| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| John T Liles, Kevin K Ida, Kristin M Joly, Joseph Chapo, Craig F Plat. Age exacerbates chronic catecholamine-induced impairments in contractile reserve in the rat. American journal of physiology. Regulatory, integrative and comparative physiology. vol 301. issue 2. 2011-10-18. PMID:21593430. |
contractile reserve decreases with advancing age and chronic isoproterenol (iso) administration is a well-characterized model of cardiac hypertrophy known to impair cardiovascular function. |
2011-10-18 |
2023-08-12 |
rat |
| FuKun W Hoffmann, Ann S Hashimoto, Byung Cheon Lee, Aaron H Rose, Ralph V Shohet, Peter R Hoffman. Specific antioxidant selenoproteins are induced in the heart during hypertrophy. Archives of biochemistry and biophysics. vol 512. issue 1. 2011-09-12. PMID:21621505. |
to determine how the selenoproteome responds to myocardial hypertrophy, two mouse models were employed: triidothyronine (t3)- or isoproterenol (iso)-treatment. |
2011-09-12 |
2023-08-12 |
mouse |
| Lianghui Zhang, Sundeep Malik, Grant G Kelley, Michael S Kapiloff, Alan V Smrck. Phospholipase C epsilon scaffolds to muscle-specific A kinase anchoring protein (mAKAPbeta) and integrates multiple hypertrophic stimuli in cardiac myocytes. The Journal of biological chemistry. vol 286. issue 26. 2011-09-09. PMID:21550986. |
nrvms with plcε depletion were stimulated with endothelin (et-1), norepinephrine, insulin-like growth factor-1 (igf-1), or isoproterenol and assessed for development of hypertrophy. |
2011-09-09 |
2023-08-12 |
rat |
| Xueying Tan, Jianping Li, Xinyue Wang, Nan Chen, Benzhi Cai, Gang Wang, Hongli Shan, Deli Dong, Yanju Liu, Xingda Li, Fan Yang, Xin Li, Peng Zhang, Xueqi Li, Baofeng Yang, Yanjie L. Tanshinone IIA protects against cardiac hypertrophy via inhibiting calcineurin/NFATc3 pathway. International journal of biological sciences. vol 7. issue 3. 2011-08-04. PMID:21494433. |
the present study was aimed to investigate whether tanshinone iia prevents cardiac hypertrophy induced by isoproterenol (iso) and to clarify its possible mechanisms. |
2011-08-04 |
2023-08-12 |
Not clear |
| David J Durgan, Ju-Yun Tsai, Maximiliano H Grenett, Betty M Pat, William F Ratcliffe, Carolina Villegas-Montoya, Merissa E Garvey, Jeevan Nagendran, Jason R B Dyck, Molly S Bray, Karen L Gamble, Jeffrey M Gimble, Martin E Youn. Evidence suggesting that the cardiomyocyte circadian clock modulates responsiveness of the heart to hypertrophic stimuli in mice. Chronobiology international. vol 28. issue 3. 2011-07-19. PMID:21452915. |
wild-type mice exhibit 5-fold greater cardiac hypertrophic growth (and 6-fold greater anf mrna induction) when challenged with the hypertrophic agonist isoproterenol at the active-to-sleep phase transition, relative to isoproterenol administration at the sleep-to-active phase transition. |
2011-07-19 |
2023-08-12 |
mouse |
| Hye-Na Cha, Jung Hyun Choi, Yong-Woon Kim, Jong-Yeon Kim, Myun-Whan Ahn, So-Young Par. Metformin Inhibits Isoproterenol-induced Cardiac Hypertrophy in Mice. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 14. issue 6. 2011-07-14. PMID:21311678. |
chronic subcutaneous infusion of isoproterenol (15 mg/kg/24 h) for 1 week using an osmotic minipump induced cardiac hypertrophy measured by the heart-to-body weight ratio and left ventricular posterior wall thickness. |
2011-07-14 |
2023-08-12 |
mouse |
| Hye-Na Cha, Jung Hyun Choi, Yong-Woon Kim, Jong-Yeon Kim, Myun-Whan Ahn, So-Young Par. Metformin Inhibits Isoproterenol-induced Cardiac Hypertrophy in Mice. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 14. issue 6. 2011-07-14. PMID:21311678. |
coinfusion of metformin (150 mg/kg/24 h) with isoproterenol partially inhibited cardiac hypertrophy that was followed by reduced il-6, tgf-β, anp, collagen i and iii, and mmp-2. |
2011-07-14 |
2023-08-12 |
mouse |
| Hye-Min Hong, Eun Joo Song, Eulsik Oh, Mohammad Humayun Kabir, Cheolju Lee, Young Sook Yo. Endothelin-1- and isoproterenol-induced differential protein expression and signaling pathway in HL-1 cardiomyocytes. Proteomics. vol 11. issue 2. 2011-04-15. PMID:21204255. |
it is well known that the two chemical compounds endothelin-1 (et-1) and isoproterenol (iso) can individually induce cardiac hypertrophy through g protein-coupled receptors in cardiomyocytes. |
2011-04-15 |
2023-08-12 |
Not clear |
| Peiguo Ding, Jian Huang, Pavan K Battiprolu, Joseph A Hill, Kristine E Kamm, James T Stul. Cardiac myosin light chain kinase is necessary for myosin regulatory light chain phosphorylation and cardiac performance in vivo. The Journal of biological chemistry. vol 285. issue 52. 2011-01-24. PMID:20943660. |
isoproterenol infusion elicited hypertrophic cardiac responses in wild type mice. |
2011-01-24 |
2023-08-12 |
mouse |
| Peiguo Ding, Jian Huang, Pavan K Battiprolu, Joseph A Hill, Kristine E Kamm, James T Stul. Cardiac myosin light chain kinase is necessary for myosin regulatory light chain phosphorylation and cardiac performance in vivo. The Journal of biological chemistry. vol 285. issue 52. 2011-01-24. PMID:20943660. |
in mice lacking cmlck, the hypertrophic hearts showed no additional increases in size with the isoproterenol treatment, suggesting a lack of rlc phosphorylation blunted the stress response. |
2011-01-24 |
2023-08-12 |
mouse |
| Guo-Xing Zhang, Shoji Kimura, Koji Murao, Xiao Yu, Koji Obata, Hiroko Matsuyoshi, Miyako Takak. Effects of angiotensin type I receptor blockade on the cardiac Raf/MEK/ERK cascade activated via adrenergic receptors. Journal of pharmacological sciences. vol 113. issue 3. 2010-11-24. PMID:20562518. |
chronic isoproterenol (iso)-induced cardiac hypertrophy was inhibited in wild-type mice and at1ar(-/-) mice treated with the arb candesartan (cv11974). |
2010-11-24 |
2023-08-12 |
mouse |
| Jwu-Lai Yeh, Jong-Hau Hsu, Ping-Ju Wu, Shu-Fen Liou, Chung-Pin Liu, Ing-Jun Chen, Bin-Nan Wu, Zen-Kong Dai, Jiunn-Ren W. KMUP-1 attenuates isoprenaline-induced cardiac hypertrophy in rats through NO/cGMP/PKG and ERK1/2/calcineurin A pathways. British journal of pharmacology. vol 159. issue 5. 2010-07-13. PMID:20132211. |
to determine whether kmup-1, a novel xanthine-based derivative, attenuates isoprenaline (iso)-induced cardiac hypertrophy in rats, and if so, whether the anti-hypertrophic effect is mediated by the nitric oxide (no) pathway. |
2010-07-13 |
2023-08-12 |
rat |
| Michael P Czubryt, Lise Lamoureux, Angela Ramjiawan, Bernard Abrenica, Jaganmohan Jangamreddy, Kristin Swa. Regulation of cardiomyocyte Glut4 expression by ZAC1. The Journal of biological chemistry. vol 285. issue 22. 2010-06-17. PMID:20363751. |
induction of hypertrophy by phenylephrine or isoproterenol resulted in increased zac1 expression. |
2010-06-17 |
2023-08-12 |
rat |
| Caroline Nunn, Min-Xu Zou, Alina J Sobiesiak, Anju A Roy, Lorrie A Kirshenbaum, Peter Chidia. RGS2 inhibits beta-adrenergic receptor-induced cardiomyocyte hypertrophy. Cellular signalling. vol 22. issue 8. 2010-06-08. PMID:20362664. |
in this study, we investigated the potential role of regulator of g protein signalling 2 (rgs2) in modulating the hypertrophic effects of the beta-ar agonist isoproterenol (iso) in rat neonatal ventricular cardiomyocytes. |
2010-06-08 |
2023-08-12 |
human |
| b' Andrea Mikusov\\xc3\\xa1, Eva Kr\\xc3\\xa1lov\\xc3\\xa1, Lucia Tylkov\\xc3\\xa1, Marta Novotov\\xc3\\xa1, Tatiana Stankovicov\\xc3\\xa. Myocardial remodelling induced by repeated low doses of isoproterenol. Canadian journal of physiology and pharmacology. vol 87. issue 8. 2010-05-06. PMID:19767889.' |
repeated administration of isoproterenol led to hypertrophy, characterized by the existence of myocytes with simultaneous signs of both mature and postnatally developing cardiomyocytes. |
2010-05-06 |
2023-08-12 |
rat |
| Kun Wang, Bo Long, Jing Zhou, Pei-Feng L. miR-9 and NFATc3 regulate myocardin in cardiac hypertrophy. The Journal of biological chemistry. vol 285. issue 16. 2010-05-06. PMID:20177053. |
our results show that myocardin expression is elevated in response to hypertrophic stimulation with isoproterenol and aldosterone. |
2010-05-06 |
2023-08-12 |
Not clear |
| Kun Wang, Bo Long, Jing Zhou, Pei-Feng L. miR-9 and NFATc3 regulate myocardin in cardiac hypertrophy. The Journal of biological chemistry. vol 285. issue 16. 2010-05-06. PMID:20177053. |
however, the hypertrophic stimulation with isoproterenol and aldosterone leads to a decrease in the expression levels of mir-9. |
2010-05-06 |
2023-08-12 |
Not clear |
| Robert Lukowski, Sergei D Rybalkin, Florian Loga, Veronika Leiss, Joseph A Beavo, Franz Hofman. Cardiac hypertrophy is not amplified by deletion of cGMP-dependent protein kinase I in cardiomyocytes. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 12. 2010-04-16. PMID:20212138. |
we have compared the effect of isoproterenol (iso) and transverse aortic constriction (tac) on hypertrophy in wt [control (ctr)] mice, total cgki-ko mice, and cgkibeta rescue mice (betarm) lacking cgki specifically in cardiomyocytes (cms). |
2010-04-16 |
2023-08-12 |
mouse |
| L C Heather, A F Catchpole, D J Stuckey, M A Cole, C A Carr, K Clark. Isoproterenol induces in vivo functional and metabolic abnormalities: similar to those found in the infarcted rat heart. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 60. issue 3. 2010-03-30. PMID:19826179. |
chronic isoproterenol administration produces a rapid, highly reproducible rodent model of cardiac hypertrophy. |
2010-03-30 |
2023-08-12 |
rat |
| L C Heather, A F Catchpole, D J Stuckey, M A Cole, C A Carr, K Clark. Isoproterenol induces in vivo functional and metabolic abnormalities: similar to those found in the infarcted rat heart. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 60. issue 3. 2010-03-30. PMID:19826179. |
in conclusion, isoproterenol infusion impaired in vivo cardiac function, induced hypertrophy, and decreased both fatty acid and glucose metabolism, changes similar in direction and magnitude to those found in the rat heart following moderate severity myocardial infarction. |
2010-03-30 |
2023-08-12 |
rat |