| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| S-S Song, G Tang, L-X Tang, L-Y Si, W Xion. NAK\\xce\\xb12 inhibits fibrosis formation and protects against cardiomyocyte hypertrophy by suppressing hypertrophy associated molecules and activating LTCC/NCX signaling pathway. European review for medical and pharmacological sciences vol 23 issue 7 2020 31002153 |
this study aimed to evaluate effects of na+/k+ aptase\xce\xb12 (nak\xce\xb12) on isoprenaline (iso) induced cardiomyocyte hypertrophy. |
2020-09-08 |
2023-01-26 |
Not clear |
| Lihua Qi, Xiaochun Chi, Xi Zhang, Xueqian Feng, Wenhui Chu, Shengchang Zhang, Junzhou Wu, Yao Song, Youyi Zhang, Wei Kong, Yu Yu, Hongquan Zhan. Kindlin-2 suppresses transcription factor GATA4 through interaction with SUV39H1 to attenuate hypertrophy. Cell death & disease vol 10 issue 12 2020 31767831 |
we found that kindlin-2 suppresses the expression of gata4 through binding to its promoter and prevents cardiomyocytes from hypertrophy induced by isoproterenol (iso) treatment. |
2020-08-31 |
2023-01-26 |
mouse |
| Toru Miyoshi, Kazufumi Nakamura, Daiji Miura, Masashi Yoshida, Yukihiro Saito, Satoshi Akagi, Yuko Ohno, Megumi Kondo, Hiroshi It. Effect of LCZ696, a dual angiotensin receptor neprilysin inhibitor, on isoproterenol-induced cardiac hypertrophy, fibrosis, and hemodynamic change in rats. Cardiology journal vol 26 issue 5 2020 29718530 |
this study evaluated whether lcz696 affects left ventricular hypertrophy, fibrosis, and hemodynamics in isoproterenol (iso)-treated rats compared with valsartan alone. |
2020-07-28 |
2023-01-26 |
rat |
| Yaoxu Chen, Huimin Beng, Hao Su, Fuping Han, Zhuo Fan, Nanying Lv, Aleksandar Jovanovi\\xc4\\x87, Wen Ta. Isosteviol prevents the development of isoprenaline\\xe2\\x80\\x91induced myocardial hypertrophy. International journal of molecular medicine vol 44 issue 5 2020 31545484 |
in the current study, whether stvna interferes with the development of cardiac hypertrophy, which is induced by isoprenaline (iso), was investigated in an experimental rat model. |
2020-07-27 |
2023-01-26 |
rat |
| Si Zhang, Zhongnan Yin, Fei-Fei Dai, Hao Wang, Meng-Jiao Zhou, Ming-Hui Yang, Shu-Feng Zhang, Zhi-Feng Fu, Ying-Wu Mei, Ming-Xi Zang, Lixiang Xu. miR-29a attenuates cardiac hypertrophy through inhibition of PPAR\\xce\\xb4 expression. Journal of cellular physiology vol 234 issue 8 2020 30580435 |
in addition, we identify a novel role of mir-29a, in which it has a cardioprotective function in isoproterenol hydrochloride-induced cardiac hypertrophy by targeting ppar\xce\xb4 and downregulating anf. |
2020-05-08 |
2023-01-26 |
Not clear |
| Si Zhang, Zhongnan Yin, Fei-Fei Dai, Hao Wang, Meng-Jiao Zhou, Ming-Hui Yang, Shu-Feng Zhang, Zhi-Feng Fu, Ying-Wu Mei, Ming-Xi Zang, Lixiang Xu. miR-29a attenuates cardiac hypertrophy through inhibition of PPAR\\xce\\xb4 expression. Journal of cellular physiology vol 234 issue 8 2020 30580435 |
finally, we provide evidence that mir-29a reduces the isoproterenol hydrochloride-induced cardiac hypertrophy response, thereby underlining the potential clinical relevance of mir-29a in which it may serve as a potent therapeutic target for heart hypertrophy treatment. |
2020-05-08 |
2023-01-26 |
Not clear |
| Isil Ozakc. Antihypertrophic Effects of Nebivolol on Neonatal Cardiomyocyte Hypertrophy Models. Journal of cardiovascular pharmacology vol 73 issue 3 2020 30601193 |
in the current study, in vitro cardiomyocyte hypertrophy model was induced with isoprenaline (10 \xce\xbcm), angiotensin ii (1 \xce\xbcm), and phenylephrine (20 \xce\xbcm) in neonatal cardiomyocytes isolated from 0- to 2-day-old sprague-dawley rats. |
2020-05-04 |
2023-01-26 |
rat |
| Zhengbo Zhao, Han Liu, Dongmei Gu. Aliskiren attenuates cardiac dysfunction by modulation of the mTOR and apoptosis pathways. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas vol 53 issue 2 2020 31994601 |
a rat model of cardiac hypertrophy was induced by isoproterenol treatment (5 mg\xc2\xb7kg-1\xc2\xb7day-1) for 4 weeks, with or without als treatment at 20 mg\xc2\xb7kg-1\xc2\xb7day-1. |
2020-04-07 |
2023-01-26 |
rat |
| Kai-Chun Cheng, Yingxiao Li, Wei-Ting Chang, Zhih-Cherng Chen, Juei-Tang Cheng, Cheng-Chia Tsa. Ubiquitin-protein ligase E3a (UBE3A) as a new biomarker of cardiac hypertrophy in cell models. Journal of food and drug analysis vol 27 issue 1 2020 30648591 |
the cardiac hypertrophy is induced in rat-derived heart cell line h9c2 cells by potassium bromate (kbro3), high glucose (hg), or isoproterenol (iso), respectively. |
2020-03-23 |
2023-01-26 |
Not clear |
| Stephanie Binas, Maria Knyrim, Julia Hupfeld, Udo Kloeckner, Sindy Rabe, Sigrid Mildenberger, Katja Quarch, Nicole Str\\xc3\\xa4tz, Danny Misiak, Michael Gekle, Claudia Grossmann, Barbara Schreie. miR-221 and -222 target CACNA1C and KCNJ5 leading to altered cardiac ion channel expression and current density. Cellular and molecular life sciences : CMLS vol 77 issue 5 2020 31312877 |
additionally, we evaluated the change of mir-221/222 in vivo in two models of pharmacologically induced heart hypertrophy (angiotensin ii, isoprenaline), thereby demonstrating a stimulus-induced increase in mir-221/222 in vivo by angiotensin ii but not by isoprenaline. |
2020-03-18 |
2023-01-26 |
Not clear |
| Yanfei Li, Linlin Ma, Sijie Gu, Jiewen Tian, Yilin Cao, Zi Jin, Jingyi Chen, Bingbing Gu, Jiayin Tu, Zhixiao Wang, Xinming Li, Zhongping Ning, Yueling Ji. UBE3A alleviates isoproterenol-induced cardiac hypertrophy through the inhibition of the TLR4/MMP-9 signaling pathway. Acta biochimica et biophysica Sinica vol 52 issue 1 2020 31681945 |
in this study, we explored the potential mechanism underlying cardiac hypertrophy induced by isoproterenol. |
2020-02-26 |
2023-01-26 |
Not clear |
| Yanfei Li, Linlin Ma, Sijie Gu, Jiewen Tian, Yilin Cao, Zi Jin, Jingyi Chen, Bingbing Gu, Jiayin Tu, Zhixiao Wang, Xinming Li, Zhongping Ning, Yueling Ji. UBE3A alleviates isoproterenol-induced cardiac hypertrophy through the inhibition of the TLR4/MMP-9 signaling pathway. Acta biochimica et biophysica Sinica vol 52 issue 1 2020 31681945 |
our results showed that isoproterenol induced cardiac hypertrophy in ac16 cells, as reflected by the increased cell surface area and increased hypertrophic markers, which was accompanied by increased ubiquitin-protein ligase e3a (ube3a) expression. |
2020-02-26 |
2023-01-26 |
Not clear |
| Yanfei Li, Linlin Ma, Sijie Gu, Jiewen Tian, Yilin Cao, Zi Jin, Jingyi Chen, Bingbing Gu, Jiayin Tu, Zhixiao Wang, Xinming Li, Zhongping Ning, Yueling Ji. UBE3A alleviates isoproterenol-induced cardiac hypertrophy through the inhibition of the TLR4/MMP-9 signaling pathway. Acta biochimica et biophysica Sinica vol 52 issue 1 2020 31681945 |
moreover, ube3a knockdown by sirnas accelerated cardiac hypertrophy, suggesting that increased ube3a expression induced by isoproterenol might be a protective response and ube3a might be a protective factor against cardiac hypertrophy. |
2020-02-26 |
2023-01-26 |
Not clear |
| Harry H Matundan, Jon Sin, Magali Noval Rivas, Michael C Fishbein, Thomas J Lehman, Shuang Chen, Roberta A Gottlieb, Timothy R Crother, Masanori Abe, Moshe Ardit. Myocardial fibrosis after adrenergic stimulation as a long-term sequela in a mouse model of Kawasaki disease vasculitis. JCI insight vol 4 issue 3 2020 30728329 |
we found that adrenergic stimulation with isoproterenol following lcwe-induced kd vasculitis in mice was associated with increased risk of cardiac hypertrophy and myocardial fibrosis, diminished ejection fraction, and increased serum levels of brain natriuretic peptide. |
2020-02-25 |
2023-01-26 |
mouse |
| Ying-Xu Wu, Jie-Kun Cheng, Le Li, Hou-Quan Ta. [Effects of chrysanthemum flower extract on cardiac hypertrophy induced by isoprenaline in mice]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology vol 35 issue 5 2020 31894685 |
[effects of chrysanthemum flower extract on cardiac hypertrophy induced by isoprenaline in mice]. |
2020-02-24 |
2023-01-26 |
mouse |
| Jing-Xia Du, Jian-Zhao Wu, Zhi Li, Cai Zhang, Meng-Ting Shi, Jia Zhao, Man-Wen Jin, Hui Li. Pentamethylquercetin protects against cardiac remodeling via activation of Sestrin2. Biochemical and biophysical research communications vol 512 issue 2 2020 30898320 |
we generated a transverse aorta constriction (tac)-induced pressure-overload cardiac-remodeling model in mice, and also established an isoproterenol (iso)-induced neonatal rat cardiomyocyte (nrcm) hypertrophy model. |
2020-02-18 |
2023-01-26 |
rat |
| Isadora Prado Cano, Thiago Jos\\xc3\\xa9 Dionisio, T\\xc3\\xa2nia Mary Cestari, Adriana Maria Calvo, Bella Luna Colombini-Ishikiriama, Fl\\xc3\\xa1vio Augusto Cardoso Faria, Walter Luiz Siqueira, Carlos Ferreira Santo. Losartan and isoproterenol promote alterations in the local renin-angiotensin system of rat salivary glands. PloS one vol 14 issue 5 2020 31116771 |
isoproterenol treatment affected gene expression profiles in parotid (ace, ace-2, at1-a, mas, agt), and submandibular (ace, at2, agt) glands, thus promoting acinar hypertrophy in serous acini, without significant changes in salivary flow or total protein content. |
2020-02-03 |
2023-01-26 |
rat |
| Xue-Cui Wu, Yun Zhao, Cong Li, Hai-Rong Xiong, Zhi-Wei Zheng, Jun Zhou, Rong Liu, Wei Gong, Chao-Qi Li. [Expression and bioinformatics analysis of miRNA in ISO-induced rat cardiac hypertrophy]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology vol 35 issue 5 2020 31894683 |
to investigate the expression changes of mirnas (mir199a-5p, mir206, mir133a-3p, mir499-5p) in rat model of cardiac hypertrophy induced by isoproterenol (iso), and to explore the main signal pathways and molecular mechanisms which related to that with the way of bioinformatics. |
2020-01-16 |
2023-01-26 |
rat |
| Miao Zhang, Qigen Du, Fubiao Yang, Ying Guo, Yunlong Hou, Pengyu Zh. Acupuncture at PC6 prevents cardiac hypertrophy in isoproterenol-treated mice. Acupuncture in medicine : journal of the British Medical Acupuncture Society vol 37 issue 1 2019 30843422 |
to investigate the effect of acupuncture at pc6 on cardiac hypertrophy in isoproterenol (iso)-treated mice. |
2019-12-03 |
2023-01-26 |
mouse |
| Jia Meng, Baoxue Yan. Protective Effect of Ganoderma (Lingzhi) on Cardiovascular System. Advances in experimental medicine and biology vol 1182 issue 2019 31777019 |
some studies found that g. lucidum prevented from heart damage in a variety of disease models, such as streptozotocin (stz)-induced diabetic, high-fat-diet-induced diabetic, isoprenaline (iso)-induced myocardial hypertrophy, acute ethanol-induced heart toxicity, and transverse aortic constriction (tac) models. |
2019-12-02 |
2023-01-26 |
Not clear |