| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brooke N Bender, Sierra J Stringfield, Mary M Torregross. Changes in dorsomedial striatum activity mediate expression of goal-directed vs. habit-like cue-induced cocaine seeking. bioRxiv : the preprint server for biology. 2023-08-07. PMID:37546826. |
changes in dorsomedial striatum activity mediate expression of goal-directed vs. habit-like cue-induced cocaine seeking. |
2023-08-07 |
2023-08-14 |
rat |
| Brooke N Bender, Sierra J Stringfield, Mary M Torregross. Changes in dorsomedial striatum activity mediate expression of goal-directed vs. habit-like cue-induced cocaine seeking. bioRxiv : the preprint server for biology. 2023-08-07. PMID:37546826. |
a preclinical model of cue exposure therapy, cue extinction, reduces cue-induced cocaine seeking when drug seeking is goal-directed but not habitual. |
2023-08-07 |
2023-08-14 |
rat |
| Brooke N Bender, Sierra J Stringfield, Mary M Torregross. Changes in dorsomedial striatum activity mediate expression of goal-directed vs. habit-like cue-induced cocaine seeking. bioRxiv : the preprint server for biology. 2023-08-07. PMID:37546826. |
we used fiber photometry to examine how dorsal striatal intracellular calcium and extracellular dopamine activity differs between goal-directed and habitual cue-induced cocaine seeking and how it is impacted by cue extinction. |
2023-08-07 |
2023-08-14 |
rat |
| Brooke N Bender, Sierra J Stringfield, Mary M Torregross. Changes in dorsomedial striatum activity mediate expression of goal-directed vs. habit-like cue-induced cocaine seeking. bioRxiv : the preprint server for biology. 2023-08-07. PMID:37546826. |
rats trained to self-administer cocaine paired with an audiovisual cue on schedules of reinforcement that promote goal-directed or habitual cocaine seeking had different patterns of dorsal striatal calcium and dopamine responses to cue-reinforced lever presses. |
2023-08-07 |
2023-08-14 |
rat |
| Bradley O Jones, Morgan S Paladino, Adelis M Cruz, Haley F Spencer, Payton L Kahanek, Lauren N Scarborough, Sandra F Georges, Rachel J Smit. Punishment resistance for cocaine is associated with inflexible habits in rats. bioRxiv : the preprint server for biology. 2023-06-19. PMID:37333299. |
we sought to test the hypothesis that punishment resistance arises from failure to exert goal-directed control over habitual cocaine seeking. |
2023-06-19 |
2023-08-14 |
rat |
| Bradley O Jones, Morgan S Paladino, Adelis M Cruz, Haley F Spencer, Payton L Kahanek, Lauren N Scarborough, Sandra F Georges, Rachel J Smit. Punishment resistance for cocaine is associated with inflexible habits in rats. bioRxiv : the preprint server for biology. 2023-06-19. PMID:37333299. |
before and after punishment testing (4 days pre-punishment and ≥4 days post-punishment), we assessed whether cocaine seeking was goal-directed or habitual using outcome devaluation via cocaine satiety. |
2023-06-19 |
2023-08-14 |
rat |
| Rachel A Davies, Britton R Barbee, Yesenia Garcia-Sifuentes, Laura M Butkovich, Shannon L Gourle. Subunit-selective PI3-kinase control of action strategies in the medial prefrontal cortex. Neurobiology of learning and memory. 2023-06-16. PMID:37328026. |
thus, pi3k control of goal-directed action strategies appears to act in accordance with an inverted u-shaped function, with "too much" (following cocaine) or "too little" (following p110β subunit silencing) obstructing goal seeking and causing mice to defer to habit-like response sequences. |
2023-06-16 |
2023-08-14 |
mouse |
| Danielle M Giangrasso, Kaliana M Veros, Maureen M Timm, Peter J West, Karen S Wilcox, Kristen A Keef. Glutamate dynamics in the dorsolateral striatum of rats with goal-directed and habitual cocaine-seeking behavior. Frontiers in molecular neuroscience. vol 16. 2023-05-30. PMID:37251646. |
therefore, we trained rats to self-administer cocaine in a chained cocaine-seeking and -taking paradigm, which yielded goal-directed, intermediate, and habitual cocaine-seeking rats. |
2023-05-30 |
2023-08-14 |
rat |
| Bradley O Jones, Adelis M Cruz, Tabitha H Kim, Haley F Spencer, Rachel J Smit. Discriminating goal-directed and habitual cocaine seeking in rats using a novel outcome devaluation procedure. Learning & memory (Cold Spring Harbor, N.Y.). vol 29. issue 12. 2023-01-09. PMID:36621907. |
discriminating goal-directed and habitual cocaine seeking in rats using a novel outcome devaluation procedure. |
2023-01-09 |
2023-08-14 |
rat |
| Jessica M Illenberger, Steven B Harrod, Charles F Mactutus, Kristen A McLaurin, Asha Kallianpur, Rosemarie M Booz. HIV Infection and Neurocognitive Disorders in the Context of Chronic Drug Abuse: Evidence for Divergent Findings Dependent upon Prior Drug History. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 15. issue 4. 2021-10-20. PMID:32533296. |
the current review will therefore explore how the fronto-striatal circuit adapts to drug use (using cocaine as an example), hiv-1 infection, and both together; emphasizing proper methods and providing future directions to develop treatments for pathologies disrupting goal-directed behaviors and improve clinical outcomes for affected patients. |
2021-10-20 |
2023-08-13 |
Not clear |
| J R Breedon, H Ziauddeen, J Stochl, K D Ersch. Feeding the addiction: Narrowing of goals to habits. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 42. 2021-08-20. PMID:33246848. |
whilst the initiation of cocaine use is typically goal-directed and motivated by the rewarding effects of the drug, drug-taking can become habitual over time, rendering the user less sensitive to cocaine's hedonic value. |
2021-08-20 |
2023-08-13 |
human |
| Andrew M Wright, Agustin Zapata, Alexander F Hoffman, Julie C Necarsulmer, Lamarque M Coke, Reinis Svarcbahs, Christopher T Richie, James Pickel, Bruce T Hope, Brandon K Harvey, Carl R Lupic. Effects of Withdrawal from Cocaine Self-Administration on Rat Orbitofrontal Cortex Parvalbumin Neurons Expressing eNeuro. vol 8. issue 4. 2021-08-13. PMID:34083381. |
rodent studies show that cocaine self-administration (csa) reduces ofc contribution to goal-directed behavior and behavioral strategies to avoid drug intake. |
2021-08-13 |
2023-08-13 |
rat |
| Alfonso Barrós-Loscertales, Víctor Costumero, Patricia Rosell-Negre, Paola Fuentes-Claramonte, Juan-José Llopis-Llacer, Juan Carlos Bustamant. Motivational factors modulate left frontoparietal network during cognitive control in cocaine addiction. Addiction biology. vol 25. issue 4. 2021-06-28. PMID:31436010. |
cocaine addiction is characterized by alterations in motivational and cognitive processes involved in goal-directed behavior. |
2021-06-28 |
2023-08-13 |
Not clear |
| Alfonso Barrós-Loscertales, Víctor Costumero, Patricia Rosell-Negre, Paola Fuentes-Claramonte, Juan-José Llopis-Llacer, Juan Carlos Bustamant. Motivational factors modulate left frontoparietal network during cognitive control in cocaine addiction. Addiction biology. vol 25. issue 4. 2021-06-28. PMID:31436010. |
the aim of this study was to investigate how cocaine addiction affected the left frontoparietal network during goal-directed behavior in a stop-signal task (sst) with reward contingencies by correct task performance. |
2021-06-28 |
2023-08-13 |
Not clear |
| Karen D Ersche, Tsen Vei Lim, Alexander G Murley, Catarina Rua, Matilde M Vaghi, Tara L White, Guy B Williams, Trevor W Robbin. Reduced Glutamate Turnover in the Putamen Is Linked With Automatic Habits in Human Cocaine Addiction. Biological psychiatry. vol 89. issue 10. 2021-06-02. PMID:33581835. |
the balance between goal-directed behavior and habits has been hypothesized to be biased toward the latter in individuals with cocaine use disorder (cud), suggesting possible neurochemical changes in the putamen, which may contribute to their compulsive behavior. |
2021-06-02 |
2023-08-13 |
human |
| Retraction: Hippocampal BDNF regulates a shift from flexible, goal-directed to habit memory system function following cocaine abstinence. Hippocampus. vol 30. issue 12. 2021-05-11. PMID:33241886. |
retraction: hippocampal bdnf regulates a shift from flexible, goal-directed to habit memory system function following cocaine abstinence. |
2021-05-11 |
2023-08-13 |
Not clear |
| Youna Vandaele, Karine Guillem, Serge H Ahme. Habitual Preference for the Nondrug Reward in a Drug Choice Setting. Frontiers in behavioral neuroscience. vol 14. 2020-09-28. PMID:32523517. |
together with our previous research, this result indicates that preference for nondrug alternatives over cocaine is under habitual control, even under conditions that normally support goal-directed control of choice between nondrug options. |
2020-09-28 |
2023-08-13 |
rat |
| Peter Zhukovsky, Mickael Puaud, Bianca Jupp, Júlia Sala-Bayo, Johan Alsiö, Jing Xia, Lydia Searle, Zoe Morris, Aryan Sabir, Chiara Giuliano, Barry J Everitt, David Belin, Trevor W Robbins, Jeffrey W Dalle. Withdrawal from escalated cocaine self-administration impairs reversal learning by disrupting the effects of negative feedback on reward exploitation: a behavioral and computational analysis. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 13. 2020-07-08. PMID:30952156. |
these findings indicate that withdrawal from escalated cocaine sa disrupts how negative feedback is used to guide goal-directed behavior for natural reinforcers and that trait anxiety may be a latent variable underlying this interaction. |
2020-07-08 |
2023-08-13 |
rat |
| Eric Harvey, Matthew Blurton-Jones, Pamela J Kenned. Hippocampal BDNF regulates a shift from flexible, goal-directed to habit memory system function following cocaine abstinence. Hippocampus. vol 29. issue 11. 2020-06-12. PMID:31206907. |
hippocampal bdnf regulates a shift from flexible, goal-directed to habit memory system function following cocaine abstinence. |
2020-06-12 |
2023-08-13 |
rat |
| Elizabeth M Colechio, Patricia S Grigso. Conditioned Aversion for a Cocaine-Predictive Cue is Associated with Cocaine Seeking and Taking in Rats. International journal of comparative psychology. vol 27. issue 3. 2019-11-20. PMID:25673916. |
indeed, rats exhibiting high conditioned aversive tr to the cocaine-paired cue also exhibited greater goal-directed behavior, were faster to take drug, self-administered more cocaine, and exhibited greater seeking during periods of drug non-availability. |
2019-11-20 |
2023-08-13 |
rat |