| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L D Leake, M Koubanaki. Central and peripheral 5-HT receptors in the leech (Hirudo medicinalis) redefined. General pharmacology. vol 26. issue 8. 1996-10-23. PMID:8745160. |
all agonists induced hyperpolarisation of r cells: the order of their potency was 5-ht > 5-ct > 2-me 5ht > alpha-me-5-ht > > cgs-12066b = 5meot > papp > buspirone. |
1996-10-23 |
2023-08-12 |
Not clear |
| L D Leake, M Koubanaki. Central and peripheral 5-HT receptors in the leech (Hirudo medicinalis) redefined. General pharmacology. vol 26. issue 8. 1996-10-23. PMID:8745160. |
the overall potency of agonists on the body wall muscle was 5-meot > 5-ct > 5-ht > alpha-me-5-ht > 2-me 5-ht > papp > buspirone > > cgs-12066b. |
1996-10-23 |
2023-08-12 |
Not clear |
| H Tanaka, T Tatsuno, H Shimizu, A Hirose, Y Kumasaka, M Nakamur. Effects of tandospirone on second messenger systems and neurotransmitter release in the rat brain. General pharmacology. vol 26. issue 8. 1996-10-23. PMID:8745167. |
we studied the effects of tandospirone, a novel serotonin (5-ht)1a receptor-related anxiolytic, on the intracellular second messenger systems and neurotransmitter release. |
1996-10-23 |
2023-08-12 |
rat |
| H Tanaka, T Tatsuno, H Shimizu, A Hirose, Y Kumasaka, M Nakamur. Effects of tandospirone on second messenger systems and neurotransmitter release in the rat brain. General pharmacology. vol 26. issue 8. 1996-10-23. PMID:8745167. |
tandospirone inhibited forskolin-stimulated adenylate cyclase activity in rat hippocampal membranes by activation of 5-ht1a receptors and had high efficacy comparable to 5-ht1a receptor agonists such as 5-ht and 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat). |
1996-10-23 |
2023-08-12 |
rat |
| H Tanaka, T Tatsuno, H Shimizu, A Hirose, Y Kumasaka, M Nakamur. Effects of tandospirone on second messenger systems and neurotransmitter release in the rat brain. General pharmacology. vol 26. issue 8. 1996-10-23. PMID:8745167. |
tandospirone did not affect the release of 5-ht, norepinephrine (ne), dopamine (da) and acetylcholine (ach) from rat brain slice preparations. |
1996-10-23 |
2023-08-12 |
rat |
| P Blier, R Bergero. Sequential administration of augmentation strategies in treatment-resistant obsessive-compulsive disorder: preliminary findings. International clinical psychopharmacology. vol 11. issue 1. 1996-10-10. PMID:8732312. |
the 5-ht1a agonist buspirone as well as 5-hydroxytryptophan, the immediate precursor of 5-ht, added to the sri-pindolol regimen, were not effective in attenuating the intensity of ocd. |
1996-10-10 |
2023-08-12 |
Not clear |
| M Abe, R Tabata, K Saito, T Matsuda, A Baba, M Egaw. Novel benzodioxan derivative, 5-[3-[((2S)-1,4-benzodioxan-2-ylmethyl) amino]propoxy]-1,3-benzodioxole HCl (MKC-242), with anxiolytic-like and antidepressant-like effects in animal models. The Journal of pharmacology and experimental therapeutics. vol 278. issue 2. 1996-09-18. PMID:8768745. |
behavioral effects of mkc-242 (5-{3-[((2>)-1,4-benzodioxan-2-ylmethyl)amino] propoxy}-1,3-benzodioxole chl), a novel and selective serotonin 1a receptor agonist, were investigated in rats and mice and compared against those of diazepam, buspirone and tandospirone. |
1996-09-18 |
2023-08-12 |
mouse |
| M Maes, A Van Gastel, H Y Meltzer, P Cosyns, P Blockx, R Desnyde. Acute administration of buspirone increases the escape of hypothalamic-pituitary-adrenal-axis hormones from suppression by dexamethasone in depression. Psychoneuroendocrinology. vol 21. issue 1. 1996-09-16. PMID:8778905. |
to further elucidate the effects of central serotonin (5-ht) activity on the negative feedback of glucocorticoids on hypothalamic-pituitary-adrenal (hpa)-axis function in depression, this study investigates the effects of buspirone, a 5-ht1a receptor agonist, on post-dst acth and cortisol levels in 75 depressed subjects. |
1996-09-16 |
2023-08-12 |
human |
| J L Mokrosz, A Dereń-Wesołek, E Tatarczyńska, B Duszyńska, A J Bojarski, M J Mokrosz, E Chojnacka-Wójci. 8-[4-[2-(1,2,3,4-Tetrahydroisoquinolinyl]butyl-8-azaspiro[4.5]decane-7,9-dione: a new 5-HT1A receptor ligand with the same activity profile as buspirone. Journal of medicinal chemistry. vol 39. issue 5. 1996-08-15. PMID:8676348. |
in was demonstrated that buspirone and its analog 6a were equipotent 5-ht(1a) ligands. |
1996-08-15 |
2023-08-12 |
Not clear |
| J L Mokrosz, A Dereń-Wesołek, E Tatarczyńska, B Duszyńska, A J Bojarski, M J Mokrosz, E Chojnacka-Wójci. 8-[4-[2-(1,2,3,4-Tetrahydroisoquinolinyl]butyl-8-azaspiro[4.5]decane-7,9-dione: a new 5-HT1A receptor ligand with the same activity profile as buspirone. Journal of medicinal chemistry. vol 39. issue 5. 1996-08-15. PMID:8676348. |
several behavioral models showed that 6a had essentially the same functional profile at 5-ht(1a) receptors as buspirone. |
1996-08-15 |
2023-08-12 |
Not clear |
| K V Harvey, R Balo. Augmentation with buspirone: a review. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists. vol 7. issue 3. 1996-07-19. PMID:8646275. |
buspirone, an azaspirone serotonin (5-ht) 1a partial agonist, has been approved by the fda as an anxiolytic. |
1996-07-19 |
2023-08-12 |
Not clear |
| I Luck. Serotonin receptor specificity in anxiety disorders. The Journal of clinical psychiatry. vol 57 Suppl 6. 1996-07-19. PMID:8647798. |
the demonstrated efficacy in anxiety disorders of drugs such as buspirone or fluoxetine has emphasized the importance of 5-hydroxytryptamine (5-ht or serotonin). |
1996-07-19 |
2023-08-12 |
Not clear |
| I Luck. Serotonin receptor specificity in anxiety disorders. The Journal of clinical psychiatry. vol 57 Suppl 6. 1996-07-19. PMID:8647798. |
buspirone is a selective agonist at a subtype of serotonin receptor termed 5-ht1a, whereas fluoxetine is a selective inhibitor of the reuptake of 5-ht. |
1996-07-19 |
2023-08-12 |
Not clear |
| R J Cadieu. Azapirones: an alternative to benzodiazepines for anxiety. American family physician. vol 53. issue 7. 1996-07-05. PMID:8638511. |
buspirone, the only azapirone currently in clinical use, is a partial serotonin agonist with low abuse potential, no sedative effects, no cognitive or psychomotor impairment properties and no significant withdrawal symptoms. |
1996-07-05 |
2023-08-12 |
Not clear |
| M S Kleven, W Koe. Pharmacological characterization of in vivo properties of putative mixed 5-HT1A agonist/5-HT2A/2C antagonist anxiolytics. I. Antipunishment effects in the pigeon. The Journal of pharmacology and experimental therapeutics. vol 276. issue 2. 1996-07-03. PMID:8632301. |
a conflict procedure in pigeons was used to characterize the antipunishment effects of the putative mixed 5-hydroxytryptamine (5-ht)1a agonist/5-ht2a/2c antagonists wy 50,324, cgs 18102a, lek 8804 and fg 5974 and to further investigate interactions between the antipunishment effects of the 5-ht1a agonists buspirone and 8-oh-dpat [8-hydroxy-2-(di-n-propylamino)tetralin] administered in combination with the mixed 5-ht2a/2c antagonist ritanserin and the alpha 1 antagonist prazosin. |
1996-07-03 |
2023-08-12 |
pigeon |
| F Cugurr. [Drug therapy and affective disorders: state of the art]. La Clinica terapeutica. vol 146. issue 10. 1996-03-27. PMID:8590559. |
from the most recent mao inhibitors we go on to tricyclic antidepressants, to the second generation (amoxapine, buspirone, venlafaxine), and to selective inhibitors of 5ht reuptake (fluoxetine and its derivates, again venlafaxine, sertaline). |
1996-03-27 |
2023-08-12 |
Not clear |
| V Hadrava, P Blier, T Dennis, C Ortemann, C de Montign. Characterization of 5-hydroxytryptamine1A properties of flesinoxan: in vivo electrophysiology and hypothermia study. Neuropharmacology. vol 34. issue 10. 1996-03-04. PMID:8570029. |
the capacity of flesinoxan to antagonize the effect of 5-ht on ca3 pyramidal neurons was similar to that of 8-hydroxy-2-(di-n-propylamino)-tetralin (8-oh-dpat) and significantly greater than that of gepirone. |
1996-03-04 |
2023-08-12 |
rat |
| M Baetz, D Malcol. Serotonin syndrome from fluvoxamine and buspirone. Canadian journal of psychiatry. Revue canadienne de psychiatrie. vol 40. issue 7. 1996-02-20. PMID:8548727. |
serotonin syndrome from fluvoxamine and buspirone. |
1996-02-20 |
2023-08-12 |
Not clear |
| R R Matsumoto, M J Hussong, D D Truon. Effects of selective serotonergic ligands on posthypoxic audiogenic myoclonus. Movement disorders : official journal of the Movement Disorder Society. vol 10. issue 5. 1996-02-20. PMID:8552114. |
in contrast, the following drugs were ineffective: (+/-)-8-hydroxy-dipropylaminotetralin hydrobromide (8-oh-dpat, 5-ht1a agonist), buspirone hydrochloride (5-ht1a agonist), 7-trifluoromethyl-4(4-methyl-l-piperazinyl)-pyrrolo[1,2- a]quinoxaline maleate (cgs 12066b, 5-ht1b agonist), ketanserin tartrate (5-ht2 antagonist), methysergide maleate (5-ht2 antagonist), fluoxetine (5-ht uptake blocker), and saline (vehicle). |
1996-02-20 |
2023-08-12 |
rat |
| M J Piera, M Beaughard, M T Michelin, R Massingha. Effects of the 5-hydroxytryptamine1A receptor agonists, 8-OH-DPAT, buspirone and flesinoxan, upon brain damage induced by transient global cerebral ischaemia in gerbils. Archives internationales de pharmacodynamie et de therapie. vol 329. issue 3. 1996-02-13. PMID:8546535. |
the ineffectiveness of buspirone and flesinoxan was not the result of too low a dose - as evidenced by the complete inhibition of hyperactivity with both compounds and by the appearance of a serotonin behavior syndrome with flesinoxan - but is possibly related to a partial agonist activity at the 5-hydroxytryptamine1a receptor, as reported for buspirone. |
1996-02-13 |
2023-08-12 |
Not clear |