| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Victoria B Risbrough, Jesse D Brodkin, Mark A Geye. GABA-A and 5-HT1A receptor agonists block expression of fear-potentiated startle in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 4. 2003-05-29. PMID:12655310. |
the gaba-a receptor agonists diazepam (3 and 6 mg/kg) and chlordiazepoxide (10 mg/kg) significantly reduced the expression of fps post-training, as did the serotonin 1a receptor partial agonist buspirone (5 and 10 mg/kg). |
2003-05-29 |
2023-08-12 |
mouse |
| R C B Silva, N R Santos, M L Brandã. Influence of housing conditions on the effects of serotonergic drugs on feeding behavior in non-deprived rats. Neuropsychobiology. vol 47. issue 2. 2003-05-29. PMID:12707493. |
we have therefore examined the effects of fluoxetine, a selective 5-ht reuptake inhibitor, and gepirone, a 5-ht1a agonist, on body weight in isolated and in group-housed rats during 3 weeks of daily treatment. |
2003-05-29 |
2023-08-12 |
rat |
| R C B Silva, N R Santos, M L Brandã. Influence of housing conditions on the effects of serotonergic drugs on feeding behavior in non-deprived rats. Neuropsychobiology. vol 47. issue 2. 2003-05-29. PMID:12707493. |
from the data obtained in this study, it is suggested that increased 5-ht transmission produced by fluoxetine during chronic administration seems to be crucial for the appetite-regulating action of 5-ht, and this hypophagic effect does not seem to be dependent on the activation of 5-ht1a receptors since it was not shared by gepirone. |
2003-05-29 |
2023-08-12 |
rat |
| R C B Silva, N R Santos, M L Brandã. Influence of housing conditions on the effects of serotonergic drugs on feeding behavior in non-deprived rats. Neuropsychobiology. vol 47. issue 2. 2003-05-29. PMID:12707493. |
the hyperphagic effects of chronic regimen with gepirone in isolated animals are probably due to the concurrent reduction of the 5-ht transmission caused by this anxiogenic condition at the earlier stages of treatment. |
2003-05-29 |
2023-08-12 |
rat |
| Jens Malmkvist, Steffen W Hansen, Birthe M Damgaar. Effect of the serotonin agonist buspirone on behaviour and hypothalamic-pituitary-adrenal axis in confident and fearful mink. Physiology & behavior. vol 78. issue 2. 2003-05-20. PMID:12576120. |
effect of the serotonin agonist buspirone on behaviour and hypothalamic-pituitary-adrenal axis in confident and fearful mink. |
2003-05-20 |
2023-08-12 |
Not clear |
| Jens Malmkvist, Steffen W Hansen, Birthe M Damgaar. Effect of the serotonin agonist buspirone on behaviour and hypothalamic-pituitary-adrenal axis in confident and fearful mink. Physiology & behavior. vol 78. issue 2. 2003-05-20. PMID:12576120. |
two groups of 2-year-old confident (n=12) and fearful (n=12) female mink were given the serotonin (5-ht) 1a receptor agonist buspirone (1.25 mg/kg/day), whereas two other groups of 2-year-old confident (n=12) and fearful (n=12) female mink were given saline, continuously for 5 weeks via osmotic minipumps. |
2003-05-20 |
2023-08-12 |
Not clear |
| Moemen Dannaw. Possible serotonin syndrome after combination of buspirone and St John's Wort. Journal of psychopharmacology (Oxford, England). vol 16. issue 4. 2003-05-19. PMID:12503845. |
possible serotonin syndrome after combination of buspirone and st john's wort. |
2003-05-19 |
2023-08-12 |
Not clear |
| Alan D Feiger, Jon F Heiser, Ram K Shrivastava, Kenneth J Weiss, Ward T Smith, J M A Sitsen, Michael Gibertin. Gepirone extended-release: new evidence for efficacy in the treatment of major depressive disorder. The Journal of clinical psychiatry. vol 64. issue 3. 2003-05-09. PMID:12716264. |
to assess the efficacy and tolerability of the 5-ht(1a) agonist gepirone in extended-release formulation (gepirone-er) versus placebo in patients with major depressive disorder. |
2003-05-09 |
2023-08-12 |
Not clear |
| Jian-Hui Liang, Xu-Hua Wang, Rui-Ke Liu, Hong-Lei Sun, Xiang-Feng Ye, Ji-Wang Zhen. Buspirone-induced antinociception is mediated by L-type calcium channels and calcium/caffeine-sensitive pools in mice. Psychopharmacology. vol 166. issue 3. 2003-05-07. PMID:12552360. |
previous studies have shown that buspirone, a partial 5-ht(1a) receptor agonist, produces antinociceptive effects in rats and mice; ca(2+) plays a critical role as a second messenger in mediating nociceptive transmission. |
2003-05-07 |
2023-08-12 |
mouse |
| Bernadette Astier, Laura Lambás Señas, Fabienne Soulière, Patricia Schmitt, Nadia Urbain, Nicolas Rentero, Lionel Bert, Luc Denoroy, Bernard Renaud, Monique Lesourd, Carmen Muñoz, Guy Chouve. In vivo comparison of two 5-HT1A receptors agonists alnespirone (S-20499) and buspirone on locus coeruleus neuronal activity. European journal of pharmacology. vol 459. issue 1. 2003-04-30. PMID:12505530. |
the aim of the present study was to compare, in chloral-hydrate anaesthetized rats, the alpha(2)-adrenergic properties of the selective 5-ht(1a) receptor agonist, alnespirone (s-20499), with those of buspirone, a 5-ht(1a) receptor agonist exhibiting potent alpha(2)-adrenoceptor antagonist properties via its principal metabolite, 1-(2-pyrimidinyl)-piperazine. |
2003-04-30 |
2023-08-12 |
rat |
| Jingyuan Chen, Changpeng Shen, Emanuel Melle. 5-HT1A receptor-mediated regulation of mitogen-activated protein kinase phosphorylation in rat brain. European journal of pharmacology. vol 452. issue 2. 2003-04-02. PMID:12354565. |
other 5-ht(1a) receptor agonists (buspirone, gepirone and ipsapirone) also reduced phospho-erk1/2 levels in hippocampus. |
2003-04-02 |
2023-08-12 |
rat |
| Takashi Nakayama, Tetsuya Suhara, Yoshiro Okubo, Tetsuya Ichimiya, Fumihiko Yasuno, Jun Maeda, Akihiro Takano, Tomoyuki Saijo, Kazutoshi Suzuk. In vivo drug action of tandospirone at 5-HT1A receptor examined using positron emission tomography and neuroendocrine response. Psychopharmacology. vol 165. issue 1. 2003-03-20. PMID:12474116. |
tandospirone is a selective 5-hydroxytryptamine (ht)(1a) receptor agonist and is clinically used as an anxiolytic in japan. |
2003-03-20 |
2023-08-12 |
human |
| A Siniscalchi, D Rodi, S Cavallini, S Marino, L Ferraro, L Beani, C Bianch. Effects of cholecystokinin tetrapeptide (CCK(4)) and of anxiolytic drugs on GABA outflow from the cerebral cortex of freely moving rats. Neurochemistry international. vol 42. issue 1. 2003-02-11. PMID:12441172. |
and the 5-ht(1a) agonist buspirone (3mg/kg, i.p.) |
2003-02-11 |
2023-08-12 |
rat |
| Agnieszka Zahorodna, Krzysztof Tokarski, Maria Bija. Imipramine but not 5-HT(1A) receptor agonists or neuroleptics induces adaptive changes in hippocampal 5-HT(1A) and 5-HT(4) receptors. European journal of pharmacology. vol 443. issue 1-3. 2003-01-27. PMID:12044792. |
we studied the effects of repeated treatment with imipramine, the 5-ht(1a) receptor agonists 8-hydroxy-2(di-n-propylamino)tetralin (8-oh-dpat) and buspirone, and the neuroleptics haloperidol and clozapine on the sensitivity of rat hippocampal ca1 neurons to 5-ht(1a)- and 5-ht(4) receptor activation. |
2003-01-27 |
2023-08-12 |
rat |
| Heather J Chial, Michael Camilleri, Duane Burton, George Thomforde, Kevin W Olden, Debra Stephen. Selective effects of serotonergic psychoactive agents on gastrointestinal functions in health. American journal of physiology. Gastrointestinal and liver physiology. vol 284. issue 1. 2003-01-23. PMID:12488239. |
participants received one of four regimens in a randomized, double-blind manner: buspirone, a 5-ht(1a) receptor agonist (10 mg twice daily); paroxetine, a selective serotonin reuptake inhibitor (20 mg daily); venlafaxine-xr, a selective serotonin and norepinephrine reuptake inhibitor (75 mg daily); or placebo for 11 days. |
2003-01-23 |
2023-08-12 |
human |
| Yutaka Masuda, Yusuke Akagawa, Yasuo Hishikaw. Effect of serotonin 1A agonist tandospirone on depression symptoms in senile patients with dementia. Human psychopharmacology. vol 17. issue 4. 2003-01-16. PMID:12404687. |
effect of serotonin 1a agonist tandospirone on depression symptoms in senile patients with dementia. |
2003-01-16 |
2023-08-12 |
Not clear |
| C K Olsen, S Hogg, M D S Lapi. Tonic immobility in guinea pigs: a behavioural response for detecting an anxiolytic-like effect? Behavioural pharmacology. vol 13. issue 4. 2002-12-24. PMID:12218506. |
compounds that reduced ti include the serotonin (5-ht) releaser fenfluramine, the 5-ht(1a) receptor agonists 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) and buspirone, the 5-ht(2c/2b) receptor antagonist sb206553, the 5-ht(2a) receptor antagonist mdl 100.151 -- but only at doses thought also to inhibit 5-ht(2c) receptors--the noradrenaline (na) reuptake inhibitor desipramine, the benzodiazepine inverse agonist fg-7142, the alpha(2)-adrenergic receptor antagonist yohimbine, the neurokinin (nk)(1) receptor antagonist l-733.060, and the nk(2) receptor antagonist sr-48968. |
2002-12-24 |
2023-08-12 |
Not clear |
| Klaas P Zuideveld, Jasna Rusiç-Pavletiç, Hugo J Maas, Lambertus A Peletier, Piet H Van der Graaf, Meindert Danho. Pharmacokinetic-pharmacodynamic modeling of buspirone and its metabolite 1-(2-pyrimidinyl)-piperazine in rats. The Journal of pharmacology and experimental therapeutics. vol 303. issue 3. 2002-12-24. PMID:12438536. |
the results of this analysis show that buspirone and 1-pp behave as partial 5-hydroxytryptamine(1a) agonists in vivo and that following intravenous administration the amount of 1-pp formed is too small to contribute to the hypothermic effect. |
2002-12-24 |
2023-08-12 |
rat |
| Franco Borsini, Kennett Evans, Kathryn Jason, Frank Rohde, Barbara Alexander, Stephan Pollentie. Pharmacology of flibanserin. CNS drug reviews. vol 8. issue 2. 2002-11-25. PMID:12177684. |
the effects of flibanserin on adenylyl cyclase are different from those of buspirone and 8-oh-dpat, two other purported 5-ht(1a) receptor agonists. |
2002-11-25 |
2023-08-12 |
Not clear |
| Alicia M Crissman, James M O'Donnel. Effects of antidepressants in rats trained to discriminate centrally administered isoproterenol. The Journal of pharmacology and experimental therapeutics. vol 302. issue 2. 2002-08-29. PMID:12130722. |
the serotonin uptake inhibitor fluoxetine, the atypical antidepressants buspirone and trazodone, and the novel, putative antidepressants n(g)-nitro-l-arginine and n-acetyl-l-tryptophan 3,5-bis benzyl ester failed to substitute for isoproterenol at the dose ranges tested. |
2002-08-29 |
2023-08-12 |
rat |