| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Gobert, J M Rivet, L Cistarelli, C Melon, M J Milla. Buspirone modulates basal and fluoxetine-stimulated dialysate levels of dopamine, noradrenaline and serotonin in the frontal cortex of freely moving rats: activation of serotonin1A receptors and blockade of alpha2-adrenergic receptors underlie its actions. Neuroscience. vol 93. issue 4. 1999-12-09. PMID:10501449. |
buspirone dose-dependently (0.01-2.5) decreased the induction by fluoxetine of serotonin levels yet potentiated (three-fold) its elevation of dopamine and noradrenaline levels. |
1999-12-09 |
2023-08-12 |
rat |
| A Gobert, J M Rivet, L Cistarelli, C Melon, M J Milla. Buspirone modulates basal and fluoxetine-stimulated dialysate levels of dopamine, noradrenaline and serotonin in the frontal cortex of freely moving rats: activation of serotonin1A receptors and blockade of alpha2-adrenergic receptors underlie its actions. Neuroscience. vol 93. issue 4. 1999-12-09. PMID:10501449. |
the serotonin1a agonist, 8-hydroxy-2-(di-n-propyl-amino)-tetralin (0.16), mimicked the action of buspirone in reducing resting levels of serotonin (-60%) and in enhancing those of dopamine (+135%) and noradrenaline (+165%). |
1999-12-09 |
2023-08-12 |
rat |
| A Gobert, J M Rivet, L Cistarelli, C Melon, M J Milla. Buspirone modulates basal and fluoxetine-stimulated dialysate levels of dopamine, noradrenaline and serotonin in the frontal cortex of freely moving rats: activation of serotonin1A receptors and blockade of alpha2-adrenergic receptors underlie its actions. Neuroscience. vol 93. issue 4. 1999-12-09. PMID:10501449. |
like buspirone, it attenuated the influence of fluoxetine upon serotonin levels, yet facilitated its influence upon dopamine and noradrenaline levels. |
1999-12-09 |
2023-08-12 |
rat |
| A Gobert, J M Rivet, L Cistarelli, C Melon, M J Milla. Buspirone modulates basal and fluoxetine-stimulated dialysate levels of dopamine, noradrenaline and serotonin in the frontal cortex of freely moving rats: activation of serotonin1A receptors and blockade of alpha2-adrenergic receptors underlie its actions. Neuroscience. vol 93. issue 4. 1999-12-09. PMID:10501449. |
further, way 100,635 abolished the inhibitory influence of buspirone upon fluoxetine-induced serotonin release, but only partly interfered with its potentiation of fluoxetine-induced increases in dopamine and noradrenaline levels. |
1999-12-09 |
2023-08-12 |
rat |
| A Gobert, J M Rivet, L Cistarelli, C Melon, M J Milla. Buspirone modulates basal and fluoxetine-stimulated dialysate levels of dopamine, noradrenaline and serotonin in the frontal cortex of freely moving rats: activation of serotonin1A receptors and blockade of alpha2-adrenergic receptors underlie its actions. Neuroscience. vol 93. issue 4. 1999-12-09. PMID:10501449. |
in conclusion, the inhibitory influence of buspirone upon resting and fluoxetine-stimulated serotonin levels reflects its agonist properties at serotonin1a autoreceptors. |
1999-12-09 |
2023-08-12 |
rat |
| C C Huang, Y C Liang, K S Hs. A role for extracellular adenosine in time-dependent reversal of long-term potentiation by low-frequency stimulation at hippocampal CA1 synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 22. 1999-12-02. PMID:10559382. |
the effect of adenosine could be mimicked by 5-ht(1a) receptor agonist buspirone, but the lfs-induced depotentiation could not be antagonized by 5-ht(1a) receptor antagonist nan-190. |
1999-12-02 |
2023-08-12 |
rat |
| E Hajós-Korcsok, T Shar. Effect of 5-HT(1A) receptor ligands on Fos-like immunoreactivity in rat brain: evidence for activation of noradrenergic transmission. Synapse (New York, N.Y.). vol 34. issue 2. 1999-11-09. PMID:10502313. |
this effect was also induced by the non-selective, partial 5-ht(1a) receptor agonist buspirone (10 mg/kg). |
1999-11-09 |
2023-08-12 |
rat |
| E Hajós-Korcsok, T Shar. Effect of 5-HT(1A) receptor ligands on Fos-like immunoreactivity in rat brain: evidence for activation of noradrenergic transmission. Synapse (New York, N.Y.). vol 34. issue 2. 1999-11-09. PMID:10502313. |
the effect of both 8-oh-dpat (0.1 mg/kg) and buspirone (10 mg/kg) on fos-li in the lc was blocked by pretreatment with the selective 5-ht(1a) receptor antagonist way 100635 (1 mg/kg). |
1999-11-09 |
2023-08-12 |
rat |
| K Matsumoto, K Yobimoto, N T Huong, M Abdel-Fattah, T Van Hien, H Watanab. Psychological stress-induced enhancement of brain lipid peroxidation via nitric oxide systems and its modulation by anxiolytic and anxiogenic drugs in mice. Brain research. vol 839. issue 1. 1999-10-20. PMID:10482801. |
), the 5-ht(1a) receptor agonists (+/-)-8-hydroxy-di-propylaminotetralin and buspirone (0.1-1 mg/kg, i. p.), but not the 5-ht(3) receptor agonist mdl72222, dose-dependently suppressed the psychological stress-induced enhancement of brain lipid peroxidation. |
1999-10-20 |
2023-08-12 |
mouse |
| P Munzar, M D Laufert, S W Kutkat, J Nováková, S R Goldber. Effects of various serotonin agonists, antagonists, and uptake inhibitors on the discriminative stimulus effects of methamphetamine in rats. The Journal of pharmacology and experimental therapeutics. vol 291. issue 1. 1999-10-12. PMID:10490910. |
both 8-hydroxy-2-dipropylaminotetralin (0.03-0.56 mg/kg), a full agonist, and buspirone (1.0-10.0 mg/kg), a partial agonist at 5-ht(1a) receptors, partially generalized to the training dose of methamphetamine but only at high doses that decreased response rate. |
1999-10-12 |
2023-08-12 |
rat |
| D S Dupuis, S Tardif, T Wurch, F C Colpaert, P J Pauwel. Modulation of 5-HT1A receptor signalling by point-mutation of cysteine351 in the rat Galpha(o) protein. Neuropharmacology. vol 38. issue 7. 1999-09-03. PMID:10428422. |
8-oh-dpat (emax: 55+/-7%) and buspirone (emax: 22+/-4%) yielded partial agonist activity as compared to 5-ht, whereas way 100635 acted as a competitive antagonist (pk(b): 9.75+/-0.17). |
1999-09-03 |
2023-08-12 |
rat |
| D S Dupuis, S Tardif, T Wurch, F C Colpaert, P J Pauwel. Modulation of 5-HT1A receptor signalling by point-mutation of cysteine351 in the rat Galpha(o) protein. Neuropharmacology. vol 38. issue 7. 1999-09-03. PMID:10428422. |
for comparison, maximal responses of 8-oh-dpat and buspirone were enhanced versus 5-ht upon co-expression of the 5-ht1a receptor with the respective galpha(o) proteins, probably due to an altered receptor: galpha(o) protein density ratio. |
1999-09-03 |
2023-08-12 |
rat |
| J S Hellewell, F S Guimaraes, M Wang, J F Deaki. Comparison of buspirone with diazepam and fluvoxamine on aversive classical conditioning in humans. Journal of psychopharmacology (Oxford, England). vol 13. issue 2. 1999-08-27. PMID:10475716. |
the main prediction was that buspirone, an anxiolytic agent which reduces activity in serotonin (5-hydroxytryptophan, 5-ht) neurones, would attenuate aversively conditioned skin conductance responses. |
1999-08-27 |
2023-08-12 |
human |
| A Pisani, W N Ros. Weak effect of neuromodulators on climbing fiber-activated [Ca(2+)](i) increases in rat cerebellar Purkinje neurons. Brain research. vol 831. issue 1-2. 1999-08-18. PMID:10411989. |
buspirone, a partial 5-ht(1a) agonist and a weak da receptor antagonist caused a small (10-15%) reduction in the response. |
1999-08-18 |
2023-08-12 |
rat |
| B Bonin, P Vandel, S Vandel, D Sechter, P Bizouar. Serotonin syndrome after sertraline, buspirone and loxapine? Therapie. vol 54. issue 2. 1999-08-03. PMID:10394270. |
serotonin syndrome after sertraline, buspirone and loxapine? |
1999-08-03 |
2023-08-12 |
Not clear |
| M Landén, E Eriksson, H Agren, T Fahlé. Effect of buspirone on sexual dysfunction in depressed patients treated with selective serotonin reuptake inhibitors. Journal of clinical psychopharmacology. vol 19. issue 3. 1999-07-27. PMID:10350034. |
effect of buspirone on sexual dysfunction in depressed patients treated with selective serotonin reuptake inhibitors. |
1999-07-27 |
2023-08-12 |
human |
| M Landén, E Eriksson, H Agren, T Fahlé. Effect of buspirone on sexual dysfunction in depressed patients treated with selective serotonin reuptake inhibitors. Journal of clinical psychopharmacology. vol 19. issue 3. 1999-07-27. PMID:10350034. |
to evaluate the possible influence of buspirone on sexual dysfunction in depressed patients treated with a selective serotonin reuptake inhibitor (ssri), we analyzed data from a placebo-controlled trial designed to explore the efficacy of buspirone as add-on treatment for patients not responding to an ssri alone. |
1999-07-27 |
2023-08-12 |
human |
| N K Jain, S K Kulkarn. Antinociceptive effect of sumatriptan in mice. Indian journal of experimental biology. vol 36. issue 10. 1999-07-07. PMID:10356959. |
the antinociceptive effect of sumatriptan was compared with an another 5-ht agonist (5-ht1a) buspirone which also produced antinociception. |
1999-07-07 |
2023-08-12 |
mouse |
| J Sandell, C Halldin, H Hall, S O Thorberg, T Werner, D Sohn, G Sedvall, L Fard. Radiosynthesis and autoradiographic evaluation of [11C]NAD-299, a radioligand for visualization of the 5-HT1A receptor. Nuclear medicine and biology. vol 26. issue 2. 1999-07-01. PMID:10100214. |
[11c]nad-299 binding was inhibited by addition of the 5-ht1a receptor ligands way-100635, pindolol, (+/-)-8-oh-dpat, 5-ht, and buspirone, leaving a low background of nonspecific binding. |
1999-07-01 |
2023-08-12 |
human |
| D T George, R Rawlings, M J Eckardt, M J Phillips, S E Shoaf, M Linnoil. Buspirone treatment of alcoholism: age of onset, and cerebrospinal fluid 5-hydroxyindolacetic acid and homovanillic acid concentrations, but not medication treatment, predict return to drinking. Alcoholism, clinical and experimental research. vol 23. issue 2. 1999-06-09. PMID:10069556. |
to test the hypothesis that increasing 5-ht function could promote treatment compliance, we randomized patients who had completed a 5-week inpatient treatment program for alcoholism to receive either buspirone or placebo for 1 year. |
1999-06-09 |
2023-08-12 |
Not clear |