| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yusuke Murata, Yuki Yanagihara, Masayoshi Mori, Kazunori Mine, Munechika Enjoj. Chronic treatment with tandospirone, a serotonin 1A receptor partial agonist, inhibits psychosocial stress-induced changes in hippocampal neurogenesis and behavior. Journal of affective disorders. vol 180. 2015-11-11. PMID:25879718. |
chronic treatment with tandospirone, a serotonin 1a receptor partial agonist, inhibits psychosocial stress-induced changes in hippocampal neurogenesis and behavior. |
2015-11-11 |
2023-08-13 |
Not clear |
| O S Levi. [The use of buspirone in clinical practice]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 115. issue 4. 2015-11-06. PMID:26288293. |
buspirone, a nonbenzodiasepine anxiolytic, is a partial serotonin 5-ht1a-receptor agonist, d2-autoreceptor antagonist and low affinity 5-ht2-receptor agonist. |
2015-11-06 |
2023-08-13 |
Not clear |
| Luciana Romina Frick, Micaela Bernardez-Vidal, Christian Hocht, Bonifacio Silvano Zanutto, Maximiliano Rapanell. Dual role of serotonin in the acquisition and extinction of reward-driven learning: involvement of 5-HT1A, 5-HT2A and 5-HT3 receptors. Behavioural brain research. vol 277. 2015-09-08. PMID:24949809. |
long evans rats were trained in an operant conditioning task while receiving fluoxetine (serotonin reuptake inhibitor, 10mg/kg), tianeptine (serotonin reuptake enhancer, 10mg/kg), buspirone (5-ht1a partial agonist, 10mg/kg), risperidone (5-ht2a antagonist, 1mg/kg), ondansetron (5-ht3 antagonist, 2mg/kg) or vehicle. |
2015-09-08 |
2023-08-13 |
rat |
| Ahmad Ghanizadeh, Anaheed Ayoobzadehshiraz. A randomized double-blind placebo-controlled clinical trial of adjuvant buspirone for irritability in autism. Pediatric neurology. vol 52. issue 1. 2015-08-24. PMID:25451017. |
buspirone is a 5-ht(1a) receptor agonist with antiaggressive effects increasing prosocial behaviors. |
2015-08-24 |
2023-08-13 |
Not clear |
| Darakhshan Jabeen Haleem, Huma Ikram, Muhammad Abdul Halee. Inhibition of apomorphine-induced conditioned place preference in rats co-injected with buspirone: relationship with serotonin and dopamine in the striatum. Brain research. vol 1586. 2015-06-02. PMID:25160128. |
inhibition of apomorphine-induced conditioned place preference in rats co-injected with buspirone: relationship with serotonin and dopamine in the striatum. |
2015-06-02 |
2023-08-13 |
rat |
| Darakhshan Jabeen Haleem, Huma Ikram, Muhammad Abdul Halee. Inhibition of apomorphine-induced conditioned place preference in rats co-injected with buspirone: relationship with serotonin and dopamine in the striatum. Brain research. vol 1586. 2015-06-02. PMID:25160128. |
the levels of serotonin and its metabolite are decreased in the caudate as well as nucleus accumbens of rats exhibiting cpp and the decreases do not occur in animals co-injected with low or higher dose of buspirone. |
2015-06-02 |
2023-08-13 |
rat |
| Darakhshan Jabeen Haleem, Huma Ikram, Muhammad Abdul Halee. Inhibition of apomorphine-induced conditioned place preference in rats co-injected with buspirone: relationship with serotonin and dopamine in the striatum. Brain research. vol 1586. 2015-06-02. PMID:25160128. |
the findings suggest a critical role of serotonin in the rewarding effects of apomorphine and imply that co-use of buspirone at low doses can help to control addictive syndromes in parkinson׳s disease patients on apomorphine therapy. |
2015-06-02 |
2023-08-13 |
rat |
| Koen Demyttenaer. Agomelatine in treating generalized anxiety disorder. Expert opinion on investigational drugs. vol 23. issue 6. 2015-01-20. PMID:24766542. |
many drug and non-drug treatments have been shown to be effective in the treatment of gad, including benzodiazepines, antidepressants (selective serotonin reuptake inhibitors, serotonin noradrenaline reuptake inhibitors and tricyclic antidepressants), anticonvulsants, azapirones, antihistamines, atypical antipsychotics, complementary/alternative medicine, psychotherapy and internet-based services. |
2015-01-20 |
2023-08-13 |
Not clear |
| Simona Bertoni, Valentina Arcaro, Valentina Vivo, Alberto Rapalli, Massimiliano Tognolini, Anna Maria Cantoni, Francesca Saccani, Lisa Flammini, Giuseppe Domenichini, Vigilio Ballabeni, Elisabetta Barocell. Suppression of inflammatory events associated to intestinal ischemia-reperfusion by 5-HT1A blockade in mice. Pharmacological research. vol 81. 2014-12-15. PMID:24548822. |
second, the effects produced by intravenous administration of 5-ht1a ligands (partial agonist buspirone 10mgkg(-1), antagonist way100135 0.5-5mgkg(-1)), 5-ht2a antagonist sarpogrelate (10mgkg(-1)), 5-ht3 antagonist alosetron (0.1mgkg(-1)), 5-ht4 antagonist gr125487 (5mgkg(-1)) and 5-ht re-uptake inhibitor fluoxetine (10mgkg(-1)) on i/r-induced inflammatory response were investigated in i/r mice and compared to those obtained in sham-operated animals (s). |
2014-12-15 |
2023-08-12 |
mouse |
| Vasilios G Masdrakis, Darko Turic, David S Baldwi. Pharmacological treatment of social anxiety disorder. Modern trends in pharmacopsychiatry. vol 29. 2014-10-23. PMID:25225024. |
augmentation of a selective serotonin reuptake inhibitor with buspirone or clonazepam can be beneficial. |
2014-10-23 |
2023-08-13 |
Not clear |
| R H McAllister-Williams, H A Alhaj, A Massey, J Pankiv, U Reckerman. Somatodendritic 5-hydroxytryptamine1A (5-HT1A) autoreceptor function in major depression as assessed using the shift in electroencephalographic frequency spectrum with buspirone. Psychological medicine. vol 44. issue 4. 2014-10-22. PMID:23809646. |
the current study examined the effect of buspirone on the electroencephalographic (eeg) centroid frequency, a putative index of somatodendritic 5-ht(1a) receptor functional status, in a cohort of medication-free depressed patients and controls. |
2014-10-22 |
2023-08-12 |
Not clear |
| Herbert Y Meltzer, Lakshmi Rajagopal, Mei Huang, Yoshihiro Oyamada, Sunoh Kwon, Masakuni Horiguch. Translating the N-methyl-D-aspartate receptor antagonist model of schizophrenia to treatments for cognitive impairment in schizophrenia. The international journal of neuropsychopharmacology. vol 16. issue 10. 2014-07-01. PMID:24099265. |
the ability of sub-effective doses of the atypical apds to ameliorate nor in the scnmdar-treated rodents can be restored by the addition of a sub-effective dose of the 5-ht(1a) partial agonist, tandospirone, or the 5-ht7 antagonist, sb269970. |
2014-07-01 |
2023-08-12 |
human |
| Takashi Uehara, Tadasu Matsuoka, Hiroko Itoh, Tomiki Sumiyosh. Chronic treatment with tandospirone, a 5-HT(1A) receptor partial agonist, suppresses footshock stress-induced lactate production in the prefrontal cortex of rats. Pharmacology, biochemistry, and behavior. vol 113. 2014-06-23. PMID:24125783. |
chronic treatment with tandospirone, a 5-ht(1a) receptor partial agonist, suppresses footshock stress-induced lactate production in the prefrontal cortex of rats. |
2014-06-23 |
2023-08-12 |
rat |
| Louis F Fabre, Cees J Timme. Effects of food on the bioavailability of gepirone from extended-release tablets in humans: results of two open-label crossover studies. Current therapeutic research, clinical and experimental. vol 64. issue 8. 2014-06-19. PMID:24944406. |
the new antidepressant gepirone acts preferentially on 5-hydroxytryptamine type 1a (5-ht1a) receptors and functions as a 5-ht1a agonist. |
2014-06-19 |
2023-08-13 |
Not clear |
| Raymond W La. Generalized anxiety disorder: how to treat, and for how long? International journal of psychiatry in clinical practice. vol 10 Suppl 1. 2014-06-17. PMID:24931538. |
in placebo-controlled, acute (<8 weeks) trials, several medications, including the selective serotonin reuptake inhibitors ([ssris] escitalopram, paroxetine, and sertraline) and others (venlafaxine, buspirone, pregabalin), have demonstrated efficacy in patients with gad. |
2014-06-17 |
2023-08-13 |
Not clear |
| David S Baldwi. Serotonin noradrenaline reuptake inhibitors: A new generation of treatment for anxiety disorders. International journal of psychiatry in clinical practice. vol 10 Suppl 2. 2014-06-14. PMID:24921677. |
the probable role of disturbed serotonergic neurotransmission in anxiety is widely accepted and is the theoretical basis for the use of serotonergic agents such as the 5-ht1a receptor partial agonist, buspirone, and the selective serotonin reuptake inhibitors (ssri), such as sertraline and paroxetine, which have largely replaced the earlier antidepressants. |
2014-06-14 |
2023-08-13 |
Not clear |
| Nancy K Mello, Peter A Fivel, Stephen J Kohu. Effects of chronic buspirone treatment on nicotine and concurrent nicotine+cocaine self-administration. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 7. 2014-01-24. PMID:23337868. |
buspirone (buspar) is a clinically available, non-benzodiazepine anxiolytic medication that acts on serotonin and dopamine systems. |
2014-01-24 |
2023-08-12 |
monkey |
| Mir Mazhar, Tariq Hassan, Tariq Munsh. Treatment of anxiety disorders and comorbid alcohol abuse with buspirone in a patient with antidepressant-induced platelet dysfunction: a case report. Case reports in psychiatry. vol 2013. 2014-01-13. PMID:24416612. |
buspirone is unlikely to have a significant effect on platelet serotonin transponder and could be an effective alternative for pharmacological treatment of anxiety in patients with a bleeding diathesis. |
2014-01-13 |
2023-08-12 |
Not clear |
| Caio Maximino, Bruna Puty, Rancés Benzecry, Juliana Araújo, Monica Gomes Lima, Evander de Jesus Oliveira Batista, Karen Renata de Matos Oliveira, Maria Elena Crespo-Lopez, Anderson Manoel Herculan. Role of serotonin in zebrafish (Danio rerio) anxiety: relationship with serotonin levels and effect of buspirone, WAY 100635, SB 224289, fluoxetine and para-chlorophenylalanine (pCPA) in two behavioral models. Neuropharmacology. vol 71. 2014-01-10. PMID:23541719. |
role of serotonin in zebrafish (danio rerio) anxiety: relationship with serotonin levels and effect of buspirone, way 100635, sb 224289, fluoxetine and para-chlorophenylalanine (pcpa) in two behavioral models. |
2014-01-10 |
2023-08-12 |
zebrafish |
| Carly Kiselycznyk, Xiaoqun Zhang, Richard L Huganir, Andrew Holmes, Per Svenningsso. Reduced phosphorylation of GluA1 subunits relates to anxiety-like behaviours in mice. The international journal of neuropsychopharmacology. vol 16. issue 4. 2013-12-27. PMID:23360771. |
here we investigate how two distinct anxiolytic agents, buspirone, a partial 5-ht(1a) agonist, and diazepam, a benzodiazepine, influence phosphorylation of glua1 subunits of ampa receptors at the potentiating residue ser(845) and ser(831) in corticolimbic regions. |
2013-12-27 |
2023-08-12 |
mouse |