| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Lilienthal, A Weinand-Härer, H Winterhoff, G Winnek. Effects of maternal exposure to 3,3',4,4'-tetrachlorobiphenyl or propylthiouracil in rats trained to discriminate apomorphine from saline. Toxicology and applied pharmacology. vol 146. issue 1. 1997-10-15. PMID:9299608. |
differences between controls and groups exposed to pcb 77 or ptu were detected in a blocking test using the mixed serotonin 5-ht1a agonist and partial d2 antagonist buspirone. |
1997-10-15 |
2023-08-12 |
rat |
| P Schoeffter, I Bobirnac, E Boddeke, D Hoye. Inhibition of cAMP accumulation via recombinant human serotonin 5-HT1A receptors: considerations on receptor effector coupling across systems. Neuropharmacology. vol 36. issue 4-5. 1997-09-15. PMID:9225266. |
the pharmacological characterization of the inhibition of cyclic amp accumulation was made using agonists (5-ht, 8-oh-dpat, buspirone, mdl 73005) and putative antagonists (sdz 216-525, nan-190, way-100135, pindolol, propranolol, way 100635). |
1997-09-15 |
2023-08-12 |
human |
| P Schoeffter, I Bobirnac, E Boddeke, D Hoye. Inhibition of cAMP accumulation via recombinant human serotonin 5-HT1A receptors: considerations on receptor effector coupling across systems. Neuropharmacology. vol 36. issue 4-5. 1997-09-15. PMID:9225266. |
it is shown that 5-ht, 8-oh-dpat, buspirone, mdl 73005 behaved as full (or nearly full) and potent agonists, whereas sdz 216-525, nan-190 and way-100135 displayed a limited (and similar) degree of intrinsic activity at human 5-ht1a receptors; on the other hand pindolol, propranolol and way 100635 behaved as "silent" antagonists. |
1997-09-15 |
2023-08-12 |
human |
| M S Kleven, M B Assié, W Koe. Pharmacological characterization of in vivo properties of putative mixed 5-HT1A agonist/5-HT(2A/2C) antagonist anxiolytics. II. Drug discrimination and behavioral observation studies in rats. The Journal of pharmacology and experimental therapeutics. vol 282. issue 2. 1997-09-11. PMID:9262338. |
to characterize their in vivo 5-hydroxytryptamine (5-ht)2a antagonist properties, the ability of the putative mixed 5-ht1a agonists/5-ht(2a,2c) antagonists (n-(29(4-(2-pyrimidinyl)-1-piperazinyl)ethyl)tricyclo(3.3.1.1(3,7) ) decane-1-carboxamide (wy-50,324), (2-(4-(4,4-bis(4-fluorophenyl)butyl)-1-piperazinyl)-3-pyridinecarboxy lic acid hydrochloride (fg5974), 9,10-didehydro-n-(2-propynyl)-6-methylergoline-8b-carboxamid e (lek-8804) and trans-1,3,4,a5,10b-hexahydro10-methoxy-4-propyl-2h-(1)benzopyra nol[3,4-b]pyridine (cgs 18102a) to antagonize both head twitches and discriminative stimulus (ds) effects produced by (+/-)-2,5-dimethoxy-4-iodoamphetamine (doi) in rats were compared with those of the 5-ht2 antagonists ketanserin and ritanserin, and the 5-ht1a agonists 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) and buspirone. |
1997-09-11 |
2023-08-12 |
rat |
| T Hamamura, Y Lee, Y Fujiwara, S Kurod. Serotonin1A receptor agonists induce Fos protein expression in the locus coeruleus of the conscious rat. Brain research. vol 759. issue 1. 1997-09-10. PMID:9219875. |
the azapirones, which are partial agonists of the serotonin (5-ht)1a receptor, possess anxiolytic activity. |
1997-09-10 |
2023-08-12 |
rat |
| C Moret, M Brile. Ex vivo inhibitory effect of the 5-HT uptake blocker citalopram on 5-HT synthesis. Journal of neural transmission (Vienna, Austria : 1996). vol 104. issue 2-3. 1997-09-03. PMID:9203078. |
the selective 5-ht reuptake inhibitor, citalopram, the 5-ht1a agonists, (+/-) 8-hydroxy-2-(di-n-propylamino)-tetralin (8-oh-dpat), ipsapirone, gepirone and the 5-ht1a/b agonist, 7-trifluoromethyl-4(4-methyl-1-piperazinyl-pyrolo[1,2-a]-quinox ali ne (cgs 12066b), the 5-ht1a/b ligands and beta-adrenoceptor antagonists, (+/-) pindolol and (+/-) alprenolol, and the non-selective 5-ht ligands, m-chlorophenylpiperazine (mcpp) and metergoline, all inhibited the synthesis of 5-ht. |
1997-09-03 |
2023-08-12 |
rat |
| R A Gillespie, J Eriksen, H L Hao, M J Drus. Effects of maternal ethanol consumption and buspirone treatment on dopamine and norepinephrine reuptake sites and D1 receptors in offspring. Alcoholism, clinical and experimental research. vol 21. issue 3. 1997-08-07. PMID:9161605. |
because fetal 5-ht is an essential trophic factor, this laboratory previously investigated the hypotheses that the early ethanol-associated 5-ht deficit contributed to subsequent development abnormalities in the serotonergic system and that the effects of the fetal 5-ht deficit could be prevented by maternal treatment with buspirone, a 5-ht1a receptor agonist. |
1997-08-07 |
2023-08-12 |
rat |
| M J Millan, S Hjorth, R Samanin, R Schreiber, R Jaffard, B De Ladonchamps, S Veiga, B Goument, J L Peglion, M Spedding, M Brocc. S 15535, a novel benzodioxopiperazine ligand of serotonin (5-HT)1A receptors: II. Modulation of hippocampal serotonin release in relation to potential anxiolytic properties. The Journal of pharmacology and experimental therapeutics. vol 282. issue 1. 1997-08-07. PMID:9223550. |
in these studies, we characterized the influence of the novel benzodioxopiperazine serotonin (5-ht)1a ligand, s 15535, on the release of 5-ht in rat hippocampus and compared its potential anxiolytic properties with those of the 5-ht1a receptor partial agonist, buspirone, the 5-ht1a antagonist, way 100,635 and the benzodiazepine, diazepam (dzm). |
1997-08-07 |
2023-08-12 |
mouse |
| P Afzelius, S D Nielsen, B Hofmann, J O Nielse. The serotonin analogue buspirone increases the function of PBMC from HIV-infected individuals in vitro. Scandinavian journal of infectious diseases. vol 29. issue 2. 1997-07-24. PMID:9181645. |
the serotonin analogue buspirone increases the function of pbmc from hiv-infected individuals in vitro. |
1997-07-24 |
2023-08-12 |
Not clear |
| P Afzelius, S D Nielsen, B Hofmann, J O Nielse. The serotonin analogue buspirone increases the function of PBMC from HIV-infected individuals in vitro. Scandinavian journal of infectious diseases. vol 29. issue 2. 1997-07-24. PMID:9181645. |
we have identified a serotonin analogue, buspirone, that inhibits the activity of adenylyl cyclase, the enzyme responsible for regulation of intracellular levels of camp. |
1997-07-24 |
2023-08-12 |
Not clear |
| J A Stanton, M S Bee. Characterisation of a cloned human 5-HT1A receptor cell line using [35S]GTP gamma S binding. European journal of pharmacology. vol 320. issue 2-3. 1997-07-14. PMID:9059863. |
5-ht, 5-carboxamidotryptamine (5-ct), 8-hydoxy-dipropylamino-tetralin (8-oh-dpat), 5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1 h-indole (ru24969), buspirone, gepirone, mesulergine and sumatriptan were equally efficacious. |
1997-07-14 |
2023-08-12 |
human |
| N Nakata, H Suda, J Izumi, Y Tanaka, Y Ikeda, H Kato, Y Itoyama, K Kogur. Role of hippocampal serotonergic neurons in ischemic neuronal death. Behavioural brain research. vol 83. issue 1-2. 1997-07-09. PMID:9062688. |
to clarify the serotonergic mechanisms involved in the protection against ischemic neuronal damage, zd-211 (citalopram hbr), a serotonin (5-hydroxytryptamine; 5-ht) re-uptake inhibitor, or buspirone, a 5-ht1a agonist, was locally administered into the hippocampus of gerbils. |
1997-07-09 |
2023-08-12 |
Not clear |
| C Bouwer, D J Stei. Buspirone is an effective augmenting agent of serotonin selective re-uptake inhibitors in severe treatment-refractory depression. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde. vol 87. issue 4 Suppl. 1997-07-07. PMID:9180827. |
buspirone is an effective augmenting agent of serotonin selective re-uptake inhibitors in severe treatment-refractory depression. |
1997-07-07 |
2023-08-12 |
Not clear |
| C Bouwer, D J Stei. Buspirone is an effective augmenting agent of serotonin selective re-uptake inhibitors in severe treatment-refractory depression. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde. vol 87. issue 4 Suppl. 1997-07-07. PMID:9180827. |
buspirone has previously been reported to be effective in the augmentation of the antidepressant effect of serotonin selective re-uptake inhibitors (ssris) in depressed outpatients. |
1997-07-07 |
2023-08-12 |
Not clear |
| M E Tancer, T W Uhd. Role of serotonin drugs in the treatment of social phobia. The Journal of clinical psychiatry. vol 58 Suppl 5. 1997-06-19. PMID:9184626. |
these include the serotonin selective reuptake inhibitors (ssris), the partial 5-ht1a agonist buspirone, and the 5-ht3 antagonist ondansetron. |
1997-06-19 |
2023-08-12 |
Not clear |
| M Filip, E Przegalińsk. Effects of MP-3022 on the 8-OH-DPAT-induced discriminative stimulus in rats. Polish journal of pharmacology. vol 48. issue 4. 1997-06-16. PMID:9112679. |
substitution studies showed that the 8-oh-dpat cue was mimicked in a dose-dependent manner by buspirone and ipsapirone, the 5-ht1a receptor partial agonists, but not by 1-(3-chlorophenyl)piperazine (m-cpp), a nonselective 5-ht agonist. |
1997-06-16 |
2023-08-12 |
rat |
| E K Nénonéné, F Radja, M Carli, N M van Gelder, S Afkhami-Dastjerdian, T A Reade. Alkylation of [3H]8-OH-DPAT binding sites in rat cerebral cortex and hippocampus. Neurochemical research. vol 21. issue 2. 1997-06-12. PMID:9182242. |
the binding of tritiated 8-hydroxy-2-(di-n-propyl-amino)tetralin, or [3h]8-oh-dpat, to membranes from rat cerebral cortex and hippocampus could be inhibited by serotonin (5-ht) and buspirone, and by the 5-ht antagonists propranolol, nan-190, pindolol, pindobind-5-ht(1a), way1oo135, spiperone and ritanserin. |
1997-06-12 |
2023-08-12 |
rat |
| K Uvnäs-Moberg, V Hillegaart, P Alster, S Ahleniu. Effects of 5-HT agonists, selective for different receptor subtypes, on oxytocin, CCK, gastrin and somatostatin plasma levels in the rat. Neuropharmacology. vol 35. issue 11. 1997-05-28. PMID:9025112. |
adult male sprague-dawley rats were administered the 5-ht subtype selective receptor agonists 8-oh-dpat (0.5-2.0 mg/kg), buspirone (2-8 mg/kg) (5-ht1a), tfmpp (0.125-2.0 mg/kg) (5-ht1b), doi (0.125-2.0 mg/kg) (5-ht2a) and m-cpbg (1.25-20.0 mg/kg) (5-ht3), subcutaneously. |
1997-05-28 |
2023-08-12 |
rat |
| W Yan, C C Wilson, J H Harin. 5-HT1a receptors mediate the neurotrophic effect of serotonin on developing dentate granule cells. Brain research. Developmental brain research. vol 98. issue 2. 1997-05-27. PMID:9051259. |
the present study used the drugs buspirone and nan-190, which have been shown to be an agonist and antagonist respectively at postsynaptic 5-ht1a receptors in vivo, to test the idea that neurotrophic actions of 5-ht result from 5-ht1a receptor stimulation. |
1997-05-27 |
2023-08-12 |
rat |
| W Yan, C C Wilson, J H Harin. 5-HT1a receptors mediate the neurotrophic effect of serotonin on developing dentate granule cells. Brain research. Developmental brain research. vol 98. issue 2. 1997-05-27. PMID:9051259. |
following 5-ht depletion with pca, pups received daily injections of buspirone (1.0 mg/kg) from p5 to p14. |
1997-05-27 |
2023-08-12 |
rat |