| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Sarkar, B Thomas, D Muralikrishnan, K P Mohanakuma. Effects of serotoninergic drugs on tremor induced by physostigmine in rats. Behavioural brain research. vol 109. issue 2. 2000-06-21. PMID:10762688. |
serotonin agonists, 8-hydroxy-2-(di-n-propylamino) tetralin (2.5 mg/kg) and buspirone (5 mg/kg) augmented the tremor response caused by physostigmine. |
2000-06-21 |
2023-08-12 |
rat |
| M Sakaue, P Somboonthum, B Nishihara, Y Koyama, H Hashimoto, A Baba, T Matsud. Postsynaptic 5-hydroxytryptamine(1A) receptor activation increases in vivo dopamine release in rat prefrontal cortex. British journal of pharmacology. vol 129. issue 5. 2000-05-04. PMID:10696105. |
fluoxetine, a selective serotonin reuptake inhibitor, increased dopamine release in the prefrontal cortex, but not in the nucleus accumbens, while buspirone, a 5-ht(1a) receptor agonist, increased dopamine release in both brain regions. |
2000-05-04 |
2023-08-12 |
rat |
| U Rao, P Lutchmansingh, R E Polan. Contribution of development to buspirone effects on REM sleep: a preliminary report. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 22. issue 4. 2000-05-01. PMID:10700663. |
in order to assess whether development influences the regulation of rapid eye movement (rem) sleep by serotonergic (5-ht) systems, the rem sleep responses to the partial 5-ht(1a) agonist, buspirone, were assessed in 14 normal adolescent and adult volunteers. |
2000-05-01 |
2023-08-12 |
human |
| L J Sim-Selley, L J Vogt, R Xiao, S R Childers, D E Selle. Region-specific changes in 5-HT(1A) receptor-activated G-proteins in rat brain following chronic buspirone. European journal of pharmacology. vol 389. issue 2-3. 2000-04-18. PMID:10688978. |
region-specific changes in 5-ht(1a) receptor-activated g-proteins in rat brain following chronic buspirone. |
2000-04-18 |
2023-08-12 |
rat |
| L J Sim-Selley, L J Vogt, R Xiao, S R Childers, D E Selle. Region-specific changes in 5-HT(1A) receptor-activated G-proteins in rat brain following chronic buspirone. European journal of pharmacology. vol 389. issue 2-3. 2000-04-18. PMID:10688978. |
these results demonstrate region-specific alterations in 5-ht(1a) and gaba(b) receptor-activated g-proteins following chronic buspirone treatment, which may contribute to the clinical effects of this drug. |
2000-04-18 |
2023-08-12 |
rat |
| T A Reader, A R Ase, N Le Marec, R Lalond. Differential effects of L-trytophan and buspirone on biogenic amine contents and metabolism in Lurcher mice cerebellum. Neuroscience letters. vol 280. issue 3. 2000-04-07. PMID:10675788. |
wild type (+/+) and lc/+ mice were treated for 40 days with l-tryptophan or buspirone, and serotonin (5-ht), dopamine (da), noradrenaline (na) and their main metabolites were measured in the cerebellum. |
2000-04-07 |
2023-08-12 |
mouse |
| T A Reader, A R Ase, N Le Marec, R Lalond. Differential effects of L-trytophan and buspirone on biogenic amine contents and metabolism in Lurcher mice cerebellum. Neuroscience letters. vol 280. issue 3. 2000-04-07. PMID:10675788. |
in +/+ mice, only buspirone increased concentrations of 5-ht metabolites. |
2000-04-07 |
2023-08-12 |
mouse |
| T A Reader, A R Ase, N Le Marec, R Lalond. Differential effects of L-trytophan and buspirone on biogenic amine contents and metabolism in Lurcher mice cerebellum. Neuroscience letters. vol 280. issue 3. 2000-04-07. PMID:10675788. |
the 5-ht turnover index was increased in +/+ mice by buspirone, while in lc/+ mutants it increased after l-tryptophan but was decreased by buspirone, indicating that in the mutants nerve terminals synthesize and accumulate 5-ht, but may not utilize it efficiently. |
2000-04-07 |
2023-08-12 |
mouse |
| R C Silva, M L Brandã. Acute and chronic effects of gepirone and fluoxetine in rats tested in the elevated plus-maze: an ethological analysis. Pharmacology, biochemistry, and behavior. vol 65. issue 2. 2000-03-14. PMID:10672971. |
in the present study we provided an ethopharmacological analysis (in addition to conventional measures) of the behavior of rats in the elevated plus-maze with transparent walls after acute and chronic treatments with gepirone, an agonist of 5-ht1a receptors, and fluoxetine, a selective inhibitor of serotonin reuptake. |
2000-03-14 |
2023-08-12 |
human |
| R C Silva, M L Brandã. Acute and chronic effects of gepirone and fluoxetine in rats tested in the elevated plus-maze: an ethological analysis. Pharmacology, biochemistry, and behavior. vol 65. issue 2. 2000-03-14. PMID:10672971. |
these data demonstrate: (a) the anxiogenic and anxiolytic effects of acute and chronic gepirone, respectively, corroborate with the observed effects of these treatments in the clinic; (b) similarly, the anxiogenic effects of acute fluoxetine observed here have also been reported in clinical studies with 5-ht reuptake blockers. |
2000-03-14 |
2023-08-12 |
human |
| A Otano, A García-Osta, S Ballaz, D Frechilla, J Del Rí. Facilitation by 8-OH-DPAT of passive avoidance performance in rats after inactivation of 5-HT(1A) receptors. British journal of pharmacology. vol 128. issue 8. 2000-03-02. PMID:10588924. |
pretraining administration of 8-hydroxy-2-di-n-propylamino-tetralin (8-oh-dpat 0.1 mg kg(-1)), a 5-ht(1a) receptor agonist, or buspirone (1 mg kg(-1)), a 5-ht(1a) receptor partial agonist, markedly impaired passive avoidance retention in rats 24 h later. |
2000-03-02 |
2023-08-12 |
rat |
| J F Velosa, M A Riddl. Pharmacologic treatment of anxiety disorders in children and adolescents. Child and adolescent psychiatric clinics of North America. vol 9. issue 1. 2000-02-29. PMID:10674193. |
tricyclic antidepressants (tcas), benzodiazepines, buspirone, and selective serotonin reuptake inhibitors (ssris) have been used to treat anxiety disorders in children and adolescents with varying degrees of success. |
2000-02-29 |
2023-08-12 |
Not clear |
| F Maekawa, S Tsukahara, H Tsukamura, K I Maeda, K Yamanouch. Prevention of inhibitory effect of dorsal raphe nucleus lesions on ovulation and LH surge by 5-HT 2A/2C receptor agonists in female rats. Neuroscience research. vol 35. issue 4. 2000-02-07. PMID:10617320. |
on the other hand, only 8% of drl rats ovulated after treatment with buspirone (5-ht 1a receptor agonist). |
2000-02-07 |
2023-08-12 |
rat |
| A Brambilla, A Baschirotto, N Grippa, F Borsin. Effect of flibanserin (BIMT 17), fluoxetine, 8-OH-DPAT and buspirone on serotonin synthesis in rat brain. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 10. issue 1. 2000-02-02. PMID:10647099. |
effect of flibanserin (bimt 17), fluoxetine, 8-oh-dpat and buspirone on serotonin synthesis in rat brain. |
2000-02-02 |
2023-08-12 |
rat |
| N F Tajuddin, M J Drus. In utero ethanol exposure decreased the density of serotonin neurons. Maternal ipsapirone treatment exerted a protective effect. Brain research. Developmental brain research. vol 117. issue 1. 1999-12-28. PMID:10536236. |
these investigations also found that maternal treatment with a 5-ht(1a) agonist, buspirone, prevented most of the ethanol-associated damage to the developing 5-ht system. |
1999-12-28 |
2023-08-12 |
rat |
| A Gobert, J M Rivet, L Cistarelli, C Melon, M J Milla. Buspirone modulates basal and fluoxetine-stimulated dialysate levels of dopamine, noradrenaline and serotonin in the frontal cortex of freely moving rats: activation of serotonin1A receptors and blockade of alpha2-adrenergic receptors underlie its actions. Neuroscience. vol 93. issue 4. 1999-12-09. PMID:10501449. |
buspirone modulates basal and fluoxetine-stimulated dialysate levels of dopamine, noradrenaline and serotonin in the frontal cortex of freely moving rats: activation of serotonin1a receptors and blockade of alpha2-adrenergic receptors underlie its actions. |
1999-12-09 |
2023-08-12 |
rat |
| A Gobert, J M Rivet, L Cistarelli, C Melon, M J Milla. Buspirone modulates basal and fluoxetine-stimulated dialysate levels of dopamine, noradrenaline and serotonin in the frontal cortex of freely moving rats: activation of serotonin1A receptors and blockade of alpha2-adrenergic receptors underlie its actions. Neuroscience. vol 93. issue 4. 1999-12-09. PMID:10501449. |
herein, we examined mechanisms underlying the influence of buspirone alone, and in association with the serotonin reuptake inhibitor, fluoxetine, upon extracellular levels of serotonin, dopamine and noradrenaline simultaneously quantified in the frontal cortex of freely moving rats. |
1999-12-09 |
2023-08-12 |
rat |
| A Gobert, J M Rivet, L Cistarelli, C Melon, M J Milla. Buspirone modulates basal and fluoxetine-stimulated dialysate levels of dopamine, noradrenaline and serotonin in the frontal cortex of freely moving rats: activation of serotonin1A receptors and blockade of alpha2-adrenergic receptors underlie its actions. Neuroscience. vol 93. issue 4. 1999-12-09. PMID:10501449. |
buspirone (0.01-2.5 mg/kg, s.c.) dose-dependently decreased dialysate levels of serotonin (-50%), and increased those of dopamine (+100%) and noradrenaline (+140%). |
1999-12-09 |
2023-08-12 |
rat |
| A Gobert, J M Rivet, L Cistarelli, C Melon, M J Milla. Buspirone modulates basal and fluoxetine-stimulated dialysate levels of dopamine, noradrenaline and serotonin in the frontal cortex of freely moving rats: activation of serotonin1A receptors and blockade of alpha2-adrenergic receptors underlie its actions. Neuroscience. vol 93. issue 4. 1999-12-09. PMID:10501449. |
the reduction by buspirone of serotonin levels was abolished by the serotonin1a receptor antagonist, way 100,635 (0.16), which did not, however, modify its influence upon dopamine and noradrenaline. |
1999-12-09 |
2023-08-12 |
rat |
| A Gobert, J M Rivet, L Cistarelli, C Melon, M J Milla. Buspirone modulates basal and fluoxetine-stimulated dialysate levels of dopamine, noradrenaline and serotonin in the frontal cortex of freely moving rats: activation of serotonin1A receptors and blockade of alpha2-adrenergic receptors underlie its actions. Neuroscience. vol 93. issue 4. 1999-12-09. PMID:10501449. |
in contrast to buspirone, the serotonin reuptake inhibitor, fluoxetine (10.0), increased frontocortical levels of serotonin (+ 120%), dopamine (+55%) and noradrenaline (+90%). |
1999-12-09 |
2023-08-12 |
rat |