| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mathew W Bridge, Andrew S Weller, Mark Rayson, David A Jone. Responses to exercise in the heat related to measures of hypothalamic serotonergic and dopaminergic function. European journal of applied physiology. vol 89. issue 5. 2004-04-06. PMID:12684806. |
we have studied 12 recreationally active men to measure their responses to exercise in the heat and relate these to measures of hypothalamic function explored with a buspirone [5-hydroxytryptamine 1a (5-ht(1a)) agonist, dopaminergic d(2) antagonist] neuroendocrine challenge, with and without pretreatment with pindolol (5-ht(1a) antagonist). |
2004-04-06 |
2023-08-12 |
human |
| Heather J Chial, Michael Camilleri, Irene Ferber, Silvia Delgado-Aros, Duane Burton, Sanna McKinzie, Alan R Zinsmeiste. Effects of venlafaxine, buspirone, and placebo on colonic sensorimotor functions in healthy humans. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. vol 1. issue 3. 2004-04-01. PMID:15017493. |
we have shown that venlafaxine-xr, a serotonin (5-ht) and norepinephrine reuptake inhibitor, enhanced gastric accommodation, whereas buspirone, a 5-ht(1a) receptor agonist, reduced postprandial symptoms after a fully satiating meal. |
2004-04-01 |
2023-08-12 |
Not clear |
| E F Carvalho-Netto, R L Nunes-de-Souz. Use of the elevated T-maze to study anxiety in mice. Behavioural brain research. vol 148. issue 1-2. 2004-03-01. PMID:14684253. |
the 5-ht1a partial receptor agonist buspirone (1.0-2.0 mg/kg) and the 5-ht releaser fenfluramine (0.15-0.30 mg/kg) impaired iaa and facilitated escape, while the full 5-ht1a receptor agonist, 8-oh-dpat (0.05-0.1 mg/kg) and the 5-ht(2b/2c) receptor antagonist, ser 082 (0.5-2.0 mg/kg) failed to modify either response. |
2004-03-01 |
2023-08-12 |
mouse |
| David E Dussour. Chemical stimulants of leaf-trenching by cabbage loopers: natural products, neurotransmitters, insecticides, and drugs. Journal of chemical ecology. vol 29. issue 9. 2004-02-10. PMID:14584674. |
active compounds included dopamine, serotonin, the insecticide imidacloprid, and various drugs such as ipratropium, apomorphine, buspirone, and metoclopramide. |
2004-02-10 |
2023-08-12 |
Not clear |
| Bankole A Johnso. The role of serotonergic agents as treatments for alcoholism. Drugs of today (Barcelona, Spain : 1998). vol 39. issue 9. 2004-02-10. PMID:14586482. |
the 5-ht(1a) partial agonist, buspirone, does not appear to be an efficacious treatment for alcoholics without co-morbid disease. |
2004-02-10 |
2023-08-12 |
Not clear |
| Nuzhath F Tajuddin, Luisa A Orrico, Jason L Eriksen, Mary J Drus. Effects of ethanol and ipsapirone on the development of midline raphe glial cells and astrocytes. Alcohol (Fayetteville, N.Y.). vol 29. issue 3. 2004-01-06. PMID:12798971. |
the reductions of both 5-ht neurons and s100b-positive glia were prevented by maternal treatment with a 5-ht(1a) agonist (i.e., ipsapirone or buspirone). |
2004-01-06 |
2023-08-12 |
rat |
| Piotr Kowalski, Piotr Suder, Teresa Kowalska, Jerzy Silberring, Beata Duszyńska, Andrzej J Bojarsk. Electrospray mass spectrometric studies of noncovalent complexes of buspirone hydrochloride and other serotonin 5-HT(1A) receptor ligands containing arylpiperazine moieties. Rapid communications in mass spectrometry : RCM. vol 17. issue 18. 2003-11-12. PMID:12955745. |
electrospray mass spectrometric studies of noncovalent complexes of buspirone hydrochloride and other serotonin 5-ht(1a) receptor ligands containing arylpiperazine moieties. |
2003-11-12 |
2023-08-12 |
Not clear |
| Piotr Kowalski, Piotr Suder, Teresa Kowalska, Jerzy Silberring, Beata Duszyńska, Andrzej J Bojarsk. Electrospray mass spectrometric studies of noncovalent complexes of buspirone hydrochloride and other serotonin 5-HT(1A) receptor ligands containing arylpiperazine moieties. Rapid communications in mass spectrometry : RCM. vol 17. issue 18. 2003-11-12. PMID:12955745. |
the observed phenomenon was investigated for the hydrochlorides of buspirone, a well-known anxiolytic drug, and 23 other arylpiperazine derivatives that had been developed as serotonin 5-ht(1a) receptor ligands. |
2003-11-12 |
2023-08-12 |
Not clear |
| Telésfora Sempere, Nemesio Cedeño, Mary Urbina, Lucimey Lim. 8-[3H]-hydroxy-2-(di-n-propylamino)tetralin binding sites in blood lymphocytes of rats and the modulation by mitogens and immobilization. Journal of neuroimmunology. vol 138. issue 1-2. 2003-11-06. PMID:12742647. |
the rank order of potency for inhibition was way-100478>pindobind>nan-190>buspirone>imipramine>serotonin. |
2003-11-06 |
2023-08-12 |
rat |
| Eva Albertsen Malt, Snorri Olafsson, Asbjoern Aakvaag, Anders Lund, Holger Ursi. Altered dopamine D2 receptor function in fibromyalgia patients: a neuroendocrine study with buspirone in women with fibromyalgia compared to female population based controls. Journal of affective disorders. vol 75. issue 1. 2003-11-04. PMID:12781354. |
buspirone induces a hypothermic response, which most likely is due to 5-ht(1a) autoreceptor stimulation, and growth hormone (gh) release, which probably is related to postsynaptic 5-ht(1a) receptor stimulation. |
2003-11-04 |
2023-08-12 |
Not clear |
| Donald S Robinson, J M Ad Sitsen, Michael Gibertin. A review of the efficacy and tolerability of immediate-release and extended-release formulations of gepirone. Clinical therapeutics. vol 25. issue 6. 2003-10-30. PMID:12860488. |
gepirone, a 5-ht(1a) receptor agonist, has been assessed for use in the treatment of anxiety and depressive disorders. |
2003-10-30 |
2023-08-12 |
Not clear |
| Donald S Robinson, J M Ad Sitsen, Michael Gibertin. A review of the efficacy and tolerability of immediate-release and extended-release formulations of gepirone. Clinical therapeutics. vol 25. issue 6. 2003-10-30. PMID:12860488. |
azapirones, including gepirone, act to maintain neurotransmission at 5-ht(1a) receptors. |
2003-10-30 |
2023-08-12 |
Not clear |
| Phillip J Seibell, Jack Demarest, Dennis E Rhoad. 5-HT1A receptor activity disrupts spontaneous alternation behavior in rats. Pharmacology, biochemistry, and behavior. vol 74. issue 3. 2003-08-04. PMID:12543219. |
onset of vicarious trial and error (vte) behavior prolonged the time required for each rat to select an arm of the t-maze when injected with either 8-oh-dpat (p<.0001) or buspirone (1-2 mg/kg), a 5-ht(1a) partial agonist. |
2003-08-04 |
2023-08-12 |
rat |
| T Wurch, F C Colpaert, P J Pauwel. Mutation in a protein kinase C phosphorylation site of the 5-HT1A receptor preferentially attenuates Ca2+ responses to partial as opposed to higher-efficacy 5-HT1A agonists. Neuropharmacology. vol 44. issue 7. 2003-08-04. PMID:12726819. |
buspirone, flesinoxan and 8-oh-dpat produced a graded partial response (26 to 62%) at the wt 5-ht(1a):g(alpha)(15) fusion protein; f 13640, 5-ct and f 14679 behaved as higher-efficacy agonists with maximal ca(2+) responses similar to 5-ht. |
2003-08-04 |
2023-08-12 |
Not clear |
| Eric P M Prinssen, Francis C Colpaert, Wouter Koe. 5-HT1A receptor activation and anti-cataleptic effects: high-efficacy agonists maximally inhibit haloperidol-induced catalepsy. European journal of pharmacology. vol 453. issue 2-3. 2003-07-08. PMID:12398907. |
the anti-cataleptic effects of 5-ht(1a) receptor ligands with positive intrinsic activity [from high to low: 3-chloro-4-fluorophenyl-(4-fluoro-4-[[(5-methyl-6-methylamino-pyridin-2-ylmethyl)-amino]-methyl]-piperidin-1-yl-methanone fumaric acid salt (f 13714), eptapirone, 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat), 2-[4-[4-(7-methoxy-1-naphtyl) piperazino]butyl]-4-methyl-2h,4h-1,2,4-triazin-3,5-dione maleic acid salt (f 11461), buspirone, 2-[4-[4-(7-benzofuranyl)piperazino]butyl]-4-methyl-2h,4h-1,2,4-triazin-3,5-dione (f 12826), ipsapirone, and (s)-n-tert-butyl-3-(4-(2-methoxyphenyl)piperazine-1-yl)-2-phenylpropanamide hydrochloride (way 100135)] and negative intrinsic activity [n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-(2-pyridinyl)cyclohexanecarboxamide dihydrochloride (way 100635)] were examined. |
2003-07-08 |
2023-08-12 |
Not clear |
| Eva Jerning, Susanne Rosqvist, Nina Mohel. Nad-299 antagonises 5-HT-stimulated and spiperone-inhibited [35S]GTPgammaS binding in cloned 5-HT1A receptors. Journal of receptor and signal transduction research. vol 22. issue 1-4. 2003-06-05. PMID:12503636. |
the kil/kih ratios for spiperone (0.66), methiothepin (0.39), way-100635 (0.32), (s)uh-301 (0.94), nad-299 (1.29), nan-190 (1.23), (s)pindolol (5.85), ipsapirone (13.1), buspirone (24.6), (+/-)8-oh-dpat (47.3), flesinoxan (55.8), 5-ht (200) and 5-ct (389) correlated highly significantly with the intrinsic activity obtained with [35s] gtpgammas (r = 0.97). |
2003-06-05 |
2023-08-12 |
human |
| Machiko Matsumoto, Taku Kojima, Hiroko Togashi, Kiyoshi Mori, Satoshi Ohashi, Ken-ichi Ueno, Mitsuhiro Yoshiok. Differential characteristics of endogenous serotonin-mediated synaptic transmission in the hippocampal CA1 and CA3 fields of anaesthetized rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 366. issue 6. 2003-06-04. PMID:12444499. |
these findings were supported in part by the results obtained by exogenously applied 5-ht receptor agonists: the 5-ht(1a) receptor agonist tandospirone (10 mg/kg i.p.) |
2003-06-04 |
2023-08-12 |
rat |
| Naotoshi Tamura, Yoshihiko Nakazato, Toshimasa Yamamoto, Shin-ichi Iwasaki, Kunio Shimaz. [Serotonin syndrome caused by tandospirone citrate alone]. Rinsho shinkeigaku = Clinical neurology. vol 42. issue 9. 2003-06-02. PMID:12710093. |
[serotonin syndrome caused by tandospirone citrate alone]. |
2003-06-02 |
2023-08-12 |
Not clear |
| Naotoshi Tamura, Yoshihiko Nakazato, Toshimasa Yamamoto, Shin-ichi Iwasaki, Kunio Shimaz. [Serotonin syndrome caused by tandospirone citrate alone]. Rinsho shinkeigaku = Clinical neurology. vol 42. issue 9. 2003-06-02. PMID:12710093. |
we describe a case of serotonin syndrome provoked by tandospirone citrate alone, a serotonergic antianxiety agent. |
2003-06-02 |
2023-08-12 |
Not clear |
| Naotoshi Tamura, Yoshihiko Nakazato, Toshimasa Yamamoto, Shin-ichi Iwasaki, Kunio Shimaz. [Serotonin syndrome caused by tandospirone citrate alone]. Rinsho shinkeigaku = Clinical neurology. vol 42. issue 9. 2003-06-02. PMID:12710093. |
serotonin syndrome caused by tandospirone alone has not been reported, although it is widely used in japan. |
2003-06-02 |
2023-08-12 |
Not clear |