| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Meili Lu, Hongxin Wang, Yuhong Yang, Lei Zhang, Chunna Liu, Jing Yang, Tak Ming Won. The function of calcineurin and ERK1/2 signal in the antihypertrophic effects of kappa-opioid receptor stimulation on myocardial hypertrophy induced by isoprenaline. Die Pharmazie vol 67 issue 2 2012 22512090 |
the function of calcineurin and erk1/2 signal in the antihypertrophic effects of kappa-opioid receptor stimulation on myocardial hypertrophy induced by isoprenaline. |
2012-05-08 |
2023-01-25 |
Not clear |
| Meili Lu, Hongxin Wang, Yuhong Yang, Lei Zhang, Chunna Liu, Jing Yang, Tak Ming Won. The function of calcineurin and ERK1/2 signal in the antihypertrophic effects of kappa-opioid receptor stimulation on myocardial hypertrophy induced by isoprenaline. Die Pharmazie vol 67 issue 2 2012 22512090 |
we determined the effects of trans-(+/-)-3,4-dichloro-n-methyl-n-[2-(1-pyrrolidinyl)-cyclohexyl]-benzeneacetamid methanesulfonate salt (u50,488h), a selective kappa-opioid receptor agonist, on the enhancement of spontaneous ca2+ transients and the induction of hypertrophy by isoprenaline, a beta-adrenoceptor agonist, in cultured neonatal ventricular myocytes. |
2012-05-08 |
2023-01-25 |
Not clear |
| Meili Lu, Hongxin Wang, Yuhong Yang, Lei Zhang, Chunna Liu, Jing Yang, Tak Ming Won. The function of calcineurin and ERK1/2 signal in the antihypertrophic effects of kappa-opioid receptor stimulation on myocardial hypertrophy induced by isoprenaline. Die Pharmazie vol 67 issue 2 2012 22512090 |
isoprenaline (10 micromol x l(-1)) increased all the three indices of hypertrophy, ca2+ transients, calcineurin activity and the level of phospho-erk1/2. |
2012-05-08 |
2023-01-25 |
Not clear |
| Li-Fang Song, Wei Jiang, Yong Qing, Xiao-Hong Hu, Yi Li, Qing-Yi Tong, Xiao-Hua W. [The antagonistic effect of PI3K-gamma inhibitor AS605240 on cardiac hypertrophy and cardiac fibrosis induced by isoproterenol in rats]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition vol 42 issue 4 2012 21866628 |
[the antagonistic effect of pi3k-gamma inhibitor as605240 on cardiac hypertrophy and cardiac fibrosis induced by isoproterenol in rats]. |
2012-05-03 |
2023-01-25 |
rat |
| Li-Fang Song, Wei Jiang, Yong Qing, Xiao-Hong Hu, Yi Li, Qing-Yi Tong, Xiao-Hua W. [The antagonistic effect of PI3K-gamma inhibitor AS605240 on cardiac hypertrophy and cardiac fibrosis induced by isoproterenol in rats]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition vol 42 issue 4 2012 21866628 |
to investigate the therapeutic effect of pi3kgamma inhibitor as605240 on cardiac hypertrophy and cardiac fibrosis induced by isoproterenol in rats. |
2012-05-03 |
2023-01-25 |
rat |
| David R Murray, Srinivas Mummidi, Anthony J Valente, Tadashi Yoshida, Naveen K Somanna, Patrice Delafontaine, Charles A Dinarello, Bysani Chandraseka. \\xce\\xb22 adrenergic activation induces the expression of IL-18 binding protein, a potent inhibitor of isoproterenol induced cardiomyocyte hypertrophy in vitro and myocardial hypertrophy in vivo. Journal of molecular and cellular cardiology vol 52 issue 1 2012 22004899 |
\xce\xb22 adrenergic activation induces the expression of il-18 binding protein, a potent inhibitor of isoproterenol induced cardiomyocyte hypertrophy in vitro and myocardial hypertrophy in vivo. |
2012-04-24 |
2023-01-25 |
mouse |
| Nada Choucair-Jaafar, Nadine Beetz, Ralf Gilsbach, Ipek Yalcin, Elisabeth Waltisperger, Marie-Jos\\xc3\\xa9 Freund-Mercier, Laurent Monassier, Lutz Hein, Michel Barro. Cardiovascular effects of chronic treatment with a \\xce\\xb22-adrenoceptor agonist relieving neuropathic pain in mice. Neuropharmacology vol 61 issue 1-2 2012 21352833 |
our data show that a chronic treatment with the \xce\xb2(2)-ar agonist terbutaline at low antiallodynic dose does not affect cardiovascular parameters, whereas the mixed \xce\xb2(1)/\xce\xb2(2)-ar agonist isoproterenol induces cardiac hypertrophy. |
2012-04-17 |
2023-01-25 |
mouse |
| Ning Liu, Kai-zheng Gong, Yuan-bin Cai, Zijian L. Identification of proteins responding to adrenergic receptor subtype-specific hypertrophy in cardiomyocytes by proteomic approaches. Biochemistry. Biokhimiia vol 76 issue 10 2012 22098239 |
we present the first proteomics study identifying proteins that are related to ar subtype-specific hypertrophy in cardiomyocytes by comparing the two-dimensional electrophoresis patterns between neonatal rat cardiomyocytes treated by phenylepinephrin (pe) and by isoproterenol (iso). |
2012-03-19 |
2023-01-25 |
rat |
| Sanjeewa A Goonasekera, Karin Hammer, Mannix Auger-Messier, Ilona Bodi, Xiongwen Chen, Hongyu Zhang, Steven Reiken, John W Elrod, Robert N Correll, Allen J York, Michelle A Sargent, Franz Hofmann, Sven Moosmang, Andrew R Marks, Steven R Houser, Donald M Bers, Jeffery D Molkenti. Decreased cardiac L-type Ca\\xc2\\xb2\\xe2\\x81\\xba channel activity induces hypertrophy and heart failure in mice. The Journal of clinical investigation vol 122 issue 1 2012 22133878 |
however, \xce\xb11c\xe2\x81\xbb/\xe2\x81\xba mice subjected to pressure overload stimulation, isoproterenol infusion, and swimming showed greater cardiac hypertrophy, greater reductions in ventricular performance, and greater ventricular dilation than \xce\xb11c\xe2\x81\xba/\xe2\x81\xba controls. |
2012-03-06 |
2023-01-25 |
mouse |
| Alex P Carll, Najwa Haykal-Coates, Darrell W Winsett, Mehdi S Hazari, Abraham Nyska, Judy H Richards, Monte S Willis, Daniel L Costa, Aimen K Farra. Dietary salt exacerbates isoproterenol-induced cardiomyopathy in rats. Toxicologic pathology vol 39 issue 6 2012 21878552 |
isoproterenol (iso) infusion can accelerate cardiomyopathy in young shhfs, while dietary salt loading in hypertensive rats induces cardiac fibrosis, hypertrophy, and--in a minority-congestive hf. |
2012-02-13 |
2023-01-25 |
rat |
| Changlin Li, Jing Li, Xiangyu Cai, Haili Sun, Jinjin Jiao, Ting Bai, Xing Wang Zhou, Xiongwen Chen, Donald L Gill, Xiang D Tan. Protein kinase D3 is a pivotal activator of pathological cardiac hypertrophy by selectively increasing the expression of hypertrophic transcription factors. The Journal of biological chemistry vol 286 issue 47 2012 21971046 |
in both in vitro and in vivo cardiac hypertrophic models, the normally undetectable pkd3 was profoundly up-regulated by isoproterenol followed by overt expression of cardiac tfs including nfatc4, nk family of transcription factor 2.5 (nkx2.5), gata4 and myocyte enhancer factor 2 (mef2). |
2012-01-16 |
2023-01-25 |
Not clear |
| Tzu-Chieh Wei, Hui-Yu Lin, Cheng-Chieh Lu, Chun-Ming Chen, Li-Ru Yo. Expression of Crip2, a LIM-domain-only protein, in the mouse cardiovascular system under physiological and pathological conditions. Gene expression patterns : GEP vol 11 issue 7 2011 21601656 |
nonetheless, experimental studies revealed that the expression level of crip2 is not altered in the isoproterenol (iso) induced hypertrophic heart. |
2011-12-27 |
2023-01-25 |
mouse |
| John T Liles, Kevin K Ida, Kristin M Joly, Joseph Chapo, Craig F Plat. Age exacerbates chronic catecholamine-induced impairments in contractile reserve in the rat. American journal of physiology. Regulatory, integrative and comparative physiology vol 301 issue 2 2011 21593430 |
contractile reserve decreases with advancing age and chronic isoproterenol (iso) administration is a well-characterized model of cardiac hypertrophy known to impair cardiovascular function. |
2011-10-18 |
2023-01-25 |
rat |
| FuKun W Hoffmann, Ann S Hashimoto, Byung Cheon Lee, Aaron H Rose, Ralph V Shohet, Peter R Hoffman. Specific antioxidant selenoproteins are induced in the heart during hypertrophy. Archives of biochemistry and biophysics vol 512 issue 1 2011 21621505 |
to determine how the selenoproteome responds to myocardial hypertrophy, two mouse models were employed: triidothyronine (t3)- or isoproterenol (iso)-treatment. |
2011-09-12 |
2023-01-25 |
Not clear |
| Lianghui Zhang, Sundeep Malik, Grant G Kelley, Michael S Kapiloff, Alan V Smrck. Phospholipase C epsilon scaffolds to muscle-specific A kinase anchoring protein (mAKAPbeta) and integrates multiple hypertrophic stimuli in cardiac myocytes. The Journal of biological chemistry vol 286 issue 26 2011 21550986 |
nrvms with plc\xce\xb5 depletion were stimulated with endothelin (et-1), norepinephrine, insulin-like growth factor-1 (igf-1), or isoproterenol and assessed for development of hypertrophy. |
2011-09-09 |
2023-01-25 |
rat |
| Xueying Tan, Jianping Li, Xinyue Wang, Nan Chen, Benzhi Cai, Gang Wang, Hongli Shan, Deli Dong, Yanju Liu, Xingda Li, Fan Yang, Xin Li, Peng Zhang, Xueqi Li, Baofeng Yang, Yanjie L. Tanshinone IIA protects against cardiac hypertrophy via inhibiting calcineurin/NFATc3 pathway. International journal of biological sciences vol 7 issue 3 2011 21494433 |
the present study was aimed to investigate whether tanshinone iia prevents cardiac hypertrophy induced by isoproterenol (iso) and to clarify its possible mechanisms. |
2011-08-04 |
2023-01-25 |
Not clear |
| David J Durgan, Ju-Yun Tsai, Maximiliano H Grenett, Betty M Pat, William F Ratcliffe, Carolina Villegas-Montoya, Merissa E Garvey, Jeevan Nagendran, Jason R B Dyck, Molly S Bray, Karen L Gamble, Jeffrey M Gimble, Martin E Youn. Evidence suggesting that the cardiomyocyte circadian clock modulates responsiveness of the heart to hypertrophic stimuli in mice. Chronobiology international vol 28 issue 3 2011 21452915 |
wild-type mice exhibit 5-fold greater cardiac hypertrophic growth (and 6-fold greater anf mrna induction) when challenged with the hypertrophic agonist isoproterenol at the active-to-sleep phase transition, relative to isoproterenol administration at the sleep-to-active phase transition. |
2011-07-19 |
2023-01-25 |
mouse |
| Hye-Na Cha, Jung Hyun Choi, Yong-Woon Kim, Jong-Yeon Kim, Myun-Whan Ahn, So-Young Par. Metformin Inhibits Isoproterenol-induced Cardiac Hypertrophy in Mice. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology vol 14 issue 6 2011 21311678 |
chronic subcutaneous infusion of isoproterenol (15 mg/kg/24 h) for 1 week using an osmotic minipump induced cardiac hypertrophy measured by the heart-to-body weight ratio and left ventricular posterior wall thickness. |
2011-07-14 |
2023-01-25 |
mouse |
| Hye-Na Cha, Jung Hyun Choi, Yong-Woon Kim, Jong-Yeon Kim, Myun-Whan Ahn, So-Young Par. Metformin Inhibits Isoproterenol-induced Cardiac Hypertrophy in Mice. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology vol 14 issue 6 2011 21311678 |
coinfusion of metformin (150 mg/kg/24 h) with isoproterenol partially inhibited cardiac hypertrophy that was followed by reduced il-6, tgf-\xce\xb2, anp, collagen i and iii, and mmp-2. |
2011-07-14 |
2023-01-25 |
mouse |
| Hye-Min Hong, Eun Joo Song, Eulsik Oh, Mohammad Humayun Kabir, Cheolju Lee, Young Sook Yo. Endothelin-1- and isoproterenol-induced differential protein expression and signaling pathway in HL-1 cardiomyocytes. Proteomics vol 11 issue 2 2011 21204255 |
it is well known that the two chemical compounds endothelin-1 (et-1) and isoproterenol (iso) can individually induce cardiac hypertrophy through g protein-coupled receptors in cardiomyocytes. |
2011-04-15 |
2023-01-25 |
Not clear |