| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J-P Boulenger, D Capdeviell. [Pharmacological treatment of generalized anxiety disorders: rationale and limitations]. L'Encephale. vol 33. issue 1. 2007-06-12. PMID:17457298. |
6 to 12 weeks) due to the fluctuating nature of generalized anxiety, the chronic evolution of this disorder in most patients often justifies the long-term prescription of serotoninergic (5-ht) or dual-action (5ht-na) antidepressants and sometimes of 5ht-la partial agonists like buspirone. |
2007-06-12 |
2023-08-12 |
Not clear |
| Samuel R Chamberlain, Ulrich Müller, Julia B Deakin, Phil R Corlett, Jonathan Dowson, Rudolf N Cardinal, Michael R F Aitken, Trevor W Robbins, Barbara J Sahakia. Lack of deleterious effects of buspirone on cognition in healthy male volunteers. Journal of psychopharmacology (Oxford, England). vol 21. issue 2. 2007-05-15. PMID:17329302. |
buspirone is a serotonin 5-ht(1a) receptor agonist licensed for the treatment of anxiety. |
2007-05-15 |
2023-08-12 |
human |
| Maarten van den Buuse, Andrea Gogo. Differential effects of antipsychotic drugs on serotonin-1A receptor-mediated disruption of prepulse inhibition. The Journal of pharmacology and experimental therapeutics. vol 320. issue 3. 2007-04-09. PMID:17194799. |
this effect was mimicked by pretreatment with the 5-ht(1a) receptor partial agonist, buspirone [n-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride]. |
2007-04-09 |
2023-08-12 |
rat |
| Noreen Samad, Tahira Perveen, Saida Haider, Mohammad A Haleem, Darakhshan J Halee. Inhibition of restraint-induced neuroendocrine and serotonergic responses by buspirone in rats. Pharmacological reports : PR. vol 58. issue 5. 2007-03-27. PMID:17085855. |
restraint-induced rise in brain 5-ht and 5-hydroxyindole-acetic acid (5-hiaa) was also attenuated by buspirone. |
2007-03-27 |
2023-08-12 |
rat |
| Oliver Grundmann, Olaf Kelber, Veronika Butterwec. Effects of St. John's wort extract and single constituents on stress-induced hyperthermia in mice. Planta medica. vol 72. issue 15. 2007-03-05. PMID:17051457. |
anxiolytic drugs (the benzodiazepine diazepam; 5 mg/kg, and the 5ht (1a) receptor agonist buspirone; 10 mg/kg) significantly reduced deltat, whereas antidepressants (imipramine and fluoxetine) had no effect on deltat. |
2007-03-05 |
2023-08-12 |
mouse |
| Aaron Ettenberg, Rick E Bernard. Anxiolytic-like actions of buspirone in a runway model of intravenous cocaine self-administration. Pharmacology, biochemistry, and behavior. vol 85. issue 2. 2007-02-20. PMID:17064759. |
buspirone, a partial 5-ht(1a) agonist, has been reported to produce anxiolytic-like actions in the clinic, but has had mixed results in experimental tests of anxiety using animal subjects. |
2007-02-20 |
2023-08-12 |
human |
| Katsuya Harada, Masaki Aota, Tatsuo Inoue, Ritsuko Matsuda, Takuma Mihara, Takayuki Yamaji, Koji Ishibashi, Nobuya Matsuok. Anxiolytic activity of a novel potent serotonin 5-HT2C receptor antagonist FR260010: a comparison with diazepam and buspirone. European journal of pharmacology. vol 553. issue 1-3. 2007-01-24. PMID:17074317. |
anxiolytic activity of a novel potent serotonin 5-ht2c receptor antagonist fr260010: a comparison with diazepam and buspirone. |
2007-01-24 |
2023-08-12 |
mouse |
| Asma Khan, Darakhshan Jabeen Halee. 5-HT-1A receptor responsiveness following subchronic administration of buspirone. Pakistan journal of pharmaceutical sciences. vol 19. issue 4. 2007-01-24. PMID:17105715. |
decreases in 5-hydroxytryptamine (5-ht) and 5-hydroxyindoleacetic acid (5-hiaa) levels were higher in saline than buspirone injected rats. |
2007-01-24 |
2023-08-12 |
rat |
| B G Oertel, A Schneider, M Rohrbacher, H Schmidt, I Tegeder, G Geisslinger, J Lötsc. The partial 5-hydroxytryptamine1A receptor agonist buspirone does not antagonize morphine-induced respiratory depression in humans. Clinical pharmacology and therapeutics. vol 81. issue 1. 2007-01-17. PMID:17186000. |
oral co-administration of a high dose of the clinically available 5-ht(1a) agonist buspirone cannot be advised as a remedy for opioid-induced respiratory depression. |
2007-01-17 |
2023-08-12 |
human |
| Mahmoud M Iravani, Kayhan Tayarani-Binazir, Wing B Chu, Michael J Jackson, Peter Jenne. In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates, the selective 5-hydroxytryptamine 1a agonist (R)-(+)-8-OHDPAT inhibits levodopa-induced dyskinesia but only with\ increased motor disability. The Journal of pharmacology and experimental therapeutics. vol 319. issue 3. 2007-01-09. PMID:16959959. |
5-hydroxytryptamine 1a (5-ht(1a)) receptor agonists, such as sarizotan and tandospirone, are reported to reduce levodopa-induced dyskinesia in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-treated macaques and in parkinson's disease without worsening motor disability. |
2007-01-09 |
2023-08-12 |
Not clear |
| Lin Xue, Michael Camilleri, G Richard Locke, Jan A J Schuurkes, Ann Meulemans, Bernard J Coulie, Joseph H Szurszewski, Gianrico Farrugi. Serotonergic modulation of murine fundic tone. American journal of physiology. Gastrointestinal and liver physiology. vol 291. issue 6. 2006-12-26. PMID:16873894. |
the 5-ht(1a) receptor agonist buspirone relaxed fundic smooth muscle, and the relaxation was inhibited by way-100135 but not by n(omega)-nitro-l-arginine or tetrodotoxin. |
2006-12-26 |
2023-08-12 |
Not clear |
| Nobuaki Egashira, Tomomi Matsuda, Emi Koushi, Kenichi Mishima, Katsunori Iwasaki, Yukihiro Shoyama, Michihiro Fujiwar. Involvement of 5-hydroxytryptamine1A receptors in Delta9-tetrahydrocannabinol-induced catalepsy-like immobilization in mice. European journal of pharmacology. vol 550. issue 1-3. 2006-12-15. PMID:17022969. |
and 5-ht(1a) receptor partial agonist buspirone (0.06 and 0.1 mg/kg, i.p.) |
2006-12-15 |
2023-08-12 |
mouse |
| Meg Van Bogaert, Ronald Oosting, Miklos Toth, Lucianne Groenink, Ruud van Oorschot, Berend Olivie. Effects of genetic background and null mutation of 5-HT1A receptors on basal and stress-induced body temperature: modulation by serotonergic and GABAA-ergic drugs. European journal of pharmacology. vol 550. issue 1-3. 2006-12-15. PMID:17022970. |
in addition, stimulation of 5-ht(1a) receptors by buspirone results in a reduced deltat, while stimulation of 5-ht(7) receptors primarily results in hypothermia. |
2006-12-15 |
2023-08-12 |
mouse |
| David J Edwards, Diane C Chugani, Harry T Chugani, Jamal Chehab, Monica Malian, Jacob V Arand. Pharmacokinetics of buspirone in autistic children. Journal of clinical pharmacology. vol 46. issue 5. 2006-12-12. PMID:16638734. |
buspirone is used to treat generalized anxiety disorder in children and may be useful in developmental disorders in which brain serotonin synthesis is altered. |
2006-12-12 |
2023-08-12 |
Not clear |
| Arturo Zazpe, Inés Artaiz, Ana Innerárity, Elena Del Olmo, Elena Castro, Luis Labeaga, Angel Pazos, Aurelio Orjale. In vitro and in vivo characterization of F-97013-GD, a partial 5-HT1A agonist with antipsychotic- and antiparkinsonian-like properties. Neuropharmacology. vol 51. issue 1. 2006-09-11. PMID:16643965. |
acute injection of 5-ht(1a) agonists 8-oh-dpat and buspirone dose-dependently counteracted the tacrine-induced oral movements (ed(50)=0.04 and 1.0mg/kg, respectively), an effect reversed by the selective 5-ht(1a) antagonist way 100,635. |
2006-09-11 |
2023-08-12 |
rat |
| David Centurión, Suneet Mehotra, Araceli Sánchez-López, Saurabh Gupta, Antoinette MaassenVanDenBrink, Carlos M Villaló. Potential vascular alpha1-adrenoceptor blocking properties of an array of 5-HT receptor ligands in the rat. European journal of pharmacology. vol 535. issue 1-3. 2006-06-21. PMID:16545797. |
these ligands included: methiothepin, methysergide and metergoline (5-ht(1)/5-ht2); way-100635, buspirone, ipsapirone and 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) (5-ht(1a)); gr127935 (5-ht(1b/1d)); ketanserin, ritanserin, spiperone and pizotifen (5-ht2); granisetron and metoclopramide (5-ht3); tropisetron (5-ht3/5-ht4); ergotamine (5-ht(1b/1d), 5-ht(5a/5b)); clozapine (5-ht6/5-ht7); as well as ly215840 and mesulergine (5-ht2/5-ht7). |
2006-06-21 |
2023-08-12 |
rat |
| A C E Linthors. Interactions between corticotropin-releasing hormone and serotonin: implications for the aetiology and treatment of anxiety disorders. Handbook of experimental pharmacology. issue 169. 2006-06-13. PMID:16594259. |
although the picture is far from complete yet--partly due to the large number of serotonin (5-ht) receptors and the often-disparate effects of receptor agonists and antagonists in animal models of anxiety--ssris and the 5-ht1a agonist buspirone have now earned their place in the treatment of anxiety disorders. |
2006-06-13 |
2023-08-12 |
Not clear |
| Arata Watanabe, Shu Hasegawa, Kyoko Nishi, Khnah Q Nguyen, Mirko Diksi. Chronic buspirone treatment normalizes regional serotonin synthesis in the olfactory bulbectomized rat brain: an autoradiographic study. Brain research bulletin. vol 69. issue 2. 2006-06-01. PMID:16533657. |
chronic buspirone treatment normalizes regional serotonin synthesis in the olfactory bulbectomized rat brain: an autoradiographic study. |
2006-06-01 |
2023-08-12 |
rat |
| Arata Watanabe, Shu Hasegawa, Kyoko Nishi, Khnah Q Nguyen, Mirko Diksi. Chronic buspirone treatment normalizes regional serotonin synthesis in the olfactory bulbectomized rat brain: an autoradiographic study. Brain research bulletin. vol 69. issue 2. 2006-06-01. PMID:16533657. |
the effects of chronic buspirone treatments, administered by minipump at doses of 10 and 20 mg/(kg day) for 14 days, on brain 5-ht synthesis in olfactory bulbectomized (obx) rats were evaluated. |
2006-06-01 |
2023-08-12 |
rat |
| Arata Watanabe, Shu Hasegawa, Kyoko Nishi, Khnah Q Nguyen, Mirko Diksi. Chronic buspirone treatment normalizes regional serotonin synthesis in the olfactory bulbectomized rat brain: an autoradiographic study. Brain research bulletin. vol 69. issue 2. 2006-06-01. PMID:16533657. |
these results suggest that 10 mg/(kg day) of buspirone for 14 days in the obx rats did not produce a significant alteration in 5-ht synthesis, but 20 mg/(kg day) for 14 days resulted in an overall significant reduction in brain 5-ht synthesis. |
2006-06-01 |
2023-08-12 |
rat |