| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael Krause, Yousheng Ji. Serotonergic modulation of carbachol-induced rhythmic activity in hippocampal slices. Neuropharmacology. vol 48. issue 3. 2005-05-24. PMID:15721170. |
the 5-ht(1a) agonists 8-oh-dpat and buspirone mimic the effect of 5-ht, whereas the selective 5-ht(1a) receptor antagonist way-100635 (1 microm) significantly prevents the effect of 5-ht. |
2005-05-24 |
2023-08-12 |
Not clear |
| Martin B Keller, Frank J L Ruwe, Cecile J J G Janssens, J M Ad Sitsen, Riitta Jokinen, Janusz Janczewsk. Relapse prevention with gepirone ER in outpatients with major depression. Journal of clinical psychopharmacology. vol 25. issue 1. 2005-04-08. PMID:15643103. |
to evaluate long-term efficacy and tolerability of the serotonin 5-ht1a receptor agonist, gepirone extended release (er), a multicenter, randomized, placebo-controlled relapse prevention study was performed in patients with recurrent major depression (dsm-iv criteria). |
2005-04-08 |
2023-08-12 |
Not clear |
| Darakhshan Jabeen Haleem, Erum Shireen, M A Halee. Somatodendritic and postsynaptic serotonin-1A receptors in the attenuation of haloperidol-induced catalepsy. Progress in neuro-psychopharmacology & biological psychiatry. vol 28. issue 8. 2005-03-07. PMID:15588759. |
the mechanism by which stimulation of somatodendritic and/or postsynaptic 5-hydroxytryptamine (5-ht, serotonin)-1a receptor could attenuate acute parkinsonian-like effects of typical antipsychotics is investigated by comparing the anticataleptic and neurochemical effects of 8-hydroxy-2-di-n-propylaminotetralin (8-oh-dpat) and buspirone in rats injected with haloperidol. |
2005-03-07 |
2023-08-12 |
rat |
| Peter H Silverston. Qualitative review of SNRIs in anxiety. The Journal of clinical psychiatry. vol 65 Suppl 17. 2005-02-01. PMID:15600378. |
many pharmacologic agents have been used to treat anxiety disorders, and among those in current use are newer benzodiazepines (alprazolam), azapirones (buspirone), selective serotonin reuptake inhibitors (paroxetine and sertraline), and venlafaxine, a serotonin-norepinephrine reuptake inhibitor (snri). |
2005-02-01 |
2023-08-12 |
Not clear |
| Bankole A Johnso. Role of the serotonergic system in the neurobiology of alcoholism: implications for treatment. CNS drugs. vol 18. issue 15. 2005-01-24. PMID:15581381. |
buspirone, a serotonin 5-ht1a partial agonist, does not appear to be an effective treatment for alcoholics without comorbid disease. |
2005-01-24 |
2023-08-12 |
Not clear |
| Digavalli V Sivarao, Kimberly Newberry, Nicholas J Lodg. Effect of the 5HT1A receptor partial agonist buspirone on colorectal distension-induced pseudoaffective and behavioral responses in the female Wistar rat. European journal of pharmacology. vol 494. issue 1. 2005-01-13. PMID:15194447. |
in the present study, we have evaluated the visceral analgesic property of buspirone, a 5ht(1a) receptor partial agonist, on colorectal distension-induced mean arterial pressure and behavioral changes in anesthetized and awake wistar rats, respectively. |
2005-01-13 |
2023-08-12 |
rat |
| David M Pache, Sabela Fernández-Pérez, Robert D E Sewel. Buspirone differentially modifies short-term memory function in a combined delayed matching/non-matching to position task. European journal of pharmacology. vol 477. issue 3. 2004-12-21. PMID:14522358. |
), a selective 5-ht reuptake inhibitor; the full 5-ht(1a) receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat; 0.3 mg/kg, s.c.); and the partial 5-ht(1a) receptor agonist, buspirone (1 mg/kg, i.p.). |
2004-12-21 |
2023-08-12 |
rat |
| David M Pache, Sabela Fernández-Pérez, Robert D E Sewel. Buspirone differentially modifies short-term memory function in a combined delayed matching/non-matching to position task. European journal of pharmacology. vol 477. issue 3. 2004-12-21. PMID:14522358. |
thus, the findings suggest that partial 5-ht(1a) receptor activation compromises cognitive function to a greater extent than full 5-ht(1a) receptor activation, although a dopaminergic component cannot be excluded since buspirone possesses some dopamine d2 receptor antagonist activity. |
2004-12-21 |
2023-08-12 |
rat |
| József Haller, József Halász, Eszter Majercsi. Psychosocial conditions and the efficacy of clinically available anxiolytics. Current drug targets. vol 5. issue 7. 2004-12-14. PMID:15473255. |
laboratory studies predict that (i) the frequent exposure of subjects to acute stressors lowers the efficacy of benzodiazepines and buspirone, but increases the efficacy of selective serotonin reuptake inhibitors (ssris); (ii) the anxiolytic efficacy of buspirone is largely affected by social support and stability, whereas (iii) the efficacy of ssris is larger in subjects experiencing early maltreatment. |
2004-12-14 |
2023-08-12 |
human |
| Manish Tandon, Mary-Margaret O'Donnell, Alex Porte, David Vensel, Donglai Yang, Rocio Palma, Alan Beresford, Mark A Ashwel. The design and preparation of metabolically protected new arylpiperazine 5-HT1A ligands. Bioorganic & medicinal chemistry letters. vol 14. issue 7. 2004-10-26. PMID:15026055. |
new arylpiperazines related to buspirone, gepirone and nan-190 were designed and screened in silico for their 5-ht(1a) affinity and potential sites of metabolism by human cytochrome p450 (cyp3a4). |
2004-10-26 |
2023-08-12 |
human |
| Wayne K Goodma. Selecting pharmacotherapy for generalized anxiety disorder. The Journal of clinical psychiatry. vol 65 Suppl 13. 2004-10-22. PMID:15384931. |
many treatments exist to aid in the realization of treatment goals, including benzodiazepines, hydroxyzine, buspirone, selective serotonin reuptake inhibitors (ssris), and serotonin-norepinephrine reuptake inhibitors (snris). |
2004-10-22 |
2023-08-12 |
Not clear |
| Telésfora Sempere, Mary Urbina, Lucimey Lim. 5-HT1A and beta-adrenergic receptors regulate proliferation of rat blood lymphocytes. Neuroimmunomodulation. vol 11. issue 5. 2004-10-18. PMID:15316241. |
the 5-ht(1a) receptor agonists, 8-hydroxy-2-(di-n-propylamino)tetralin and buspirone (0.1-100 microm) were also tested in the cultures. |
2004-10-18 |
2023-08-12 |
rat |
| Telésfora Sempere, Mary Urbina, Lucimey Lim. 5-HT1A and beta-adrenergic receptors regulate proliferation of rat blood lymphocytes. Neuroimmunomodulation. vol 11. issue 5. 2004-10-18. PMID:15316241. |
serotonin, 8-hydroxy-2-(di-n-propylamino)tetralin and buspirone neither had any effect by themselves, nor modified the proliferation induced by the mitogens. |
2004-10-18 |
2023-08-12 |
rat |
| Mary J Druse, Nuzhath F Tajuddin, Roberta A Gillespie, Elizabeth Dickson, Mohammed Atieh, Constance A Pietrzak, Phong T L. The serotonin-1A agonist ipsapirone prevents ethanol-associated death of total rhombencephalic neurons and prevents the reduction of fetal serotonin neurons. Brain research. Developmental brain research. vol 150. issue 2. 2004-08-23. PMID:15158072. |
previously, this laboratory showed that in utero and in vitro ethanol exposure significantly reduces developing serotonin (5-ht) neurons and that treatment with a 5-ht1a agonist such as buspirone or ipsapirone prevents the ethanol-associated loss. |
2004-08-23 |
2023-08-12 |
Not clear |
| Y P Liu, L S Wilkinson, T W Robbin. Effects of acute and chronic buspirone on impulsive choice and efflux of 5-HT and dopamine in hippocampus, nucleus accumbens and prefrontal cortex. Psychopharmacology. vol 173. issue 1-2. 2004-08-06. PMID:14726995. |
effects of acute and chronic buspirone on impulsive choice and efflux of 5-ht and dopamine in hippocampus, nucleus accumbens and prefrontal cortex. |
2004-08-06 |
2023-08-12 |
rat |
| Y P Liu, L S Wilkinson, T W Robbin. Effects of acute and chronic buspirone on impulsive choice and efflux of 5-HT and dopamine in hippocampus, nucleus accumbens and prefrontal cortex. Psychopharmacology. vol 173. issue 1-2. 2004-08-06. PMID:14726995. |
behavioural and neurochemical effects of 5-ht(1a) agonists such as buspirone depend critically on the dose and the duration of treatment. |
2004-08-06 |
2023-08-12 |
rat |
| Y P Liu, L S Wilkinson, T W Robbin. Effects of acute and chronic buspirone on impulsive choice and efflux of 5-HT and dopamine in hippocampus, nucleus accumbens and prefrontal cortex. Psychopharmacology. vol 173. issue 1-2. 2004-08-06. PMID:14726995. |
we thus undertook a parametric study of the effects of acute and chronic buspirone on the performance on a test of delayed gratification, as well as on the efflux of serotonin and dopamine (da) in cortical and subcortical regions in rats. |
2004-08-06 |
2023-08-12 |
rat |
| Tsuguka Shiwa, Taku Amano, Hiroaki Matsubayashi, Takahiro Seki, Masashi Sasa, Norio Saka. Perospirone, a novel antipsychotic agent, hyperpolarizes rat dorsal raphe neurons via 5-HT1A receptor. Journal of pharmacological sciences. vol 93. issue 1. 2004-07-09. PMID:14501160. |
this effect of perospirone on dr neurons is similar to that of typical 5ht(1a)-receptor agonists, including 8-oh-dpat or tandospirone. |
2004-07-09 |
2023-08-12 |
rat |
| Anna Agnieszka Strzelczyk, Malgorzata Jarończyk, Zdzislaw Chilmonczyk, Aleksander Pawel Mazurek, Ewa Chojnacka-Wójcik, Ingebrigt Sylt. Intrinsic activity and comparative molecular dynamics of buspirone analogues at the 5-HT(1A) receptors. Biochemical pharmacology. vol 67. issue 12. 2004-07-09. PMID:15163553. |
intrinsic activity and comparative molecular dynamics of buspirone analogues at the 5-ht(1a) receptors. |
2004-07-09 |
2023-08-12 |
Not clear |
| Jing-Yu Yang, Chun-Fu Wu, Fang Wang, Hong-Rui Song, Wen-Jun Pan, Yu-Ling Wan. The serotonergic system may be involved in the sleep-inducing action of oleamide in rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 368. issue 6. 2004-06-17. PMID:14615880. |
the oleamide-induced increase in sws was prevented by 5-ht reuptake inhibitors such as fluoxetine or fenfluramine and by agonists at 5-ht(1a) receptors such as buspirone or 8-hydroxy-2-(di- n-propylamino) tetralin (8-oh-dpat). |
2004-06-17 |
2023-08-12 |
rat |