| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Debabrata Chowdhury, Dinesh Kumar, Utpal Bhadra, Tangutur Anjana Devi, Manika Pal Bhadr. Prohibitin confers cytoprotection against ISO-induced hypertrophy in H9c2 cells via attenuation of oxidative stress and modulation of Akt/Gsk-3\\xce\\xb2 signaling. Molecular and cellular biochemistry vol 425 issue 1-2 2017 27854077 |
numerous hypertrophic stimuli, including \xce\xb2-adrenergic agonists such as isoproterenol (iso), result in generation of reactive oxygen species (ros) and alteration in the mitochondrial membrane potential (\xce\x94\xcf\x88) leading to oxidative stress. |
2017-02-17 |
2023-01-26 |
rat |
| Yan Lin, Jingbin Zhu, Xiaojie Zhang, Jun Wang, Wei Xiao, Bo Li, Li Jin, Jie Lian, Li Zhou, Jicheng Li. Inhibition of Cardiomyocytes Hypertrophy by Resveratrol Is Associated with Amelioration of Endoplasmic Reticulum Stress. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology vol 39 issue 2 2017 27467279 |
this study was undertaken to investigate whether res can protect the heart suffering from hypertrophy injuries induced by isoproterenol (iso), and whether the protective effect is mediated by endoplasmic reticulum (er) stress. |
2017-02-10 |
2023-01-25 |
Not clear |
| Xilan Tang, Xiaohong Tracey Gan, Venkatesh Rajapurohitam, Cathy Xiaoling Huang, Jenny Xue, Edmund M K Lui, Morris Karmazy. North American ginseng (Panax quinquefolius) suppresses \\xce\\xb2-adrenergic-dependent signalling, hypertrophy, and cardiac dysfunction. Canadian journal of physiology and pharmacology vol 94 issue 12 2017 27797280 |
here, we determined whether north american ginseng can modulate the deleterious effects of the \xce\xb2-adrenoceptor agonist isoproterenol on cardiac hypertrophy and function using in vitro and in vivo approaches. |
2017-02-10 |
2023-01-26 |
rat |
| Xilan Tang, Xiaohong Tracey Gan, Venkatesh Rajapurohitam, Cathy Xiaoling Huang, Jenny Xue, Edmund M K Lui, Morris Karmazy. North American ginseng (Panax quinquefolius) suppresses \\xce\\xb2-adrenergic-dependent signalling, hypertrophy, and cardiac dysfunction. Canadian journal of physiology and pharmacology vol 94 issue 12 2017 27797280 |
in in vitro studies, ginseng (10 \xce\xbcg/ml) completely suppressed the hypertrophic response to 1 \xce\xbcmol/l isoproterenol in terms of myocyte surface area, as well as reduction in the upregulation of fetal gene expression. |
2017-02-10 |
2023-01-26 |
rat |
| Chonghua Xu, Futian Tang, Meili Lu, Jing Yang, Ronghui Han, Meng Mei, Jin Hu, Mingsheng Zhou, Hongxin Wan. Astragaloside IV improves the isoproterenol-induced vascular dysfunction via attenuating eNOS uncoupling-mediated oxidative stress and inhibiting ROS-NF-\\xce\\xbaB pathways. International immunopharmacology vol 33 issue 2016 26903414 |
our previous studies demonstrated that astragaloside iv (asiv) could protect against cardiac hypertrophy in rats induced by isoproterenol (iso), but its effects on the aorta are not known. |
2016-12-13 |
2023-01-25 |
rat |
| Govindan Sangaran Jagadeesh, M F Nagoor Meeran, Palanisamy Selvara. Protective Effects of 7-Hydroxycoumarin on Dyslipidemia and Cardiac Hypertrophy in Isoproterenol-Induced Myocardial Infarction in Rats. Journal of biochemical and molecular toxicology vol 30 issue 3 2016 26995004 |
this study evaluates the protective effects of 7-hydroxycoumarin (7-hc) on dyslipidemia and cardiac hypertrophy in isoproterenol (iso) induced myocardial infarction (mi) in rats. |
2016-11-14 |
2023-01-25 |
rat |
| Meng Mei, Futian Tang, Meili Lu, Xin He, Hongxin Wang, Xuwei Hou, Jin Hu, Chonghua Xu, Ronghui Ha. Astragaloside IV attenuates apoptosis of hypertrophic cardiomyocyte through inhibiting oxidative stress and calpain-1 activation. Environmental toxicology and pharmacology vol 40 issue 3 2016 26433482 |
the present study was designed to investigate whether the inhibitory effect of asiv on isoproterenol (iso)-induced apoptosis of hypertrophic cardiomyocyte was associated with the anti-oxidation and calpain-1 inhibition. |
2016-10-05 |
2023-01-25 |
rat |
| Lejla Medzikovic, Cees A Schumacher, Arie O Verkerk, Elza D van Deel, Rianne Wolswinkel, Ingeborg van der Made, Natascha Bleeker, Daniella Cakici, Maarten M G van den Hoogenhof, Farid Meggouh, Esther E Creemers, Carol Ann Remme, Antonius Baartscheer, Robbert J de Winter, Carlie J M de Vries, E Karin Arkenbout, Vivian de Waar. Orphan nuclear receptor Nur77 affects cardiomyocyte calcium homeostasis and adverse cardiac remodelling. Scientific reports vol 5 issue 2016 26486271 |
in vivo, these differences resulted in larger cardiomyocytes, increased expression of hypertrophic genes, and more cardiac fibrosis in nur77-ko mice upon chronic isoproterenol stimulation. |
2016-09-14 |
2023-01-25 |
mouse |
| Rukhsana Gul, Dae-Ryoung Park, Asif Iqbal Shawl, Soo-Yeul Im, Tae-Sik Nam, Sun-Hwa Lee, Jae-Ki Ko, Kyu Yoon Jang, Donghee Kim, Uh-Hyun Ki. Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Cyclic ADP-Ribose (cADPR) Mediate Ca2+ Signaling in Cardiac Hypertrophy Induced by \\xce\\xb2-Adrenergic Stimulation. PloS one vol 11 issue 3 2016 26959359 |
we investigated the role of ca2+-mobilizing second messengers, naadp and cadpr, in the cardiac hypertrophy induced by \xce\xb2-adrenergic stimulation by isoproterenol. |
2016-08-03 |
2023-01-25 |
mouse |
| Rukhsana Gul, Dae-Ryoung Park, Asif Iqbal Shawl, Soo-Yeul Im, Tae-Sik Nam, Sun-Hwa Lee, Jae-Ki Ko, Kyu Yoon Jang, Donghee Kim, Uh-Hyun Ki. Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Cyclic ADP-Ribose (cADPR) Mediate Ca2+ Signaling in Cardiac Hypertrophy Induced by \\xce\\xb2-Adrenergic Stimulation. PloS one vol 11 issue 3 2016 26959359 |
cd38 knockout mice were rescued from chronic isoproterenol infusion-induced myocardial hypertrophy, interstitial fibrosis, and decrease in fractional shortening and ejection fraction. |
2016-08-03 |
2023-01-25 |
mouse |
| Xinying Zhang, Tiemin Zhang, Jichao Wu, Xiangjing Yu, Dan Zheng, Fan Yang, Ting Li, Lina Wang, Yajun Zhao, Shiyun Dong, Xin Zhong, Songbin Fu, Chang-qing Xu, Fanghao Lu, Wei-hua Zhan. Calcium sensing receptor promotes cardiac fibroblast proliferation and extracellular matrix secretion. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology vol 33 issue 3 2016 24603056 |
the present study investigated whether car played a role in cardiac fibroblast proliferation and extracellular matrix (ecm) secretion, both in cultured rat neonatal cardiac fibroblasts and in a model of cardiac hypertrophy induced by isoproterenol (iso). |
2016-08-01 |
2023-01-25 |
rat |
| Xiangbo An, Jingjing Wang, Hao Li, Zhizhen Lu, Yan Bai, Han Xiao, Youyi Zhang, Yao Son. Speckle Tracking Based Strain Analysis Is Sensitive for Early Detection of Pathological Cardiac Hypertrophy. PloS one vol 11 issue 2 2016 26871457 |
here we report that speckle tracking-based strain analysis is more sensitive than conventional echocardiography for early detection of pathological cardiac hypertrophy in the isoproterenol (iso) mouse model. |
2016-07-21 |
2023-01-25 |
Not clear |
| Qiaoling Li, Jun Xie, Bingjian Wang, Ran Li, Jian Bai, Liang Ding, Rong Gu, Lian Wang, Biao X. Overexpression of microRNA-99a Attenuates Cardiac Hypertrophy. PloS one vol 11 issue 2 2016 26914935 |
to evaluate the role of mir-99a in cardiac hypertrophy, we assessed the expression of mir-99a in hypertrophic cardiomyocytes induced by isoprenaline (iso)/angiotensin-ii (ang ii) and in mice model of cardiac hypertrophy induced by transverse aortic constriction (tac). |
2016-07-20 |
2023-01-25 |
mouse |
| Yong Xie, Lihua Zhang, Bin Zhang, Li Fan. Roles of heat shock factor 1 in isoproterenol\\xe2\\x80\\x91induced myocardial fibrosis in mice. Molecular medicine reports vol 12 issue 4 2016 26239834 |
although it is well known that isoproterenol (iso) causes myocardial hypertrophy and myocardial fibrosis in rats, it has remained elusive whether heat shock factor 1 (hsf1) has a role in this process. |
2016-06-27 |
2023-01-25 |
rat |
| Rebecca A Capel, Emma L Bolton, Wee K Lin, Daniel Aston, Yanwen Wang, Wei Liu, Xin Wang, Rebecca-Ann B Burton, Duncan Bloor-Young, Kai-Ting Shade, Margarida Ruas, John Parrington, Grant C Churchill, Ming Lei, Antony Galione, Derek A Terra. Two-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic \\xce\\xb2-Adrenoceptor Signaling in the Heart. The Journal of biological chemistry vol 290 issue 50 2016 26438825 |
hearts from tpcn2(-/-) mice chronically exposed to isoproterenol showed less cardiac hypertrophy and increased threshold for arrhythmogenesis compared with wt controls. |
2016-05-10 |
2023-01-25 |
mouse |
| Jennifer L Major, Maysoon Salih, Balwant S Tuan. Interplay between the E2F pathway and \\xce\\xb2-adrenergic signaling in the pathological hypertrophic response of myocardium. Journal of molecular and cellular cardiology vol 84 issue 2016 25944088 |
we assessed the mechanisms of the apparent failure of compensatory hypertrophic growth as well as their response to the \xce\xb2-adrenergic agonist isoproterenol. |
2016-04-07 |
2023-01-25 |
mouse |
| Robrecht Thoonen, Laura Ernande, Juan Cheng, Yasuko Nagasaka, Vincent Yao, Alexandre Miranda-Bezerra, Chan Chen, Wei Chao, Marcello Panagia, David E Sosnovik, Dheeraj Puppala, Antonis A Armoundas, Allyson Hindle, Kenneth D Bloch, Emmanuel S Buys, Marielle Scherrer-Crosbi. Functional brown adipose tissue limits cardiomyocyte injury and adverse remodeling in catecholamine-induced cardiomyopathy. Journal of molecular and cellular cardiology vol 84 issue 2016 25968336 |
isoproterenol infusion increased ctni and myocardial fibrosis and induced left ventricular (lv) hypertrophy in both wt and ucp1(-/-) mice. |
2016-04-07 |
2023-01-25 |
mouse |
| Nouf M Al-Rasheed, Maha M Al-Oteibi, Reem Z Al-Manee, Sarah A Al-Shareef, Nawal M Al-Rasheed, Iman H Hasan, Raeesa A Mohamad, Ayman M Mahmou. Simvastatin prevents isoproterenol-induced cardiac hypertrophy through modulation of the JAK/STAT pathway. Drug design, development and therapy vol 9 issue 2016 26150695 |
the present study was designed to investigate the effect of pretreatment with sim on isoproterenol (iso)-induced cardiac hypertrophy in rats. |
2016-03-29 |
2023-01-25 |
rat |
| Aina Luan, Futian Tang, Yuhong Yang, Meili Lu, Hongxin Wang, Yingjie Zhan. Astragalus polysaccharide attenuates isoproterenol-induced cardiac hypertrophy by regulating TNF-\\xce\\xb1/PGC-1\\xce\\xb1 signaling mediated energy biosynthesis. Environmental toxicology and pharmacology vol 39 issue 3 2016 25880160 |
bge, attenuates hypertrophy of neonatal rat ventricular myocytes (nrvms) induced by isoproterenol (iso). |
2016-03-22 |
2023-01-25 |
rat |
| Hassan N Althurwi, Zaid H Maayah, Osama H Elshenawy, Ayman O S El-Kad. Early Changes in Cytochrome P450s and Their Associated Arachidonic Acid Metabolites Play a Crucial Role in the Initiation of Cardiac Hypertrophy Induced by Isoproterenol. Drug metabolism and disposition: the biological fate of chemicals vol 43 issue 8 2016 26033621 |
early changes in cytochrome p450s and their associated arachidonic acid metabolites play a crucial role in the initiation of cardiac hypertrophy induced by isoproterenol. |
2016-03-10 |
2023-01-25 |
rat |