| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Louis F Fabre, Anita H Clayton, Louis C Smith, Irwin Goldstein, Leonard R Derogati. The effect of gepirone-ER in the treatment of sexual dysfunction in depressed men. The journal of sexual medicine. vol 9. issue 3. 2012-06-18. PMID:22240272. |
gepirone extended release (gepirone-er) differs from the ssris in only affecting the 5-ht(1a) receptor and has demonstrated efficacy in treatment of depression and sexual dysfunction in depressed women. |
2012-06-18 |
2023-08-12 |
Not clear |
| Małgorzata Jarończyk, Karol Wołosewicz, Mari Gabrielsen, Gabriel Nowak, Irina Kufareva, Aleksander P Mazurek, Aina W Ravna, Ruben Abagyan, Andrzej J Bojarski, Ingebrigt Sylte, Zdzisław Chilmonczy. Synthesis, in vitro binding studies and docking of long-chain arylpiperazine nitroquipazine analogues, as potential serotonin transporter inhibitors. European journal of medicinal chemistry. vol 49. 2012-06-12. PMID:22309909. |
it is well known that 6-nitroquipazine exhibits about 150-fold higher affinity for the serotonin transporter (sert) than quipazine and recently we showed quipazine buspirone analogues with high to moderate sert affinity. |
2012-06-12 |
2023-08-12 |
human |
| Huma Ikram, Darakhshan Jabeen Halee. Attenuation of apomorphine-induced sensitization by buspirone. Pharmacology, biochemistry, and behavior. vol 99. issue 3. 2012-05-16. PMID:21530573. |
repeated administration of buspirone attenuates the effectiveness of somatodendritic 5-ht(1a) receptors. |
2012-05-16 |
2023-08-12 |
Not clear |
| Huma Ikram, Darakhshan Jabeen Halee. Attenuation of apomorphine-induced sensitization by buspirone. Pharmacology, biochemistry, and behavior. vol 99. issue 3. 2012-05-16. PMID:21530573. |
it is suggested that buspirone may oppose the development of sensitization to apomorphine by decreasing the sensitivity of somatodendritic 5-ht(1a) receptors. |
2012-05-16 |
2023-08-12 |
Not clear |
| Valérie Guille, Andrea Gogos, Pradeep J Nathan, Rodney J Croft, Maarten van den Buus. Interaction of estrogen with central serotonergic mechanisms in human sensory processing: loudness dependence of the auditory evoked potential and mismatch negativity. Journal of psychopharmacology (Oxford, England). vol 25. issue 12. 2012-04-26. PMID:20562170. |
we examined the effects of estrogen pre-treatment on modulation of loudness dependence of the auditory evoked potential (ldaep) and mismatch negativity by the 5-ht(1a) receptor partial agonist, buspirone. |
2012-04-26 |
2023-08-12 |
human |
| Takahisa Kawano, Takayuki Kosuge, Shunsuke Takagi, Akira Shimoyama, Nobuyuki Harunari, Yoshio Tahara, Noriyuki Suzuk. [First death case of serotonin syndrome in Japan induced by fluvoxamine and tandospirone]. Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology. vol 24. issue 4. 2012-04-24. PMID:22338341. |
[first death case of serotonin syndrome in japan induced by fluvoxamine and tandospirone]. |
2012-04-24 |
2023-08-12 |
Not clear |
| Takahisa Kawano, Takayuki Kosuge, Shunsuke Takagi, Akira Shimoyama, Nobuyuki Harunari, Yoshio Tahara, Noriyuki Suzuk. [First death case of serotonin syndrome in Japan induced by fluvoxamine and tandospirone]. Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology. vol 24. issue 4. 2012-04-24. PMID:22338341. |
we experienced the first death case of the serotonin syndrome in japan caused by fluvoxamine and tandospirone. |
2012-04-24 |
2023-08-12 |
Not clear |
| Leigh Miles, Michael Davis, David Walke. Phasic and sustained fear are pharmacologically dissociable in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 8. 2012-03-22. PMID:21471958. |
before testing, rats received a single injection of vehicle, the benzodiazepine chlordiazepoxide, the 5ht(1a) agonist and dopamine d2 antagonist buspirone, the selective serotonin reuptake inhibitor fluoxetine, or a 3-week treatment with either vehicle or fluoxetine. |
2012-03-22 |
2023-08-12 |
human |
| Javad Mahmoudi, Alireza Mohajjel Nayebi, Morteza Samini, Siamak Reyhani-Rad, Vahab Babapou. Buspirone improves the anti-cataleptic effect of levodopa in 6-hydroxydopamine-lesioned rats. Pharmacological reports : PR. vol 63. issue 4. 2012-02-10. PMID:22001978. |
furthermore, the effect of buspirone (0.5 mg/kg, ip) on the anti-cataleptic effect of l-dopa (15 mg/kg, ip) was reversed by 1-(2-methoxyphenyl)-4-(4-phthalimidobutyl)piperazine hydrobromide (nan-190; 0.5 mg/kg, ip), a 5-ht(1a) receptor antagonist. |
2012-02-10 |
2023-08-12 |
rat |
| Javad Mahmoudi, Alireza Mohajjel Nayebi, Morteza Samini, Siamak Reyhani-Rad, Vahab Babapou. Buspirone improves the anti-cataleptic effect of levodopa in 6-hydroxydopamine-lesioned rats. Pharmacological reports : PR. vol 63. issue 4. 2012-02-10. PMID:22001978. |
from these results, it may be concluded that buspirone improves the anti-cataleptic effect of l-dopa in a 6-ohda-induced animal model of pd through the activation of 5-ht(1a) receptors. |
2012-02-10 |
2023-08-12 |
rat |
| Janaina M Zanoveli, Roger L H Pobbe, Valquiria C de Bortoli, Milene C Carvalho, Marcus L Brandão, Helio Zangross. Facilitation of 5-HT1A-mediated neurotransmission in dorsal periaqueductal grey matter accounts for the panicolytic-like effect of chronic fluoxetine. The international journal of neuropsychopharmacology. vol 13. issue 8. 2011-12-19. PMID:19941697. |
as a comparison, the effect of chronic treatment with the anxiolytic 5-ht(1a) receptor agonist buspirone on dpag 5-ht levels was assessed. |
2011-12-19 |
2023-08-12 |
rat |
| Lydia Günther, Julia Rothe, André Rex, Jörg-Peter Voigt, Mark J Millan, Heidrun Fink, Bettina Ber. 5-HT(1A)-receptor over-expressing mice: genotype and sex dependent responses to antidepressants in the forced swim-test. Neuropharmacology. vol 61. issue 3. 2011-10-14. PMID:21419787. |
furthermore, we investigated their response to the serotonin selective reuptake inhibitor (ssri) citalopram in comparison to the selective noradrenaline reuptake inhibitor reboxetine, as well as the partial 5-ht(1a)-receptor agonists, buspirone and s 15535. |
2011-10-14 |
2023-08-12 |
mouse |
| S Kawana, Y Kato, T Om. Efficacy of a 5-HT1a receptor agonist in atopic dermatitis. Clinical and experimental dermatology. vol 35. issue 8. 2011-04-14. PMID:20089082. |
we recently showed that pretreatment with tandospirone citrate (tc), a serotonin (5-ht) agonist for the 5-ht(1a) receptor subtype, significantly inhibits stress-induced degranulation of mouse dermal mast cells. |
2011-04-14 |
2023-08-12 |
mouse |
| Denis Boulay, Ronan Depoortere, Caroline Louis, Martine Lacave, Marie Thérèse Lucas, Guy Griebe. SSR181507, a dopamine D₂ receptor and 5-HT(₁A) receptor ligand: evidence for mixed anxiolytic- and antidepressant-like activities. Pharmacology, biochemistry, and behavior. vol 97. issue 3. 2011-04-11. PMID:20920519. |
ssr181507 also reduced uv (0.3 & 1 mg/kg ip), an effect not reversed by sl88.0338, and observed with olanzapine, haloperidol, fluoxetine and the 5-ht(₁a) receptor agonists 8-oh-dpat and buspirone, but not diazepam. |
2011-04-11 |
2023-08-12 |
human |
| Abd El-Galil E Amr, Mohamed H Sherif, Mohamed G Assy, Mohamed A Al-Omar, Islam Raga. Antiarrhythmic, serotonin antagonist and antianxiety activities of novel substituted thiophene derivatives synthesized from 2-amino-4,5,6,7-tetrahydro-N-phenylbenzo[b]thiophene-3-carboxamide. European journal of medicinal chemistry. vol 45. issue 12. 2011-03-07. PMID:20950897. |
all the compounds were screened for their antiarrhythmic, serotonin antagonist and antianexiety activities and they showed high activity compared with procaine amide, lidocaine, diazepam and buspirone as positive controls. |
2011-03-07 |
2023-08-12 |
Not clear |
| D F Avgustinovich, G B Vishnivetskaya, L A Koryakin. Effect of acute and chronic buspirone administration on communicativeness of mice with experience of defeats in social conflicts. Bulletin of experimental biology and medicine. vol 149. issue 1. 2011-03-02. PMID:21113459. |
we studied the effect of 5-ht(1a)receptor agonist buspirone on behavior of male c57bl/6j mice in the "partition" test, which reflects communicativeness of animals. |
2011-03-02 |
2023-08-12 |
mouse |
| Georgianna G Gould, Julie G Hensler, Teresa F Burke, Robert H Benno, Emmanuel S Onaivi, Lynette C Daw. Density and function of central serotonin (5-HT) transporters, 5-HT1A and 5-HT2A receptors, and effects of their targeting on BTBR T+tf/J mouse social behavior. Journal of neurochemistry. vol 116. issue 2. 2011-01-20. PMID:21070242. |
in btbr mice, the sert blocker, fluoxetine (10 mg/kg) and the 5-ht(1a) receptor partial-agonist, buspirone (2 mg/kg) enhanced social interactions. |
2011-01-20 |
2023-08-12 |
mouse |
| Hiroki Sato, Ivan Skelin, Mirko Diksi. Chronic buspirone treatment decreases 5-HT1B receptor densities and the serotonin transporter but increases the density of 5-HT2A receptors in the bulbectomized rat model of depression: an autoradiographic study. Brain research. vol 1345. 2010-10-21. PMID:20501324. |
chronic buspirone treatment decreases 5-ht1b receptor densities and the serotonin transporter but increases the density of 5-ht2a receptors in the bulbectomized rat model of depression: an autoradiographic study. |
2010-10-21 |
2023-08-12 |
rat |
| Hiroki Sato, Ivan Skelin, Mirko Diksi. Chronic buspirone treatment decreases 5-HT1B receptor densities and the serotonin transporter but increases the density of 5-HT2A receptors in the bulbectomized rat model of depression: an autoradiographic study. Brain research. vol 1345. 2010-10-21. PMID:20501324. |
buspirone is a partial agonist of 5-ht(1a) receptors and is used in the treatment of depression and anxiety. |
2010-10-21 |
2023-08-12 |
rat |
| Hiroki Sato, Ivan Skelin, Mirko Diksi. Chronic buspirone treatment decreases 5-HT1B receptor densities and the serotonin transporter but increases the density of 5-HT2A receptors in the bulbectomized rat model of depression: an autoradiographic study. Brain research. vol 1345. 2010-10-21. PMID:20501324. |
the aim of this study was to assess, in obx rats and sham operated controls, the effect of chronic buspirone treatment on the densities of 5-ht(2a) and 5-ht(1b) receptors, as well as the 5-ht transporter (5-htt), which are all important mediators of 5-ht transmission. |
2010-10-21 |
2023-08-12 |
rat |