| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C A Naranjo, N Herrmann, N Mittmann, K E Bremne. Recent advances in geriatric psychopharmacology. Drugs & aging. vol 7. issue 3. 1996-02-07. PMID:8535049. |
buspirone, a partial serotonin 5-ht1a-agonist which is better tolerated than benzodiazepines in the elderly, may be used as an alternative. |
1996-02-07 |
2023-08-12 |
Not clear |
| U Freo, P Pietrini, G Pizzolato, M Furey-Kurkjian, A Merico, S Ruggero, M Dam, L Battisti. Dose-dependent effects of buspirone on behavior and cerebral glucose metabolism in rats. Brain research. vol 677. issue 2. 1995-11-14. PMID:7552245. |
in this study we compared the effects of the anxiolytic buspirone on behavior and regional cerebral metabolic rates for glucose (rcmrglc) with those of the reference serotonin (5-ht)1a agonist 8-hydroxy-2(di-n-propylamino)tetralin (dpat). |
1995-11-14 |
2023-08-12 |
rat |
| U Freo, P Pietrini, G Pizzolato, M Furey-Kurkjian, A Merico, S Ruggero, M Dam, L Battisti. Dose-dependent effects of buspirone on behavior and cerebral glucose metabolism in rats. Brain research. vol 677. issue 2. 1995-11-14. PMID:7552245. |
whereas dpat produced an intense 5-ht syndrome, buspirone had no behavioral effect. |
1995-11-14 |
2023-08-12 |
rat |
| A B Alfieri, L X Cubedd. Comparative efficacy of a single oral dose of ondansetron and of buspirone against cisplatin-induced emesis in cancer patients. British journal of cancer. vol 72. issue 4. 1995-11-08. PMID:7547213. |
buspirone, an agonist of the 5-ht1a subtype of serotonin receptors, has shown antiemetic activity in animal models. |
1995-11-08 |
2023-08-12 |
Not clear |
| J S Lou, L Goldfarb, L McShane, P Gatev, M Hallet. Use of buspirone for treatment of cerebellar ataxia. An open-label study. Archives of neurology. vol 52. issue 10. 1995-11-08. PMID:7575226. |
to evaluate the efficacy of buspirone hydrochloride, a serotonin (5-hydroxytryptamine1a) agonist, in treating patients with cerebellar ataxia. |
1995-11-08 |
2023-08-12 |
Not clear |
| T Croci, M Landi, A Bianchetti, L Manar. Drug-induced defaecation in rats: role of central 5-HT1A receptors. British journal of pharmacology. vol 115. issue 1. 1995-09-26. PMID:7647978. |
we investigated the acute effects of 5-hydroxytryptamine (5-ht), and of the 5-ht1a receptor agonists, 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat), buspirone and sr 57746a, on rat faecal pellet output and water content. |
1995-09-26 |
2023-08-12 |
rat |
| T Croci, M Landi, A Bianchetti, L Manar. Drug-induced defaecation in rats: role of central 5-HT1A receptors. British journal of pharmacology. vol 115. issue 1. 1995-09-26. PMID:7647978. |
5-ht, 8-oh-dpat, buspirone and sr 57746a, a new selective 5-ht1a receptor agonist, displaced [3h]-8-oh-dpat from specific binding sites in rat hippocampus membranes (ki, nm; 1.8, 1.2, 15, 3.1 respectively) and stimulated rat defaecation dose-dependently. |
1995-09-26 |
2023-08-12 |
rat |
| T Croci, M Landi, A Bianchetti, L Manar. Drug-induced defaecation in rats: role of central 5-HT1A receptors. British journal of pharmacology. vol 115. issue 1. 1995-09-26. PMID:7647978. |
the putative 5-ht1a receptor antagonist, pindolol, injected s.c. or i.c.v., significantly reduced the defaecation induced by systemically administered 8-oh-dpat, buspirone or sr 57746a, but not 5-ht. |
1995-09-26 |
2023-08-12 |
rat |
| T Croci, M Landi, A Bianchetti, L Manar. Drug-induced defaecation in rats: role of central 5-HT1A receptors. British journal of pharmacology. vol 115. issue 1. 1995-09-26. PMID:7647978. |
), according to protocols designed to cause either generalized or cns-limited 5-ht depletion respectively, also reduced the defaecation induced by buspirone or sr 57746a. |
1995-09-26 |
2023-08-12 |
rat |
| Y Wada, J Shiraishi, M Nakamura, H Hasegaw. Prolonged but not acute fluoxetine administration produces its inhibitory effect on hippocampal seizures in rats. Psychopharmacology. vol 118. issue 3. 1995-08-23. PMID:7617823. |
this effect is possibly related to the well-demonstrated evidence that fluoxetine and gepirone, on long-term treatment, facilitate net 5-ht neurotransmission through desensitization of presynaptic 5-ht autoreceptors. |
1995-08-23 |
2023-08-12 |
rat |
| C Routledge, J Gurling, M A Ashworth-Preece, C T Douris. Differential effects of WAY-100135 on the decrease in 5-hydroxytryptamine release induced by buspirone and NAN-190. European journal of pharmacology. vol 276. issue 3. 1995-08-10. PMID:7601215. |
differential effects of way-100135 on the decrease in 5-hydroxytryptamine release induced by buspirone and nan-190. |
1995-08-10 |
2023-08-12 |
Not clear |
| C Routledge, J Gurling, M A Ashworth-Preece, C T Douris. Differential effects of WAY-100135 on the decrease in 5-hydroxytryptamine release induced by buspirone and NAN-190. European journal of pharmacology. vol 276. issue 3. 1995-08-10. PMID:7601215. |
1-(2-methoxyphenyl)-4-[(phthalimido)butyl] piperazine (nan-190) and 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5] decane-7,9-dione (buspirone) are 5-ht1a receptor partial agonists which decrease 5-hydroxytryptamine (5-ht) release in vivo. |
1995-08-10 |
2023-08-12 |
Not clear |
| C Routledge, J Gurling, M A Ashworth-Preece, C T Douris. Differential effects of WAY-100135 on the decrease in 5-hydroxytryptamine release induced by buspirone and NAN-190. European journal of pharmacology. vol 276. issue 3. 1995-08-10. PMID:7601215. |
nan-190 (0.1 mg/kg s.c.) and buspirone (1.0 mg/kg s.c.) significantly decreased extracellular levels of 5-ht in hippocampal dialysates. |
1995-08-10 |
2023-08-12 |
Not clear |
| C Routledge, J Gurling, M A Ashworth-Preece, C T Douris. Differential effects of WAY-100135 on the decrease in 5-hydroxytryptamine release induced by buspirone and NAN-190. European journal of pharmacology. vol 276. issue 3. 1995-08-10. PMID:7601215. |
way-100135 (10.0 mg/kg s.c.) attenuated the effect of buspirone but had no significant effect on the nan-190-induced decreased in 5-ht release. |
1995-08-10 |
2023-08-12 |
Not clear |
| C Routledge, J Gurling, M A Ashworth-Preece, C T Douris. Differential effects of WAY-100135 on the decrease in 5-hydroxytryptamine release induced by buspirone and NAN-190. European journal of pharmacology. vol 276. issue 3. 1995-08-10. PMID:7601215. |
these data demonstrate that buspirone is an agonist at the somatodendritic 5-ht1a receptor but that the inhibitory effects of nan-190 on 5-ht release may be mediated via a mechanism other than, or in addition to, 5-ht1a receptor agonism. |
1995-08-10 |
2023-08-12 |
Not clear |
| I S Ebenezer, J Brooma. Pretreatment with the 5-HT1A receptor agonists 8-OH-DPAT or gepirone does not attenuate the inhibitory effect of systemically administered cholecystokinin (CCK) on food intake in rats. Methods and findings in experimental and clinical pharmacology. vol 16. issue 8. 1995-06-26. PMID:7760584. |
in order to investigate whether the inhibitory effect of systemically administered cholecystokinin (cck) on food intake is dependent on an interaction with central 5-hydroxytryptamine (5-ht) processes, we examined the effects of pretreating rats that were deprived of food for various periods of time (22 h in experiments 1 and 3, 3 h in experiment 2, and 1 h in experiment 4) with the 5-ht1a receptor agonists, 8-oh-dpat or gepirone, on the suppression of feeding induced by intraperitoneal cck. |
1995-06-26 |
2023-08-12 |
rat |
| I S Ebenezer, J Brooma. Pretreatment with the 5-HT1A receptor agonists 8-OH-DPAT or gepirone does not attenuate the inhibitory effect of systemically administered cholecystokinin (CCK) on food intake in rats. Methods and findings in experimental and clinical pharmacology. vol 16. issue 8. 1995-06-26. PMID:7760584. |
as it has been established that the doses of 8-oh-dpat and gepirone used in this study decrease 5-ht function in the central nervous system, the present results indicate that it is unlikely that the inhibitory effect of systemically administered cck on food intake is dependent on an interaction with intact central 5-ht systems. |
1995-06-26 |
2023-08-12 |
rat |
| X O Zhu, N McNaughto. The interaction of serotonin depletion with anxiolytics and antidepressants on reticular-elicited hippocampal RSA. Neuropharmacology. vol 33. issue 12. 1995-06-26. PMID:7760982. |
rats received buspirone (10 mg/kg), chlordiazepoxide (5 mg/kg) and imipramine (30 mg/kg) after 5-ht depletion with p-chlorophenylalanine (pcpa, 100 mg/kg/day for 3 days or 350 mg/kg/day for 2 days) or after pretreatment with 5-htp (40 mg/kg, to replete 5-ht) as well as pcpa. |
1995-06-26 |
2023-08-12 |
rat |
| X O Zhu, N McNaughto. The interaction of serotonin depletion with anxiolytics and antidepressants on reticular-elicited hippocampal RSA. Neuropharmacology. vol 33. issue 12. 1995-06-26. PMID:7760982. |
these data suggest that: (1) buspirone obtains its frequency-reducing effects via pre- or post-synaptic 5-ht1a receptors rather than 5-ht1a autoreceptors; (2) chlordiazepoxide obtains its frequency-reducing effect via benzodiazepine receptors and gaba with no direct or indirect involvement of 5-ht systems; and (3) imipramine obtains its frequency-reducing effect by increasing the availability of 5-ht at 5-ht1a receptors which are not autoreceptors. |
1995-06-26 |
2023-08-12 |
rat |
| C A Naranjo, K E Bremne. Clinical pharmacology of serotonin-altering medications for decreasing alcohol consumption. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement. vol 2. 1995-06-22. PMID:7748304. |
for example, buspirone, a 5-ht1a receptor partial agonist, reduced anxiety and alcohol craving, but not ac; a 5-ht partial agonist, m-cpp, increased alcohol craving in abstinent alcoholics; modest reductions in ac were observed with a 5-ht3 antagonist, ondansetron (0.5 mg/day, but not 4 mg/day). |
1995-06-22 |
2023-08-12 |
rat |