| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M.A. Nader, S. Hoffmann, S. Gleeson, J.E. Barret. Further characterization of the discriminative stimulus effects of buspirone using monoamine agonists and antagonists in the pigeon. Behavioural pharmacology. vol 1. issue 1. 2019-11-20. PMID:11175387. |
coadministration of the beta-adrenergic agonist isoproterenol (1.0-5.6mg/kg) or the 5-ht(1a) partial agonist bmy 7378 (0.01-10.0mg/kg) with 1.0mg/kg buspirone did not block the discriminative stimulus effects of buspirone. |
2019-11-20 |
2023-08-12 |
human |
| M.A. Nader, S. Hoffmann, S. Gleeson, J.E. Barret. Further characterization of the discriminative stimulus effects of buspirone using monoamine agonists and antagonists in the pigeon. Behavioural pharmacology. vol 1. issue 1. 2019-11-20. PMID:11175387. |
results from the present study suggest that (1) the discriminative stimulus effects of buspirone, 8-oh-dpat, bmy 7378, ru 24969 and spiroxatrine are mediated through the 5-ht(1a) receptor; (2) buspirone's discriminative stimulus effects do not interact with the noradrenergic or dopaminergic system; and 3) under this procedure bmy 7378 was a partial agonist at 5-ht(1a) receptors. |
2019-11-20 |
2023-08-12 |
human |
| D.J. Sanger, D. Jol. Performance of a passive avoidance response is disrupted by compounds acting at 5HT(1A) receptors. Behavioural pharmacology. vol 1. issue 3. 2019-11-20. PMID:11224034. |
neither ritanserin, a 5ht(2) antagonist, nor 1-pp, a metabolite of buspirone known to have alpha(2)-adrenoceptor antagonist properties, was active. |
2019-11-20 |
2023-08-12 |
rat |
| J.M. Witkin, L.A. Pere. Comparison of effects of buspirone and gepirone with benzodiazepines and antagonists of dopamine and serotonin receptors on punished behavior of rats. Behavioural pharmacology. vol 1. issue 3. 2019-11-20. PMID:11224036. |
comparison of effects of buspirone and gepirone with benzodiazepines and antagonists of dopamine and serotonin receptors on punished behavior of rats. |
2019-11-20 |
2023-08-12 |
rat |
| N.A. Ato. Discriminative stimulus effects of the novel anxiolytic buspirone. Behavioural pharmacology. vol 2. issue 1. 2019-11-20. PMID:11224042. |
complete generalization to 8-oh-dpat occurred, consistent with buspirone's prominent 5ht(1a)-receptor activity and replicating findings in the pigeon. |
2019-11-20 |
2023-08-12 |
rat |
| I. Lucki, J.M. Marcocci. Discriminated taste aversion with a 5-HT(1A) agonist measured using saccharin preference. Behavioural pharmacology. vol 2. issue 4 And 5. 2019-11-20. PMID:11224077. |
other drugs with high affinity for 5-ht(1a) receptors, such as the azapirones gepirone, ipsapirone and buspirone, produced selective reductions of saccharin preference in rats trained to discriminate 8-oh-dpat from saline but not in controls. |
2019-11-20 |
2023-08-12 |
rat |
| I. Lucki, J.M. Marcocci. Discriminated taste aversion with a 5-HT(1A) agonist measured using saccharin preference. Behavioural pharmacology. vol 2. issue 4 And 5. 2019-11-20. PMID:11224077. |
three drugs with low affinity for 5-ht(1a) receptors, the benzodiazepine anxiolytic diazepam, d-amphetamine, and a common metabolite of the azapirones 1-(2-pyrimidinyl) piperazine (1-pp) altered fluid intake significantly but failed to produce significant changes in saccharin preference in either the discrimination or control groups. |
2019-11-20 |
2023-08-12 |
rat |
| L. Zhang, J.E. Barret. Modification of the discriminative stimulus effects of 8-OH-DPAT, buspirone and the beta-adrenoreceptor antagonist pindolol after chronic administration of the 5-HT(1A) agonist 8-OH-DPAT in the pigeon. Behavioural pharmacology. vol 2. issue 4 And 5. 2019-11-20. PMID:11224080. |
modification of the discriminative stimulus effects of 8-oh-dpat, buspirone and the beta-adrenoreceptor antagonist pindolol after chronic administration of the 5-ht(1a) agonist 8-oh-dpat in the pigeon. |
2019-11-20 |
2023-08-12 |
pigeon |
| L. Zhang, J.E. Barret. Modification of the discriminative stimulus effects of 8-OH-DPAT, buspirone and the beta-adrenoreceptor antagonist pindolol after chronic administration of the 5-HT(1A) agonist 8-OH-DPAT in the pigeon. Behavioural pharmacology. vol 2. issue 4 And 5. 2019-11-20. PMID:11224080. |
cumulative dose-response curves were determined for 8-oh-dpat, the beta-adrenergic antagonist pindolol, the alpha(1)-antagonist prazosin, as well as for the 5-ht(1a) agonist buspirone, before, during and after (8-oh-dpat and pindolol) chronic administration of 8-oh-dpat (3.0mg/kg/day for 6 weeks). |
2019-11-20 |
2023-08-12 |
pigeon |
| L. Zhang, J.E. Barret. Modification of the discriminative stimulus effects of 8-OH-DPAT, buspirone and the beta-adrenoreceptor antagonist pindolol after chronic administration of the 5-HT(1A) agonist 8-OH-DPAT in the pigeon. Behavioural pharmacology. vol 2. issue 4 And 5. 2019-11-20. PMID:11224080. |
chronic administration of 8-oh-dpat resulted in a heightened sensitivity not only to the 5-ht(1a) agonists 8-oh-dpat and buspirone, but also to what appear to be partial agonist effects of pindolol. |
2019-11-20 |
2023-08-12 |
pigeon |
| A.J. Goudie, M.J. Leathle. Effects of the 5HT(1A) agonist anxiolytic gepirone on benzodiazepine withdrawal signs in rats. Behavioural pharmacology. vol 2. issue 6. 2019-11-20. PMID:11224088. |
effects of the 5ht(1a) agonist anxiolytic gepirone on benzodiazepine withdrawal signs in rats. |
2019-11-20 |
2023-08-12 |
rat |
| T. Klin. Effects of 8-OH-DPAT and buspirone in a passive avoidance test and in the elevated plus-maze test in rats. Behavioural pharmacology. vol 2. issue 6. 2019-11-20. PMID:11224090. |
the effects of the two 5-ht(1a) agonists 8-oh-dpat and buspirone were studied in a passive avoidance test and in an elevated plus-maze test. |
2019-11-20 |
2023-08-12 |
rat |
| M.A. Nader, M. Hanneman. Interactions of buspirone or gepirone with nicotine on schedule-controlled behavior of pigeons. Behavioural pharmacology. vol 4. issue 3. 2019-11-20. PMID:11224194. |
the buspirone analog gepirone (0.3-10mg/kg), which like buspirone is a serotonin (5-ht(1a)) agonist, but unlike buspirone is relatively devoid of d2 antagonist activity, was also tested in combination with nicotine. |
2019-11-20 |
2023-08-12 |
Not clear |
| M. Galizio, K.L. Hale, M.O. Liborio, M. Mille. Variable-ratio schedules of timeout from avoidance: effects of anxiolytic drugs. Behavioural pharmacology. vol 4. issue 5. 2019-11-20. PMID:11224215. |
two 5-ht(1a) agonists, buspirone and 8-oh-dpat, had different effects. |
2019-11-20 |
2023-08-12 |
rat |
| M. Galizio, K.L. Hale, M.O. Liborio, M. Mille. Variable-ratio schedules of timeout from avoidance: effects of anxiolytic drugs. Behavioural pharmacology. vol 4. issue 5. 2019-11-20. PMID:11224215. |
differences between the behavioral effects of buspirone and 8-oh-dpat may reflect differential activity at the 5-ht(1a) receptor or the dopaminergic properties of buspirone. |
2019-11-20 |
2023-08-12 |
rat |
| C.E. Ybema, J.L. Slangen, B. Olivier, J. Mo. Dose-dependent discriminative stimulus properties of 8-OH-DPAT. Behavioural pharmacology. vol 4. issue 6. 2019-11-20. PMID:11224230. |
buspirone substituted completely for 8-oh-dpat in l and partially in h, whereas the 5-ht(1a/1b) receptor agonist eltoprazine substituted completely for 8-oh-dpat in h but only partially in l. the 5-ht(1a/1b) receptor agonist ru24969, the 5-ht(1b/2c/1a) receptor agonist tfmpp and the 5-ht reuptake blocker fluvoxamine did not completely mimic the effect of 8-oh-dpat in either l or h and the 5-ht(1a) mixed agonists/antagonists bmy 7378 and nan-190 produced partial generalization in l, but no generalization in h. in antagonism tests, nan-190 and bmy 7378 only partially blocked the 8-oh-dpat cue in both groups. |
2019-11-20 |
2023-08-12 |
rat |
| M.A. Nader, W.L. Woolverto. Blockade of the discriminative stimulus effects of d-amphetamine in rhesus monkeys with serotonin 5-HT(1A) agonists. Behavioural pharmacology. vol 5. issue 6. 2019-11-20. PMID:11224238. |
with saline or various doses of amph (0.1-1.7mg/kg), alone or in combination with intramuscular injections of the serotonin (5-ht(1a)) agonists buspirone (0.3-1.0mg/kg), gepirone (0.56-3.0mg/kg), 8-hydroxy-2(di-n-propylamino) tetralin (8-oh-dpat; 0.01-0.1mg/kg), the dopamine d2 antagonist raclopride (0.03 and 0.1mg/kg), or pentobarbital (10mg/kg). |
2019-11-20 |
2023-08-12 |
monkey |
| M.A. Nader, W.L. Woolverto. Blockade of the discriminative stimulus effects of d-amphetamine in rhesus monkeys with serotonin 5-HT(1A) agonists. Behavioural pharmacology. vol 5. issue 6. 2019-11-20. PMID:11224238. |
for the 5-ht(1a) agonists, the order of potency for attenuating the amph discriminative stimulus was 8-oh-dpat>buspirone>gepirone, similar to their binding affinities at 5-ht(1a) receptors. |
2019-11-20 |
2023-08-12 |
monkey |
| M.A. Nader, W.L. Woolverto. Blockade of the discriminative stimulus effects of d-amphetamine in rhesus monkeys with serotonin 5-HT(1A) agonists. Behavioural pharmacology. vol 5. issue 6. 2019-11-20. PMID:11224238. |
in addition, although the effect of buspirone and gepirone could be surmounted by increasing the dose of amph, the effect of 8-oh-dpat, the 5-ht(1a) agonist with the highest intrinsic activity (efficacy), was insurmountable in two of the three monkeys tested. |
2019-11-20 |
2023-08-12 |
monkey |
| C. López-Rubalcava, A. Fernández-Guast. Noradrenaline-serotonin interactions in the anxiolytic effects of 5-HT(1A) agonists. Behavioural pharmacology. vol 5. issue 1. 2019-11-20. PMID:11224250. |
the purpose of this study was to analyse adrenergic and serotonergic interactions in the anxiolytic effects of several 5-ht(1a) agonists including ipsapirone, buspirone, indorenate and 8-oh-dpat. |
2019-11-20 |
2023-08-12 |
Not clear |