison of the effects of deramciclane, ritanserin and buspirone on extracellular dopamine and its metabolites in striatum and nucleus accumbens of freely moving rats. Basic & clinical pharmacology & toxicology. vol 102. issue 1. 2008-01-17. PMID:17971064.' |
dual probe in vivo microdialysis in freely moving rats was used to compare the effects of graded doses of deramciclane fumarate (3, 10 and 30 mg/kg), 5-ht(2a/c )antagonist ritanserin (1 mg/kg) and a partial 5-ht(1a) agonist buspirone hydrochloride (5 mg/kg) on the extracellular levels of dopamine, 3,4-dihydroxyphenylacetic acid (dopac) and homovanillic acid (hva) in nucleus accumbens and striatum assayed by high performance liquid chromatography with electrochemical detection. |
2008-01-17 |
2023-08-12 |
rat |
| Yoshiaki Utsu, Kazuaki Shinomiya, Shin Tokunaga, Asae Ohmori, Chiaki Kame. Effect of tandospirone on sleep latency in rats placed on a grid suspended over water. Journal of pharmacological sciences. vol 105. issue 1. 2007-12-20. PMID:17827866. |
for investigating the mechanism of tandospirone, the effect of tandospirone on sleep latency was also studied using rats that were depleted with neuronal serotonin (5-ht) after p-chlorophenylalanine administration. |
2007-12-20 |
2023-08-12 |
rat |
| Yoshiaki Utsu, Kazuaki Shinomiya, Shin Tokunaga, Asae Ohmori, Chiaki Kame. Effect of tandospirone on sleep latency in rats placed on a grid suspended over water. Journal of pharmacological sciences. vol 105. issue 1. 2007-12-20. PMID:17827866. |
from these findings, a shortening of sleep latency induced by tandospirone may occur through the pre-synaptic 5-ht(1a) receptors in rats. |
2007-12-20 |
2023-08-12 |
rat |
| Hiroyuki Nishikawa, Takeshi Inoue, Takeshi Izumi, Tsukasa Koyam. Synergistic effects of tandospirone and selective serotonin reuptake inhibitors on the contextual conditioned fear stress response in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 17. issue 10. 2007-12-06. PMID:17368862. |
synergistic effects of tandospirone and selective serotonin reuptake inhibitors on the contextual conditioned fear stress response in rats. |
2007-12-06 |
2023-08-12 |
rat |
| Hiroyuki Nishikawa, Takeshi Inoue, Takeshi Izumi, Tsukasa Koyam. Synergistic effects of tandospirone and selective serotonin reuptake inhibitors on the contextual conditioned fear stress response in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 17. issue 10. 2007-12-06. PMID:17368862. |
the purpose of this study was to investigate the effects of co-administration of tandospirone (a 5-ht(1a) receptor agonist) and individual selective serotonin reuptake inhibitors (ssris) on the contextual conditioned fear stress, using an anxiety model in rats. |
2007-12-06 |
2023-08-12 |
rat |
| Harvey Wong, Randy C Dockens, Lori Pajor, Suresh Yeola, James E Grace, Arlene D Stark, Rebecca A Taub, Frank D Yocca, Robert C Zaczek, Yu-Wen L. 6-Hydroxybuspirone is a major active metabolite of buspirone: assessment of pharmacokinetics and 5-hydroxytryptamine1A receptor occupancy in rats. Drug metabolism and disposition: the biological fate of chemicals. vol 35. issue 8. 2007-11-02. PMID:17494642. |
after intravenous infusions to steady-state levels in plasma, 6-oh-buspirone and buspirone increased 5-hydroxytryptamine (ht)(1a) receptor occupancy in a concentration-dependent manner with ec(50) values of 1.0 +/- 0.3 and 0.38 +/- 0.06 microm in the dorsal raphe and 4.0 +/- 0.6 and 1.5 +/- 0.3 microm in the hippocampus, respectively. |
2007-11-02 |
2023-08-12 |
rat |
| b' Ricard Navin\\xc3\\xa9s, Esther G\\xc3\\xb3mez-Gil, Roc\\xc3\\xado Mart\\xc3\\xadn-Santos, Mar\\xc3\\xada J Mart\\xc3\\xadnez de Osaba, Gin\\xc3\\xa9s Escolar, Crist\\xc3\\xb3bal Gast\\xc3\\xb. Hormonal response to buspirone is not impaired in major depression. Human psychopharmacology. vol 22. issue 6. 2007-10-23. PMID:17563921.' |
a cross-sectional case-control study was designed to assess the effect of the 5-ht(1a) receptor agonist, buspirone, on 5-ht(1a) receptor function in 30 patients with major depression (dsm-iv) and in 30 age- and sex-matched healthy controls. |
2007-10-23 |
2023-08-12 |
Not clear |
| b' Ricard Navin\\xc3\\xa9s, Esther G\\xc3\\xb3mez-Gil, Roc\\xc3\\xado Mart\\xc3\\xadn-Santos, Mar\\xc3\\xada J Mart\\xc3\\xadnez de Osaba, Gin\\xc3\\xa9s Escolar, Crist\\xc3\\xb3bal Gast\\xc3\\xb. Hormonal response to buspirone is not impaired in major depression. Human psychopharmacology. vol 22. issue 6. 2007-10-23. PMID:17563921.' |
these results indicate no consistent changes in the hormonal response to the 5-ht(1a) agonist buspirone in depressed patients. |
2007-10-23 |
2023-08-12 |
Not clear |
| Satoru Tamaoki, Yukinao Yamauchi, Youichi Nakano, Sayuri Sakano, Akira Asagarasu, Michitaka Sat. Pharmacological properties of 3-amino-5,6,7,8-tetrahydro-2-[4-[4-(quinolin-2-yl)piperazin-1-yl]butyl]quinazolin-4(3H)-one (TZB-30878), a novel therapeutic agent for diarrhea-predominant irritable bowel syndrome (IBS) and its effects on an experimental IBS model. The Journal of pharmacology and experimental therapeutics. vol 322. issue 3. 2007-10-19. PMID:17540858. |
normalized stress-induced defecation in a dose-dependent manner, whereas the 5-ht(1a) agonist tandospirone (30 and 100 mg/kg p.o.) |
2007-10-19 |
2023-08-12 |
human |
| Karen L Eskow, Vikas Gupta, Salmahn Alam, John Y Park, Christopher Bisho. The partial 5-HT(1A) agonist buspirone reduces the expression and development of l-DOPA-induced dyskinesia in rats and improves l-DOPA efficacy. Pharmacology, biochemistry, and behavior. vol 87. issue 3. 2007-10-12. PMID:17553556. |
the partial 5-ht(1a) agonist buspirone reduces the expression and development of l-dopa-induced dyskinesia in rats and improves l-dopa efficacy. |
2007-10-12 |
2023-08-12 |
rat |
| Karen L Eskow, Vikas Gupta, Salmahn Alam, John Y Park, Christopher Bisho. The partial 5-HT(1A) agonist buspirone reduces the expression and development of l-DOPA-induced dyskinesia in rats and improves l-DOPA efficacy. Pharmacology, biochemistry, and behavior. vol 87. issue 3. 2007-10-12. PMID:17553556. |
in experiment 1, l-dopa-primed rats were pre-treated with vehicle (0.9% nacl), various doses of the partial 5-ht(1a) agonist, buspirone (0.25, 1.0 or 2.5 mg/kg, ip) or buspirone (2.5 mg/kg, ip)+the 5-ht(1a) antagonist, way100635 (0.5 mg/kg, ip) 5 min prior to l-dopa (12 mg/kg+15 mg/kg benserazide, ip). |
2007-10-12 |
2023-08-12 |
rat |
| Karen L Eskow, Vikas Gupta, Salmahn Alam, John Y Park, Christopher Bisho. The partial 5-HT(1A) agonist buspirone reduces the expression and development of l-DOPA-induced dyskinesia in rats and improves l-DOPA efficacy. Pharmacology, biochemistry, and behavior. vol 87. issue 3. 2007-10-12. PMID:17553556. |
in l-dopa-primed rats, buspirone dose-dependently reduced lid and improved l-dopa-related motor performance due to action at the 5-ht(1a) receptor. |
2007-10-12 |
2023-08-12 |
rat |
| Karen L Eskow, Vikas Gupta, Salmahn Alam, John Y Park, Christopher Bisho. The partial 5-HT(1A) agonist buspirone reduces the expression and development of l-DOPA-induced dyskinesia in rats and improves l-DOPA efficacy. Pharmacology, biochemistry, and behavior. vol 87. issue 3. 2007-10-12. PMID:17553556. |
in l-dopa-naïve rats, buspirone delayed lid development while improving l-dopa's anti-parkinsonian efficacy indicating the potential long-term benefits of 5-ht(1a) agonists for reduction of l-dopa-related side effects. |
2007-10-12 |
2023-08-12 |
rat |
| Reshma Farooq, Darakhshan J Haleem, M A Halee. Dose related effects of buspirone on serum electrolyte balance, plasma osmolality and systolic blood pressure (SBP) in rats. Pakistan journal of pharmaceutical sciences. vol 20. issue 4. 2007-08-09. PMID:17604252. |
buspirone is a potent anxiolytic that decreases serotonin transmission. |
2007-08-09 |
2023-08-12 |
human |
| Aaron Ettenberg, Rick E Bernard. Effects of buspirone on the immediate positive and delayed negative properties of intravenous cocaine as measured in the conditioned place preference test. Pharmacology, biochemistry, and behavior. vol 87. issue 1. 2007-08-06. PMID:17524462. |
these results are consistent with the view that attenuation of 5-ht neurotransmission (via the autoreceptor agonist properties of buspirone) can reverse the negative impact of iv cocaine. |
2007-08-06 |
2023-08-12 |
rat |
| Hiroyuki Nishikawa, Takeshi Inoue, Takuya Masui, Takeshi Izumi, Tsukasa Koyam. Effects of cytochrome P450 (CYP) 3A4 inhibitors on the anxiolytic action of tandospirone in rat contextual conditioned fear. Progress in neuro-psychopharmacology & biological psychiatry. vol 31. issue 4. 2007-08-03. PMID:17376576. |
the azapirone derivatives, including tandospirone and buspirone, are anxiolytics with 5-ht(1a) receptor agonistic action. |
2007-08-03 |
2023-08-12 |
human |
| Oliver Grundmann, Jun-Ichiro Nakajima, Shujiro Seo, Veronika Butterwec. Anti-anxiety effects of Apocynum venetum L. in the elevated plus maze test. Journal of ethnopharmacology. vol 110. issue 3. 2007-06-13. PMID:17101250. |
and the 5-ht(1a) agonist buspirone (10 mg/kg p.o.). |
2007-06-13 |
2023-08-12 |
mouse |