| Reference |
Sentence |
Publish Date |
Extraction Date |
Species |
| Atsuki Imaeda, Shota Tanaka, Kota Tonegawa, Shota Fuchigami, Masanori Obana, Makiko Maeda, Miho Kihara, Hiroshi Kiyonari, Simon J Conway, Yasushi Fujio, Hiroyuki Nakayam. Myofibroblast \\xce\\xb22 adrenergic signaling amplifies cardiac hypertrophy in mice. Biochemical and biophysical research communications vol 510 issue 1 2019 30683314 |
\xce\xb22ar null mice exhibited attenuated hypertrophic responses to chronic \xce\xb2ar stimulation upon continuous infusion of an agonist, isoprenaline (iso), compared to those in wildtype controls, suggesting that \xce\xb22ar activation in the heart induces pro-hypertrophic effects in mice. |
2019-11-29 |
2023-01-26 |
rat |
| X Fan, L Liu, Z Li, X Peng, Z Jiang, Y Guan, X Wu, X Yang, J Wan. Cardiomyocyte-specific T\\xce\\xb2R2 knockout mice are more susceptible to cardiac hypertrophy induced by adrenergic agonist stimulation. Current molecular medicine vol issue 2019 26349497 |
although the mutant mice displayed no obvious physiological abnormality, they developed severer cardiac hypertrophy in response to isoproterenol (iso) stimulation than control mice did. |
2019-11-20 |
2023-01-25 |
mouse |
| Erratum for \"Utility of Isoproterenol to Provoke Outflow Tract Gradients in Patients with Hypertrophic Cardiomyopathy\" Am J Cardiol 2008;101:516-520. The American journal of cardiology vol 120 issue 2 2019 27887686 |
erratum for "utility of isoproterenol to provoke outflow tract gradients in patients with hypertrophic cardiomyopathy" am j cardiol 2008;101:516-520. |
2019-11-20 |
2023-01-26 |
Not clear |
| Xiuli Fang, Yajun Liu, Jing Lu, Huiqi Hong, Jing Yuan, Yuhong Zhang, Panxia Wang, Peiqing Liu, Jiantao Y. Protocatechuic aldehyde protects against isoproterenol-induced cardiac hypertrophy via inhibition of the JAK2/STAT3 signaling pathway. Naunyn-Schmiedeberg's archives of pharmacology vol 391 issue 12 2019 30132020 |
in this study, we showed that isoproterenol treatment (iso, 10\xc2\xa0\xce\xbcm for 24\xc2\xa0h) induced significant hypertrophy in cultured neonatal rat cardiomyocytes, as manifested by enlargement of cell surface area (1.74-fold greater than that of the control, p\xe2\x80\x89<\xe2\x80\x890.05) and upregulation of hypertrophic gene markers (2.44- to 2.75-fold increase in anf and \xce\xb2-mhc protein expression, p\xe2\x80\x89<\xe2\x80\x890.05). |
2019-10-31 |
2023-01-26 |
rat |
| Tahir Ali, Iram Mushtaq, Sonia Maryam, Anam Farhan, Kiran Saba, Muhammad Ishtiaq Jan, Aneesa Sultan, Mariam Anees, Burcu Duygu, Sadia Hamera, Sobia Tabassum, Qamar Javed, Paula A da Costa Martins, Iram Murtaz. Interplay of N acetyl cysteine and melatonin in regulating oxidative stress-induced cardiac hypertrophic factors and microRNAs. Archives of biochemistry and biophysics vol 661 issue 2019 30439361 |
we aimed to measure the micrornas expressions in oxidative stress linked cardiac hypertrophic condition induced through stimulants as endothelin and isoproterenol. |
2019-10-23 |
2023-01-26 |
Not clear |
| Linyuan Shen, Mailin Gan, Zhengdong Tan, Dongmei Jiang, Yanzhi Jiang, Mingzhou Li, Jinyong Wang, Xuewei Li, Shunhua Zhang, Li Zh. A Novel Class of tRNA-Derived Small Non-Coding RNAs Respond to Myocardial Hypertrophy and Contribute to Intergenerational Inheritance. Biomolecules vol 8 issue 3 2019 30012983 |
in this study, we used an isoproterenol (iso)-induced myocardial hypertrophy rat model. |
2019-09-18 |
2023-01-26 |
Not clear |
| Linyuan Shen, Mailin Gan, Zhengdong Tan, Dongmei Jiang, Yanzhi Jiang, Mingzhou Li, Jinyong Wang, Xuewei Li, Shunhua Zhang, Li Zh. A Novel Class of tRNA-Derived Small Non-Coding RNAs Respond to Myocardial Hypertrophy and Contribute to Intergenerational Inheritance. Biomolecules vol 8 issue 3 2019 30012983 |
isoproterenol successfully induced a typical cardiac hypertrophy model in our study. |
2019-09-18 |
2023-01-26 |
Not clear |
| Yapeng Li, Dianhong Zhang, Lingyao Kong, Huiting Shi, Xinyu Tian, Lu Gao, Yuzhou Liu, Leiming Wu, Binbin Du, Zhen Huang, Cui Liang, Zheng Wang, Rui Yao, Yanzhou Zhan. Aldolase promotes the development of cardiac hypertrophy by targeting AMPK signaling. Experimental cell research vol 370 issue 1 2019 29902536 |
the mrna and protein levels of aldoa were significantly up-regulated in transverse aortic constriction (tac)- and isoproterenol (iso)-induced hypertrophic mouse hearts. |
2019-09-16 |
2023-01-26 |
mouse |
| Jing Yuan, Huiqi Hong, Yuhong Zhang, Jing Lu, Youhui Yu, Xueying Bi, Junjian Wang, Jiantao Y. Chrysophanol attenuated isoproterenol-induced cardiac hypertrophy by inhibiting Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway. Cell biology international vol 43 issue 6 2019 30977566 |
in the current study, we found that chrysophanol could protect against isoproterenol (iso)-induced cardiac hypertrophy both in vitro and in vivo. |
2019-09-09 |
2023-01-26 |
rat |
| Qian Li, Zhuo-Ming Li, Shu-Ya Sun, Lu-Ping Wang, Pan-Xia Wang, Zhen Guo, Han-Wei Yang, Jian-Tao Ye, Jing Lu, Pei-Qing Li. PARP1 interacts with HMGB1 and promotes its nuclear export in pathological myocardial hypertrophy. Acta pharmacologica Sinica vol 40 issue 5 2019 30030529 |
primary-cultured neonatal rat cardiomyocytes (nrcms) were respectively incubated with three cardiac hypertrophic stimulants, including angiotensin ii (ang ii), phenylephrine (pe), and isoproterenol (iso), and cell surface area and the mrna expression of hypertrophic biomarkers were measured. |
2019-07-29 |
2023-01-26 |
rat |
| Mailin Gan, Ting Zheng, Linyuan Shen, Ya Tan, Yuan Fan, Surong Shuai, Lin Bai, Xuewei Li, Jinyong Wang, Shunhua Zhang, Li Zh. Genistein reverses isoproterenol-induced cardiac hypertrophy by regulating miR-451/TIMP2. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie vol 112 issue 2019 30798118 |
in this study, h9c2 cells were treated with genistein, mir-451 mimic, mir-451 inhibitor and isoproterenol for 24\xe2\x80\x89h, to study the effect of genistein on isoproterenol-induced myocardial hypertrophy in vitro. |
2019-07-22 |
2023-01-26 |
mouse |
| Mailin Gan, Ting Zheng, Linyuan Shen, Ya Tan, Yuan Fan, Surong Shuai, Lin Bai, Xuewei Li, Jinyong Wang, Shunhua Zhang, Li Zh. Genistein reverses isoproterenol-induced cardiac hypertrophy by regulating miR-451/TIMP2. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie vol 112 issue 2019 30798118 |
results showed that isoproterenol induced cardiac hypertrophy and down-regulated the expression of mir-451 and up-regulated mir-451's target gene timp2. |
2019-07-22 |
2023-01-26 |
mouse |
| Xiao-Chun Xiao, Wei-Hong Chen, Yuan-Yuan Cao, Yong-Jun Lou, Yuan Liu, Jin Wang, Xu-Feng Zhai, Nian-Sheng Li, Ying L. [Protective effect of Dendrobium candidum on isoproterenol induced cardiac hypertrophy in rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica vol 43 issue 4 2019 29600658 |
[protective effect of dendrobium candidum on isoproterenol induced cardiac hypertrophy in rats]. |
2019-07-11 |
2023-01-26 |
rat |
| Christoph D Rau, Milagros C Romay, Mary Tuteryan, Jessica J-C Wang, Marc Santolini, Shuxun Ren, Alain Karma, James N Weiss, Yibin Wang, Aldons J Lusi. Systems Genetics Approach Identifies Gene Pathways and Adamts2 as Drivers of Isoproterenol-Induced Cardiac Hypertrophy and Cardiomyopathy in Mice. Cell systems vol 4 issue 1 2019 27866946 |
we previously reported a genetic analysis of heart failure traits in a population of inbred mouse strains treated with isoproterenol to mimic catecholamine-driven cardiac hypertrophy. |
2019-07-01 |
2023-01-26 |
rat |
| Linlin Shang, Lv Pin, Shanshan Zhu, Xiaohang Zhong, Yubiao Zhang, Mao Shun, Yunen Liu, Mingxiao Ho. Plantamajoside attenuates isoproterenol-induced cardiac hypertrophy associated with the HDAC2 and AKT/ GSK-3\\xce\\xb2 signaling pathway. Chemico-biological interactions vol 307 issue 2019 31009642 |
here, we investigated the effects and mechanism of pms on isoproterenol (iso)-induced cardiac hypertrophy. |
2019-06-26 |
2023-01-26 |
Not clear |
| Xinlei Hu, Qiong Ou-Yang, Lanlan Wang, Tingting Li, Xiaoxue Xie, Jun Li. AdipoRon prevents l-thyroxine or isoproterenol-induced cardiac hypertrophy through regulating the AMPK-related pathway. Acta biochimica et biophysica Sinica vol 51 issue 1 2019 30566571 |
in the present study, we explored whether adiporon attenuates isoprenaline (iso) or l-thyroxine-induced cardiac hypertrophy in sprague-dawley (sd) rats and whether the anti-hypertrophy effect is mediated by ampk-related pathway. |
2019-05-24 |
2023-01-26 |
rat |
| Jia-Shen Li, Xiao-Yu Zhu, Mei-Li Lu, Jun-Hong Gao, Hong-Xin Wang, Xiao-Chun Y. [Effect of Combined Intervention of Electroacupuncture and Astragaloside IV on Myocardial Hypertrophy and TGF-\\xce\\xb2 1/Smad Signaling in Rats with Myocardial Fibrosis]. Zhen ci yan jiu = Acupuncture research vol 42 issue 6 2019 29318851 |
to observe the effect of combined intervention of electroacupuncture (ea) and astragaloside iv(asiv) on cardiac hypertrophy and transforming growth factor \xce\xb2 1 (tgf-\xce\xb2 1)/smad signaling in isoproterenol (iso) induced cardiac hypertrophy rats, so as to investigate its underlying mechanisms in improving myocardial fibrosis. |
2019-04-03 |
2023-01-26 |
rat |
| Sumia A Bageghni, Karen E Hemmings, Ngonidzashe Zava, Christopher P Denton, Karen E Porter, Justin F X Ainscough, Mark J Drinkhill, Neil A Turne. Cardiac fibroblast-specific p38\\xce\\xb1 MAP kinase promotes cardiac hypertrophy via a putative paracrine interleukin-6 signaling mechanism. FASEB journal : official publication of the Federation of American Societies for Experimental Biology vol 32 issue 9 2019 29601781 |
isoproterenol infusion in control mice promoted overt cardiac hypertrophy and dysfunction (reduced ejection fraction, increased end systolic volume, increased cardiac weight index, increased cardiomyocyte area, increased fibrosis, and up-regulation of myocyte fetal genes and hypertrophy-associated micrornas). |
2019-03-21 |
2023-01-26 |
mouse |
| Chih-Chung Feng, Po-Hsiang Liao, Hsiang-I Tsai, Shiu-Min Cheng, Liang-Yo Yang, Vijaya PadmaViswanadha, Lung-Fa Pan, Ray-Jade Chen, Jeng-Fan Lo, Chih-Yang Huan. Tumorous imaginal disc 1 (TID1) inhibits isoproterenol-induced cardiac hypertrophy and apoptosis by regulating c-terminus of hsc70-interacting protein (CHIP) mediated degradation of G\\xce\\xb1s. International journal of medical sciences vol 15 issue 13 2019 30443176 |
tid1 also plays a major role in preventing dcm; however, the role of tid1 in isoproterenol (iso)-induced cardiac apoptosis and hypertrophy remains unclear. |
2019-02-26 |
2023-01-26 |
human |
| Asmaa A Ahmed, Amany A E Ahmed, Engy M El Morsy, Shahira Nofa. Dimethyl fumarate interferes with MyD88-dependent toll-like receptor signalling pathway in isoproterenol-induced cardiac hypertrophy model. The Journal of pharmacy and pharmacology vol 70 issue 11 2019 30175489 |
to investigate the effect of dimethyl fumarate (dmf) on toll-like receptor (tlr) signalling pathway in isoproterenol (iso)-induced cardiac hypertrophy in rats. |
2019-01-18 |
2023-01-26 |
rat |