| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pierre Blier, Bernard Seletti, Francois Gilbert, Simon N Young, Chawki Benkelfa. Serotonin 1A receptor activation and hypothermia in humans: lack of evidence for a presynaptic mediation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 27. issue 2. 2002-08-07. PMID:12093604. |
in order to address this issue in humans, 12 healthy volunteers underwent a dietary tryptophan depletion paradigm to decrease 5-ht availability, under double-blind conditions, during which body temperature was monitored following oral administration of the 5-ht1a agonist buspirone (30 mg). |
2002-08-07 |
2023-08-12 |
human |
| Pierre Blier, Bernard Seletti, Francois Gilbert, Simon N Young, Chawki Benkelfa. Serotonin 1A receptor activation and hypothermia in humans: lack of evidence for a presynaptic mediation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 27. issue 2. 2002-08-07. PMID:12093604. |
in conclusion, these results strongly suggest that the hypothermia and the increases in prolactin and growth hormone produced by buspirone are attributable to the enhanced activation of postsynaptic 5-ht1a receptors, and not to a decrease in 5-ht transmission resulting from the activation of the 5-ht1a cell body autoreceptors on 5-ht neurons. |
2002-08-07 |
2023-08-12 |
human |
| Susana Esteban, David Moranta, Antoni Sastre-Coll, Antonio Miralles, Jesús A García-Sevill. Withdrawal from chronic ethanol increases the sensitivity of presynaptic 5-HT(1A) receptors modulating serotonin and dopamine synthesis in rat brain in vivo. Neuroscience letters. vol 326. issue 2. 2002-08-06. PMID:12057843. |
similar effects were induced by the mixed 5-ht(1a) agonist/d(2) antagonist buspirone (1 mg/kg, i.p., 1 h) which also decreased 5-htp synthesis in the hippocampus (24%), cerebral cortex (36%) and striatum (35%) of chronic ethanol-withdrawn rats. |
2002-08-06 |
2023-08-12 |
rat |
| A Bronowska, Z Chilmonczyk, A Leś, O Edvardsen, R Ostensen, I Sylt. Molecular dynamics of 5-HT1A and 5-HT2A serotonin receptors with methylated buspirone analogues. Journal of computer-aided molecular design. vol 15. issue 11. 2002-06-10. PMID:11989622. |
molecular dynamics of 5-ht1a and 5-ht2a serotonin receptors with methylated buspirone analogues. |
2002-06-10 |
2023-08-12 |
Not clear |
| A Bronowska, Z Chilmonczyk, A Leś, O Edvardsen, R Ostensen, I Sylt. Molecular dynamics of 5-HT1A and 5-HT2A serotonin receptors with methylated buspirone analogues. Journal of computer-aided molecular design. vol 15. issue 11. 2002-06-10. PMID:11989622. |
in the present study experimentally determined ligand selectivity of three methylated buspirone analogues (denoted as mm2, mm5 and p55) towards 5-ht1a and 5-ht2a serotonin receptors was theoretically investigated on a molecular level. |
2002-06-10 |
2023-08-12 |
Not clear |
| M Kotlyar, M Golding, D K Hatsukami, B D Jamerso. Effect of nonnicotine pharmacotherapy on smoking behavior. Pharmacotherapy. vol 21. issue 12. 2002-05-08. PMID:11765304. |
drugs that modulate noradrenergic neurotransmission (bupropion, nortriptyline, moclobemide) are more effective than those affecting serotonin (selective serotonin reuptake inhibitors, buspirone, ondansetron) or other neurotransmitters. |
2002-05-08 |
2023-08-12 |
Not clear |
| M Markuszewski, T Frackowiak, R Kalisza. Estimation of buspirone-bovine serum albumin binding by affinity capillary electrophoresis. Acta poloniae pharmaceutica. vol 58. issue 5. 2002-04-23. PMID:11876437. |
capillary electrophoresis was employed, specifically the hummel-dreyer method and scatchard analysis, to study the interactions of an anxiolytic drug, buspirone, with pure bovine serum albumin (bsa) and with bsa present in the human recombinant 5-ht(1a) serotonin receptor preparation. |
2002-04-23 |
2023-08-12 |
human |
| M Markuszewski, T Frackowiak, R Kalisza. Estimation of buspirone-bovine serum albumin binding by affinity capillary electrophoresis. Acta poloniae pharmaceutica. vol 58. issue 5. 2002-04-23. PMID:11876437. |
the method was found to be inadequate for measuring the specific binding interactions between buspirone and the 5-ht(1a) receptor in the preparation employed. |
2002-04-23 |
2023-08-12 |
human |
| Dan Dwyer, John Flyn. Short term aerobic exercise training in young males does not alter sensitivity to a central serotonin agonist. Experimental physiology. vol 87. issue 1. 2002-04-17. PMID:11805862. |
serotonin receptor sensitivity was assessed indirectly by measuring the neuroendocrine response following administration of a serotonin agonist (buspirone hydrochloride). |
2002-04-17 |
2023-08-12 |
human |
| Tatsuki Yoshino, Koichi Nisijima, Satoshi Katoh, Kunio Yui, Mitsutaka Nakamur. Tandospirone potentiates the fluoxetine-induced increases in extracellular dopamine via 5-HT(1A) receptors in the rat medial frontal cortex. Neurochemistry international. vol 40. issue 4. 2002-04-05. PMID:11792466. |
tandospirone potentiates the fluoxetine-induced increases in extracellular dopamine via 5-ht(1a) receptors in the rat medial frontal cortex. |
2002-04-05 |
2023-08-12 |
rat |
| Tatsuki Yoshino, Koichi Nisijima, Satoshi Katoh, Kunio Yui, Mitsutaka Nakamur. Tandospirone potentiates the fluoxetine-induced increases in extracellular dopamine via 5-HT(1A) receptors in the rat medial frontal cortex. Neurochemistry international. vol 40. issue 4. 2002-04-05. PMID:11792466. |
recent clinical studies suggest that 5-ht(1a) receptor agonists, including buspirone, may have an antidepressant effect and potentiate the efficacy of selective serotonin reuptake inhibitors (ssri) in major depressive disorders. |
2002-04-05 |
2023-08-12 |
rat |
| Tatsuki Yoshino, Koichi Nisijima, Satoshi Katoh, Kunio Yui, Mitsutaka Nakamur. Tandospirone potentiates the fluoxetine-induced increases in extracellular dopamine via 5-HT(1A) receptors in the rat medial frontal cortex. Neurochemistry international. vol 40. issue 4. 2002-04-05. PMID:11792466. |
in the present study, we investigated the effect of tandospirone, a highly potent and selective 5-ht(1a) receptor agonist, on dopamine release and potentiation of fluoxetine-induced dopamine outflow in the medial frontal cortex using microdialysis in freely moving rats. |
2002-04-05 |
2023-08-12 |
rat |
| Tatsuki Yoshino, Koichi Nisijima, Satoshi Katoh, Kunio Yui, Mitsutaka Nakamur. Tandospirone potentiates the fluoxetine-induced increases in extracellular dopamine via 5-HT(1A) receptors in the rat medial frontal cortex. Neurochemistry international. vol 40. issue 4. 2002-04-05. PMID:11792466. |
pretreatment with the selective 5-ht(1a) receptor antagonist, way 100635 (1mg/kg), blocked the effect of tandospirone. |
2002-04-05 |
2023-08-12 |
rat |
| Tatsuki Yoshino, Koichi Nisijima, Satoshi Katoh, Kunio Yui, Mitsutaka Nakamur. Tandospirone potentiates the fluoxetine-induced increases in extracellular dopamine via 5-HT(1A) receptors in the rat medial frontal cortex. Neurochemistry international. vol 40. issue 4. 2002-04-05. PMID:11792466. |
these results indicate that tandospirone potentiates the fluoxetine-induced increase in dopamine release via 5-ht(1a) receptors in the rat medial frontal cortex, and suggest that tandospirone may have therapeutic potential for the treatment of depression. |
2002-04-05 |
2023-08-12 |
rat |
| G S Sonavane, V P Sarveiya, V S Kasture, S B Kastur. Anxiogenic activity of Myristica fragrans seeds. Pharmacology, biochemistry, and behavior. vol 71. issue 1-2. 2002-04-05. PMID:11812528. |
inhibition of anxiolytic activity of ondansetron (5-ht3 receptor antagonist), buspirone (5-ht1a receptor agonist), and diazepam [acting on gamma-aminobutyric acid (gabaa) receptor] suggests a nonspecific anxiogenic activity of tm and also a link between 5-ht and gaba systems in the anxiogenic activity of tm. |
2002-04-05 |
2023-08-12 |
mouse |
| A Siniscalchi, D Rodi, S Cavallini, S Marino, L Beani, C Bianch. Effects of cholecystokinin tetrapeptide (CCK(4)) and anxiolytic drugs on the electrically evoked [(3)H]5-hydroxytryptamine outflow from rat cortical slices. Brain research. vol 922. issue 1. 2002-02-19. PMID:11730707. |
gv150013 30 nm, the 5-ht(1a) partial agonist buspirone 300 nm and the gaba(a) receptor modulator diazepam 10 nm, known to have anxiolytic properties, all significantly reduced the [(3)h] amine outflow from cortical slices by about 20%. |
2002-02-19 |
2023-08-12 |
rat |
| M W Bridge, G Marvin, C E Thompson, A Sharma, D A Jones, M J Kendal. Quantifying the 5-HT1A agonist action of buspirone in man. Psychopharmacology. vol 158. issue 3. 2002-02-12. PMID:11713611. |
buspirone is used as a neuroendocrine challenge in which the increase of circulating prolactin is taken as a measure of the sensitivity of central serotonergic (5-ht(1a)) pathways. |
2002-02-12 |
2023-08-12 |
Not clear |
| M W Bridge, G Marvin, C E Thompson, A Sharma, D A Jones, M J Kendal. Quantifying the 5-HT1A agonist action of buspirone in man. Psychopharmacology. vol 158. issue 3. 2002-02-12. PMID:11713611. |
interpretation of the test is complicated, however, by the fact that buspirone possesses d(2) antagonist and 5-ht(1a) agonist activity, both of which will result in the release of prolactin. |
2002-02-12 |
2023-08-12 |
Not clear |
| J L Eriksen, M J Drus. Astrocyte-mediated trophic support of developing serotonin neurons: effects of ethanol, buspirone, and S100B. Brain research. Developmental brain research. vol 131. issue 1-2. 2002-02-04. PMID:11718831. |
astrocyte-mediated trophic support of developing serotonin neurons: effects of ethanol, buspirone, and s100b. |
2002-02-04 |
2023-08-12 |
mouse |
| J L Eriksen, M J Drus. Astrocyte-mediated trophic support of developing serotonin neurons: effects of ethanol, buspirone, and S100B. Brain research. Developmental brain research. vol 131. issue 1-2. 2002-02-04. PMID:11718831. |
however, maternal treatment with a 5-ht(1a) agonist, e.g., buspirone or ipsapirone, between gestational days 13 and 20 prevented most of the ethanol-associated changes to developing 5-ht neurons and s100b-immunopositive glia in offspring. |
2002-02-04 |
2023-08-12 |
mouse |