Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
S E File, N Andrews, M al-Farhan, P Y W. The role of 5-HT in the anxiogenic effects of acute ethanol withdrawal and in the long-lasting cognitive deficits. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement. vol 2. 1995-06-22. PMID:7748345. |
the anxiogenic behaviour observed 12 h after ethanol withdrawal was inhibited by the 5-ht1a partial agonist, buspirone (200 micrograms/kg s.c.), indicating that the increased 5-ht release might underlie the anxiogenic response. |
1995-06-22 |
2023-08-12 |
rat |
H E Molewijk, A M van der Poel, J Mos, J A van der Heyden, B Olivie. Conditioned ultrasonic distress vocalizations in adult male rats as a behavioural paradigm for screening anti-panic drugs. Psychopharmacology. vol 117. issue 1. 1995-05-25. PMID:7724700. |
the triazolobenzodiazepine alprazolam, the 5-ht uptake inhibitors fluvoxamine and clomipramine, the mixed 5-ht/na uptake inhibitor imipramine, the full 5-ht1a receptor agonists 8-oh-dpat and flesinoxan, the partial 5-ht1a receptor agonists buspirone, ipsapirone and bmy 7378, the alpha 2-adrenoceptor agonist clonidine and the alpha 2-adrenoceptor antagonist yohimbine reduced conditioned usv. |
1995-05-25 |
2023-08-12 |
rat |
J E Barrett, K E Vanove. 5-HT receptors as targets for the development of novel anxiolytic drugs: models, mechanisms and future directions. Psychopharmacology. vol 112. issue 1. 1995-03-29. PMID:7870996. |
the introduction of buspirone for the treatment of anxiety, together with the eventual suggestion of a mode of action involving the serotonin (5-ht)1a receptor subtype, has generated considerable research activity and renewed interest in the potential role of 5-ht in anxiety. |
1995-03-29 |
2023-08-12 |
pigeon |
N Andrews, S E Fil. Increased 5-HT release mediates the anxiogenic response during benzodiazepine withdrawal: a review of supporting neurochemical and behavioural evidence. Psychopharmacology. vol 112. issue 1. 1995-03-29. PMID:7871006. |
other drugs that reduce 5-ht function (tianeptine which increases 5-ht uptake; buspirone, a 5-ht1a receptor agonist/partial agonist; zacopride, a 5-ht3 receptor antagonist) also reversed this anxiogenic response. |
1995-03-29 |
2023-08-12 |
rat |
G Tanda, E Carboni, R Frau, G Di Chiar. Increase of extracellular dopamine in the prefrontal cortex: a trait of drugs with antidepressant potential? Psychopharmacology. vol 115. issue 1-2. 1995-03-20. PMID:7862908. |
extracellular 5ht was increased by fluoxetine, clomipramine and imipramine but not by desipramine while 8-ohdpat and buspirone decreased it. |
1995-03-20 |
2023-08-12 |
rat |
J A Vivian, W J Farrell, S B Sapperstein, K A Micze. Diazepam withdrawal: effects of diazepam and gepirone on acoustic startle-induced 22 kHz ultrasonic vocalizations. Psychopharmacology. vol 114. issue 1. 1995-03-08. PMID:7846191. |
three experiments evaluated the association between usv and "distress" by comparing the effects of diazepam as a prototypic benzodiazepine agonist and the putative anxiolytic gepirone with affinity for 5-hydroxytryptamine (5-ht1a) receptors in naive and diazepam-withdrawn subjects. |
1995-03-08 |
2023-08-12 |
human |
J B Richards, K E Sabol, T H Hand, D C Jolly, G J Marek, L S Seide. Buspirone, gepirone, ipsapirone, and zalospirone have distinct effects on the differential-reinforcement-of-low-rate 72-s schedule when compared with 5-HTP and diazepam. Psychopharmacology. vol 114. issue 1. 1995-03-08. PMID:7846206. |
the effects of four serotonin (5-ht)-1a compounds (buspirone, gepirone, ipsapirone and zalospirone) were compared with 5-hydroxytryptophan (5-htp) [a 5-ht precursor with antidepressant (ad) efficacy], and diazepam (a benzodiazepine anxiolytic), on a differential-reinforcement-of-low-rate 72-s (drl 72-s) schedule. |
1995-03-08 |
2023-08-12 |
Not clear |
J B Richards, K E Sabol, T H Hand, D C Jolly, G J Marek, L S Seide. Buspirone, gepirone, ipsapirone, and zalospirone have distinct effects on the differential-reinforcement-of-low-rate 72-s schedule when compared with 5-HTP and diazepam. Psychopharmacology. vol 114. issue 1. 1995-03-08. PMID:7846206. |
disruption of the irt distribution by buspirone, gepirone, ipsapirone and zalospirone may result from decreased 5-ht transmission mediated by the presynaptic, somatodendritic 5-ht1a receptor. |
1995-03-08 |
2023-08-12 |
Not clear |
M Ballarín, A Carceller, X Guitar. Effect of acute administration of the 5-HT1A receptor ligand, lesopitron, on rat cortical 5-HT and dopamine turnover. British journal of pharmacology. vol 113. issue 2. 1995-03-01. PMID:7530571. |
produced a marked decrease in cortical 5-ht levels (to 20% of the basal value), but in contrast to lesopitron, buspirone produced a pronounced increase in cortical dopac (to 300% of the basal value) and hva (to 400% of the basal value) levels. |
1995-03-01 |
2023-08-12 |
rat |
F G Moeller, J L Steinberg, F Petty, M Fulton, D R Cherek, G Kramer, D L Garve. Serotonin and impulsive/aggressive behavior in cocaine dependent subjects. Progress in neuro-psychopharmacology & biological psychiatry. vol 18. issue 6. 1995-02-16. PMID:7824757. |
all subjects were also administered a buspirone neuroendocrine challenge as a measure of serotonin function. |
1995-02-16 |
2023-08-12 |
human |
N N Bogdanov, M B Bogdano. The role of 5-HT1A serotonin and D2 dopamine receptors in buspirone effects on cortical electrical activity in rats. Neuroscience letters. vol 177. issue 1-2. 1995-02-10. PMID:7824156. |
the role of 5-ht1a serotonin and d2 dopamine receptors in buspirone effects on cortical electrical activity in rats. |
1995-02-10 |
2023-08-12 |
rat |
P J McGrath, J W Stewart, F M Quitkin, S Wager, S W Jenkins, D G Archibald, J C Stringfellow, D S Robinso. Gepirone treatment of atypical depression: preliminary evidence of serotonergic involvement. Journal of clinical psychopharmacology. vol 14. issue 5. 1995-02-01. PMID:7806692. |
this is a report of a controlled trial of gepirone, a 5-hydroxytryptamine (5-ht1a) partial agonist azapirone related to buspirone, in the treatment of atypical depression. |
1995-02-01 |
2023-08-12 |
Not clear |
A Moulignie. [Central serotonin receptors. Principal fundamental and functional aspects. Therapeutic applications]. Revue neurologique. vol 150. issue 1. 1995-01-26. PMID:7801037. |
better knowledge of 5-ht receptors has already led to the development of new drugs, such as buspirone, a 5-ht1a partial agonist devoid of benzodiazepine-like properties for the treatment of generalized anxiety. |
1995-01-26 |
2023-08-12 |
Not clear |
J Strosznajder, M Samochocki, M Dura. Serotonin, a potent modulator of arachidonic acid turnover, interaction with glutamatergic receptor in brain cortex. Neurochemistry international. vol 25. issue 2. 1995-01-19. PMID:7994200. |
buspirone, an agonist of 5-ht1a receptor, has a similar effect on aa incorporation into membrane lipids as serotonin itself. |
1995-01-19 |
2023-08-12 |
Not clear |
L Lima, P Matus, M Urbin. Serotonin inhibits outgrowth of goldfish retina and impairs the trophic effect of taurine. Journal of neuroscience research. vol 38. issue 4. 1994-11-23. PMID:7523693. |
serotonin, its precursor, 5-hydroxytryptophan, and the 5ht1a receptor agonists, 8-hydroxy-2-(di-n-propylamino)tetralin and buspirone, inhibited the outgrowth. |
1994-11-23 |
2023-08-12 |
Not clear |
O L Baughma. Rapid diagnosis and treatment of anxiety and depression in primary care: the somatizing patient. The Journal of family practice. vol 39. issue 4. 1994-11-04. PMID:7931117. |
selective serotonin reuptake inhibitors have proved extremely effective in the treatment of major depression, and buspirone has excellent efficacy for the management of generalized anxiety disorder. |
1994-11-04 |
2023-08-12 |
Not clear |
C J McDougle, W K Goodman, L H Pric. Dopamine antagonists in tic-related and psychotic spectrum obsessive compulsive disorder. The Journal of clinical psychiatry. vol 55 Suppl. 1994-10-03. PMID:7521326. |
the addition of drugs that enhance serotonin (5-ht) neurotransmission, such as lithium and buspirone, to ongoing treatment in sui-refractory patients has generally proved to be an ineffective strategy. |
1994-10-03 |
2023-08-12 |
Not clear |
K J Weis. Management of anxiety and depression syndromes in the elderly. The Journal of clinical psychiatry. vol 55 Suppl. 1994-09-30. PMID:7915714. |
once the threshold is reached for drug therapy, there are safe and effective remedies, including azapirones, short-acting benzodiazepines, serotonin reuptake inhibitors, and others. |
1994-09-30 |
2023-08-12 |
Not clear |
T R Norman, M Apostolopoulos, G D Burrows, F K Jud. Neuroendocrine responses to single doses of buspirone in obsessive-compulsive disorder. International clinical psychopharmacology. vol 9. issue 2. 1994-09-15. PMID:8056999. |
prolactin and cortisol responses to buspirone, a partial serotonin agonist with effects on the 5-ht1a receptor, were measured in 16 patients with dsm-iii-r obsessive-compulsive disorder (ocd) and 16 normal controls. |
1994-09-15 |
2023-08-12 |
Not clear |
Y Mizuki, M Suetsugi, I Ushijima, M Yamad. Characteristics of the anxiolytic effects of buspirone in high- and low-anxious normal humans assessed by frontal midline theta activity. Methods and findings in experimental and clinical pharmacology. vol 16. issue 4. 1994-09-02. PMID:7519702. |
in the fmtheta group, buspirone dose-dependently produced a decrease in plasma 5-ht and 5-hiaa concentrations and in state anxiety scores and an increase in fmtheta amounts. |
1994-09-02 |
2023-08-12 |
human |