| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michal Tzadok, Shimrit Uliel-Siboni, Ilan Linder, Uri Kramer, Orna Epstein, Shay Menascu, Andrea Nissenkorn, Omer Bar Yosef, Eli Hyman, Dorit Granot, Michael Dor, Tali Lerman-Sagie, Bruria Ben-Zee. CBD-enriched medical cannabis for intractable pediatric epilepsy: The current Israeli experience. Seizure. vol 35. 2016-12-13. PMID:26800377. |
to describe the experience of five israeli pediatric epilepsy clinics treating children and adolescents diagnosed as having intractable epilepsy with a regimen of medical cannabis oil. |
2016-12-13 |
2023-08-13 |
Not clear |
| Alberto Verrotti, Miriam Castagnino, Mauro Maccarrone, Filomena Fezz. Plant-Derived and Endogenous Cannabinoids in Epilepsy. Clinical drug investigation. vol 36. issue 5. 2016-12-13. PMID:26892745. |
the aim of this review was to analyze the efficacy of cannabis in the treatment of epilepsy in adults and children. |
2016-12-13 |
2023-08-13 |
human |
| Alberto Verrotti, Miriam Castagnino, Mauro Maccarrone, Filomena Fezz. Plant-Derived and Endogenous Cannabinoids in Epilepsy. Clinical drug investigation. vol 36. issue 5. 2016-12-13. PMID:26892745. |
several anecdotal reports and clinical trials suggest that in the human population cannabis has anticonvulsant properties and could be effective in treating partial epilepsies and generalized tonic-clonic seizures, still known as "grand mal." |
2016-12-13 |
2023-08-13 |
human |
| Alberto Verrotti, Miriam Castagnino, Mauro Maccarrone, Filomena Fezz. Plant-Derived and Endogenous Cannabinoids in Epilepsy. Clinical drug investigation. vol 36. issue 5. 2016-12-13. PMID:26892745. |
they are based, among other factors, on the observation that in individuals who smoke marijuana to treat epilepsy, cessation of cannabis use precipitates the re-emergence of convulsive seizures, whereas resuming consumption of this psychotropic drug controls epilepsy in a reproducible manner. |
2016-12-13 |
2023-08-13 |
human |
| Alberto Verrotti, Miriam Castagnino, Mauro Maccarrone, Filomena Fezz. Plant-Derived and Endogenous Cannabinoids in Epilepsy. Clinical drug investigation. vol 36. issue 5. 2016-12-13. PMID:26892745. |
in conclusion, there is some anecdotal evidence for the potential efficacy of cannabis in treating epilepsy. |
2016-12-13 |
2023-08-13 |
human |
| James S Brodie, Vincenzo Di Marzo, Geoffrey W Gu. Polypharmacology Shakes Hands with Complex Aetiopathology. Trends in pharmacological sciences. vol 36. issue 12. 2016-10-24. PMID:26434643. |
indeed, two combined cannabis extracts were approved as a single medicine (sativex(®)), while pure cannabidiol, a multitarget cannabinoid, is emerging as a treatment for paediatric drug-resistant epilepsy. |
2016-10-24 |
2023-08-13 |
Not clear |
| Barry E Gida. Cannabidiol and Epilepsy: Sifting, Winnowing and Buzz. Epilepsy currents. vol 16. issue 4. 2016-09-01. PMID:27582660. |
cannabidiol and epilepsy: sifting, winnowing and buzz. |
2016-09-01 |
2023-08-13 |
Not clear |
| Christopher P Stanley, William H Hind, Cristina Tufarelli, Saoirse E O'Sulliva. Cannabidiol causes endothelium-dependent vasorelaxation of human mesenteric arteries via CB1 activation. Cardiovascular research. vol 107. issue 4. 2016-08-16. PMID:26092099. |
the protective effects of cannabidiol (cbd) have been widely shown in preclinical models and have translated into medicines for the treatment of multiple sclerosis and epilepsy. |
2016-08-16 |
2023-08-13 |
human |
| Kamil Detyniecki, Lawrence J Hirsc. Cannabidiol for epilepsy: trying to see through the haze. The Lancet. Neurology. vol 15. issue 3. 2016-08-10. PMID:26776916. |
cannabidiol for epilepsy: trying to see through the haze. |
2016-08-10 |
2023-08-13 |
Not clear |
| Orrin Devinsky, Eric Marsh, Daniel Friedman, Elizabeth Thiele, Linda Laux, Joseph Sullivan, Ian Miller, Robert Flamini, Angus Wilfong, Francis Filloux, Matthew Wong, Nicole Tilton, Patricia Bruno, Judith Bluvstein, Julie Hedlund, Rebecca Kamens, Jane Maclean, Srishti Nangia, Nilika Shah Singhal, Carey A Wilson, Anup Patel, Maria Roberta Cili. Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial. The Lancet. Neurology. vol 15. issue 3. 2016-08-09. PMID:26724101. |
cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial. |
2016-08-09 |
2023-08-13 |
Not clear |
| Orrin Devinsky, Eric Marsh, Daniel Friedman, Elizabeth Thiele, Linda Laux, Joseph Sullivan, Ian Miller, Robert Flamini, Angus Wilfong, Francis Filloux, Matthew Wong, Nicole Tilton, Patricia Bruno, Judith Bluvstein, Julie Hedlund, Rebecca Kamens, Jane Maclean, Srishti Nangia, Nilika Shah Singhal, Carey A Wilson, Anup Patel, Maria Roberta Cili. Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial. The Lancet. Neurology. vol 15. issue 3. 2016-08-09. PMID:26724101. |
we aimed to establish whether addition of cannabidiol to existing anti-epileptic regimens would be safe, tolerated, and efficacious in children and young adults with treatment-resistant epilepsy. |
2016-08-09 |
2023-08-13 |
Not clear |
| Evan C Rosenberg, Richard W Tsien, Benjamin J Whalley, Orrin Devinsk. Cannabinoids and Epilepsy. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 12. issue 4. 2016-07-22. PMID:26282273. |
in this study, we review current understanding of the endocannabinoid system, characterize the pro- and anticonvulsive effects of cannabinoids [e.g., Δ9-tetrahydrocannabinol and cannabidiol (cbd)], and highlight scientific evidence from pre-clinical and clinical trials of cannabinoids in epilepsy. |
2016-07-22 |
2023-08-13 |
Not clear |
| Doodipala Samba Reddy, Victoria M Golu. The Pharmacological Basis of Cannabis Therapy for Epilepsy. The Journal of pharmacology and experimental therapeutics. vol 357. issue 1. 2016-07-19. PMID:26787773. |
the pharmacological basis of cannabis therapy for epilepsy. |
2016-07-19 |
2023-08-13 |
Not clear |
| Doodipala Samba Reddy, Victoria M Golu. The Pharmacological Basis of Cannabis Therapy for Epilepsy. The Journal of pharmacology and experimental therapeutics. vol 357. issue 1. 2016-07-19. PMID:26787773. |
claims of clinical efficacy in epilepsy of cbd-predominant cannabis or medical marijuana come mostly from limited studies, surveys, or case reports. |
2016-07-19 |
2023-08-13 |
Not clear |
| Doodipala Samba Reddy, Victoria M Golu. The Pharmacological Basis of Cannabis Therapy for Epilepsy. The Journal of pharmacology and experimental therapeutics. vol 357. issue 1. 2016-07-19. PMID:26787773. |
this article highlights the pharmacological basis of cannabis therapy, with an emphasis on the endocannabinoid mechanisms underlying the emerging neurotherapeutics of cbd in epilepsy. |
2016-07-19 |
2023-08-13 |
Not clear |
| Dana Ekstei. Issues and promise in clinical studies of botanicals with anticonvulsant potential. Epilepsy & behavior : E&B. vol 52. issue Pt B. 2016-07-18. PMID:26341963. |
although the currently available evidence for the use of cannabinoids in epilepsy is similarly lacking, several carefully designed and well controlled industry-sponsored clinical trials of cannabis derivatives are planned to be completed in the next couple of years, providing the needed reliable data for the use of these products. |
2016-07-18 |
2023-08-13 |
human |
| Lady Diana Ladino, Lizbeth Hernández-Ronquillo, José Francisco Téllez-Zenten. Medicinal marijuana for epilepsy: a case series study. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. vol 41. issue 6. 2016-07-06. PMID:25377755. |
medicinal marijuana for epilepsy: a case series study. |
2016-07-06 |
2023-08-13 |
Not clear |
| Murali K Kolikonda, Kavitha Srinivasan, Manasa Enja, Vishwanath Sagi, Steven Lippman. Medical Marijuana for Epilepsy? Innovations in clinical neuroscience. vol 13. issue 3-4. 2016-06-29. PMID:27354925. |
medical marijuana for epilepsy? |
2016-06-29 |
2023-08-13 |
Not clear |
| Murali K Kolikonda, Kavitha Srinivasan, Manasa Enja, Vishwanath Sagi, Steven Lippman. Medical Marijuana for Epilepsy? Innovations in clinical neuroscience. vol 13. issue 3-4. 2016-06-29. PMID:27354925. |
there is clinical evidence of success in diminishing seizure frequencies with cannabis derivatives, but also documentation about exacerbating epilepsy or of no discernible effect. |
2016-06-29 |
2023-08-13 |
Not clear |
| Natalia Brzozowska, Kong M Li, Xiao Suo Wang, Jessica Booth, Jordyn Stuart, Iain S McGregor, Jonathon C Arnol. ABC transporters P-gp and Bcrp do not limit the brain uptake of the novel antipsychotic and anticonvulsant drug cannabidiol in mice. PeerJ. vol 4. 2016-06-03. PMID:27257556. |
cannabidiol (cbd) is currently being investigated as a novel therapeutic for the treatment of cns disorders like schizophrenia and epilepsy. |
2016-06-03 |
2023-08-13 |
mouse |