| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christine Ibrahim, Victor M Tang, Daniel M Blumberger, Saima Malik, Rachel Tyndale, Allison Trevizol, Mera S Barr, Zafiris J Daskalakis, Abraham Zangen, Bernard Le Fol. Efficacy of insula deep repetitive transcranial magnetic stimulation combined with varenicline for smoking cessation: A randomized, double-blind, sham controlled trial. Brain stimulation. 2023-10-08. PMID:37806524. |
there is a large amount of evidence implicating the insula in nicotine addiction. |
2023-10-08 |
2023-10-15 |
Not clear |
| Wenyu Jiang, Luhui Cai, Ze Wan. Common hyper-entropy patterns identified in nicotine smoking, marijuana use, and alcohol use based on uni-drug dependence cohorts. Medical & biological engineering & computing. 2023-09-17. PMID:37718388. |
marijuana dependence and nicotine dependence showed overlapped hyper-brain entropy in bilateral dorso-lateral prefrontal cortex, anterior cingulate cortex, and right insula. |
2023-09-17 |
2023-10-07 |
human |
| Yu Chen, Shefali Chaudhary, Wuyi Wang, Chiang-Shan R L. Gray matter volumes of the insula and anterior cingulate cortex and their dysfunctional roles in cigarette smoking. Addiction neuroscience. vol 1. 2023-05-23. PMID:37220533. |
the salience network, including the insula and anterior cingulate cortex (acc), has been implicated in nicotine addiction. |
2023-05-23 |
2023-08-14 |
human |
| Yu Chen, Shefali Chaudhary, Wuyi Wang, Chiang-Shan R L. Gray matter volumes of the insula and anterior cingulate cortex and their dysfunctional roles in cigarette smoking. Addiction neuroscience. vol 1. 2023-05-23. PMID:37220533. |
the gmvs of the insula or dacc/sma were not significantly correlated with years of smoking or fagerstrom test for nicotine dependence (ftnd) scores. |
2023-05-23 |
2023-08-14 |
human |
| Dara G Ghahremani, Jean-Baptiste F Pochon, Maylen Perez Diaz, Rachel F Tyndale, Andy C Dean, Edythe D Londo. Nicotine dependence and insula subregions: functional connectivity and cue-induced activation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-03-03. PMID:36869233. |
nicotine dependence and insula subregions: functional connectivity and cue-induced activation. |
2023-03-03 |
2023-08-14 |
human |
| Dara G Ghahremani, Jean-Baptiste F Pochon, Maylen Perez Diaz, Rachel F Tyndale, Andy C Dean, Edythe D Londo. Nicotine dependence and insula subregions: functional connectivity and cue-induced activation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-03-03. PMID:36869233. |
nicotine dependence was negatively correlated with connectivity of the left and right dorsal, and left ventral anterior insula with regions within the superior parietal lobule (spl), including the left precuneus. |
2023-03-03 |
2023-08-14 |
human |
| Dara G Ghahremani, Jean-Baptiste F Pochon, Maylen Perez Diaz, Rachel F Tyndale, Andy C Dean, Edythe D Londo. Nicotine dependence and insula subregions: functional connectivity and cue-induced activation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-03-03. PMID:36869233. |
no relationship between posterior insula connectivity and nicotine dependence was found. |
2023-03-03 |
2023-08-14 |
human |
| Dara G Ghahremani, Jean-Baptiste F Pochon, Maylen Perez Diaz, Rachel F Tyndale, Andy C Dean, Edythe D Londo. Nicotine dependence and insula subregions: functional connectivity and cue-induced activation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023-03-03. PMID:36869233. |
cue-induced activation in the left dorsal anterior insula was positively associated with nicotine dependence and negatively associated with rsfc of the same region with spl, suggesting that craving-related responsivity in this subregion was greater among participants who were more dependent. |
2023-03-03 |
2023-08-14 |
human |
| Hussein Ghareh, Isis Alonso-Lozares, Dustin Schetters, Rae J Herman, Tim S Heistek, Yvar Van Mourik, Philip Jean-Richard-Dit-Bressel, Gerald Zernig, Huibert D Mansvelder, Taco J De Vries, Nathan J Marchan. Role of anterior insula cortex in context-induced relapse of nicotine-seeking. eLife. vol 11. 2022-05-10. PMID:35536612. |
the insular cortex (ic) is thought to be a critical substrate of nicotine addiction and relapse. |
2022-05-10 |
2023-08-13 |
rat |
| Hiroki Toyoda, Kohei Kog. Nicotine Exposure during Adolescence Leads to Changes of Synaptic Plasticity and Intrinsic Excitability of Mice Insular Pyramidal Cells at Later Life. International journal of molecular sciences. vol 23. issue 1. 2022-01-11. PMID:35008455. |
however, it has not been addressed whether and how nicotine exposure during adolescence alters these synaptic events and intrinsic excitability in the insular cortex in adulthood. |
2022-01-11 |
2023-08-13 |
mouse |
| Hiroki Toyoda, Kohei Kog. Nicotine Exposure during Adolescence Leads to Changes of Synaptic Plasticity and Intrinsic Excitability of Mice Insular Pyramidal Cells at Later Life. International journal of molecular sciences. vol 23. issue 1. 2022-01-11. PMID:35008455. |
to address this question, we performed whole-cell patch-clamp recordings to examine the effects of adolescent nicotine exposure on synaptic transmission, plasticity and intrinsic excitability in layer v pyramidal neurons (pns) of the mice insular cortex five weeks after the treatment. |
2022-01-11 |
2023-08-13 |
mouse |
| Hiroki Toyoda, Kohei Kog. Nicotine Exposure during Adolescence Leads to Changes of Synaptic Plasticity and Intrinsic Excitability of Mice Insular Pyramidal Cells at Later Life. International journal of molecular sciences. vol 23. issue 1. 2022-01-11. PMID:35008455. |
our data indicate that adolescent nicotine exposure enhances synaptic transmission, plasticity and intrinsic excitability in layer v pns of the mice insular cortex at later life, which might contribute to severe nicotine dependence in adulthood. |
2022-01-11 |
2023-08-13 |
mouse |
| Gregory C Loney, Christopher P King, Paul J Meye. Systemic nicotine enhances opioid self-administration and modulates the formation of opioid-associated memories partly through actions within the insular cortex. Scientific reports. vol 11. issue 1. 2021-11-11. PMID:33558613. |
systemic nicotine enhances opioid self-administration and modulates the formation of opioid-associated memories partly through actions within the insular cortex. |
2021-11-11 |
2023-08-13 |
Not clear |
| Gregory C Loney, Christopher P King, Paul J Meye. Systemic nicotine enhances opioid self-administration and modulates the formation of opioid-associated memories partly through actions within the insular cortex. Scientific reports. vol 11. issue 1. 2021-11-11. PMID:33558613. |
given the involvement of the insula in the maintenance of substance abuse, its importance in nicotine addiction, and findings that insular inactivation impairs contextual drug conditioning, we examined whether nicotine administered directly to the insula could recapitulate the effects of systemic nicotine. |
2021-11-11 |
2023-08-13 |
Not clear |
| Gregory C Loney, Christopher P King, Paul J Meye. Systemic nicotine enhances opioid self-administration and modulates the formation of opioid-associated memories partly through actions within the insular cortex. Scientific reports. vol 11. issue 1. 2021-11-11. PMID:33558613. |
in conclusion, these data demonstrate that nicotine facilitates opioid intake and is partly acting within the insular cortex to obfuscate aversive opiate memories while potentiating approach to morphine-associated stimuli at higher doses. |
2021-11-11 |
2023-08-13 |
Not clear |
| Maylen Perez Diaz, Jean-Baptiste Pochon, Dara G Ghahremani, Andy C Dean, Paul Faulkner, Nicole Petersen, Rachel F Tyndale, Andrea Donis, Diana Paez, Citlaly Cahuantzi, Gerhard S Hellemann, Edythe D Londo. Sex Differences in the Association of Cigarette Craving With Insula Structure. The international journal of neuropsychopharmacology. vol 24. issue 8. 2021-10-06. PMID:33830218. |
because cigarette craving is associated with nicotine dependence and structure of the insula, this study addressed whether a person's sex influences these associations. |
2021-10-06 |
2023-08-13 |
Not clear |
| Chao Wang, Shuyue Wang, Peiyu Huang, Zhujing Shen, Wei Qian, Xiao Luo, Kaicheng Li, Qingze Zeng, Quanquan Gu, Hualiang Yu, Yihong Yang, Minming Zhan. Abnormal white matter tracts of insula in smokers. Brain imaging and behavior. vol 15. issue 4. 2021-09-06. PMID:32974850. |
the insula, a cortical region that is thought to play a central role in this reward circuitry, has been implicated in the maintenance of nicotine addiction. |
2021-09-06 |
2023-08-13 |
Not clear |
| Chao Wang, Shuyue Wang, Peiyu Huang, Zhujing Shen, Wei Qian, Xiao Luo, Kaicheng Li, Qingze Zeng, Quanquan Gu, Hualiang Yu, Yihong Yang, Minming Zhan. Abnormal white matter tracts of insula in smokers. Brain imaging and behavior. vol 15. issue 4. 2021-09-06. PMID:32974850. |
however, it remains largely unclear about the white matter (wm) microstructural alterations of insula in nicotine addiction and whether the wm alterations of insula could predict smoking cessation outcomes. |
2021-09-06 |
2023-08-13 |
Not clear |
| Kainan S Wang, Maya Zegel, Elena Molokotos, Lauren V Moran, David P Olson, Diego A Pizzagalli, Amy C Jane. The acute effects of nicotine on corticostriatal responses to distinct phases of reward processing. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 7. 2021-05-27. PMID:31931509. |
during outcome, nicotine reduced nacc functional connectivity with cortical regions including the anterior cingulate cortex, orbitofrontal cortex, and insula. |
2021-05-27 |
2023-08-13 |
Not clear |
| Irene Perini, Robin Kämpe, Theodor Arlestig, Hanna Karlsson, Andreas Löfberg, Michal Pietrzak, Abraham Zangen, Markus Heili. Repetitive transcranial magnetic stimulation targeting the insular cortex for reduction of heavy drinking in treatment-seeking alcohol-dependent subjects: a randomized controlled trial. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 5. 2021-03-30. PMID:31711065. |
insula responses to drug cues are correlated with cravings, and lesions in this area reduce nicotine seeking. |
2021-03-30 |
2023-08-13 |
human |