| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhen Guo, Yue-Huai Hu, Guo-Shuai Feng, Carla Valenzuela Ripoll, Zhen-Zhen Li, Si-Dong Cai, Qian-Qian Wang, Wen-Wei Luo, Qian Li, Li-Ying Liang, Zhong-Kai Wu, Ji-Guo Zhang, Ali Javaheri, Lei Wang, Jing Lu, Pei-Qing Li. JMJD6 protects against isoproterenol-induced cardiac hypertrophy via inhibition of NF-κB activation by demethylating R149 of the p65 subunit. Acta pharmacologica Sinica. 2023-05-15. PMID:37186122. |
cardiac hypertrophy was induced in rats by subcutaneous injection of isoproterenol (iso, 1.2 mg·kg |
2023-05-15 |
2023-08-14 |
rat |
| Zhuang Ma, Zuheng Liu, Xudong Li, Hao Zhang, Dunzheng Han, Wenjun Xiong, Haobin Zhou, Xi Yang, Qingchun Zeng, Hao Ren, Dingli X. Metformin Collaborates with PINK1/Mfn2 Overexpression to Prevent Cardiac Injury by Improving Mitochondrial Function. Biology. vol 12. issue 4. 2023-04-28. PMID:37106782. |
we studied the function of pink1 in mitophagy in isoproterenol (iso)-induced cardiomyocyte injury and transverse aortic constriction (tac)-induced myocardial hypertrophy. |
2023-04-28 |
2023-08-14 |
mouse |
| HuiTing Liu, ZhiXiang Zhou, HuaNian Deng, Zhen Tian, ZeFan Wu, XiYan Liu, Zhong Ren, ZhiSheng Jian. Trim65 attenuates isoproterenol-induced cardiac hypertrophy by promoting autophagy and ameliorating mitochondrial dysfunction via the Jak1/Stat1 signaling pathway. European journal of pharmacology. 2023-04-20. PMID:37080331. |
in this study, the effects of trim65 on isoproterenol (iso)-induced cardiac hypertrophy and the underlying mechanisms were investigated. |
2023-04-20 |
2023-08-14 |
mouse |
| Sandra Tejedor, Marc Buigues, Hernán González-King, Andreia M Silva, Nahuel Aquiles García, Niek Dekker, Pilar Sepúlved. Oncostatin M-Enriched Small Extracellular Vesicles Derived from Mesenchymal Stem Cells Prevent Isoproterenol-Induced Fibrosis and Enhance Angiogenesis. International journal of molecular sciences. vol 24. issue 7. 2023-04-13. PMID:37047440. |
when injected intraperitoneally into mice treated with isoproterenol, osm-loaded sevs reduced fibrosis, prevented cardiac hypertrophy, and increased angiogenesis. |
2023-04-13 |
2023-08-14 |
mouse |
| Jing Liu, Xiaoli Li, Lu Ding, Wei Li, Xiaolin Niu, Dengfeng Ga. GRK2 participation in cardiac hypertrophy induced by isoproterenol through the regulation of Nrf2 signaling and the promotion of NLRP3 inflammasome and oxidative stress. International immunopharmacology. vol 117. 2023-04-04. PMID:37012864. |
grk2 participation in cardiac hypertrophy induced by isoproterenol through the regulation of nrf2 signaling and the promotion of nlrp3 inflammasome and oxidative stress. |
2023-04-04 |
2023-08-14 |
Not clear |
| Jing Liu, Xiaoli Li, Lu Ding, Wei Li, Xiaolin Niu, Dengfeng Ga. GRK2 participation in cardiac hypertrophy induced by isoproterenol through the regulation of Nrf2 signaling and the promotion of NLRP3 inflammasome and oxidative stress. International immunopharmacology. vol 117. 2023-04-04. PMID:37012864. |
in this study, we clarified the effect of grk2 on cardiac hypertrophy in h9c2 cells induced by isoproterenol (iso) and examined the underlying mechanisms. |
2023-04-04 |
2023-08-14 |
Not clear |
| Yu Li, Bo He, Chao Zhang, Yanji He, Tianyang Xia, Chunyu Zen. Naringenin Attenuates Isoprenaline-Induced Cardiac Hypertrophy by Suppressing Oxidative Stress through the AMPK/NOX2/MAPK Signaling Pathway. Nutrients. vol 15. issue 6. 2023-03-29. PMID:36986070. |
in the present study, different dosage regimens (25, 50, and 100 mg/kg/d for three weeks) of naringenin (nar) were orally gavaged in an isoprenaline (iso) (7.5mg/kg)-induced cardiac hypertrophic c57bl/6j mouse model. |
2023-03-29 |
2023-08-14 |
mouse |
| Kevin Agostinucci, Marianne K O Grant, Wongel Melaku, Chandini Nair, Beshay N Zordok. Exposure to Doxorubicin Modulates the Cardiac Response to Isoproterenol in Male and Female Mice. Pharmaceuticals (Basel, Switzerland). vol 16. issue 3. 2023-03-29. PMID:36986490. |
additionally, pre-exposure to doxorubicin abrogated the hypertrophic response to isoproterenol in castrated male mice but not in ovariectomized female mice. |
2023-03-29 |
2023-08-14 |
mouse |
| Cai-Xia Ma, Zhi-Ru Wei, Tong Sun, Ming-Hui Yang, Yu-Qie Sun, Kun-Lun Kai, Jia-Chen Shi, Meng-Jiao Zhou, Zi-Wei Wang, Jing Chen, Wei Li, Tian-Qi Wang, Shan-Feng Zhang, Lixiang Xue, Min Zhang, Qianqian Yin, Ming-Xi Zan. Circ-sh3rf3/GATA-4/miR-29a regulatory axis in fibroblast-myofibroblast differentiation and myocardial fibrosis. Cellular and molecular life sciences : CMLS. vol 80. issue 2. 2023-01-24. PMID:36694058. |
circ-sh3rf3 (circular rna sh3 domain containing ring finger 3) is a novel circular rna which was induced in hypertrophied ventricles by isoproterenol hydrochloride, and our work has established that it is a potential regulator in cardiac hypertrophy, but whether circ-sh3rf3 plays a role in cardiac fibrosis remains unclear, especially in the conversion of cardiac fibroblasts into myofibroblasts. |
2023-01-24 |
2023-08-14 |
rat |
| James T Pearso. Set7 methyltransferase roles in myocardial protection from chronic stressors. Clinical science (London, England : 1979). vol 137. issue 1. 2023-01-05. PMID:36601782. |
recent transcriptome and fourier transform infrared spectroscopy analyses and in vivo assessments of cardiac function by lunardon and colleagues now reveal a clear role of set7 in the regulation of the extracellular matrix composition and cardiac hypertrophy in response to chronic isoproterenol induced cardiac stress. |
2023-01-05 |
2023-08-14 |
Not clear |
| Shrook Y Abdellatif, Nagui H Fares, Samar H Elsharkawy, Yomna I Mahmou. Calanus oil attenuates isoproterenol-induced cardiac hypertrophy by regulating myocardial remodeling and oxidative stress. Ultrastructural pathology. 2023-01-01. PMID:36588172. |
cardiac hypertrophy was induced by subcutaneous injections with isoproterenol (5 mg/kg b.w) for 14 consecutive days. |
2023-01-01 |
2023-08-14 |
Not clear |
| Hongming Li, Yumei Qiu, Mengdie Xie, Changsheng Ouyang, Xiaoyun Ding, Hao Zhang, Wei Dong, Yinhua Xiong, Xilan Tan. Momordicine I alleviates isoproterenol-induced cardiomyocyte hypertrophy through suppression of PLA2G6 and DGK-ζ. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 27. issue 1. 2022-12-28. PMID:36575935. |
this study aimed to observe the protective effect of momordicine i, a triterpenoid compound extracted from momordica charantia l., on isoproterenol (iso)-induced hypertrophy in rat h9c2 cardiomyocytes and investigate its potential mechanism. |
2022-12-28 |
2023-08-14 |
rat |
| Bo Liu, Beilei Qiu, Suchuan Zhan. Effect of Hesperetin on Isoprenaline-induced Hypertrophy of H9C2 Cardiomyocytes. Cellular and molecular biology (Noisy-le-Grand, France). vol 68. issue 7. 2022-12-10. PMID:36495513. |
for this aim, h9c2 cardiomyocytes were coincubated with different concentrations of hesperetin (0.125, 0.25, 0.5, 1μmol/l) and isoproterenol to detect the changes in the area of h9c2 cells, the expression of cardiac hypertrophy marker β-mhc mrna and autophagy marker lc3ii; h9c2 cells were coincubated with hesperetin and isoproterenol at the optimal intervention concentration, and the intervention time was set to 6h, 12h, 24h, respectively, and the changes of h9c2 cell area, β-mhc mrna and lc3ii expression were detected. |
2022-12-10 |
2023-08-14 |
Not clear |
| Bo Liu, Beilei Qiu, Suchuan Zhan. Effect of Hesperetin on Isoprenaline-induced Hypertrophy of H9C2 Cardiomyocytes. Cellular and molecular biology (Noisy-le-Grand, France). vol 68. issue 7. 2022-12-10. PMID:36495513. |
conclusion hesperetin may improve the hypertrophy of h9c2 cardiomyocytes induced by isoproterenol by activating autophagy. |
2022-12-10 |
2023-08-14 |
Not clear |
| Xixi Jiang, Kaina Zhang, Chenying Gao, Wenzhuo Ma, Mengqing Liu, Xinyu Guo, Gaowa Bao, Bing Han, Hao Hu, Zhenghang Zha. Activation of FMS-like tyrosine kinase 3 protects against isoprenaline-induced cardiac hypertrophy by improving autophagy and mitochondrial dynamics. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36. issue 12. 2022-11-28. PMID:36440960. |
in vivo, cardiac hypertrophy was established by subcutaneous injection of isoprenaline (6 mg/kg·day) in c57bl/6 mice for 7 consecutive days. |
2022-11-28 |
2023-08-14 |
mouse |
| Xixi Jiang, Kaina Zhang, Chenying Gao, Wenzhuo Ma, Mengqing Liu, Xinyu Guo, Gaowa Bao, Bing Han, Hao Hu, Zhenghang Zha. Activation of FMS-like tyrosine kinase 3 protects against isoprenaline-induced cardiac hypertrophy by improving autophagy and mitochondrial dynamics. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36. issue 12. 2022-11-28. PMID:36440960. |
our results revealed that the expression level of flt3 protein was significantly increased in the hypertrophic myocardium provoked by isoprenaline administration. |
2022-11-28 |
2023-08-14 |
mouse |
| Xixi Jiang, Kaina Zhang, Chenying Gao, Wenzhuo Ma, Mengqing Liu, Xinyu Guo, Gaowa Bao, Bing Han, Hao Hu, Zhenghang Zha. Activation of FMS-like tyrosine kinase 3 protects against isoprenaline-induced cardiac hypertrophy by improving autophagy and mitochondrial dynamics. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36. issue 12. 2022-11-28. PMID:36440960. |
isoprenaline stimulation impaired autophagic flux in hypertrophic mouse hearts, supported by the accumulation of lc3ii and p62 proteins, while flt3-ligand restored the impairment of autophagic flux. |
2022-11-28 |
2023-08-14 |
mouse |
| Guilherme Lunardon, Tábatha de Oliveira Silva, Caroline A Lino, Yao Wei Lu, Juliane B Miranda, Paula F Asprino, Amanda de Almeida Silva, Gabrielle T Nepomuceno, Maria Cláudia Costa Irigoyen, Marcela S Carneiro-Ramos, Ana Paula C Takano, Herculano da Silva Martinho, Maria Luiza M Barreto-Chaves, Da-Zhi Wang, Gabriela P Dini. Set7 deletion attenuates isoproterenol-induced cardiac fibrosis and delays cardiac dysfunction. Clinical science (London, England : 1979). 2022-10-26. PMID:36285636. |
in addition, wt and set7 ko mice injected with isoproterenol exhibited cardiac hypertrophy. |
2022-10-26 |
2023-08-14 |
mouse |
| Guilherme Lunardon, Tábatha de Oliveira Silva, Caroline A Lino, Yao Wei Lu, Juliane B Miranda, Paula F Asprino, Amanda de Almeida Silva, Gabrielle T Nepomuceno, Maria Cláudia Costa Irigoyen, Marcela S Carneiro-Ramos, Ana Paula C Takano, Herculano da Silva Martinho, Maria Luiza M Barreto-Chaves, Da-Zhi Wang, Gabriela P Dini. Set7 deletion attenuates isoproterenol-induced cardiac fibrosis and delays cardiac dysfunction. Clinical science (London, England : 1979). 2022-10-26. PMID:36285636. |
interestingly, set7 deletion exacerbated cardiac hypertrophy in response to isoproterenol, but attenuated myocardial fibrosis. |
2022-10-26 |
2023-08-14 |
mouse |
| Sitong Ming, Mo Kan, Liu Liu, Zhuang Zhang, Xiaoran Liu, Yaxin Liu, Zhen Li, Yanhong Zhang, Qihang Pang, Jianan Lin, Hui Li, Qing Yang, Xin Sui, Xiaobo Qu, Na L. Protective Effect of Shengmaiyin in Myocardial Hypertrophy-Induced Rats: A Genomic Analysis by 16S rDNA. Evidence-based complementary and alternative medicine : eCAM. vol 2022. 2022-09-19. PMID:36118100. |
therefore, this study aimed to investigate the protective effect and mechanism of smy on isoproterenol (iso)-induced myocardial hypertrophy in rats. |
2022-09-19 |
2023-08-14 |
rat |