| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pooja S Salvi, Matthew P Shaughnessy, Kaelyn D Sumigray, Robert A Cowle. Antibiotic-induced microbial depletion enhances murine small intestinal epithelial growth in a serotonin-dependent manner. American journal of physiology. Gastrointestinal and liver physiology. 2023-05-09. PMID:37158470. |
serotonin potentiation was achieved through either genetic knockout of the serotonin transporter (sert) or pharmacologic sert inhibition, and inhibition of serotonin synthesis was achieved with para-chlorophenylalanine. |
2023-05-09 |
2023-08-14 |
mouse |
| Yanbo Liu, Zhen Li, Tianning Sun, Zhigang He, Hongbing Xiang, Jun Xion. Gut microbiota-generated short-chain fatty acids are involved in para-chlorophenylalanine-induced cognitive disorders. Frontiers in microbiology. vol 13. 2022-11-24. PMID:36419424. |
existing studies have reported that para-chlorophenylalanine (pcpa), a 5-ht scavenger, has a negative effect on cognitive function. |
2022-11-24 |
2023-08-14 |
mouse |
| Hakimeh Saadati, Safa Ghaheri, Farshid Sadegzadeh, Nona Sakhaie, Maryam Abdollahzade. Beneficial effects of enriched environment on behavior, cognitive functions, and hippocampal BDNF level following postnatal serotonin depletion in male rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2022-11-07. PMID:36342785. |
therefore, the present study aimed to evaluate the influences of the ee housing (postnatal day: pnd21-60) following postnatal serotonin depletion (by para-chlorophenylalanine: pcpa, 100mg/kg, s.c, in pnd 10-20) on anxiety-related behaviors, cognitive functions, and brain-derived neurotrophic factor (bdnf) mrna expression in the hippocampus of male rats. |
2022-11-07 |
2023-08-14 |
rat |
| Hakimeh Saadati, Farshid Sadegzadeh, Nona Sakhaie, Hamdollah Panahpour, Mohsen Sagh. Serotonin depletion during the postnatal developmental period causes behavioral and cognitive alterations and decreases BDNF level in the brain of rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 81. issue 2. 2021-11-18. PMID:33404066. |
therefore, in the present study, we examined the effects of postnatal days (pnd 10-20) administration of para-chlorophenylalanine (pcpa, 100 mg/kg, s.c) a 5-ht synthesis inhibitor, on anxiety-related behaviors, pain sensitivity, short-term recognition memory, and hippocampal and prefrontal cortex (pfc) brain-derived neurotrophic factor (bdnf) mrna expression in adult male and female rats. |
2021-11-18 |
2023-08-13 |
rat |
| Sarah M Turgeon, Alifayaz Abdulzahir, Kaylin Hwang, Jordan Sanfor. Pharmacological depletion of serotonin and norepinephrine with para-chlorophenylalanine and alpha-methyl-p-tyrosine reverses the antidepressant-like effects of adolescent caffeine exposure in the male rat. Behavioural pharmacology. vol 31. issue 8. 2021-09-07. PMID:32897889. |
pharmacological depletion of serotonin and norepinephrine with para-chlorophenylalanine and alpha-methyl-p-tyrosine reverses the antidepressant-like effects of adolescent caffeine exposure in the male rat. |
2021-09-07 |
2023-08-13 |
rat |
| Sarah M Turgeon, Alifayaz Abdulzahir, Kaylin Hwang, Jordan Sanfor. Pharmacological depletion of serotonin and norepinephrine with para-chlorophenylalanine and alpha-methyl-p-tyrosine reverses the antidepressant-like effects of adolescent caffeine exposure in the male rat. Behavioural pharmacology. vol 31. issue 8. 2021-09-07. PMID:32897889. |
the present study attempted to clarify the possible neurochemical mechanisms of caffeine's action by selectively depleting norepinephrine with alpha-methyl-p-tyrosine or serotonin with para-chlorophenylalanine in two separate experiments and assessing the ability for caffeine to alter anxiety-like and depressive-like behavior. |
2021-09-07 |
2023-08-13 |
rat |
| Yuan-Yuan Wu, Yong-Liang Jiang, Xiao-Fen He, Xiao-Yun Zhao, Xiao-Mei Shao, Jing Sun, Zui Shen, Shen-Yun Shou, Jun-Jun Wei, Jia-Yu Ye, Si-Si Yan, Jian-Qiao Fan. 5-HT in the dorsal raphe nucleus is involved in the effects of 100-Hz electro-acupuncture on the pain-depression dyad in rats. Experimental and therapeutic medicine. vol 14. issue 1. 2020-09-30. PMID:28672900. |
intracerebroventricular injection of para-chlorophenylalanine, an inhibitor of 5-ht resynthesis, suppressed the upregulation of 5-ht in the drn by 100-hz ea and partially counteracted the analgesic and anti-depressive effects of 100-hz ea. |
2020-09-30 |
2023-08-13 |
rat |
| Epifanio F Silva, Aldemara I Silva, Laila Asth, Lisiane S Souza, Nurulain T Zaveri, Remo Guerrini, Girolamo Calo', Chiara Ruzza, Elaine C Gaviol. Nociceptin/orphanin FQ receptor agonists increase aggressiveness in the mouse resident-intruder test. Behavioural brain research. vol 356. 2019-03-22. PMID:30142397. |
in contrast, para-chlorophenylalanine (pcpa), an inhibitor of 5-ht synthesis, increased aggressiveness in mice. |
2019-03-22 |
2023-08-13 |
mouse |
| Károly Elekes, László Hiripi, Gábor Balog, Gábor Maász, Izabella Battonyai, Marina Yu Khabarova, Réka Horváth, Elena E Voronezhskay. Serotonergic regulation of the buccal (feeding) rhythm of the pond snail, Lymnaea stagnalis. An immunocytochemical, biochemical and pharmacological approach. Acta biologica Hungarica. vol 69. issue 3. 2018-12-11. PMID:30257576. |
in order to have a detailed insight into this process, we investigated the serotonergic regulation of the buccal (feeding) rhythm in 100% stage embryos of the pond snail, lymnaea stagnalis, applying quantitative immunohistochemistry combined with the pharmacological manipulation of the serotonin (5-ht) synthesis, by either stimulating (by the 5-ht precursor 5-hydroxytryptophan, 5-htp) or inhibiting (by the 5-ht synthesis blocker para-chlorophenylalanine, pcpa) it. |
2018-12-11 |
2023-08-13 |
Not clear |
| Kevin Chen, Abbey Kardys, Yibu Chen, Stephen Flink, Boris Tabakoff, Jean C Shi. Altered gene expression in early postnatal monoamine oxidase A knockout mice. Brain research. vol 1669. 2018-04-12. PMID:28535982. |
we showed that administration of the serotonin synthesis inhibitor para-chlorophenylalanine (pcpa) from post-natal day 1 (p1) through 7 (p7) in mao a ko mice reduced the serotonin level to normal and reverses the repetitive behavior. |
2018-04-12 |
2023-08-13 |
mouse |
| Jenny Stracke, Winfried Otten, Armin Tuchscherer, Birger Puppe, Sandra Düpja. Serotonin depletion induces pessimistic-like behavior in a cognitive bias paradigm in pigs. Physiology & behavior. vol 174. 2018-02-26. PMID:28257935. |
for this purpose, we modified a serotonin depletion model using para-chlorophenylalanine (pcpa) to decrease serotonin levels in brain areas involved in cognitive and affective processing (part 1). |
2018-02-26 |
2023-08-13 |
human |
| Jakob Näslund, Erik Studer, Elin Johansson, Elias Eriksso. Effects of gonadectomy and serotonin depletion on inter-individual differences in anxiety-like behaviour in male Wistar rats. Behavioural brain research. vol 308. 2017-11-21. PMID:27083304. |
to shed further light on the influence of sex steroids and serotonin - and on the interplay between the two - on proneness for epm-assessed anxiety in males, outbred wistar rats were divided into those with high and low anxiety, respectively, and exposed to gonadectomy or sham operation followed by administration of a serotonin synthesis inhibitor, para-chlorophenylalanine, or saline. |
2017-11-21 |
2023-08-13 |
rat |
| Denis A Nikishin, Ivan Milošević, Milorad Gojković, Ljubisav Rakić, Vladimir V Bezuglov, Yuri B Shmukle. Expression and functional activity of neurotransmitter system components in sea urchins' early development. Zygote (Cambridge, England). vol 24. issue 2. 2016-12-20. PMID:25920999. |
the activities of the enzymes of serotonin synthesis and serotonin transporter were shown using immunohistochemistry and incubation with para-chlorophenylalanine (pСРА) and 5-hydroxytryptophan (htp). |
2016-12-20 |
2023-08-13 |
Not clear |
| Francis R Bambico, Andrea Duranti, José N Nobrega, Gabriella Gobb. The fatty acid amide hydrolase inhibitor URB597 modulates serotonin-dependent emotional behaviour, and serotonin1A and serotonin2A/C activity in the hippocampus. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 26. issue 3. 2016-12-13. PMID:26747370. |
the 5-ht synthesis inhibitor para-chlorophenylalanine (pcpa), but not the ne neurotoxin n-(2-chloroethyl)-n-ethyl-2-bromobenzylamine (dsp4) prevented urb597-mediated antidepressant/anxiolytic-like response in the fst and nsft, while dsp4 did not further affect urb597-mediated increase in raphe 5-ht neuron firing. |
2016-12-13 |
2023-08-13 |
Not clear |
| J Kregiel, J Golebiowska, P Popik, R Rygul. Dopamine induces an optimism bias in rats-Pharmacological proof for the translational validity of the ambiguous-cue interpretation test. Behavioural brain research. vol 297. 2016-09-15. PMID:26462571. |
to test whether similar effects might be observed when manipulating another neurotransmitter implicated in learning about reward and punishment, we administered the serotonin (5-ht) reuptake inhibitor escitalopram to a third group of animals and the selective and irreversible tryptophan hydroxylase inhibitor para-chlorophenylalanine (pcpa) to a fourth group. |
2016-09-15 |
2023-08-13 |
human |
| Franciane Bobinski, Tamara A A Ferreira, Marina M Córdova, Patrícia A Dombrowski, Cláudio da Cunha, Caroline C do Espírito Santo, Anicleto Poli, Rita G W Pires, Cristina Martins-Silva, Kathleen A Sluka, Adair R S Santo. Role of brainstem serotonin in analgesia produced by low-intensity exercise on neuropathic pain after sciatic nerve injury in mice. Pain. vol 156. issue 12. 2016-09-13. PMID:26447701. |
reduction of serotonin (5-hydroxytryptamine) synthesis using the tryptophan hydroxylase inhibitor para-chlorophenylalanine methyl ester prevented the analgesic effect of exercise. |
2016-09-13 |
2023-08-13 |
mouse |
| Mostafa El Mansari, Agnes Crnic, Chris Oosterhof, Pierre Blie. Long-term administration of the antidepressant vilazodone modulates rat brain monoaminergic systems. Neuropharmacology. vol 99. 2016-08-30. PMID:26362359. |
following depletion of 5-ht with para-chlorophenylalanine methyl-ester hydrochloride (pcpa), vilazodone still suppressed neuronal firing of dorsal raphe nucleus (drn) 5-ht neurons to a similar extent than controls, indicating that this inhibition is via 5-ht1a receptors activation. |
2016-08-30 |
2023-08-13 |
human |
| Nicholas M Murray, Gordon F Buchanan, George B Richerso. Insomnia Caused by Serotonin Depletion is Due to Hypothermia. Sleep. vol 38. issue 12. 2016-08-24. PMID:26194567. |
early experiments using the tryptophan hydroxylase inhibitor para-chlorophenylalanine (pcpa) had led to the opposite conclusion, that 5-ht causes sleep, but those studies were subsequently contradicted by electrophysiological and behavioral data. |
2016-08-24 |
2023-08-13 |
Not clear |
| Erik Studer, Jakob Näslund, Erik Andersson, Staffan Nilsson, Lars Westberg, Elias Eriksso. Serotonin depletion-induced maladaptive aggression requires the presence of androgens. PloS one. vol 10. issue 5. 2016-04-18. PMID:25978464. |
using the resident intruder test, we now show that administration of the serotonin synthesis inhibitor para-chlorophenylalanine (300 mg/kg x 3 days) increases the total time of attack as well as the percentage amount of social behavior spent on attack but not that spent on threat - i.e. |
2016-04-18 |
2023-08-13 |
mouse |
| Umut İrfan Üçel, Özgür Devrim Can, Ümide Demir Özkay, Yusuf Öztür. Antihyperalgesic and antiallodynic effects of mianserin on diabetic neuropathic pain: a study on mechanism of action. European journal of pharmacology. vol 756. 2016-01-28. PMID:25771454. |
the same effects were not reversed, however, by para-chlorophenylalanine methyl ester (pcpa; an inhibitor of serotonin synthesis). |
2016-01-28 |
2023-08-13 |
rat |