| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W Koek, J F Patoiseau, M B Assié, C Cosi, M S Kleven, E Dupont-Passelaigue, E Carilla-Durand, C Palmier, J P Valentin, G John, P J Pauwels, J P Tarayre, F C Colpaer. F 11440, a potent, selective, high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential. The Journal of pharmacology and experimental therapeutics. vol 287. issue 1. 1998-11-05. PMID:9765347. |
in vivo, f 11440 was 4- to 20-fold more potent than flesinoxan, and 30- to 60-fold more potent than buspirone, in exerting 5-ht1a agonist activity at pre- and postsynaptic receptors in rats (measured by, for example, its ability to decrease hippocampal extracellular serotonin (5-ht) levels and to increase plasma corticosterone levels, respectively). |
1998-11-05 |
2023-08-12 |
human |
| W Koek, J F Patoiseau, M B Assié, C Cosi, M S Kleven, E Dupont-Passelaigue, E Carilla-Durand, C Palmier, J P Valentin, G John, P J Pauwels, J P Tarayre, F C Colpaer. F 11440, a potent, selective, high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential. The Journal of pharmacology and experimental therapeutics. vol 287. issue 1. 1998-11-05. PMID:9765347. |
in hela cells expressing human 5-ht1a receptors, f 11440 decreased the forskolin-induced increase in amp, and, based on its maximal effect, was found to have an intrinsic activity of 1.0 relative to that of 5-ht, which was significantly higher than that of buspirone (0.49), ipsapirone (0.46) and flesinoxan (0.93). |
1998-11-05 |
2023-08-12 |
human |
| J P Redrobe, M Bouri. Dose-dependent influence of buspirone on the activities of selective serotonin reuptake inhibitors in the mouse forced swimming test. Psychopharmacology. vol 138. issue 2. 1998-10-26. PMID:9718290. |
dose-dependent influence of buspirone on the activities of selective serotonin reuptake inhibitors in the mouse forced swimming test. |
1998-10-26 |
2023-08-12 |
mouse |
| J P Redrobe, M Bouri. Dose-dependent influence of buspirone on the activities of selective serotonin reuptake inhibitors in the mouse forced swimming test. Psychopharmacology. vol 138. issue 2. 1998-10-26. PMID:9718290. |
recent clinical data suggest that buspirone may enhance the efficacy and/or reduce the latency to therapeutic effect of selective serotonin reuptake inhibitors (ssris) in unipolar major depressive disorder. |
1998-10-26 |
2023-08-12 |
mouse |
| P Fischer, J Tauscher, B Küfferle, S Kaspe. Weak antidepressant response after buspirone augmentation of serotonin reuptake inhibitors in refractory severe depression. International clinical psychopharmacology. vol 13. issue 2. 1998-10-01. PMID:9669189. |
weak antidepressant response after buspirone augmentation of serotonin reuptake inhibitors in refractory severe depression. |
1998-10-01 |
2023-08-12 |
Not clear |
| P Fischer, J Tauscher, B Küfferle, S Kaspe. Weak antidepressant response after buspirone augmentation of serotonin reuptake inhibitors in refractory severe depression. International clinical psychopharmacology. vol 13. issue 2. 1998-10-01. PMID:9669189. |
buspirone acts as a partial serotonin agonist at the 5-ht1a receptor. |
1998-10-01 |
2023-08-12 |
Not clear |
| D J Bootle, J J Adcock, A G Ramag. The role of central 5-HT receptors in the bronchoconstriction evoked by inhaled capsaicin in anaesthetised guinea-pigs. Neuropharmacology. vol 37. issue 2. 1998-10-01. PMID:9680249. |
the effects of intracisternal (i.c) injections of the 5-ht1a receptor agonists, buspirone and 8-oh-dpat, and the antagonists way-100635; and (-)-pindolol, the 5-ht1b/1d receptor agonist sumatriptan and antagonist gr127935, the 5-ht2 receptor agonist doi and the antagonist cinanserin, the 5-ht3 receptor antagonist granisetron, the alpha-adrenoceptor agonist clonidine and the antagonist idazoxan, the d2 receptor antagonists (-)-sulpiride and the 5-ht uptake inhibitor fluoxetine on capsaicin-evoked increase in tracheal inflation pressure (bronchoconstriction) were investigated in alpha-chloralose anaesthetised, neuromuscularly blocked, artificially ventilated guinea-pigs. |
1998-10-01 |
2023-08-12 |
Not clear |
| N Sussma. Anxiolytic antidepressant augmentation. The Journal of clinical psychiatry. vol 59 Suppl 5. 1998-06-24. PMID:9635547. |
on the other hand, the anxiolytic agent buspirone does facilitate direct antidepressant response, largely through its ability to activate both presynaptic and postsynaptic 5-ht1a receptors and thus modulate serotonin release. |
1998-06-24 |
2023-08-12 |
Not clear |
| R H Alper, D L Nelso. Characterization of 5-HT1A receptor-mediated [35S]GTPgammaS binding in rat hippocampal membranes. European journal of pharmacology. vol 343. issue 2-3. 1998-06-09. PMID:9570480. |
the non-selective agonists serotonin and 5-carboxamidotryptamine were 30-35% more efficacious, whereas the partial agonists buspirone and s(-)-8-hydroxy-2-(di-n-propylamino)tetralin stimulated gtpgammas binding by 19 +/- 1 and 43 +/- 3%, respectively, compared to r(+)-8-oh-dpat. |
1998-06-09 |
2023-08-12 |
rat |
| G J Kant, R M Wylie, K Chu, S Ghos. Effects of the serotonin agonists 8-OH-DPAT, buspirone, and DOI on water maze performance. Pharmacology, biochemistry, and behavior. vol 59. issue 3. 1998-05-05. PMID:9512079. |
effects of the serotonin agonists 8-oh-dpat, buspirone, and doi on water maze performance. |
1998-05-05 |
2023-08-12 |
rat |
| P J Pauwels, S Tardif, T Wurch, F C Colpaer. Stimulated [35S]GTP gamma S binding by 5-HT1A receptor agonists in recombinant cell lines. Modulation of apparent efficacy by G-protein activation state. Naunyn-Schmiedeberg's archives of pharmacology. vol 356. issue 5. 1998-02-19. PMID:9402034. |
in the c6-glial preparation at 0.3 microm gdp, the rank order of maximal effects was: 5-ht (1.00) > 8-oh-dpat (0.90) = r(+)-8-oh-dpat (0.87) = 5-ct (0.86) = l694247 (0.84) > s(-)8-oh-dpat (0.68) = buspirone (0.67) = spiroxatrine (0.67) = flesinoxan (0.64) > ipsapirone (0.53) = (-)-pindolol (0.50) > sdz216525 (0.25). |
1998-02-19 |
2023-08-12 |
Not clear |
| J A Kim, R A Gillespie, M J Drus. Effects of maternal ethanol consumption and buspirone treatment on 5-HT1A and 5-HT2A receptors in offspring. Alcoholism, clinical and experimental research. vol 21. issue 7. 1997-12-16. PMID:9347075. |
because fetal 5-ht functions as an essential neurotrophic factor, these studies also determined whether treatment of pregnant rats with buspirone, a 5-ht1a agonist, could overcome the effects of the fetal 5-ht deficit and prevent ethanol-associated receptor abnormalities. |
1997-12-16 |
2023-08-12 |
rat |
| C J McDougl. Update on pharmacologic management of OCD: agents and augmentation. The Journal of clinical psychiatry. vol 58 Suppl 12. 1997-12-15. PMID:9393391. |
when drugs affecting serotonin function (e.g., tryptophan, fenfluramine, lithium, buspirone) are added to sri therapy in sri-refractory patients, results are mixed and not consistently encouraging. |
1997-12-15 |
2023-08-12 |
Not clear |
| C Pou, E K Nénonéné, T A Reader, A Fargi. The human 5-HT1A receptor: comparison of its binding properties in transfected cells and cortical tissue. General pharmacology. vol 29. issue 5. 1997-12-04. PMID:9347319. |
most of the drugs used in competitions inhibited [3h]8-oh-dpat binding, following a two-site model, and maintained their rank order of binding potency in both systems; that is, 5-ht > or = 8-oh-dpat > buspirone > pindolol. |
1997-12-04 |
2023-08-12 |
human |
| D Sprenge. Buspirone augmentation of a selective serotonin reuptake inhibitor: efficacy in two depressed patients with comorbid anxiety and type I alcohol dependence. Journal of clinical psychopharmacology. vol 17. issue 5. 1997-11-21. PMID:9315996. |
buspirone augmentation of a selective serotonin reuptake inhibitor: efficacy in two depressed patients with comorbid anxiety and type i alcohol dependence. |
1997-11-21 |
2023-08-12 |
Not clear |
| J Moncrieff, D C Drummon. New drug treatments for alcohol problems: a critical appraisal. Addiction (Abingdon, England). vol 92. issue 8. 1997-11-12. PMID:9376777. |
the evidence from randomized controlled trials for the efficacy of some of the main candidates: acamprosate, naltrexone, bromocriptine, selective serotonin re-uptake inhibitors and buspirone, was examined. |
1997-11-12 |
2023-08-12 |
Not clear |
| N Collinson, G R Dawso. On the elevated plus-maze the anxiolytic-like effects of the 5-HT(1A) agonist, 8-OH-DPAT, but not the anxiogenic-like effects of the 5-HT(1A) partial agonist, buspirone, are blocked by the 5-HT1A antagonist, WAY 100635. Psychopharmacology. vol 132. issue 1. 1997-10-20. PMID:9272757. |
on the elevated plus-maze the anxiolytic-like effects of the 5-ht(1a) agonist, 8-oh-dpat, but not the anxiogenic-like effects of the 5-ht(1a) partial agonist, buspirone, are blocked by the 5-ht1a antagonist, way 100635. |
1997-10-20 |
2023-08-12 |
Not clear |
| N Collinson, G R Dawso. On the elevated plus-maze the anxiolytic-like effects of the 5-HT(1A) agonist, 8-OH-DPAT, but not the anxiogenic-like effects of the 5-HT(1A) partial agonist, buspirone, are blocked by the 5-HT1A antagonist, WAY 100635. Psychopharmacology. vol 132. issue 1. 1997-10-20. PMID:9272757. |
in the present study we evaluated the effects of the 5-ht(1a) receptor partial agonist, buspirone hydrochloride and the 5-ht(1a) receptor agonist, 8-hydroxy-2-(di-n-propylamino) tetralin (8-oh-dpat) on the elevated plus-maze. |
1997-10-20 |
2023-08-12 |
Not clear |
| N Collinson, G R Dawso. On the elevated plus-maze the anxiolytic-like effects of the 5-HT(1A) agonist, 8-OH-DPAT, but not the anxiogenic-like effects of the 5-HT(1A) partial agonist, buspirone, are blocked by the 5-HT1A antagonist, WAY 100635. Psychopharmacology. vol 132. issue 1. 1997-10-20. PMID:9272757. |
these data suggest that the anxiolytic-like effects of 8-oh-dpat, but not the anxiogenic-like effects of buspirone, on the elevated plus-maze are mediated via 5-ht(1a) receptors in the cns. |
1997-10-20 |
2023-08-12 |
Not clear |
| G Griebel, R J Rodgers, G Perrault, D J Sange. Risk assessment behaviour: evaluation of utility in the study of 5-HT-related drugs in the rat elevated plus-maze test. Pharmacology, biochemistry, and behavior. vol 57. issue 4. 1997-10-16. PMID:9259011. |
the drugs used were 5-ht1a receptor partial (buspirone and ipsapirone) and full (8-oh-dpat and flesinoxan) agonists, mixed 5-ht2a/2c receptor antagonists (ritanserin, ketanserin, mianserin, and pirenperone), selective 5-ht3 receptor antagonists (ics 205-930, mdl 72222, ondansetron, and (rs)-zacopride), and selective (fluoxetine, fluvoxamine, and zimelidine) and nonselective (imipramine) 5-ht reuptake inhibitors. |
1997-10-16 |
2023-08-12 |
rat |