| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sonali Meshram, Vipin Kumar Verma, Ekta Mutneja, Anil Kumar Sahu, Salma Malik, Prashant Mishra, Jagriti Bhatia, Dharamvir S Ary. Evidence based mechanistic role of Chrysin towards protection of cardiac hypertrophy & fibrosis in rats. The British journal of nutrition. 2022-02-18. PMID:35177130. |
to investigate the cardio-protective potential of chrysin against isoproterenol (iso) induced cardiac hypertrophy and fibrosis in rats. |
2022-02-18 |
2023-08-13 |
rat |
| Sonali Meshram, Vipin Kumar Verma, Ekta Mutneja, Anil Kumar Sahu, Salma Malik, Prashant Mishra, Jagriti Bhatia, Dharamvir S Ary. Evidence based mechanistic role of Chrysin towards protection of cardiac hypertrophy & fibrosis in rats. The British journal of nutrition. 2022-02-18. PMID:35177130. |
; as vehicle), hc (hypertrophy control) (isoproterenol 3 mg/kg, s.c.), chy15+h, chy30+h & chy60+h (chrysin; p.o.15, 30 and 60 mg/kg + isoproterenol at 3 mg/kg, s.c.), chy60 (chrysin 60 mg/kg in per se) and lst+h (losartan 10 mg/kg p.o. |
2022-02-18 |
2023-08-13 |
rat |
| Jie Li, Xiaohe Chen, Xiang Li, Jiayang Tang, Yan Li, Bin Liu, Shuzhen Gu. Cryptochlorogenic acid and its metabolites ameliorate myocardial hypertrophy through a HIF1α-related pathway. Food & function. 2022-02-10. PMID:35141734. |
our preliminary study found that 4-cqa has a good effect on isoproterenol (iso)-induced myocardial hypertrophy, while the mechanism remains largely unknown. |
2022-02-10 |
2023-08-13 |
Not clear |
| Laia Yáñez-Bisbe, Anna Garcia-Elias, Marta Tajes, Isaac Almendros, Antonio Rodríguez-Sinovas, Javier Inserte, Marisol Ruiz-Meana, Ramón Farré, Núria Farré, Begoña Benit. Aging Impairs Reverse Remodeling and Recovery of Ventricular Function after Isoproterenol-Induced Cardiomyopathy. International journal of molecular sciences. vol 23. issue 1. 2022-01-11. PMID:35008601. |
following isoproterenol infusion, elderly mice developed similar hfref features compared to young animals, except for greater cell hypertrophy and tissue fibrosis. |
2022-01-11 |
2023-08-13 |
mouse |
| Akihito Ishikita, Shouji Matsushima, Soichiro Ikeda, Kosuke Okabe, Ryohei Nishimura, Tomonori Tadokoro, Nobuyuki Enzan, Taishi Yamamoto, Masashi Sada, Yoshitomo Tsutsui, Ryo Miyake, Masataka Ikeda, Tomomi Ide, Shintaro Kinugawa, Hiroyuki Tsutsu. GFAT2 mediates cardiac hypertrophy through HBP-O-GlcNAcylation-Akt pathway. iScience. vol 24. issue 12. 2021-12-22. PMID:34934932. |
we here demonstrate that glutamine-fructose-6-phosphate amidotransferase 2 (gfat2), a critical hbp enzyme, is a major isoform of gfat in the heart and is increased in response to several hypertrophic stimuli, including isoproterenol (iso). |
2021-12-22 |
2023-08-13 |
mouse |
| Yuqiao Yang, Zhuoran Wang, Mengran Yao, Wei Xiong, Jun Wang, Yu Fang, Wei Yang, Haixia Jiang, Ning Song, Lan Liu, Jinqiao Qia. Oxytocin Protects Against Isoproterenol-Induced Cardiac Hypertrophy by Inhibiting PI3K/AKT Pathway via a lncRNA GAS5/miR-375-3p/KLF4-Dependent Mechanism. Frontiers in pharmacology. vol 12. 2021-12-20. PMID:34925023. |
the rats with cardiac hypertrophy induced by isoproterenol (iso) were treated with or without oxytocin. |
2021-12-20 |
2023-08-13 |
rat |
| Chao Yang, Yong Zhang, Baofeng Yan. MIAT, a potent CVD-promoting lncRNA. Cellular and molecular life sciences : CMLS. 2021-12-18. PMID:34921634. |
emerging evidence supports that lncr-miat is susceptible in its expression to multiple deleterious factors like angiotensin ii, isoproterenol, hypoxia, and infection and is anomaly overexpressed in serum, plasma, blood cells and myocardial tissues under a variety of cardiovascular conditions including myocardial infarction, cardiac hypertrophy, diabetic cardiomyopathy, dilated cardiomyopathy, sepsis cardiomyopathy, atrial fibrillation and microvascular dysfunction. |
2021-12-18 |
2023-08-13 |
Not clear |
| Le Li, Pu Fang, Jiekun Chen, Cailing Zhang, Houquan Ta. Protective effect of sinomenine on isoproterenol-induced cardiac hypertrophy in mice. Journal of applied biomedicine. vol 19. issue 3. 2021-12-15. PMID:34907757. |
to study the effect of sinomenine (sin) on isoproterenol (iso, β-agonist)-induced cardiac hypertrophy (ch), we set up four mouse groups: control, iso model, iso+metoprolol (met, β blocker) 60 mg/kg and iso+sin 120 mg/kg. |
2021-12-15 |
2023-08-13 |
mouse |
| Abu Mohammad Syed, Sourav Kundu, Chetan Ram, Uttam Kulhari, Akhilesh Kumar, Madhav Nilakanth Mugale, Upadhyayula Suryanarayana Murty, Bidya Dhar Sah. Aloin alleviates pathological cardiac hypertrophy via modulation of the oxidative and fibrotic response. Life sciences. vol 288. 2021-12-11. PMID:34801516. |
this study investigated the effect of aloin against the isoproterenol (iso)-induced cardiac hypertrophy in rats. |
2021-12-11 |
2023-08-13 |
rat |
| Mi-Hyeon Hong, Se-Won Na, Youn-Jae Jang, Jung-Joo Yoon, Yun-Jung Lee, Ho-Sub Lee, Hye-Yoom Kim, Dae-Gill Kan. Betulinic Acid Improves Cardiac-Renal Dysfunction Caused by Hypertrophy through Calcineurin-NFATc3 Signaling. Nutrients. vol 13. issue 10. 2021-11-18. PMID:34684485. |
however, as the potential effect of ba on cardiac hypertrophy and consequent renal dysfunction is unknown, we investigated the effect of ba on isoprenaline (iso)-induced cardiac hypertrophy and related signaling. |
2021-11-18 |
2023-08-13 |
Not clear |
| Xue-Cui Wu, Cheng-Fu Yuan, Yu-Min He, Zhi-Yong Zhou, Yue Luo, Meng-Ting Yang, Xiao-Xiao Li, Chao-Qi Li. [Chikusetsu saponin Ⅳa ameliorates myocardial hypertrophy of rats through regulating expression of miR199a-5p/Atg5]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 19. 2021-11-08. PMID:34738402. |
the present study investigated the effects of chikusetsu saponin Ⅳa(chs Ⅳa) on isoproterenol(iso)-induced myocardial hypertrophy in rats and explored the underlying molecular mechanism. |
2021-11-08 |
2023-08-13 |
rat |
| Kuniya Asai, Koji Murai, Akihiro Shirakabe, Masataka Kamiya, Satsuki Noma, Naoki Sato, Kyoichi Mizuno, Wataru Shimiz. Effect of Gonadectomy and Angiotensin II Receptor Blockade in a Mouse Model of Isoproterenol-induced Cardiac Diastolic Dysfunction. Journal of Nippon Medical School = Nippon Ika Daigaku zasshi. vol 88. issue 2. 2021-10-26. PMID:32475904. |
we examined the effect of gonadectomy with or without the angiotensin receptor blocker olmesartan (olm) in an isoproterenol (iso) -induced mouse model of left ventricular hypertrophy (lvh) and cardiac diastolic dysfunction. |
2021-10-26 |
2023-08-13 |
mouse |
| Lingmin Mu, Changqin Jing, Zhikun Gu. Expression of N-cadherin proteins in myocardial hypertrophy in rats. Experimental and therapeutic medicine. vol 7. issue 2. 2021-10-21. PMID:24396404. |
a myocardial hypertrophy model was established by subcutaneously injecting isoprenaline into healthy adult sprague-dawley rats. |
2021-10-21 |
2023-08-12 |
rat |
| Stacey L House, Brian E House, Betty Glascock, Thomas Kimball, Eyad Nusayr, Jo El J Schultz, Thomas Doetschma. Fibroblast Growth Factor 2 Mediates Isoproterenol-induced Cardiac Hypertrophy through Activation of the Extracellular Regulated Kinase. Molecular and cellular pharmacology. vol 2. issue 4. 2021-10-20. PMID:21274419. |
to ascertain the role of fgf2 in cardiac hypertrophy, wildtype, fgf2 knockout, non-transgenic, and fgf2 transgenic mice were treated with isoproterenol or saline via subcutaneous mini-osmotic pump implants to induce a hypertrophic response to β-adrenergic stimulation. |
2021-10-20 |
2023-08-12 |
mouse |
| Stacey L House, Brian E House, Betty Glascock, Thomas Kimball, Eyad Nusayr, Jo El J Schultz, Thomas Doetschma. Fibroblast Growth Factor 2 Mediates Isoproterenol-induced Cardiac Hypertrophy through Activation of the Extracellular Regulated Kinase. Molecular and cellular pharmacology. vol 2. issue 4. 2021-10-20. PMID:21274419. |
echocardiography reveals significantly decreased fractional shortening in isoproterenol-treated fgf2 transgenic mice but not in fgf2 knockout mice suggesting that fgf2 mediates the maladaptive cardiac dysfunction seen in cardiac hypertrophy induced by isoproterenol. |
2021-10-20 |
2023-08-12 |
mouse |
| Yonglin Zhang, Zhenglu Shang, Aijun Li. Angiotensin-(3-7) alleviates isoprenaline-induced cardiac remodeling via attenuating cAMP-PKA and PI3K/Akt signaling pathways. Amino acids. vol 53. issue 10. 2021-10-19. PMID:34494132. |
the administration of ang-(3-7) alleviated isoprenaline (iso)-induced cardiac hypertrophy and fibrosis of mice. |
2021-10-19 |
2023-08-13 |
mouse |
| Yuan Li, Wei-Wei Zhou, Jia-Huan Sun, Hong-Xia Yang, Geng-Rui Xu, Yue Zhang, Qiu-Hang Song, Chuang Zhang, Wei-Zhe Liu, Xing-Chao Liu, Ai-Ying L. Modified citrus pectin prevents isoproterenol-induced cardiac hypertrophy associated with p38 signalling and TLR4/JAK/STAT3 pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 143. 2021-10-15. PMID:34649308. |
the aim of this study is to investigate the role and mechanism of mcp in isoproterenol (iso)-induced cardiac hypertrophy. |
2021-10-15 |
2023-08-13 |
rat |
| Jing Lu, Suowen Xu, Yuqing Huo, Duanping Sun, Yuehuai Hu, Junjian Wang, Xiaolei Zhang, Panxia Wang, Zhuoming Li, Mengya Liang, Zhongkai Wu, Peiqing Li. Sorting nexin 3 induces heart failure via promoting retromer-dependent nuclear trafficking of STAT3. Cell death and differentiation. vol 28. issue 10. 2021-10-09. PMID:33947971. |
we report that snx3-cko in mice significantly protected against isoproterenol (iso)-induced cardiac hypertrophy at 12 weeks. |
2021-10-09 |
2023-08-13 |
mouse |
| Bing-Yan Liu, Ling Li, Gao-Li Liu, Wei Ding, Wen-Guang Chang, Tao Xu, Xiao-Yu Ji, Xian-Xin Zheng, Jing Zhang, Jian-Xun Wan. Baicalein attenuates cardiac hypertrophy in mice via suppressing oxidative stress and activating autophagy in cardiomyocytes. Acta pharmacologica Sinica. vol 42. issue 5. 2021-09-27. PMID:32796955. |
cardiac hypertrophy was induced in mice by injection of isoproterenol (iso, 30 mg·kg |
2021-09-27 |
2023-08-13 |
mouse |
| Naijin Zhang, Ying Zhang, Hao Qian, Shaojun Wu, Liu Cao, Yingxian Su. Selective targeting of ubiquitination and degradation of PARP1 by E3 ubiquitin ligase WWP2 regulates isoproterenol-induced cardiac remodeling. Cell death and differentiation. vol 27. issue 9. 2021-09-23. PMID:32139900. |
we determined that the knockout of wwp2 specifically in myocardium decreased the level of parp1 ubiquitination and increased the effects of isoproterenol (iso)-induced parp1 and parylation, in turn aggravating iso-induced myocardial hypertrophy, heart failure, and myocardial fibrosis. |
2021-09-23 |
2023-08-13 |
Not clear |